*  Detection of Carcinogen-DNA Adducts: Development of New Methods| Research Project Database | Grantee Research Project |...
Detection of Carcinogen-DNA Adducts: Development of New Methods. EPA Grant Number: R828112C061. Subproject: this is subproject ... react with DNA, they form structures called DNA adducts. Because such adducts can be detected in tissues and blood cells, ... DNA adducts, a class of DNA adducts associated with exposure to constituents of diesel emissions and other combustion products ... Title: Detection of Carcinogen-DNA Adducts: Development of New Methods. Investigators: Giese, Roger W. , Vouros, Paul ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2324
*  Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer.
... the functional consequences of the carcinogens in tobacco smoke and BLCA-associated metabolic alterations remains poorly ... Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer. September 13, 2017 Smoking ... DNA adducts, and extensive DNA damage in BLCA cells. Co-treatment of BLCA cells with these carcinogens and the methylation ... DNA adducts and DNA damage. DNA methyltransferase 1 (DNMT1) expression was significantly higher in smokers than non-smokers ...
  https://www.urotoday.com/recent-abstracts/urologic-oncology/bladder-cancer/98317-tobacco-specific-carcinogens-induce-hypermethylation-dna-adducts-and-dna-damage-in-bladder-cancer.html
*  The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective,...
... a particular mutagen/carcinogen forms adducts at many sites in DNA, making it impossible to determine which type of adduct ... a particular mutagen/carcinogen forms adducts at many sites in DNA, making it impossible to determine which type of adduct ... The adduct can be situated in double-stranded DNA, single-stranded DNA or in a single-stranded gap, and the benefit and ... The adduct can be situated in double-stranded DNA, single-stranded DNA or in a single-stranded gap, and the benefit and ...
  http://oxfordindex.oup.com/view/10.1093/carcin/17.5.895
*  Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens. |...
In the urea-based solvents, the pancreas DNA adducts co-migrated with the reference adducts. However, the pancreas DNA adducts ... Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens.. ... Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens. ... Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens. ...
  http://cancerres.aacrjournals.org/content/66/8_Supplement/1220.3
*  Abstract 5550: Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental...
Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ... Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ... Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ... Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ...
  http://cancerres.aacrjournals.org/content/71/8_Supplement/5550
*  WikiGenes
Metabolic activation and carcinogen-DNA adduct detection in human larynx.. Putative carcinogen-DNA adducts in human larynx ... Metabolic activation and carcinogen-DNA adduct detection in human larynx. Degawa, M., Stern, S.J., Martin, M.V., Guengerich, F. ... NAT-1 activity was not correlated with total DNA adducts, which is again consistent with the lack of aromatic amine-DNA adducts ... Hydrophobic DNA adducts were evident only in smokers, and chromatographic profiles of the adducts were similar using either the ...
  https://www.wikigenes.org/e/ref/e/8069857.html
*  Biomarkers of Environmental Exposure and Multivariate Approaches for Assessment and Monitoring | SpringerLink
Soileau, S. D. (1987). Carcinogen-DNA adducts: introduction, literature summary, and recommendations. Environmental Protection ... 1987). Relationship between benzo(a)pyrene-DNA adduct levels and genotoxic effects in mammalian cells. Cancer Research, 47, ... 1990). 32P-postlabeling detection of DNA adducts in fish from chemically contaminated waterways. The Science of the Total ... 1989). Protein adduct forming chemicals for exposure monitoring: chemicals selected for further study. Environmental Protection ...
  https://link.springer.com/chapter/10.1007/978-1-4615-4659-7_16
*  Closing Remarks | SpringerLink
Poirier, M. C., 1981, Antibodies to carcinogen-DNA adducts, J. Natl. Cancer Inst., 67: 515.PubMedGoogle Scholar ... glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA, Proc. Natl. Acad. Sci., U.S.A., ... Randerath, K., Haglund, R. E., Phillips, D. H., and Reddy, M. V., 1984, 32P-post-labelling analysis of DNA adducts formed in ... Fuchs, R. P. P., 1984, DNA binding spectrum of the carcinogen N-acetoxyN-2-acetylaminofluorene significantly differs from the ...
  https://link.springer.com/chapter/10.1007/978-1-4684-5134-4_100
*  Final Report | The National Morbidity, Mortality, and Air Pollution Study: Morbidity and Mortality from Air Pollution in the...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2399/report/F
*  Changes in Complex Carbohydrate Content and Structure in Rat Lungs Caused by Prolonged Ozone Inhalation| Research...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2330
*  Metabolism of Ether Oxygenates Added to Gasoline| Research Project Database | Grantee Research Project | ORD | US EPA
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2407
*  Noninvasive Methods for Measuring Ventilation in Mobile Subjects | Research Project Database | Grantee Research Project ...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2322/report/0
*  The Consequences of Prolonged Inhalation of Ozone on Rats: An Integrative Summary of the Results of Eight Collaborative...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2336
*  hydrocarbons
Carcinogen-DNA Adducts: Topology, Conformation and Repair (Renewal). Suse Broyde; Fiscal Year: 2013 ... Excision of Carcinogen-DNA Adducts in Nucleosomes. Nicholas E Geacintov; Fiscal Year: 2013 ... PAH-DNA adduct) and indirect oxidative (8-oxo-dG) DNA .. ... PAH Exposure and DNA Damage in Roofers. Berrin Serdar; Fiscal ... of carcinogens believed to play a significant role in lung cancer development in smokers: polycyclic aromatic hydrocarbons (PAH ...
  https://www.labome.org/topics/chemicals/organic/hydrocarbons-10118.html
*  Aflatoxin B1 Antibody (6A10) [Biotin] (NB600-443B): Novus Biologicals
There is no cross-reactivity with other carcinogen-DNA adducts.. Packaging, Storage & Formulations. Storage. Store at 4C in the ... Aflatoxin B1 DNA (against the midazole ring-opened persistent form of the major N-7 guanine adduct of AFB1). ...
  https://www.novusbio.com/products/aflatoxin-b1-antibody-6a10_nb600-443b
*  rs1801131 - SNPedia
MTHFR polymorphisms, folate intake and carcinogen DNA adducts in the lung. [PMID 22706675] Folic acid supplementation, MTHFR ... Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide ... PMID 21347786] DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the ... Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. ...
  https://www.snpedia.com/index.php/Rs1801131
*  HON: Hepatitis B V4.1 - Complementary Medicine
... decreases carcinogen-induced DNA damage, and prevents the ultimate formation of carcinogen-DNA adducts.(30) All of these ... The ability of NAC to prevent carcinogen-DNA adducts offers hope for more than preventing cancer. For instance, multiple DNA ... DNA adduct formation in other organs could explain numerous consequences of carcinogen exposure. They hypothesised that DNA ... Administration of NAC to these animals inhibited the formation of these carcinogen-DNA adducts in all organs.(31) These authors ...
  http://www.hon.ch/Library/Theme/HepB/comp.html
*  O-Toluidine - Wikipedia
Kadlubar, F. F.; Badawi, A. F. (1995). "Genetic susceptibility and carcinogen-DNA adduct formation in human urinary bladder ... o-Toluidine was first listed in the Third Annual Report on Carcinogens as 'reasonably anticipated to be a human carcinogen' in ... calf thymus DNA, and DNA fragments from key genes thought to be involved in carcinogenesis (the c-Ha-ras oncogene and the p53 ... including metabolic activation that results in binding of reactive metabolites to DNA and proteins, mutagenicity, oxidative DNA ...
  https://en.wikipedia.org/wiki/O-Toluidine
*  Norman H. Chiu , UNCG NC DOCKS (North Carolina Digital Online Collection of Knowledge and Scholarship)
... and form covalently bound carcinogen-DNA adducts. Clinically, carcinogen-DNA adducts have been linked to various cancer ... Accurate characterization of carcinogenic DNA adducts using MALDI tandem time-of-flight mass spectrometry.. 2009. 981. Many ... The DNA label contains a firefly luciferase coding sequence downstream from a T7 RNA polymerase promoter. The target DNA (200 ... Although the UV absorbance of DNA at 260 nm has been recognized as a standard method for DNA quantitation, there are ...
  http://libres.uncg.edu/ir/uncg/clist.aspx?id=473
*  WikiGenes - B3GALNT1 - beta-1,3-N-acetylgalactosaminyltransferase...
Metabolic activation and carcinogen-DNA adduct detection in human larynx. Degawa, M., Stern, S.J., Martin, M.V., Guengerich, F. ... Hydrophobic DNA adducts were evident only in smokers, and chromatographic profiles of the adducts were similar using either the ... "Antiparallel" DNA loop in gal repressosome visualized by atomic force microscopy. Virnik, K., Lyubchenko, Y.L., Karymov, M.A., ... In addition, Northern blot analysis of polyadenylated RNA isolated from human LAK cells using a murine P1 complementary DNA ...
  https://www.wikigenes.org/e/gene/e/8706.html
*  Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in...
Blocking agents are chemopreventive agents that prevent tumorigenesis by blocking the carcinogen-DNA adduct formation [4]. Our ... and DNA to oxidative damage. The antioxidant capability of thymoquinone has been implicated in the prevention of chemical- ... a potent colon carcinogen, undergoes oxidative metabolism resulting in the production of electrophilic diazonium ion, which is ... have shown antitumor promotion activities in rats or mice treated with chemical carcinogens [3]. It suppresses benzo(a)pyrene ...
  https://www.hindawi.com/journals/omcl/2012/854065/
*  Epidemiological Notes and Reports Pentachlorophenol Poisoning in Newborn Infants -- St. Louis, Missouri, April-August 1967
Perera F, Weinsten P. Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of cancer causation ...
  https://www.cdc.gov/mmwr/preview/mmwrhtml/00042776.htm
*  CiNii 論文 - Decreased Levels of 2-Amino-3-methylimidazo[4,5-f]quinoline-DNA Adducts in Rats...
Enhanced sensitivity of ^,32,P-post-labeling analysis of aromatic carcinogen : DNA adducts GUPTA R. C. ... DNA adducts formed by 2-amino-3,8-dimethyl imidazole 〔4, 5-f〕 quinoxaline in rat liver: dose-response on chronic administration ... Nuclease P1-mediated enhancement of sensitivity of ^,32,P-postlabeling test for structually diverse DNA adducts REDDY M. V. ... Decreased Levels of 2-Amino-3-methylimidazo[4,5-f]quinoline-DNA Adducts in Rats Treated with β-Carotene, α-Tocopherol and ...
  https://ci.nii.ac.jp/naid/10008072678
*  WikiGenes - Genetic Predisposition to Disease
Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. Kato, S., Bowman, E.D., Harrington, A.M., ... PURPOSE: Using DNA-adduct detection methods specific for 7-methyl-dGMP and PAH-dGMP, we sought to determine whether an ... is related to DNA adduct formation in lung tissue [33].. *INTERPRETATION: Exposure to a diabetic environment in utero is ... DNA sequence analysis of major histocompatibility complex (MHC) class II genes from humans and rodents with type 1 (insulin- ...
  https://www.wikigenes.org/e/mesh/e/18731.html
*  Lung Cancer | Encyclopedia.com
In humans, cigarette smokers have increased levels of tobacco carcinogen DNA adducts in the lung and bronchus when compared ... Carcinogen- Any substance capable of causing cancer.. Chemotherapy- Treatment of cancer with synthetic drugs that destroy the ... Carcinogens in tobacco smoke can damage the cells in the lungs, which may lead to the development of lung cancer. More than ... In addition, they are inhaled very deeply-as a result, the carcinogens in the smoke are held in the lungs for a longer time. ...
  https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/lung-cancer