Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | Circulation
Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophys J. 1995;69:418-427. ... Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes. Carmen Valenzuela, Dirk J. ... Valenzuela C, Bennett P, Hondeghem L. Stereospecific block of cardiac Na+ channels by bupivacaine. Biophys J. 1990;57:108a. ... If the R(+)-enantiomer is more potent in blocking cardiac sodium channels, then the S(−)-enantiomer could be used with less ...http://circ.ahajournals.org/content/92/10/3014
Cardiac Memory Is Associated With Decreased Levels of the Transcriptional Factor CREB Modulated by Angiotensin II and Calcium |...
31 the potassium channel pore-forming unit Kv1.5,32 and protein phosphatase 2Aα.33 The effects of modulation by ventricular ... Role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart. Circulation. 2003; ... Mori Y, Matsubara H, Folco E, Siegel A, Koren G. The transcription of a mammalian voltage-gated potassium channel is regulated ... downstream changes in ion channels that regulate cardiac electrical activity have been described. As one example, induction of ...http://circres.ahajournals.org/content/93/5/472
XEN-D0101 - Wikipedia
XEN-D0101 is a selective antagonist of the voltage-gated potassium channel Kv1.5. Atrial fibrillation is the main focus of ... Over Other Cardiac Ion Channels. Circulation, 118, 342-357. Milnes, J., Louis, L., Madge, D., & Ford, J. (2008). The Atrial ... Journal of Cardiovascular Pharmacology Tamargo, J., Caballero, R., Gomez, R., & Delpon, E. (2009). I(Kur)/Kv1.5 channel ... Journal of Cardiovascular Pharmacology Tamargo, J., Caballero, R., Gomez, R., & Delpon, E. (2009). I(Kur)/Kv1.5 channel ...https://en.wikipedia.org/wiki/XEN-D0101
Potassium voltage-gated channel subfamily A member 2
Isoenzyme-specific regulation of cardiac Kv1.5/Kv?1.2 ion channel complex by protein kinase C: central role of PKC?II.. ... Pore size matters for potassium channel conductance.. 26503718. 2015. Bimodal regulation of an Elk subfamily K+ channel by ... Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural ... Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain ...https://pharos.nih.gov/idg/targets/P16389
KCNA5 - Wikipedia
... "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS ... Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans ... "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS ... Kv1.5 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH) KCNA5 protein, human at the US ...https://en.wikipedia.org/wiki/KCNA5
KCNA5 Gene - GeneCards | KCNA5 Protein | KCNA5 Antibody
Potassium Voltage-Gated Channel Subfamily A Member 5, including: function, proteins, disorders, pathways, orthologs, and ... Cardiac Potassium Channel 3 * Potassium Channel 1 3 * ATFB7 3 * KV1.5 3 ... voltage-gated potassium channel activity. IEA. --. GO:0005251. delayed rectifier potassium channel activity. IEA,IMP. 19343045 ... Potassium Voltage-Gated Channel Subfamily A Member 5 2 3 5 * Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member ...http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=3741
Patent US6605625 - Ortho, meta-substituted bisaryl compounds, processes for their preparation ... - Google Patents
Kv1.5 potassium channel' and, as an ultra-rapidly activating delayed rectifier, inhibit a designated potassium current in the ... Methods of treating or preventing cardiac arrhythmia. WO1999037607A1. Jan 27, 1999. Jul 29, 1999. Icagen, Inc.. Potassium ... Novel Potassium Channel Blockers. US20100087437 *. Aug 31, 2009. Apr 8, 2010. Xention Limited. Novel Potassium Channel Blockers ... and WO 99 37 607 claim aminoindans and aminotetrahydro-naphthalenes as potassium channel blockers which block the Kv1.5 channel ...http://www.google.com/patents/US6605625?dq=5,742,768
Thyroid Disease and the Heart | Circulation
... and the ion channels sodium potassium ATPase (Na+,K+-ATPase), the voltage-gated potassium channels (Kv1.5, Kv4.2, Kv4.3), and ... Cardiac contractility is enhanced, and resting heart rate and cardiac output are increased. Cardiac output may be increased by ... The effect of diltiazem, a calcium channel-blocking drug, on cardiac rate and rhythm in hyperthyroid patients. Arch Intern Med ... Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res. ...http://circ.ahajournals.org/content/116/15/1725.long
Abstract 1519: The Atrial Antiarrhythmic Drug XEN-D0101 Selectively Inhibits the Human Ultra-Rapid Delayed-Rectifier Potassium...
The ultra-rapid delayed-rectifier cardiac potassium ionic current (IKur), encoded by Kv1.5 in man, is a putative atrial- ... Cardiac safety screening against the cloned channels hERG and hNav1.5 revealed ,50- and ,100-fold selectivity respectively for ... The effect of XEN-D0101 on native atrial and cloned cardiac ion channels was studied. Whole-cell patch-clamp experiments were ... Over Other Cardiac Ion Channels. James T Milnes, Laurence Louis, Marc Rogers, David J Madge, John Ford ...http://circ.ahajournals.org/content/118/Suppl_18/S_342.3
CARG: Coronary Artery Rehabilitation Group Blog: Cardiac imaging breakthrough helps determine diminished blood flow to the heart
Kv1.5 Potassium Channel (1) * LAMP2 gene (1) * LaRC-SI (1) * Lateral thoracotomy (1) ... However, a group of cardiac investigators are now finding that in addition to the degree of blockage, composition of the plaque ...http://cargsaskatoon.blogspot.com/2010/06/cardiac-imaging-breakthrough-helps.html
CARG: Coronary Artery Rehabilitation Group Blog: Ontario's first cardiac stem cell transplant performed at the Peter Munk...
Kv1.5 Potassium Channel (1) * LAMP2 gene (1) * LaRC-SI (1) * Lateral thoracotomy (1) ... Terrence Yau, Cardiac Surgeon and Director of the Cardiac Stem Cell Therapy Program at the Peter Munk Cardiac Centre. A second ... Ontario's first cardiac stem cell transplant performed at the Peter Munk Cardiac Centre (Canada) ... physicians at the Peter Munk Cardiac Centre performed the first cardiac stem cell transplant in Ontario using stem cells ...http://cargsaskatoon.blogspot.com/2012/01/ontarios-first-cardiac-stem-cell.html
CARG: Coronary Artery Rehabilitation Group Blog: Hockey player in cardiac arrest revived with AED (Canada)
Kv1.5 Potassium Channel (1) * LAMP2 gene (1) * LaRC-SI (1) * Lateral thoracotomy (1) ... Ottawa paramedics are crediting a defibrillator for helping revive a hockey player who collapsed November 19 from cardiac ... drastically improves survival rates in people who suffer sudden cardiac arrest. ...http://cargsaskatoon.blogspot.com/2011/11/hockey-player-in-cardiac-arrest-revived.html
CARG: Coronary Artery Rehabilitation Group Blog: Girl Scouts sew pillows for cardiac patients (USA)
Kv1.5 Potassium Channel (1) * LAMP2 gene (1) * LaRC-SI (1) * Lateral thoracotomy (1) ... the help of local eighth-grade science teacher Mary Bley the Girl Scouts sewed and tied 10 pillows for patients in the cardiac ...http://cargsaskatoon.blogspot.com/2010/06/girl-scouts-sew-pillows-for-cardiac.html
CARG: Coronary Artery Rehabilitation Group Blog: Stomach drug may have cardiac risk (Canada)
Kv1.5 Potassium Channel (1) * LAMP2 gene (1) * LaRC-SI (1) * Lateral thoracotomy (1) ... Health Canada noted that recent studies show that the risk of abnormal heart beats and cardiac arrest may be higher in patients ... could have serious risks to cardiac health. Domperidone is also used to prevent symptoms such as nausea and vomiting caused by ...http://cargsaskatoon.blogspot.com/2012/03/stomach-drug-may-have-cardiac-risk.html
Frontiers | The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of...
BKCa channels and/or DPO-1 sensitive Kv1.5 channels in VSMCs are not the downstream mediators of the XE991 effects on PVAT- ... since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl ... since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl ... We conclude that Kv channels are involved in the control of arterial vascular tone by PVAT. These channels are present in VSMCs ...https://www.frontiersin.org/articles/10.3389/fphys.2016.00335/full
SGK1 - Wikipedia
... channel ClC2 Cardiac voltage-gated Na+ channel SCN5A Cardiac and epithelial K+ channels KCNE1/KCNQ1 Voltage-gated K+ channels ... This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of ... Kv1.3, Kv1.5, and Kv4.3 Glutamate Receptors The following carriers and pumps are influenced by SGK1: Glucose Transporters ... SGK1 has been shown to regulate the following ion channels: Epithelial Na+ channel ENaC Renal outer medullary K+ channel ROMK1 ...https://en.wikipedia.org/wiki/SGK1
KCNAB1 - Wikipedia
"Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel". J. Biol. Chem. 273 (52): 35095- ... 2001). "KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression". Am. J. Physiol., Cell Physiol. 281 (1 ... Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene. Potassium channels ... Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ...https://en.wikipedia.org/wiki/KCNAB1
KCNE4 - Wikipedia
KCNE4 strongly inhibits the KCNQ1 potassium channel, which is known to play important roles in human cardiac myocyte ... KCNE4 augments Kv1.5 current and surface expression twofold in CHO cells (but had no effect in Xenopus oocytes). Kcne4 deletion ... Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and ... Voltage-gated potassium channel Published version Geoffrey W Abbott (30 July 2016). "KCNE4 and KCNE5: K(+) channel regulation ...https://en.wikipedia.org/wiki/KCNE4
... inhibited the cloned human cardiac potassium channel Kv1.5 expressed in Xenopus oocytes and CHO cells with IC50 values of ~0.6 ... Studies on heterologously expressed Kv1.5 channels revealed Midazolam as an open channel inhibitor of cardiac Kv1.5 channels, ... may elicit cardiac toxicity via Kv1.5 channels. Whole cell patch clamp recording of CHO cells expressing rat Kv1.5 channels ... Channel trafficking by myosins. Myosin-V motor proteins regulate Kv1.5 channel trafficking in cardiac myocytes. MYO5A and MYO5B ...http://channelpedia.epfl.ch/reports/interaction
CDH2 - Wikipedia
... reduced density of inward rectifier potassium channel and decreased expression of Kv1.5, KCNE2 and cortactin combined with ... "Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac ... Cheng, L; Yung, A; Covarrubias, M; Radice, GL (10 June 2011). "Cortactin is required for N-cadherin regulation of Kv1.5 channel ... of N-cadherin knockout mice revealed that the arrhythmias were likely due to ion channel remodeling and aberrant Kv1.5 channel ...https://en.wikipedia.org/wiki/CDH2
Glucocorticoids Regulate V1a Vasopressin Receptor Expression by Increasing mRNA Stability in Vascular Smooth Muscle Cells |...
Mori Y, Matsubara H, Folco E, Siegel A, Koren G. The transcription of a mammalian voltage-gated potassium channel is regulated ... as previously observed in cardiac fibroblasts24 and vascular smooth muscle cells,6 confirming the validity of our nuclear run- ... Kv1.4 mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 and Kv1.5 genes in myocardial ... Matsubara H, Suzuki J, Inada M. Shaker-related potassium channel, ...http://hyper.ahajournals.org/content/26/4/665
Heteromultimeric Kv1.2-Kv1.5 Channels Underlie 4-Aminopyridine-Sensitive Delayed Rectifier K+ Current of Rabbit Vascular...
Slow gating charge immobilization in the human potassium channel Kv1.5 and its prevention by 4-aminopyridine. J Physiol. 1996; ... as well as cardiac myocytes,5 which are also known to express Kv1.2 and Kv1.5. ... Kv1.5 channels are not affected by charybdotoxin,28,29 but we found that RPV Kv1.5 did not exhibit the shift in activation ... Fedida D, Bouchard R, Closed-, and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J ...http://circres.ahajournals.org/content/89/11/1038
Final Report Summary - EUTRAF (The European Network for Translational Research in Atrial Fibrillation) | Report Summary |...
Kv1.5 at the plasma membrane as evidenced by single channel recording and TIRF microscopy. Shear stress stimulates channel ... outward potassium current from atrial myocytes which is due to the increase in the density of the functional potassium channel ... the extracellular matrix and cardiac ion channels. Selected genes, up- or down-regulated in CREM-TG atria were further studied ... Activation of this pathway that enhances Kv1.5 trafficking may explain the increase in IKur despite reduced total Kv1.5 ...https://cordis.europa.eu/result/rcn/183644_es.html
KAKEN - Research Projects | Cloning of a cardiac inward rectifier k^+ channel and its gating mechanisms (KAKENHI-PROJECT...
... current through the inward rectifier potassium channel clomed from rabbit heart-Comparison with the native potassium channel-' ... Publications] Y.Sasaki et al.: 'Voltage-dependent K^+ channel (Kv1.5) cloned from rabbit heart and facilitation of inactivation ... curkent through the inwarol rectifier potassium channel cloned from rabbit heart-Comparison with the native potassium channel ... Unitary current through the inward rectifier potassium channel cloned from rabbit heart -Comparison with the native potassium ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670096/
Status of Antiarrhythmic Drug Development for Atrial Fibrillation | Circulation: Arrhythmia and Electrophysiology
... primarily by inhibiting potassium channels, or by blocking sodium channels, which increases cardiac excitation threshold, slows ... Xention-D0101 is selective antagonist of the potassium channel Kv1.5. It has been demonstrated to prolong atrial refractoriness ... the rapidly activating delayed rectifier potassium channels (IKr), and the inward-rectifing potassium channels (IKAch and IKATP ... the degree of channel block was found to be use-dependent for all 3 ion channels, particularly INa and ICa(L). Therefore, ...http://circep.ahajournals.org/content/9/3/e002479