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*  Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in...
Myosin light chain kinase (MLCK)-dependent phosphorylation of the regulatory light chain (RLC) of cardiac myosin is known to ... Journal Article: Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic ... Title: Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic ... Tg-S15D-D166V mice were generated with the human cardiac RLC-S15D-D166V construct substituted for mouse cardiac RLC and were ...
  https://www.osti.gov/scitech/biblio/1212938-constitutive-phosphorylation-cardiac-myosin-regulatory-light-chain-prevents-development-hypertrophic-cardiomyopathy-mice
*  Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase
Keywords: Ca2+/calmodulin, Muscle contraction, Myosin light chain kinase, Regulatory myosin light chain ... Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase. Osamu ... Cardiac-specific myosin light chain kinase (cMLCK) is the kinase predominantly responsible for the maintenance of the basal ... level of phosphorylation of cardiac myosin light chain 2 (MLC2), which it phosphorylates at Ser-15. This phosphorylation repels ...
  https://www.jstage.jst.go.jp/article/circj/77/9/77_CJ-13-0627/_article
*  Arachidonic Acid-Dependent Phosphorylation of Troponin I and Myosin Light Chain 2 in Cardiac Myocytes | Circulation Research
Phosphorylation of cardiac myosin light chain 2 by protein kinase C and myosin light chain kinase increases Ca2+-stimulated ... Isolation of cardiac myofibrils and myosin light chains with in vivo levels of light chain phosphorylation. Biochem Biophys ... TnT indicates troponin T; Tm, tropomyosin; TnI, troponin I; MLC1, myosin light chain 1; and MLC2, myosin light chain 2. After ... myosin light chain 2; MLC1, myosin light chain 1; TnI, troponin I; Tm, tropomyosin; and TnT, troponin T. Similar results were ...
  http://circres.ahajournals.org/content/76/6/1011
*  A functional recombinant myosin II lacking a regulatory light chain-binding site. - Semantic Scholar
... is a hexamer of two heavy chains, two essential light chains, and two regulatory light chains (RLCs). Dictyostelium myosin II ... Cells in which the wild-type myosin II heavy chain was replaced with a recombinant form that lacks the binding site for RLC ... the heavy chain plays an inhibitory role for adenosine triphosphatase activity and a structural role for the movement of myosin ... Myosin II, which converts the energy of adenosine triphosphate hydrolysis into the movement of actin filaments, ...
  https://www.semanticscholar.org/paper/A-functional-recombinant-myosin-II-lacking-a-light-Uyeda-Spudich/667f777bf6f06fa257f474a566eefb26dc90e813
*  Goat Anti-HSPC150 Polyclonal Antibody, Unconjugated from Abcam
Mouse monoclonal [MLM544] to cardiac Myosin light chain 1 ( Abpromise for all tested applications). entrezGeneID: 4634 ... Clone RMT1-4 from BioLegendRABBIT HAEMOLYTIC SERA from AbD SerotecMouse Anti-Myosin, light chain 1, cardiac Monoclonal Antibody ...
  http://www.bio-medicine.org/biology-products/Goat-Anti-HSPC150-Polyclonal-Antibody--Unconjugated-from-Abcam-5553-1/
*  Anti-Myosin Light Chain 2 antibody (ab48003) | Abcam
Rabbit polyclonal Myosin Light Chain 2 antibody validated for WB, ELISA, IHC, ICC/IF and tested in Rat. Referenced in 8 ... Lane 1 : Vascular myosin (rat aorta), loaded with 35 µg of lysate. Lane 2 : Cardiac myosin (mouse heart, loaded with 35 µg of ... Anti-Myosin Light Chain 2 antibody. See all Myosin Light Chain 2 primary antibodies. ... ab48003 (2µg/ml) staining Myosin Light Chain 2 in human skeletal muscle using an automated system (DAKO Autostainer Plus). ...
  http://www.abcam.com/myosin-light-chain-2-antibody-ab48003.html
*  Frontiers | Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases | Pharmacology
... induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain. ... induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain. ... 2016). Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Proc. Natl ... 2014). Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00292/full
*  Development of an immunoradiometric assay kit for ventricular myosin light chain I with monoclonal antibodies. - Semantic...
Development of an immunoradiometric assay kit for ventricular myosin light chain I with monoclonal antibodies.' by Hideki Katoh ... Fractionation of the light chains from rat and rabbit cardiac myosin.. *Y Yazaki, S Mochinaga, M S Raben ... Radioimmunoassay of cardiac myosin light chain II in the serum following experimental myocardial infarction.. *R Nagai, S Ueda ... Quantitative relationship between left ventricular function and serum cardiac myosin light chain I levels after coronary ...
  https://www.semanticscholar.org/paper/Development-of-an-immunoradiometric-assay-kit-for-I-Katoh-Sugi/dc963349864898b2c0c5292f9d22479ef24add1d
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Neuregulin infusion in rodents increases cardiac myosin light chain kinase (cMLCK) expression and cardiac myosin regulatory ... The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. ... This study involved experimental autoimmune myocarditis (EAM) induced with cardiac myosin heavy chain (Myhc)-α 334-352 in A/J ...
  https://www.jove.com/visualize/abstract/23776695/the-effects-neuregulin-on-cardiac-myosin-light-chain-kinase-gene
*  Myl3 - PrimePCR Assay and Template | Life Science | Bio-Rad
predominant myosin light chain in cardiac tissue [RGD, Feb 2006]. Select a product type :. All. qPCR. ddPCR. ... Myosin light chain 3 Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5173586 Info: FAM; Same primer pair ... Myosin light chain 3 Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5173587 Info: HEX; Same primer pair ... Myosin light chain 3 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dRnoEG5138804 Info: EG; Same primer ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/gene/myl3-rat
*  Neuregulin 1 - Wikipedia
Downstream effectors of NRG-1/ErbB, include cardiac-specific myosin light chain kinase (cMLCK), Protein Phosphatase type 1 (PP1 ... "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812-24. ... "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571-80. doi:10.1161/CIRCRESAHA.107.161687. ... The cMLCK protein is an important regulator of sarcomere assembly through activation of the myosin regulatory light chain, as ...
  https://en.wikipedia.org/wiki/Neuregulin_1
*  Myosin light chain 3 Research Products: Novus Biologicals
Browse our Myosin light chain 3 product catalog backed by our Guarantee+. ... Myosin light chain 3 products available through Novus Biologicals. ... Cardiac Arrhythmia. Pathways for Myosin light chain 3. View related products by pathway and learn more about each of the ... Diseases related to Myosin light chain 3. Discover more about diseases related to Myosin light chain 3.. Cardiomyopathies. ...
  https://www.novusbio.com/common-name/myosin-light-chain-3
*  Abnormalities of calcium cycling in the hypertrophied and failing heart. - Semantic Scholar
... regulatory defects in the early stages of cardiac diseases can delay or prevent the onset of CHF. ... Progressive deterioration of cardiac contractility is a central feature of congestive heart failure (CHF) in humans. In this ... Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.. * ... KChIP2 is a core transcriptional regulator of cardiac excitability. *Drew M Nassal, Xiaoping Wan, +6 authors Isabelle Deschênes ...
  https://www.semanticscholar.org/paper/Abnormalities-of-calcium-cycling-in-the-hypertroph-Houser-Piacentino/00506b1360be239c1263619f3624c95e1190235d
*  Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy | Journal of Translational Medicine | Full Text
Induced expression of some of the respiratory chain enzymes suggests a metabolic shift towards an oxidative phosphorylation ... We also identified PTRF as a potential signaling regulator of volume overload-induced cardiac hypertrophy. ... Hemodynamic load leads to cardiac hypertrophy and heart failure. While afterload (pressure overload) induces concentric ... Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiacperformance in vivo ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0898-5
*  MYLK3 - Wikipedia
Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates ... 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): ... "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812-24. ... "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571-80. doi:10.1161/CIRCRESAHA.107.161687. ...
  https://en.wikipedia.org/wiki/MYLK3
*  Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning | Philosophical Transactions of...
g) Whole-mount in situ hybridization of a 48 hours post-fertilization larva with cardiac myosin light chain to illustrate heart ... 2004 A southpaw joins the roster: the role of the zebrafish nodal-related gene southpaw in cardiac LR asymmetry. Trends ...
  http://rstb.royalsocietypublishing.org/content/363/1495/1377
*  MYLK - Wikipedia
2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): ... This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce ... Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is ... "Entrez Gene: MYLK myosin, light chain kinase". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...
  https://en.wikipedia.org/wiki/MYLK
*  Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka,...
Using the zebrafish cardiac myosin light chain 2 (cmlc2) promoter, we visualized the heart for screening transgene-positive ... Using the zebrafish cardiac myosin light chain 2 (cmlc2) promoter, we visualized the heart for screening transgene-positive ... This construct contains the cardiac myosin light chain 2 (cmlc2) promoter region to express EGFP in the heart for screening. (b ... This construct contains the cardiac myosin light chain 2 (cmlc2) promoter region to express EGFP in the heart for screening. (b ...
  https://www.deepdyve.com/lp/ou_press/morphological-analysis-of-the-axonal-projections-of-egfp-labeled-esr1-1TD28XcU54
*  Biology | Free Full-Text | Next-Generation Sequencing: From Understanding Biology to Personalized Medicine | HTML
A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo ... Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol. Med. 2013, 5, 1-17. [Google Scholar] ... Sanger, F.; Nicklen, S.; Coulson, A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 1977, 74, ... Biesiadecki, B.J.; Elder, B.D.; Yu, Z.B.; Jin, J.P. Cardiac troponin t variants produced by aberrant splicing of multiple exons ...
  http://www.mdpi.com/2079-7737/2/1/378/htm
*  MYL2 - ddPCR Primer Pair - EvaGreen - Digital PCR | PrimePCR | Bio-Rad
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the ... phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid- ... myosin, light chain 2, regulatory, cardiac, slow. Aliases:. CMH10, DKFZp779C0562, MLC2. RefSeq:. NC_000012.11 NG_007554.1 NT_ ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/assay/dhsaeg5018811-primepcr-ddpcr-expression-evagreen-assay-myl2-human
*  MYL2 - PrimePCR Assay and Template | Life Science | Bio-Rad
Myosin, light chain 2, regulatory, cardiac, slow Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression ... Myosin, light chain 2, regulatory, cardiac, slow Assay Type: Probe Assay Design: Exonic Application: Gene Expression Unique ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/gene/myl2-cow
*  Patente US20030204206 - Electrically responsive promoter system - Google Patentes
... and the cardiac-specific myosin light chain-2 promoter (a 2.1 kbp KpnI/EcoRI fragment from the rat cardiac myosin light chain-2 ... Knowlton, K. U., et al., Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 gnes during α- ... Included are the cardiac alpha-myosin heavy chain (AMHC) promoter and the cardiac alpha-actin promoter. Suitable kidney- ... Mahdavi, V., et al., Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem, Proc Natl Acad Sci U S A. 81(9): ...
  http://www.google.es/patents/US20030204206
*  MYL4 - Wikipedia
Auckland LM, Lambert SJ, Cummins P (November 1986). "Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot". ... Shift in atrial myosin heavy chains and in ventricular myosin light chains". European Heart Journal. 5 Suppl F: 85-93. doi: ... "Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular ... Morano I, Haase H (May 1997). "Different actin affinities of human cardiac essential myosin light chain isoforms". FEBS Letters ...
  https://en.wikipedia.org/wiki/MYL4
*  Katarína Horáková - Wikipedia
"Peroxidase labelled monoclonal antibody against light chains of human cardiac myosin". General physiology and biophysics. 10 (1 ...
  https://en.wikipedia.org/wiki/Katar%C3%ADna_Hor%C3%A1kov%C3%A1