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*  Cardiac glycoside - Wikipedia
... as done by cardiac glycosides. Nevertheless, due to questions of toxicity and dosage, cardiac glycosides have been replaced ... Kanji, Salmaan; MacLean, Robert D. (2012-10-01). "Cardiac glycoside toxicity: more than 200 years and counting". Critical Care ... Cheeke, Peter R. (1989-07-31). Toxicants of Plant Origin: Glycosides. CRC Press. ISBN 9780849369919. "Cardiac Glycoside Plant ... Cardiac glycosides have long served as the main medical treatment to congestive heart failure and cardiac arrhythmia, due to ...
  https://en.wikipedia.org/wiki/Cardiac_glycoside
*  Slouched posture | definition of slouched posture by Medical dictionary
Cardiac glycosides: increased risk of cardiac glycoside toxicity. Iron salts: decreased iron absorption ... Cardiac arrest. Adults: 0.027 to 0.054 mEq/kg calcium chloride I.V., 4.5 to 6.3 mEq calcium gluceptate I.V., or 2.3 to 3.7 mEq ... CV: mild blood pressure decrease, bradycardia, arrhythmias, cardiac arrest (with rapid I.V. injection) ...
  https://medical-dictionary.thefreedictionary.com/slouched+posture
*  Tips From Other Journals - American Family Physician
Cardiac glycosides cause symptoms similar to digoxin toxicity. Responds to digoxin antibody treatment ... and strophanthus contain an active cardiac glycoside that can potentiate digoxin.. The authors conclude that the growing use of ... Cardiac glycosides cause symptoms similar to digoxin toxicity. Responds to digoxin antibody treatment ... Herbal laxatives such as buckthorn, cascara sagrada, and senna can cause potassium loss that can lead to digitalis toxicity. A ...
  https://www.aafp.org/afp/2002/1001/p1318.html
*  Adelfa / Nerium oleander / SOUTH SEA ROSE : Philippine Medicinal Herbs / Philippine Alternative Medicine
Toxicity / Cardiac Glycosides / Oleandrin & Oleandrigenin: Considered a poisonous plant because of compounds that exhibit ... and glycosides. (33). - Study yielded glycoside, oleandrin; tannin; volatile oil, 0.25%.. - Yielded two principles: neriin and ... Toxicity was attributed to two potent cardiac glycosides, oleandrin and neriin, a strychnine like toxin, and a heart-active ... Toxicity / Seed Extract / Rodenticide: Study evaluated to basic toxicity of seed extract of Indian oleander on the bandicoot ...
  http://www.stuartxchange.com/Adelfa
*  Propranolol and Hydrochlorothiazide (Professional Patient Advice) - Drugs.com
Specifically, cardiac glycoside toxicity may be enhanced by the hypokalemic and hypomagnesemic effect of thiazide diuretics. ... Cardiac Glycosides: Beta-Blockers may enhance the bradycardic effect of Cardiac Glycosides. Monitor therapy ... Cardiac Glycosides: Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. ... When concurrent use is not avoidable, monitor patients closely for signs/symptoms of toxicity. Consider therapy modification ...
  https://www.drugs.com/ppa/propranolol-and-hydrochlorothiazide.html
*  Furosemide (Professional Patient Advice) - Drugs.com
Loop Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. Specifically, cardiac glycoside toxicity may be ... Management: Monitor for increased methotrexate and/or loop diuretic levels/toxicity with concomitant use of these agents and ... Electrolyte disturbances can predispose a patient to serious cardiac arrhythmias.. • Hyperuricemia: Asymptomatic hyperuricemia ...
  https://www.drugs.com/ppa/furosemide.html
*  Methyldopa and Hydrochlorothiazide (Professional Patient Advice) - Drugs.com
Specifically, cardiac glycoside toxicity may be enhanced by the hypokalemic and hypomagnesemic effect of thiazide diuretics. ... Cardiac Glycosides: Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. ...
  https://www.drugs.com/ppa/methyldopa-and-hydrochlorothiazide.html
*  Enalapril and Hydrochlorothiazide (Professional Patient Advice) - Drugs.com
Specifically, cardiac glycoside toxicity may be enhanced by the hypokalemic and hypomagnesemic effect of thiazide diuretics. ... Cardiac Glycosides: Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. ... Fetal toxicity:. When pregnancy is detected, discontinue enalapril/hydrochlorothiazide as soon as possible. Drugs that act ... Cholestatic jaundice: A rare toxicity associated with ACE inhibitors includes cholestatic jaundice, which may progress to ...
  https://www.drugs.com/ppa/enalapril-and-hydrochlorothiazide.html
*  Olmesartan and Hydrochlorothiazide (Professional Patient Advice) - Drugs.com
Specifically, cardiac glycoside toxicity may be enhanced by the hypokalemic and hypomagnesemic effect of thiazide diuretics. ... Cardiac Glycosides: Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. ... Fetal toxicity:. When pregnancy is detected, discontinue olmesartan/hydrochlorothiazide as soon as possible. Drugs that act ...
  https://www.drugs.com/ppa/olmesartan-and-hydrochlorothiazide.html
*  Indapamide (Professional Patient Advice) - Drugs.com
Specifically, cardiac glycoside toxicity may be enhanced by the hypokalemic and hypomagnesemic effect of thiazide diuretics. ... Cardiac Glycosides: Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. ... Cardiovascular: Cardiac arrhythmia, chest pain, flushing, orthostatic hypotension, palpitations, peripheral edema, vasculitis, ...
  https://www.drugs.com/ppa/indapamide.html
*  Poisonous Plants in Pastures
Milkweed (Asclepias syriaca) contains cardiac glycosides and has low to moderate toxicity. Milkweeds are unpalatable, and death ... The toxins include solanine, an alkaloidal glycoside; other glycosides; and atropine. They affect the gastric and nervous ... The toxicity depends on nitrogen levels in the soil and resulting nitrate levels in the plant. Redroot pigweed (Amaranthus ... The stage of growth or form in which it is eaten can affect the toxicity of some plants. Sweet clovers (Melilotus spp.) are ...
  http://www.mofga.org/Publications/MaineOrganicFarmerGardener/Summer2011/Pastures/tabid/1933/Default.aspx
*  Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain | PNAS
Clinically, the antagonism between cardiac glycosides and serum K+ is a well-known factor in cardiac glycoside toxicity. ... 1986) Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity. J Med Chem 29:1945-1952. ... 1985) Effects of K+ on the interaction between cardiac glycosides and Na,K-ATPase. Eur J Pharmacol 111:147-157. ... Cardiac glycosides have a tripartite structure: A 5- or 6-membered lactone ring, a steroid core and a carbohydrate moiety ...
  https://www.pnas.org/content/106/33/13742?ijkey=b8539f911fcb8aac7f84c75ad016f77edf19f01d&keytype2=tf_ipsecsha
*  Quinidine sulfate | definition of quinidine sulfate by Medical dictionary
Cardiac glycosides: increased cardiac glycoside blood level, greater risk of toxicity. Cholinergics: decreased quinidine effect ... Teach patient to recognize and immediately report signs and symptoms of toxicity, including tinnitus, nausea, headache, ... Because newer antiarrhythmics have replaced quinidine in many cardiac uses, it may not be readily available and prescribers may ...
  https://medical-dictionary.thefreedictionary.com/quinidine+sulfate
*  UZAPLEX (SYRUP)
UZAPLEX in combination with these herbs must be avoided because it can increase the risk of cardiac glycoside toxicity. ... you are currently receiving treatment with cardiac glycosides. UZAPLEX is contra-indicated in patients with heart disease. The ... Care should be taken to not exceed the maximum daily dose of UZAPLEX as side-effects typical of cardiac glycosides may occur. ... Cardiac glycoside-containing herbs including black hellebore, Canadian hemp roots, digitalis leaf, hedge mustard, lily of the ...
  http://home.intekom.com/pharm/lamar/uzaplex.html
*  NaK alpha1-subunit and in vitro growth inhibition of ca | Open-i
A: Correlation of Ki for inhibition of human α1β1 by cardiac glycosides and the growth inhi ... Cardiac Glycosides/chemistry/metabolism/pharmacology/toxicity. *Cell Line, Tumor. *Cell Proliferation/drug effects ... steroid aglycones usually display weaker binding affinity and in vitro anticancer activity than the corresponding glycoside, ... Bottom Line: In addition, while some cardiac steroid glycosides (e.g., digoxin), but not the aglycones, display a higher ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3722118_1476-4598-12-33-2&req=4
*  Drug Summary
Amphotericin B: (Moderate) Amphotericin B-induced hypokalemia can potentiate the cardiac toxicity of cardiac glycosides (e.g., ... can accelerate the metabolism of cardiac glycosides, including digoxin. Decreasing cardiac glycoside serum concentrations could ... Administration of mannitol to patients receiving cardiac glycosides can increase the risk of developing cardiac toxicity ... Administration of mannitol to patients receiving cardiac glycosides can increase the risk of developing cardiac toxicity ...
  http://www.pdr.net/drug-summary/Lanoxin-Injection-digoxin-208
*  Lanoxin Injection (digoxin) dose, indications, adverse effects, interactions... from PDR.net
Amphotericin B: (Moderate) Amphotericin B-induced hypokalemia can potentiate the cardiac toxicity of cardiac glycosides (e.g., ... can accelerate the metabolism of cardiac glycosides, including digoxin. Decreasing cardiac glycoside serum concentrations could ... Administration of mannitol to patients receiving cardiac glycosides can increase the risk of developing cardiac toxicity ... Administration of mannitol to patients receiving cardiac glycosides can increase the risk of developing cardiac toxicity ...
  https://www.pdr.net/drug-summary/Lanoxin-Injection-digoxin-208
*  Plus it
... which resembles cardiac glycoside toxicity (James et al., 1999).. In humans, the situation is complicated by the fact that α1, ... It has been postulated that the interaction of cardiac glycosides with the Na,K-ATPase occurs in at least two steps: an initial ... In rodents, the α1 isoform exhibits a nearly 1000-fold lower affinity for cardiac glycosides than α2 or α3 isoforms. Because ... Middleton DA, Rankin S, Esmann M, and Watts A (2000) Structural insights into the binding of cardiac glycosides to the ...
  http://molpharm.aspetjournals.org/content/65/2/335
*  Digoxin (Professional Patient Advice) - Drugs.com
Loop Diuretics: May enhance the adverse/toxic effect of Cardiac Glycosides. Specifically, cardiac glycoside toxicity may be ... May enhance the adverse/toxic effect of Cardiac Glycosides. Specifically, cardiac glycoside toxicity may be enhanced by the ... Itraconazole: May increase the serum concentration of Cardiac Glycosides. Management: Consider preemptive cardiac glycoside ... Metaraminol: May enhance the arrhythmogenic effect of Cardiac Glycosides. Monitor therapy. Midodrine: Cardiac Glycosides may ...
  https://www.drugs.com/ppa/digoxin.html
*  K-Strophanthidin - Wikipedia
Ouabain Digoxin Myocardial infarction Toxicity Detoxification Muscle contraction Cardiac glycosides 新药研发咨询中心. "k-Strophanthidin ... is a cardiac glycoside which works as an inhibitor of Na+ /K+-ATPase . This inhibition has an inotropic effect on the cardiac ... Aglycone or genin is glycoside with a non-sugar, while glucoside is a glycoside with a sugar as glucose. The strophanthin from ... Strophantidin is a cardiac glycoside which mechanism of action is similar to Digitalis, Ouabain and digitoxin. It specifically ...
  https://en.wikipedia.org/wiki/K-Strophanthidin
*  Cerberin - Wikipedia
... the following is general information regarding cardiac glycoside toxicity, with an emphasis on information from cardenolides (i ... those who are poisoned by ingesting cardiac glycosides experience, within an hour, a variety of gastrointestinal and cardiac ... Cerberin, as a cardiac glycoside, is seen as binding to and inhibiting the cellular Na+/K+ -ATPase, because it binds to the ... Cerberin, like all cardiac glycosides, has as its core a steroid-type set of four carbocycles (all-carbon rings). In cerberin, ...
  https://en.wikipedia.org/wiki/Cerberin
*  Nerium - Wikipedia
... known as cardiac glycosides, which are known to have a narrow therapeutic index and can be toxic when ingested. Toxicity ... are relatively sensitive to the effects of cardiac glycosides and the clinical manifestations of "glycoside intoxication". ... Cardiac Glycosides. Prince Leopold Institute of Tropical Medicine. Retrieved on 2009-07-27. Desai, Umesh R. Cardiac glycosides ... Newman, R. A; Yang, P; Pawlus, A. D; Block, K. I (2008). "Cardiac Glycosides as Novel Cancer Therapeutic Agents". Molecular ...
  https://en.wikipedia.org/wiki/Nerium
*  Oleandrin - Wikipedia
There is also accumulation in the cardiac tissue, which explains its potential for cardiac toxicity. In mouse studies, it also ... Oleandrin has been used for many years in China and Russia for its properties as a cardiac glycoside, for both suicidal and ... Frese, S.; Frese-Schaper, M; Andres, AC; Miescher, D; Zumkehr, B; Schmid, RA (2006). "Cardiac Glycosides Initiate Apo2L/TRAIL- ... Oleandrin is a toxic cardiac glycoside found in oleander (Nerium oleander L.). Along with neandrin it is primarily responsible ...
  https://en.wikipedia.org/wiki/Oleandrin
*  Arenobufagin - Wikipedia
There is a rather large homology in structure between arenobufagin and cardiac glycosides. Cardiac glycosides are natural ... Structure of Arenobufagin Structure of a Cardiac Glycoside Although a low dosis of arenobufagin can be used as a medicine of ... Toxicity because of chronic exposure was not clearly documented thus far. However it is discussed that the chronic exposure to ... Arenobufagin works like Cardiac glycosides. It inhibits the sodium-potassium pump because it stabalises the E2-P transition ...
  https://en.wikipedia.org/wiki/Arenobufagin
*  Medicinal plants - Wikipedia
... a cardiac glycoside. The plant was used on heart conditions long before the glycoside was identified. Digoxin is used to treat ... The cardiac glycosides are powerful drugs from medicinal plants including foxglove and lily of the valley. They include digoxin ... Freye, Enno (2010). Toxicity of Datura Stramonium. Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related ... Cardiac Glycoside". Texas A&M University. Retrieved 26 February 2017. The man credited with the introduction of digitalis into ...
  https://en.wikipedia.org/wiki/Medicinal_plants