Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile...
2001) Smooth muscle excitation-contraction coupling: a role for caveolae and caveolins? News Physiol. Sci. 16:61-65, pmid: ... Blood was collected via cardiac puncture into EDTA-coated tubes (Sarstedt). Plasma separated via centrifugation at 13000 g for ... 2007) Control of uterine Ca2+ by membrane voltage: toward understanding the excitation-contraction coupling in human myometrium ... Spike bundle contractions are multiphasic, resulting from asynchronous contraction and relaxation of uterine smooth muscle ...http://www.clinsci.org/content/130/3/183
Cardiac excitation-contraction coupling - Wikipedia
Cardiac excitation-contraction coupling (Cardiac EC coupling) describes the series of events, from the production of an ... Processes that remove calcium from the cytoplasm during excitation-contraction coupling in intact rat heart cells', 474(3). ... EC coupling results in the sequential contraction of the heart muscles that allows blood to be pumped, first to the lungs ( ... How does the shape of the cardiac action potential control calcium signaling and contraction in the heart?', 49(6). Gordan, R ...https://en.wikipedia.org/wiki/Cardiac_excitation-contraction_coupling
ß-Adrenergic Stimulation Synchronizes Intracellular Ca2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes |...
ß-Adrenergic Stimulation Synchronizes Intracellular Ca2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes. ... ß-Adrenergic Stimulation Synchronizes Intracellular Ca2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes ... ß-Adrenergic Stimulation Synchronizes Intracellular Ca2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes ... ß-Adrenergic Stimulation Synchronizes Intracellular Ca2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes ...http://circres.ahajournals.org/content/early/2001/04/13/hh0801.090461
A specific cyclic ADP-ribose antagonist inhibits cardiac excitation-contraction coupling. - Department of Pharmacology
There is controversy over the effects of cADPR in cardiac muscle, although one possibility is that endogenous cADPR increases ... are consistent with the hypothesis that endogenous cADPR plays an important role during normal contraction of cardiac myocytes ... In intact cardiac myocytes isolated from guinea-pig ventricle, cytosolic injection of 8-amino-cADPR substantially reduced ... leading to reduced Ca2+ transients and contractions). A direct effect of 8-amino-cADPR on CICR cannot be excluded, but ...https://pharm.ox.ac.uk/publications/677868
Table of Contents - May 02, 1997, 276 (5313) | Science
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure. By A. M. Gómez, H. H. Valdivia ...http://science.sciencemag.org/content/276/5313
Swarm Study Offers a New Way to Look at Collective Animal Motion
Study Shows Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish Science ... "There's something binding them to the swarm" that is not an external force, said Ouellette, assistant professor of mechanical ... "This is a field where there's been almost no quantitative data," said Nicholas T. Ouellette of the Yale School of Engineering ...https://scitechdaily.com/swarm-study-offers-a-new-way-to-look-at-collective-animal-motion/
Beating Heart Patch Repairs Damage Caused by Heart Attack
Study Shows Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish Be the first to comment on "Beating Heart Patch ... Cardiac Stem Cells Offer New Ways to Prevent and Treat Heart Failure ... For a heart patch to ever actually replace the work of dead cardiac muscle in human patients, however, it would need to be much ... "Creating individual cardiac muscle cells is pretty commonplace, but people have been focused on growing miniature tissues for ...https://scitechdaily.com/beating-heart-patch-repairs-damage-caused-by-heart-attack/
Cardiac Stem Cells Offer New Ways to Prevent and Treat Heart Failure
Study Shows Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish Science ... 1 Comment on "Cardiac Stem Cells Offer New Ways to Prevent and Treat Heart Failure" * katesisco , August 19, 2013 at 6:54 pm , ... "Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair," Cell, Volume ... Cardiac Stem Cells Offer New Ways to Prevent and Treat Heart Failure TOPICS:DiseaseHealthHeart AttackKing's College London ...https://scitechdaily.com/cardiac-stem-cells-offer-new-ways-to-prevent-and-treat-heart-failure/
Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation | Circulation
Cardiac excitation-contraction coupling. Nature. 2002; 415: 198-205.. OpenUrlCrossRefPubMed ... Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res. ... PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004; 10: 248-254. ... Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res. 2005; 66: 12-21. ...http://circ.ahajournals.org/content/114/7/670
Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase-Anchoring Proteins | SpringerLink
Bers DM (2002) Cardiac excitation-contraction coupling. Nature 415:198-205. doi: 10.1038/415198a CrossRefPubMedGoogle Scholar ... Katz AM, Lorell BH (2000) Regulation of cardiac contraction and relaxation. Circulation 102:Iv-69-Iv-74CrossRefGoogle Scholar ... Hill JA, Olson EN (2008) Cardiac plasticity. N Engl J Med 358:1370-1380. doi: 10.1056/NEJMra072139 CrossRefPubMedGoogle Scholar ... Chen L, Kass RS (2006) Dual roles of the A kinase-anchoring protein Yotiao in the modulation of a cardiac potassium channel: a ...https://link.springer.com/chapter/10.1007/978-3-319-54579-0_3
cAMP Compartmentalisation and Hypertrophy of the Heart: 'Good' Pools of cAMP and 'Bad' Pools of cAMP Coexist in the Same...
Bers DM (2002) Cardiac excitation-contraction coupling. Nature 415(6868):198-205. doi: 10.1038/415198a PubMedCrossRefGoogle ... Initially, cardiac hypertrophy is a compensatory response aimed at increasing cardiac output. However, prolonged cardiac ... coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ ... Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res 89(5):445-452 ...https://link.springer.com/chapter/10.1007/978-3-319-54579-0_7
The Role of Na-Ca Exchange in Heart | SpringerLink
... an important difference is that cardiac cells contract when placed in Na-free salines while skeletal muscle fibers do not.... ... Cardiac muscle cells differ from those of skeletal muscle in many respects; ... Chapman RA: Excitation-contraction coupling in cardiac muscle. Prog Biophys Mol Biol 35: 1-52, 1979.PubMedCrossRefGoogle ... Fabiato A, Fabiato F: Calcium and cardiac excitation-contraction coupling. Annu Rev Physiol 41: 473-484, 1979.PubMedCrossRef ...https://link.springer.com/chapter/10.1007/978-1-4757-1171-4_10
Reinduction of Atrial Fibrillation Immediately After Termination of the Arrhythmia Is Mediated by Late Phase 3 Early...
Excitation-Contraction Coupling and Cardiac Contractile Force. 2nd ed. Amsterdam, Netherlands: Kluwer Academic Publishers: 2001 ... Strong phasic contraction after the first few post-AF beats is likely to cause a stretch, known to induce premature beats and ... Based on the time course of contraction, levels of intracellular calcium (Cai) would be expected to peak during the plateau of ... Our study provides evidence in support of the hypothesis that very rapid rates of excitation, as occur during AF, lead to an ...http://circ.ahajournals.org/content/107/18/2355
Negative Inotropy of the Gastric Proton Pump Inhibitor Pantoprazole in Myocardium From Humans and Rabbits | Circulation
Excitation-Contraction Coupling and Cardiac Contractile Force. 2nd ed. Dordrecht, Netherlands: Kluwer Academic Publishers; 2001 ... In addition, the mode of action in cardiac tissue was further analyzed in isolated cardiac tissue from rabbits. ... Their effect on cardiac contractility has not been assessed directly.. Methods and Results- Under physiological conditions (37° ... Thus, cardiac effects of proton pump inhibitors should be evaluated in vivo because of their extensive use for acid-related ...http://circ.ahajournals.org/content/116/1/57
Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, I | Circulation Research
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997;276:800-806. ... Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, the Netherlands: Kluwer Academic Publishing; 1991. ... Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, I. Experimental Studies. ... Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B. Mechanisms of altered excitation-contraction coupling in canine tachycardia- ...http://circres.ahajournals.org/content/84/5/562
Sarcoplasmic Reticulum and Nuclear Envelope Are One Highly Interconnected Ca2+ Store Throughout Cardiac Myocyte | Circulation...
Excitation-Contraction Coupling and Cardiac Contractile Force. 2nd ed. Dordrecht, The Netherlands: Kluwer Academic Publishers; ... An important mechanism in cardiac myocytes is excitation-contraction coupling (ECC).1 Electrical depolarization of the cell ... Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006; 116 ... and are critical in excitation-contraction coupling, whereas the inositol trisphosphate (InsP3) receptors are separately ...http://circres.ahajournals.org/content/99/3/283
Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes |...
Cardiac excitation-contraction coupling. Nature. 2002; 415: 198-205.. OpenUrlCrossRefPubMed ... thereby promoting the phosphorylation and activation of key components of the excitation-contraction coupling process. These ... A number of previous studies demonstrated that basal cAMP levels are controlled by PDEs in resting cardiac cells.6,9,10,16,29 ... Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A. 2006; 103: 12923 ...http://circres.ahajournals.org/content/102/9/1091
Insulin-Like Growth Factor-1 and PTEN Deletion Enhance Cardiac L-Type Ca2+ Currents via Increased PI3Kα/PKB Signaling |...
Cardiac excitation-contraction coupling. Nature. 2002; 415: 198-205.. OpenUrlCrossRefPubMed ... Although cardiac ICa,L was increased in PTEN-deficient mice, it was not different in myocytes with inhibition of cardiac PI3Kα ... We have previously demonstrated that cardiac PTEN ablation impairs contractile function and induces cardiac hypertrophy in mice ... Skeletal and cardiac muscle-specific inactivation of PTEN gene (PTEN−/−) was achieved by flanking exons 4 and 5 of the PTEN ...http://circres.ahajournals.org/content/98/11/1390
Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited CaV1.2 Channels in HeartNovelty and Significance |...
... and also provide the trigger Ca2+ for Ca2+-induced Ca2+ release that underlies cardiac excitation-contraction coupling. ... calcium channels links electric excitation to contraction (excitation-contraction coupling), controls the action potential ... acting as the trigger for Ca2+-induced Ca2+ release that underlies cardiac excitation-contraction coupling; adjusting the ... Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Circ Res. 2010;106:317-327. ...http://circres.ahajournals.org/content/107/5/620
Trimeric Intracellular Cation Channels and Sarcoplasmic/Endoplasmic Reticulum Calcium Homeostasis | Circulation Research
Immuno-proteomic approach to excitation-contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the ... The mechanical hypothesis of excitation-contraction (EC) coupling in skeletal muscle. J Muscle Res Cell Motil. 1991;12:127-135. ... Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol. 2007;102:369-392. ... Inositol-1,4,5-trisphosphate-dependent Ca(2+) signalling in cat atrial excitation-contraction coupling and arrhythmias. J ...http://circres.ahajournals.org/content/114/4/706
"Ryanogate" | Circulation...
... implications for defective excitation-contraction coupling during cardiac ischemia and failure. Circ Res. 2005; 96: 551-557. ... Excitation-contraction coupling in the heart begins when calcium entry through voltage-gated L-type calcium channels in the ... to the growing body of data showing that CaMKII plays a key role in the regulation of cardiac excitation-contraction coupling. ... Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science. 1993; 262: 740-744. ...http://circres.ahajournals.org/content/98/2/165
Advances in Experimental Medicine and Biology - Springer
New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling Jessica Gambardella, Bruno Trimarco, Guido ...https://link.springer.com/bookseries/5584
Understanding Cardiac Alternans | Circulation Research
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997; 276: 800-806. ... Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, the Netherlands: Kluwer Academic Publishers; 2001.. ... Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol ( ... Calcium gradients during excitation-contraction coupling in cat atrial myocytes. J Physiol (Lond). 1996; 494: 641-651. ...http://circres.ahajournals.org/content/94/5/570
Measuring Local Gradients of Intramitochondrial [Ca2+] in Cardiac Myocytes During Sarcoplasmic Reticulum Ca2+ ReleaseNovelty...
During excitation-contraction coupling cardiac myocytes increases in [Ca2+]mito can enhance ATP synthesis via Ca2+-dependent ... Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, Netherlands: Kluwer Academic Press; 1991;258. ... Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. ... excitation-contraction coupling. ISO. isoproterenol. MCU. mitochondrial Ca2+ uniporter. SR. sarcoplasmic reticulum. ...http://circres.ahajournals.org/content/112/3/424
Na+-Ca2+ Exchange Current and Submembrane [Ca2+] During the Cardiac Action Potential | Circulation Research
Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, the Netherlands: Kluwer Academic Publishers; 2001.. ... Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Biophys J. 2000; 79: 2682- ... Calcium concentration and movement in the ventricular cardiac cell during an excitation-contraction cycle. Biophys J. 1998; 74 ... O'Rourke B, Kass DA, Tomaselli GF, Kääb S, Tunin R, Marbán E. Mechanisms of altered excitation-contraction coupling in canine ...http://circres.ahajournals.org/content/90/2/182
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