Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II...
Of the subjects with cardiac involvement, 9 (81%) had cardiac bio-marker stage II or III defined by either a troponin I over ... 1Amyloid Treatment and Research Program, Section of Hematology and Oncology, Boston University School of Medicine, Boston ... Amyloid Treatment and Research Program, Section of Hematology and Oncology, Boston University School of Medicine, Boston ... Amyloid Treatment and Research Program, Section of Hematology and Oncology, Boston University School of Medicine, Boston ...http://www.haematologica.org/content/98/5/789
Transthyretin-Related Familial Amyloid Polyneuropathy (TTR-FAP): A Single-Center Experience in Sicily, an Italian Endemic Area ...
Background: Familial amyloid polyneuropathy related to transthyretin gene (TTR-FAP) is a life-threatening disease transmitted ... absent cardiac uptake and normal bone uptake; score 1, mild cardiac uptake, lower than bone uptake; score 2, moderate cardiac ... EF and cardiac MRI were still normal. On the contrary, 99mTc-DPD scan showed a mild cardiac uptake (score 1) confirmed by some ... cardiac MRI and 99mTc-DPD scintigraphy were also normal; the latter showed no significant cardiac uptake (score 0) and normal ...https://content.iospress.com/articles/journal-of-neuromuscular-diseases/jnd150091
The heart in hereditary transthyretin amyloidosis : clinical studies on the impact of amyloid fibril composition
... cardiac, neuropathic, or a mixed cardiac and neuropathic. In addition, two different types of amyloid fibrils have been ... has the potential to specifically identify cardiac amyloid depositions irrespective of amyloid fibril composition. The heart ... This thesis work aims to in depth investigate the impact amyloid fibril composition has on cardiac manifestations of the ... to assess the impact of amyloid fibril composition on the outcome of DPD scintigraphy and its relationship with cardiac ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A1141459&dswid=6270
PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans | Circulation
The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today. 1994 ... To check for possible artifacts in autopsy samples, heart specimens from 15 patients undergoing cardiac surgery were collected ... The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994;331:417- ... Interleukin-1-inducible genes in endothelial cells: cloning of a new gene related to C-reactive protein and serum amyloid P ...http://circ.ahajournals.org/content/102/6/636
Wild-type transthyretin amyloid - Wikipedia
Updates in Cardiac Amyloidosis: A Review. Journal of the American Heart Association. 2012; 1: e000364 Sekijima Y. Postgraduate ... Wild-type transthyretin amyloid (WTTA), also known as senile systemic amyloidosis (SSA) and abbreviated as ATTR, is a disease ... Wild-type transthyretin amyloid accumulates mainly in the heart, where it causes stiffness and often thickening of its walls, ... Low ECG signals such as QRS complexes are widely considered a marker of cardiac amyloidosis. A much better survival has been ...https://en.wikipedia.org/wiki/Wild-type_transthyretin_amyloid
Most recent papers with the keyword Cardiac amyloid | Read by QxMD
Cardiac amyloidosis occurs because of abnormal protein (amyloid) deposition in the cardiac tissue. Even with advanced ... account for the majority of diagnosed cardiac amyloid deposition. The extent of cardiac disease independently predicts ... In the mean time, new tools are being developed to detect earlier TTR amyloid deposition such as cardiac scintigraphy with ... Cardiac ATTR amyloid nuclear imaging-not all bone scintigraphy radionuclide tracers are created equal. ...https://www.readbyqxmd.com/keyword/73673
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient - preLights
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient. Paolo Swuec, ... Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient ... Amyloid light chain (AL) amyloidosis is the most common of these diseases, and is caused by the clonal expansion of a plasma ... Perhaps best known are the proteins that misfold in the brain, e.g. amyloid-β and tau in Alzheimer's disease, and α-synuclein ...https://prelights.biologists.com/highlights/cryo-em-structure-cardiac-amyloid-fibrils-immunoglobulin-light-chain-al-amyloidosis-patient/
Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease | SpringerLink
... to prevent cardiac remodeling and identify worsening diastolic dysfunction (DD) was investigated. The anti-fibrotic potential ... The potential for serum amyloid P-component (SAP) ... Serum Amyloid P-Component Prevents Cardiac Remodeling in ... The potential for serum amyloid P-component (SAP) to prevent cardiac remodeling and identify worsening diastolic dysfunction ( ... 1997). Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene. Nature Medicine, 3(8 ...https://link.springer.com/article/10.1007%2Fs12265-015-9661-1
Native T1 mapping in transthyretin amyloidosis. - PubMed - NCBI
... detect cardiac involvement in patients with transthyretin amyloidosis (ATTR amyloidosis); 2) track the cardiac amyloid burden; ... Here, the diagnostic role of native T1 mapping in the other key type of cardiac amyloid, ATTR amyloidosis, is assessed. ... Native myocardial T1 mapping detects cardiac ATTR amyloid with similar diagnostic performance and disease tracking to AL ... T1 tracked cardiac amyloid burden as determined semiquantitatively by DPD scintigraphy (p , 0.0001). T1 was not elevated in ...https://www.ncbi.nlm.nih.gov/pubmed/24412190
Disphosphonates cardiac uptake in familial amyloid neuropathy: Comparison between DPD and HMDP | Orphanet Journal of Rare...
AmyloidosisCardiac InvolvementCardiac AmyloidosisAverage CountSPECT Acquisition. Background. Familial amyloid polyneuropathy ( ... Disphosphonates cardiac uptake in familial amyloid neuropathy: Comparison between DPD and HMDP. ... resulting in tissue amyloid deposits. Cardiac involvement is of major prognostic value. Diphosphonate scintigraphy has been ... This suggests that DPD should be prioritized for initial assessment of patients suspected of cardiac involvement of TTR-related ...https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-10-S1-P41
Pablo Lamata de la Orden - Research Outputs - Research Portal, King's College, London
Quantitative assessment of myocardial mechanics in patients with cardiac amyloid using cardiovascular magnetic resonance ... and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular ... Improving the stability of cardiac mechanical simulations. Land, S., Niederer, S. A., Lamata de la Orden, P. & Smith, N. P. Mar ... An automatic service for the personalization of ventricular cardiac meshes. Lamata de la Orden, P., Sinclair, M., Kerfoot, E., ...https://kclpure.kcl.ac.uk/portal/en/persons/pablo-lamata-de-la-orden
Left Ventricular Structure and Function in Transthyretin-Related Versus Light-Chain Cardiac AmyloidosisCLINICAL PERSPECTIVE |...
Thus, AL cardiac amyloidosis is characterized by worse strain values at a given level of thickness than ATTR amyloid; this ... Background-Immunoglobulin amyloid light-chain (AL)-related cardiac amyloidosis (CA) has a worse prognosis than either wild-type ... Echocardiographic evaluation of cardiac amyloid. Curr Cardiol Rep. 2010;12:272-276. ... Biochemical characterisation of amyloid by endomyocardial biopsy. Amyloid. 2009;16:9-14. ...http://circ.ahajournals.org/content/129/18/1840
Massachusetts General Hospital, Boston, MA
The MGH is one of only seven hospitals in the United States studying cardiac amyloid transplants - and the only one in the ... It was not part of their job description, but that did not stop nurses on the MGH Cardiac Intensive Care Unit from taking on ... Cardiac ECMO survivors celebrate each other and MGH staff. Friday, July 13, 2012 Mass General ... MGH Hotline 010909 Willard M. Daggett, MD, retired MGH cardiac surgeon and founder of the MGH Laboratory of Surgical ...http://www.massgeneral.org/transplant/news/
Search of: Recruiting, Not yet recruiting, Available Studies | 'Aortic Valve Stenosis' - List Results - ClinicalTrials.gov
The Role of Occult Cardiac Amyloid in the Elderly With Aortic Stenosis.. *Cardiac Amyloidosis ... Combination of overall mortality and cardiac morbidity. *Each items of the composite criteria, overall and cardiovascular ... all cause death, Major Adverse Cardiac Event (MACE) including: ( Acute Myocardial Infarction - AMI, Stroke - CVI, unplanned ... Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac ...https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Aortic+Valve+Stenosis%22
Rare disease: Amyloid disease and the danger of late diagnosis
Cardiac amyloid deposition. (A) There is pink smudging of the walls of the intramyocardial arteries and interstitial amyloid ... Cardiac amyloid is a progressive disorder and is usually treated with conventional heart failure therapies with a focus on salt ... Low voltage (QRS voltage amplitude ≤0.5 mV in all the limb leads) is a common feature in cardiac amyloid. It reflects the fact ... Half of all AL amyloid patients will have cardiac involvement of whom many develop heart failure.1 ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3027836/
Muscle biopsy - Lifestyle News
... cardiac,care,changes,charcot,choice,compression,condition,conditions,congenital,connective,cut,damage,death,defects,dejerine, ... amyloid,anatomy,anesthesia,anesthetic,apply,area,ataxia,atrophy,awake,becker,becomes,biopsy,bleeding,blood,broken,bruising,burn ... Senile cardiac amyloid. *. Thyrotoxic periodic paralysis. What the risks are. The risks are small, but may include:. *. ...https://www.indiatoday.in/lifestyle/health/story/story/muscle-biopsy/1/388726-298169-2014-09-24
Future growth and success of nuclear cardiology | SpringerLink
19 F-18-Florbetapir binds to cardiac amyloid light-chain and transthyretin-related amyloid deposits.20 This PET approach to ... promoting the unique benefits of cardiac PET, modernizing the practice of cardiac SPECT, promoting nonperfusion applications of ... Joint SNMMI-ASNC expert consensus document on the role of F-18-FDG PET/CT in cardiac sarcoid detection and therapy monitoring. ... The Industry Forum report identifies the need for educating third-party payers on the value of cardiac PET imaging, which was ...https://link.springer.com/article/10.1007/s12350-018-1211-1
Florbetapir shows promise in preclinical Alzheimer's study - SNMMI
Scanning for cardiac amyloid could help predict heart attacks. Jun 11, 2015 - While amyloid imaging is typically discussed with ... have found that amyloid scans of the heart can predict major cardiac events. ... Florbetaben-PET detects cardiac amyloidosis. Nov 4, 2016 - Australian researchers have shown the proficiency of PET with the ... PET/MR shows arterial CO2 as potent vasodilator for cardiac stress testing. Jun 5, 2017 - Using PET/MR imaging, a new ...https://www.snmmi.org/NewsPublications/NewsList.aspx?metadataid=33
Familial amyloid cardiomyopathy - Wikipedia
... cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin. Transthyretin cardiac amyloid study (TRACS). Circ ... Familial Amyloid Cardiomyopathy (FAC), or Transthyretin Amyloid Cardiomyopathy (ATTR-CM) results from the aggregation and ... Cardiac involvement is often identified with the presence of conduction system disease (sinus node or atrioventricular node ... Amyloid 10 Suppl 1, 48-54. Falk, R. H. & Elkayam, U. (2010). Cardiomyopathy: the importance of recognizing the uncommon ...https://en.wikipedia.org/wiki/Familial_amyloid_cardiomyopathy
Cardiac amyloidosis--a case report.
A 75-year-old male patient presented with resistant congestive cardiac failure. Echocardiographic examination revealed normal ... Possibility of cardiac amyloid was considered, and the diagnosis was confirmed on rectal biopsy.. ... A 75-year-old male patient presented with resistant congestive cardiac failure. Echocardiographic examination revealed normal ... 1190048 - The functional defect in amyloid heart disease. the "stiff heart" syndrome.. 2985318 - Scintigraphic characterization ...http://www.biomedsearch.com/nih/Cardiac-amyloidosis-case-report/2599548.html
Ronald Witteles, MD | Stanford Medicine Profiles
Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). Journal of the ... Genotype and Phenotype of Transthyretin Cardiac Amyloidosis THAOS (Transthyretin Amyloid Outcome Survey) JOURNAL OF THE ... Biomarkers as Predictors of Cardiac Toxicity From Targeted Cancer Therapies JOURNAL OF CARDIAC FAILURE Witteles, R. M. 2016; 22 ... Five patients remain alive up to 25 months after OHT, without evidence of recurrent cardiac amyloid deposition. A novel ...https://med.stanford.edu/profiles/ronald-witteles
Stanley Schrier | Stanford Medicine Profiles
Five patients remain alive up to 25 months after OHT, without evidence of recurrent cardiac amyloid deposition. A novel ... This article reviews 6 patients who underwent OHT for cardiac amyloidosis at the Stanford University Amyloid Center from 2008 ... Heart transplantation and cardiac amyloidosis: Approach to screening and novel management strategies JOURNAL OF HEART AND LUNG ... As a result, uncertainty exists over the best approach to OHT for cardiac amyloidosis and for the timing of critical post- ...https://med.stanford.edu/profiles/stanley-schrier
Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain...
Amyloid cardiac biomarker stage I or II disease. *The amyloid cardiac staging system is based on NT-proBNP and troponin-T ... Cardiac involvement is defined as the presence of a mean left ventricular wall thickness of , 12 mm by echocardiogram in the ... NOTE: *Carpal tunnel syndrome skin purpura or the presence of vascular amyloid on a bone marrow biopsy alone are not sufficient ... Proportion of Patients With Hematologic Overall Response (Partial Response [PR]+ Very Good PR [VGPR]+ Amyloid Complete Response ...https://clinicaltrials.gov/ct2/show/study/NCT01078454?show_locs=Y
Assessment of Fetal Myocardial Deformation Using Speckle Tracking Techniques.
19922329 - Serum levels of nt-probnp as surrogate for cardiac amyloid burden: new evidence from ga.... 25303079 - The impact of ...http://www.biomedsearch.com/nih/Assessment-Fetal-Myocardial-Deformation-Using/22626849.html
ASMscience | Protein Analysis in the
Relationship between monoclonal gammopathy and cardiac amyloid type. Cardiovasc Pathol 22:189-194.[CrossRef].[PubMed]. ... Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis. Curr Opin Nephrol Hypertens 11:649-655.[ ... Exploring the amyloid proteome in immunoglobulin-derived lymph node amyloidosis using laser microdissection/tandem mass ... Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy. J ...http://www.asmscience.org/content/book/10.1128/9781555818722.ch4