*  Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in...
Myosin light chain kinase (MLCK)-dependent phosphorylation of the regulatory light chain (RLC) of cardiac myosin is known to ... Journal Article: Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic ... Title: Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic ... Tg-S15D-D166V mice were generated with the human cardiac RLC-S15D-D166V construct substituted for mouse cardiac RLC and were ...
  https://www.osti.gov/scitech/biblio/1212938-constitutive-phosphorylation-cardiac-myosin-regulatory-light-chain-prevents-development-hypertrophic-cardiomyopathy-mice
*  Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase
Keywords: Ca2+/calmodulin, Muscle contraction, Myosin light chain kinase, Regulatory myosin light chain ... Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase. Osamu ... Cardiac-specific myosin light chain kinase (cMLCK) is the kinase predominantly responsible for the maintenance of the basal ... level of phosphorylation of cardiac myosin light chain 2 (MLC2), which it phosphorylates at Ser-15. This phosphorylation repels ...
  https://www.jstage.jst.go.jp/article/circj/77/9/77_CJ-13-0627/_article
*  Arachidonic Acid-Dependent Phosphorylation of Troponin I and Myosin Light Chain 2 in Cardiac Myocytes | Circulation Research
Phosphorylation of cardiac myosin light chain 2 by protein kinase C and myosin light chain kinase increases Ca2+-stimulated ... Isolation of cardiac myofibrils and myosin light chains with in vivo levels of light chain phosphorylation. Biochem Biophys ... TnT indicates troponin T; Tm, tropomyosin; TnI, troponin I; MLC1, myosin light chain 1; and MLC2, myosin light chain 2. After ... myosin light chain 2; MLC1, myosin light chain 1; TnI, troponin I; Tm, tropomyosin; and TnT, troponin T. Similar results were ...
  http://circres.ahajournals.org/content/76/6/1011
*  Anti-Myosin Light Chain 2 antibody (ab48003) | Abcam
Rabbit polyclonal Myosin Light Chain 2 antibody validated for WB, ELISA, IHC, ICC/IF and tested in Rat. Referenced in 8 ... Lane 1 : Vascular myosin (rat aorta), loaded with 35 µg of lysate. Lane 2 : Cardiac myosin (mouse heart, loaded with 35 µg of ... Anti-Myosin Light Chain 2 antibody. See all Myosin Light Chain 2 primary antibodies. ... ab48003 (2µg/ml) staining Myosin Light Chain 2 in human skeletal muscle using an automated system (DAKO Autostainer Plus). ...
  http://www.abcam.com/myosin-light-chain-2-antibody-ab48003.html
*  Frontiers | Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases | Pharmacology
... induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain. ... induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain. ... 2016). Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Proc. Natl ... 2014). Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00292/full
*  Development of an immunoradiometric assay kit for ventricular myosin light chain I with monoclonal antibodies. - Semantic...
Development of an immunoradiometric assay kit for ventricular myosin light chain I with monoclonal antibodies.' by Hideki Katoh ... Fractionation of the light chains from rat and rabbit cardiac myosin.. *Y Yazaki, S Mochinaga, M S Raben ... Radioimmunoassay of cardiac myosin light chain II in the serum following experimental myocardial infarction.. *R Nagai, S Ueda ... Quantitative relationship between left ventricular function and serum cardiac myosin light chain I levels after coronary ...
  https://www.semanticscholar.org/paper/Development-of-an-immunoradiometric-assay-kit-for-I-Katoh-Sugi/dc963349864898b2c0c5292f9d22479ef24add1d
*  Goat Anti-HSPC150 Polyclonal Antibody, Unconjugated from Abcam
Mouse monoclonal [MLM544] to cardiac Myosin light chain 1 ( Abpromise for all tested applications). entrezGeneID: 4634 ... Clone RMT1-4 from BioLegendRABBIT HAEMOLYTIC SERA from AbD SerotecMouse Anti-Myosin, light chain 1, cardiac Monoclonal Antibody ...
  http://www.bio-medicine.org/biology-products/Goat-Anti-HSPC150-Polyclonal-Antibody--Unconjugated-from-Abcam-5553-1/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Neuregulin infusion in rodents increases cardiac myosin light chain kinase (cMLCK) expression and cardiac myosin regulatory ... The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. ... This study involved experimental autoimmune myocarditis (EAM) induced with cardiac myosin heavy chain (Myhc)-α 334-352 in A/J ...
  https://www.jove.com/visualize/abstract/23776695/the-effects-neuregulin-on-cardiac-myosin-light-chain-kinase-gene
*  Myosin light chain 3 Research Products: Novus Biologicals
Browse our Myosin light chain 3 product catalog backed by our Guarantee+. ... Myosin light chain 3 products available through Novus Biologicals. ... Cardiac Arrhythmia. Pathways for Myosin light chain 3. View related products by pathway and learn more about each of the ... Diseases related to Myosin light chain 3. Discover more about diseases related to Myosin light chain 3.. Cardiomyopathies. ...
  https://www.novusbio.com/common-name/myosin-light-chain-3
*  Abnormalities of calcium cycling in the hypertrophied and failing heart. - Semantic Scholar
... regulatory defects in the early stages of cardiac diseases can delay or prevent the onset of CHF. ... Progressive deterioration of cardiac contractility is a central feature of congestive heart failure (CHF) in humans. In this ... Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.. * ... KChIP2 is a core transcriptional regulator of cardiac excitability. *Drew M Nassal, Xiaoping Wan, +6 authors Isabelle Deschênes ...
  https://www.semanticscholar.org/paper/Abnormalities-of-calcium-cycling-in-the-hypertroph-Houser-Piacentino/00506b1360be239c1263619f3624c95e1190235d
*  Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka,...
Using the zebrafish cardiac myosin light chain 2 (cmlc2) promoter, we visualized the heart for screening transgene-positive ... Using the zebrafish cardiac myosin light chain 2 (cmlc2) promoter, we visualized the heart for screening transgene-positive ... This construct contains the cardiac myosin light chain 2 (cmlc2) promoter region to express EGFP in the heart for screening. (b ... This construct contains the cardiac myosin light chain 2 (cmlc2) promoter region to express EGFP in the heart for screening. (b ...
  https://www.deepdyve.com/lp/ou_press/morphological-analysis-of-the-axonal-projections-of-egfp-labeled-esr1-1TD28XcU54
*  Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning | Philosophical Transactions of...
g) Whole-mount in situ hybridization of a 48 hours post-fertilization larva with cardiac myosin light chain to illustrate heart ... 2004 A southpaw joins the roster: the role of the zebrafish nodal-related gene southpaw in cardiac LR asymmetry. Trends ...
  http://rstb.royalsocietypublishing.org/content/363/1495/1377
*  Isometric and Dynamic Contractile Properties of Porcine Skinned Cardiac Myocytes After Stunning | Circulation Research
Reversible dissociation of dog cardiac myosin regulatory light chain 2 and its influence on ATP hydrolysis. J Biol Chem.. 1985; ... Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Circulation. 1992;85:1720-1733. ... Effects of partial extraction of light chain 2 on the Ca2+ sensitivities of isometric tension, stiffness, and velocity of ... extraction of MLC2 caused a reduction in the maximal actin-activated cardiac myosin ATPase rate,31 and mechanical studies found ...
  http://circres.ahajournals.org/content/77/5/964
*  Patente US20030204206 - Electrically responsive promoter system - Google Patentes
... and the cardiac-specific myosin light chain-2 promoter (a 2.1 kbp KpnI/EcoRI fragment from the rat cardiac myosin light chain-2 ... Knowlton, K. U., et al., Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 gnes during α- ... Included are the cardiac alpha-myosin heavy chain (AMHC) promoter and the cardiac alpha-actin promoter. Suitable kidney- ... Mahdavi, V., et al., Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem, Proc Natl Acad Sci U S A. 81(9): ...
  http://www.google.es/patents/US20030204206
*  Neuregulin 1 - Wikipedia
Downstream effectors of NRG-1/ErbB, include cardiac-specific myosin light chain kinase (cMLCK), Protein Phosphatase type 1 (PP1 ... "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812-24. ... "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571-80. doi:10.1161/CIRCRESAHA.107.161687. ... The cMLCK protein is an important regulator of sarcomere assembly through activation of the myosin regulatory light chain, as ...
  https://en.wikipedia.org/wiki/Neuregulin_1
*  Publications
Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in vivo. Audrey N. Chang, Pavan K. Battiprolu, Patrick M ...
  http://www.msbioworks.com/resources/publications/
*  Biology | Free Full-Text | Next-Generation Sequencing: From Understanding Biology to Personalized Medicine | HTML
A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo ... Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol. Med. 2013, 5, 1-17. [Google Scholar] ... Sanger, F.; Nicklen, S.; Coulson, A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 1977, 74, ... Biesiadecki, B.J.; Elder, B.D.; Yu, Z.B.; Jin, J.P. Cardiac troponin t variants produced by aberrant splicing of multiple exons ...
  http://www.mdpi.com/2079-7737/2/1/378/htm
*  MYL2 - PrimePCR Assay and Template | Life Science | Bio-Rad
Myosin, light chain 2, regulatory, cardiac, slow Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression ... Myosin, light chain 2, regulatory, cardiac, slow Assay Type: Probe Assay Design: Exonic Application: Gene Expression Unique ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/gene/myl2-cow
*  Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium | Development
... line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain ... also known as myosin heavy chain 6 (myh6)] contributes cardiac muscle to the apex of the growing ventricle. Our findings ... 1985). Slow and fast myosin heavy chain content defines three types of myotubes in early muscle cell cultures. J. Cell. Biol. ... 2011). Zebrafish as a model to study cardiac development and human cardiac disease. Circ. Res. 91, 279-288. doi:10.1093/cvr/ ...
  http://dev.biologists.org/content/143/10/1688
*  MYLK3 - Wikipedia
Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates ... 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): ... "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812-24. ... "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571-80. doi:10.1161/CIRCRESAHA.107.161687. ...
  https://en.wikipedia.org/wiki/MYLK3
*  Differential roles for 3-OSTs in the regulation of cilia length and motility | Development
... line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain ... 1999). Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Dev. Biol. ... In light of the advances in molecular and cellular biology since then, a succinct modern view of the question states: how do ... 1996). Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Dev. Biol. 177, 96-103. ...
  http://dev.biologists.org/content/140/18/3892
*  Blog on Optical Tweezers: October 2009
Here, we studied the role of the cardiac myosin regulatory light chains (RLCs) in the capacity of myosin to produce force using ... Removal of the cardiac myosin regulatory light chain increases isometric force production ... The myosin neck, which is supported by the interactions between light chains and the underlying alpha-helical heavy chain, is ... myosin, RLC-depleted PC (PCdepl) myosin, and PC myosin reconstituted with recombinant bacterially expressed human cardiac RLC ( ...
  http://opticaltweezers.blogspot.com/2009_10_01_archive.html
*  Regulation of Very-Low-Density Lipoprotein Receptor in Hypertrophic Rat Heart | Circulation Research
Transcriptional activation of the cardiac myosin light chain-2 and atrial natriuretic factor genes by protein kinase C in ... Heart myosin light chain 2 gene: nucleotide sequence of full length cDNA and expression in normal and hypertensive rat. J Biol ... The cardiac β-myosin heavy chain isogene is induced selectively in α1-adrenergic receptor-stimulated hypertrophy of cultured ... of the rat β-myosin heavy chain promoter by an α1-adrenergic agonist and activated β-protein kinase C in hypertrophy of cardiac ...
  http://circres.ahajournals.org/content/78/1/8
*  Faculty Briefs - 2009
2009). "Repression of the cardiac myosin light chain-2 gene in skeletal muscle requires site-specific association on antithetic ... Bhagavati, S., P.J. Maccabee, W. Xu (2009). "The neurofilament light chain gene (NEFL) mutation Pro22Ser can be associated with ... 2009). "Cardiac repolarization indices in epilepsy patients." Cardiology 114(4): 255-260.. Newman, M.D., M> Stotland, J.I. ... 2009). "Witnessing a rare event - cardiac thromboembolism." Clinical Cardiology 32(7): E18-E19.. Kies, M.S., J. Harris, M.Z. ...
  http://library.downstate.edu/resources/facultybriefs2009.htm
*  skMLCK (human)
Myosin light chain kinase 2, skeletal/cardiac muscle Show on y-axis - ...
  https://www.phosphosite.org/proteinAction.action?id=2115&showAllSites=true