*  Na,K-ATPase is essential for embryonic heart development in the zebrafish | Development
K-ATPase α subunit is known to be associated with multiple cytoskeletal proteins (for a review, see Therien and Blostein, 2000 ... Cardiac cells (arrows) are visualized by in situ hybridization analysis using a vmhc probe. (A) Bilateral cardiac primordia ... The predicted protein of this minor splice variant has a stop codon at amino acid 822, which results in a truncated protein ... Both cardiac chambers (atrium and ventricle) and both cardiac cell types (myocardium and endocardium) are developed in two-day- ...
  http://dev.biologists.org/content/130/25/6165
*  Abstract 16094: RAB3 GTPase Activating Protein Subunit 1 is a Novel Candidate Gene for Sudden Cardiac Death | Circulation
Abstract 16094: RAB3 GTPase Activating Protein Subunit 1 is a Novel Candidate Gene for Sudden Cardiac Death. Adriana Huertas- ... Abstract 16094: RAB3 GTPase Activating Protein Subunit 1 is a Novel Candidate Gene for Sudden Cardiac Death ... Abstract 16094: RAB3 GTPase Activating Protein Subunit 1 is a Novel Candidate Gene for Sudden Cardiac Death ... Abstract 16094: RAB3 GTPase Activating Protein Subunit 1 is a Novel Candidate Gene for Sudden Cardiac Death ...
  http://circ.ahajournals.org/content/126/Suppl_21/A16094
*  Eva Neer - Wikipedia
Location and function of reactive sulfhydryl groups of alpha subunit 39 (1987) Action of G protein subunits on the cardiac ... "Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel". ... for her discoveries on G-protein subunit structure and function. She described the physiological roles of these subunits as an ... Neer, EJ; Clapham, DE (May 12, 1988). "Roles of G protein subunits in transmembrane signalling". Nature. 333 (6169): 129-34. ...
  https://en.wikipedia.org/wiki/Eva_Neer
*  Activators of TRPM2: Getting it right | JGP
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc. ... For example, the roles of different G protein subunits in activating G protein-coupled inwardly rectifying potassium (GIRK) ... The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 325:321-326. doi:10.1038/ ... The alpha subunit of the GTP binding protein Gk opens atrial potassium channels. Science. 236:442-445. doi:10.1126/science. ...
  http://jgp.rupress.org/content/early/2015/05/05/jgp.201511405
*  Plus it
Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits ... In this regard, atorvastatin can modulate β-adrenergic cAMP generation and signaling by isoprenylation of G-protein γ subunits ... Although one target of isoprenylation is monomeric G-proteins (e.g., Ras), heterotrimeric G-proteins can also undergo ... 2001) Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1−/− cells. J Biol Chem 276:7240-7245. ...
  http://www.jneurosci.org/content/30/16/5579
*  Frontiers | Connexin diversity in the heart: insights from transgenic mouse models | Pharmacology
... protein subunits. The connexin family of proteins consists of 24 members, varying in their biophysical properties and ability ... We discuss the cardiac phenotype in these models and compare Cx expression between mice and men. Mouse models have enhanced our ... protein subunits. The connexin family of proteins consists of 24 members, varying in their biophysical properties and ability ... We discuss the cardiac phenotype in these models and compare Cx expression between mice and men. Mouse models have enhanced our ...
  https://www.frontiersin.org/articles/10.3389/fphar.2013.00081/full
*  The future of male birth control may be found in poisonous arrow tips
Some of the ion-transporting protein subunits targeted by ouabain are found in cardiac tissue - its ability to disrupt proper ... A cross-section of a cell membrane shows how pumps made of protein subunits move sodium and potassium ions in and out of the ... But ouabain also affects another type of transporter subunit called α4, which is found only in sperm cells. This protein is ... versions of the molecule that are more likely to bind to the α4 protein in sperm than other subunits in heart tissue. ...
  http://theweek.com/articles/754761/future-male-birth-control-may-found-poisonous-arrow-tips
*  Search | eLife
The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers Kouki K Touhara et al. ... The GIRK1 subunit contains a defective Na+-binding site but behaves as if it is permanently bound to a sodium ion, and ... blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein ...
  https://elifesciences.org/search?for=Down%20syndrome&sort=relevance&order=ascending
*  Atp1b1 - Sodium/potassium-transporting ATPase subunit beta-1 - Rattus norvegicus (Rat) - Atp1b1 gene & protein
The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma ... relaxation of cardiac muscle Source: Ensembl. *response to hypoxia Source: RGD ,p>Inferred from Direct Assay,/p> ,p>Used to ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P07340. P05026. A3KLL5. V9GYR2. B7Z9S8. Q58I20. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P07340. P05026. A3KLL5. V9GYR2. B7Z9S8. Q58I20. ...
  http://www.uniprot.org/uniprot/P07340
*  gq g11 gtp binding protein alpha subunits
Research Grants about gq g11 gtp binding protein alpha subunits ... to contribute to the transition from hypertrophy to cardiac ... gi go gtp binding protein alpha subunits*phospholipase c*g protein coupled receptors*calcium*rgs proteins*transfection*protein ... gtp binding protein alpha subunits*cyclic amp*knockout mice*g12 g13 gtp binding protein alpha subunits*patch clamp techniques* ... gtp binding protein beta subunits*estrenes*calcium channels*gtp binding protein gamma subunits*platelet aggregation*inositol ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/heterotrimeric/gtp/gq-g11-gtp-binding-protein-alpha-subunits-12352.html
*  Downregulation of cardiac myocyte Na+-K+-ATPase by adenovirus-mediated expression of an α-subunit fragment | Heart and...
Downregulations of the α1- and the α3-subunit proteins in neonatal cardiac myocytes transfected with the α2-adenovirus. ... Therefore, by disruption of such protein-protein interactions, a fragment or a mutant of a Na+-K+-ATPase subunit may also exert ... Downregulation of cardiac myocyte Na+-K+-ATPase by adenovirus-mediated expression of an α-subunit fragment. Peter Kometiani, ... 1999) Rat skeletal muscle in culture expresses the α1 but not the α2 protein subunit isoform of the Na+/K+ pump. J Cell Physiol ...
  http://ajpheart.physiology.org/content/280/3/H1415.long
*  HADHA - Wikipedia
"hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit". Cardiac ... trifunctional protein), alpha subunit is a protein that in humans is encoded by the HADHA gene. HADHA is a 82.9 kDa protein ... The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the ... This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of ...
  https://en.wikipedia.org/wiki/HADHA
*  Atp1a2 - Sodium/potassium-transporting ATPase subunit alpha-2 precursor - Rattus norvegicus (Rat) - Atp1a2 gene & protein
relaxation of cardiac muscle Source: BHF-UCL ,p>Inferred by Curator,/p> ,p>Used for cases where an annotation is not supported ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P06686. Q6PIE5. Q3UHK5. Q8R3A9. UPI000A323A4A. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P06686. P13637. F7HPP6. A0A0D9S121. F6Z1R0. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P06686. P50993. A0A0S2Z3W6. H2N554. UPI0004F45268 ...
  http://www.uniprot.org/uniprot/P06686
*  FSH Regulation of cAMP-Dependent Protein Kinase Regulatory Subunits in Rat and Porcine Ovarian Tissues | SpringerLink
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and ... The regulatory subunit of neural cAMPdependent protein kinase II represents a unique gene product. J Biol Chem 1985; 260: 6440- ... Coelution of the type II holoenzyme form of cAMP-dependent protein kinase with regulatory subunits of the type I form of cAMP- ... The neural type II regulatory subunit of cAMP-dependent protein kinase is present and regulated by hormones in the rat ovary. J ...
  https://link.springer.com/chapter/10.1007/978-1-4684-7103-8_12
*  SCN5A Antibody
Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V ... Protein Aliases: cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CMD1E; CMPD2; HB1; ... protein binding. calmodulin binding. fibroblast growth factor binding. enzyme binding. protein kinase binding. protein domain ... cardiac muscle cell action potential involved in contraction regulation of cardiac muscle cell contraction ventricular cardiac ...
  https://www.thermofisher.com/antibody/product/Nav15-SCN5A-Antibody-Polyclonal/PA5-34190
*  Atp1a4 - Sodium/potassium-transporting ATPase subunit alpha-4 - Mus musculus (Mouse) - Atp1a4 gene & protein
Specifically inhibited by an endogenous cardiac glycoside, ouabain.By similarity. Sites. Feature key. Position(s). Description ... Protein-protein interaction databases. Protein interaction database and analysis system. More...IntActi. Q9WV27. 5 interactors. ... Protein-protein interaction databases. Protein interaction database and analysis system. More...IntActi. Q9WV27. 5 interactors. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q9WV27. Q91ZN9. Mus musculus (Mouse). 1,032. ...
  http://www.uniprot.org/uniprot/Q9WV27
*  Atp1a4 - Sodium/potassium-transporting ATPase subunit alpha-4 - Rattus norvegicus (Rat) - Atp1a4 gene & protein
Specifically inhibited by an endogenous cardiac glycoside, ouabain.By similarity. Sites. Feature key. Position(s). Description ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 10116. ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 10116. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q64541. Q5PQV3. Rattus norvegicus (Rat). 1,028. ...
  http://www.uniprot.org/uniprot/Q64541
*  The AMEDEO Literature Guide
Association of G-protein beta3 subunit gene C825T polymorphism with cardiac and cerebrovascular events in Chinese hypertensive ... Retinoblastoma-associated protein 140 as a candidate for a novel etiological gene to hypertension.. Clin Exp Hypertens. 2016.. ... Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects ... VEGF-C-mediated cardiac lymphangiogenesis in high salt intake accelerated progression of left ventricular remodeling in ...
  http://amedeo.com/medicine/hyp/clexhy.htm
*  HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
View protein in InterPro. IPR011598. bHLH_dom. IPR001321. HIF-1_alpha. IPR014887. HIF-1_TAD_C. IPR021537. HIF_alpha_subunit. ... cardiac ventricle morphogenesis Source: Ensembl. *cartilage development Source: Ensembl. *cellular iron ion homeostasis Source ... View protein in InterPro. IPR011598. bHLH_dom. IPR001321. HIF-1_alpha. IPR014887. HIF-1_TAD_C. IPR021537. HIF_alpha_subunit. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. A0JND0. Q16665. D0VY79. Q0PGG5. UPI0007047D94. ...
  http://www.uniprot.org/uniprot/A0JND0
*  Camk2a - Calcium/calmodulin-dependent protein kinase type II subunit alpha - Mus musculus (Mouse) - Camk2a gene & protein
positive regulation of cardiac muscle cell apoptotic process Source: MGI ,p>Inferred from Mutant Phenotype,/p> ,p>Describes ... View protein in PROSITE. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 ... View protein in PROSITE. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 ... Index of Protein Data Bank (PDB) cross-references *Human and mouse protein kinases. Human and mouse protein kinases: ...
  http://www.uniprot.org/uniprot/P11798-2
*  Sdhb - Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor - Mus musculus (Mouse) - Sdhb gene &...
... subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is ... Protein. Similar proteins. Species. Score. Length. Source. Q9CQA3. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, ... ENSMUSG00000009863 Expressed in 314 organ(s), highest expression level in cardiac ventricle. ... Protein. Similar proteins. Species. Score. Length. Source. Q9CQA3. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, ...
  https://www.uniprot.org/uniprot/Q9CQA3
*  GNAQ - Guanine nucleotide-binding protein G(q) subunit alpha - Homo sapiens (Human) - GNAQ gene & protein
G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection ... Note: Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.By similarity ... help/subunit_structure' target='_top'>More...,/a>,/p>Subunit structurei. G proteins are composed of 3 units; alpha, beta and ... Guanine nucleotide-binding protein G(q) subunit alphaAdd BLAST. 359. Amino acid modifications. Feature key. Position(s). ...
  https://www.uniprot.org/uniprot/P50148
*  Gnaq - Guanine nucleotide-binding protein G(q) subunit alpha - Rattus norvegicus (Rat) - Gnaq gene & protein
G proteins) are involved as modulators or transducers in various transmembrane signaling systems. ... Note: Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.By similarity ... G-protein beta/gamma-subunit complex binding Source: GO_Central. *protein complex binding Source: RGD ,p>Inferred from Physical ... help/subunit_structure' target='_top'>More...,/a>,/p>Subunit structurei. G proteins are composed of 3 units; alpha, beta and ...
  http://www.uniprot.org/uniprot/P82471
*  Characterization of G-Protein-Gated K+ Channels Composed of Kir3.2 Subunits in Dopaminergic Neurons of the Substantia Nigra |...
1995) Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward ... 1996) The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. FEBS Lett 379:31- ... Characterization of G-Protein-Gated K+ Channels Composed of Kir3.2 Subunits in Dopaminergic Neurons of the Substantia Nigra. ... When tagged with GFP, the Kir3.2c protein was localized at the plasma membrane (Fig.7 Af). Thus, the Kir3.2c subunit seems to ...
  http://www.jneurosci.org/content/19/3/1006
*  Integrin-regulated Secretion of Interleukin 4: A Novel Pathway of Mechanotransduction in Human Articular Chondrocytes | JCB
1989) G-protein β gamma-subunits activate the cardiac muscarinic K+ channel via phospholipase A2. Nature 337:557-560, pmid: ... 1996) Mechanical stretch activates the stress activated protein kinases in cardiac myocytes. FASEB (Fed Am Soc Exp Biol) J 10: ... protein kinase C. RT-PCR. reverse transcriptase-PCR. SK. small conductance Ca2+-dependent K+ channels. TGF-β1. transforming ... 1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595, pmid:3106339.. ...
  http://jcb.rupress.org/content/145/1/183