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*  Detection of Carcinogen-DNA Adducts: Development of New Methods| Research Project Database | Grantee Research Project |...
Detection of Carcinogen-DNA Adducts: Development of New Methods. EPA Grant Number: R828112C061. Subproject: this is subproject ... react with DNA, they form structures called DNA adducts. Because such adducts can be detected in tissues and blood cells, ... DNA adducts, a class of DNA adducts associated with exposure to constituents of diesel emissions and other combustion products ... Title: Detection of Carcinogen-DNA Adducts: Development of New Methods. Investigators: Giese, Roger W. , Vouros, Paul ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2324
*  Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer.
... the functional consequences of the carcinogens in tobacco smoke and BLCA-associated metabolic alterations remains poorly ... Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer. September 13, 2017 Smoking ... DNA adducts, and extensive DNA damage in BLCA cells. Co-treatment of BLCA cells with these carcinogens and the methylation ... DNA adducts and DNA damage. DNA methyltransferase 1 (DNMT1) expression was significantly higher in smokers than non-smokers ...
  https://www.urotoday.com/recent-abstracts/urologic-oncology/bladder-cancer/98317-tobacco-specific-carcinogens-induce-hypermethylation-dna-adducts-and-dna-damage-in-bladder-cancer.html
*  The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective,...
... a particular mutagen/carcinogen forms adducts at many sites in DNA, making it impossible to determine which type of adduct ... a particular mutagen/carcinogen forms adducts at many sites in DNA, making it impossible to determine which type of adduct ... The adduct can be situated in double-stranded DNA, single-stranded DNA or in a single-stranded gap, and the benefit and ... The adduct can be situated in double-stranded DNA, single-stranded DNA or in a single-stranded gap, and the benefit and ...
  http://oxfordindex.oup.com/view/10.1093/carcin/17.5.895
*  Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5...
The strongest inhibition of PhIP-DNA adduct formation in the colon was observed upon pretreatment with black tea, ... a pilot study was conducted in which PhIP-DNA-adduct levels were quantified in the colons of male F344 rats that had been ... decreases in colon PhIP-DNA adduct levels, as compared with controls. Preliminary studies on their mechanism of action ... is a pyrolysis product in cooked foods that has been shown to be a rat colon carcinogen and has been implicated in the etiology ...
  https://www.semanticscholar.org/paper/Chemoprotection-against-the-formation-of-colon-DNA-Huber-McDaniel/dd63df92ba85730fe773bca4fd4fd02b39e1169b
*  Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens. |...
In the urea-based solvents, the pancreas DNA adducts co-migrated with the reference adducts. However, the pancreas DNA adducts ... Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens.. ... Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens. ... Lipophilic DNA adducts detected in the pancreas of cigarette smokers are unrelated to typical polyaromatic carcinogens. ...
  http://cancerres.aacrjournals.org/content/66/8_Supplement/1220.3
*  Abstract 5550: Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental...
Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ... Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ... Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ... Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ ...
  http://cancerres.aacrjournals.org/content/71/8_Supplement/5550
*  WikiGenes
Metabolic activation and carcinogen-DNA adduct detection in human larynx.. Putative carcinogen-DNA adducts in human larynx ... Metabolic activation and carcinogen-DNA adduct detection in human larynx. Degawa, M., Stern, S.J., Martin, M.V., Guengerich, F. ... NAT-1 activity was not correlated with total DNA adducts, which is again consistent with the lack of aromatic amine-DNA adducts ... Hydrophobic DNA adducts were evident only in smokers, and chromatographic profiles of the adducts were similar using either the ...
  https://www.wikigenes.org/e/ref/e/8069857.html
*  The Effect of Environment on Breast Cancer Risk | SpringerLink
Carcinogen-DNA adducts in human breast tissue. Cancer Epidemiol Biomark Prev 4: 233-238, 1995Google Scholar ... Li D, Zhang W, Shain AA, Hittleman WN: DNA adducts in normal tissue adjacent to breast cancer: a review. Cancer Detect Prev 23 ... Characterization of a major aromatic DNA adduct detected in human breast tissues. Environ Mol Mutagen 39: 193-200, 2002Google ... Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancer. Environ Mol Mutagen 39: 201- ...
  https://link.springer.com/article/10.1023%2FB%3ABREA.0000019964.33963.09
*  Biomarkers of Environmental Exposure and Multivariate Approaches for Assessment and Monitoring | SpringerLink
Soileau, S. D. (1987). Carcinogen-DNA adducts: introduction, literature summary, and recommendations. Environmental Protection ... 1987). Relationship between benzo(a)pyrene-DNA adduct levels and genotoxic effects in mammalian cells. Cancer Research, 47, ... 1990). 32P-postlabeling detection of DNA adducts in fish from chemically contaminated waterways. The Science of the Total ... 1989). Protein adduct forming chemicals for exposure monitoring: chemicals selected for further study. Environmental Protection ...
  https://link.springer.com/chapter/10.1007/978-1-4615-4659-7_16
*  Is the Association between Cigarette Smoking and Breast Cancer Modified by Genotype? A Review of Epidemiologic Studies and Meta...
Carcinogen-DNA adducts in human breast tissue. Cancer Epidemiol Biomarkers Prev 1995;4:233-8. ... Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer risk ... pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation. Carcinogenesis 2002;23:1969-77. ... DNA adducts in normal tissue adjacent to breast cancer: a review. Cancer Detect Prev 1999;23:454-62. ...
  http://cebp.aacrjournals.org/content/15/4/602?ijkey=8be6597472fcac41f5fed27289199cfc98da83a4&keytype2=tf_ipsecsha
*  Closing Remarks | SpringerLink
Poirier, M. C., 1981, Antibodies to carcinogen-DNA adducts, J. Natl. Cancer Inst., 67: 515.PubMedGoogle Scholar ... glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA, Proc. Natl. Acad. Sci., U.S.A., ... Randerath, K., Haglund, R. E., Phillips, D. H., and Reddy, M. V., 1984, 32P-post-labelling analysis of DNA adducts formed in ... Fuchs, R. P. P., 1984, DNA binding spectrum of the carcinogen N-acetoxyN-2-acetylaminofluorene significantly differs from the ...
  https://link.springer.com/chapter/10.1007/978-1-4684-5134-4_100
*  Statistical Methods for Epidemiologic Studies of the Health Effects of Air Pollution | Research Project Database |...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2390/report/0
*  Final Report | The National Morbidity, Mortality, and Air Pollution Study: Morbidity and Mortality from Air Pollution in the...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2399/report/F
*  Changes in Complex Carbohydrate Content and Structure in Rat Lungs Caused by Prolonged Ozone Inhalation| Research...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2330
*  Metabolism of Ether Oxygenates Added to Gasoline| Research Project Database | Grantee Research Project | ORD | US EPA
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2407
*  Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis | Research Project Database | Grantee Research Project...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... Such combinations of chemicals with DNA are called DNA adducts. Because adducts interfere with normal DNA replication, their ... between the location of DNA adducts and mutation, the investigators compared the regions in DNA where adducts formed to those ... carcinogens, human exposure, ambient particle health effects, inhalation, lung inflammation, particulate exposure, DNA adducts ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2318/report/0
*  Noninvasive Methods for Measuring Ventilation in Mobile Subjects | Research Project Database | Grantee Research Project ...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2322/report/0
*  The Consequences of Prolonged Inhalation of Ozone on Rats: An Integrative Summary of the Results of Eight Collaborative...
R828112C061 Detection of Carcinogen-DNA Adducts: Development of New Methods. R828112C062 Effects of Carbon Monoxide on Heart ... R828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust. R828112C073 Developmental Neurotoxicity ... R828112C055 Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. R828112C056 Particle Trap Effects on Heavy-Duty ... R828112C067 Detection of Formaldehyde DNA Adducts: Development of New Methods. R828112C068I Comparison of the Carcinogenicity ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2336
*  hydrocarbons
Carcinogen-DNA Adducts: Topology, Conformation and Repair (Renewal). Suse Broyde; Fiscal Year: 2013 ... Excision of Carcinogen-DNA Adducts in Nucleosomes. Nicholas E Geacintov; Fiscal Year: 2013 ... PAH-DNA adduct) and indirect oxidative (8-oxo-dG) DNA .. ... PAH Exposure and DNA Damage in Roofers. Berrin Serdar; Fiscal ... of carcinogens believed to play a significant role in lung cancer development in smokers: polycyclic aromatic hydrocarbons (PAH ...
  https://www.labome.org/topics/chemicals/organic/hydrocarbons-10118.html
*  Adducting | definition of adducting by Medical dictionary
... adducting explanation free. What is adducting? Meaning of adducting medical term. What does adducting mean? ... Looking for online definition of adducting in the Medical Dictionary? ... Molecular oncology A chemical bond between any substance and DNA, which may upregulate a gene; DNA-carcinogen adducts can drive ... adduct. /ad·duct/ (ă´dukt) inclusion complex.. adduct. (ə-dŭkt′, ă-dŭkt′). tr.v. ad·ducted, ad·ducting, ad·ducts Physiology To ...
  https://medical-dictionary.thefreedictionary.com/adducting
*  Aflatoxin B1 Antibody (6A10) [Biotin] (NB600-443B): Novus Biologicals
There is no cross-reactivity with other carcinogen-DNA adducts.. Packaging, Storage & Formulations. Storage. Store at 4C in the ... Aflatoxin B1 DNA (against the midazole ring-opened persistent form of the major N-7 guanine adduct of AFB1). ...
  https://www.novusbio.com/products/aflatoxin-b1-antibody-6a10_nb600-443b
*  rs1801131 - SNPedia
MTHFR polymorphisms, folate intake and carcinogen DNA adducts in the lung. [PMID 22706675] Folic acid supplementation, MTHFR ... Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide ... PMID 21347786] DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the ... Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. ...
  https://www.snpedia.com/index.php/Rs1801131
*  HON: Hepatitis B V4.1 - Complementary Medicine
... decreases carcinogen-induced DNA damage, and prevents the ultimate formation of carcinogen-DNA adducts.(30) All of these ... The ability of NAC to prevent carcinogen-DNA adducts offers hope for more than preventing cancer. For instance, multiple DNA ... DNA adduct formation in other organs could explain numerous consequences of carcinogen exposure. They hypothesised that DNA ... Administration of NAC to these animals inhibited the formation of these carcinogen-DNA adducts in all organs.(31) These authors ...
  http://www.hon.ch/Library/Theme/HepB/comp.html
*  Norman H. Chiu , UNCG NC DOCKS (North Carolina Digital Online Collection of Knowledge and Scholarship)
... and form covalently bound carcinogen-DNA adducts. Clinically, carcinogen-DNA adducts have been linked to various cancer ... Accurate characterization of carcinogenic DNA adducts using MALDI tandem time-of-flight mass spectrometry.. 2009. 981. Many ... The DNA label contains a firefly luciferase coding sequence downstream from a T7 RNA polymerase promoter. The target DNA (200 ... Although the UV absorbance of DNA at 260 nm has been recognized as a standard method for DNA quantitation, there are ...
  http://libres.uncg.edu/ir/uncg/clist.aspx?id=473
*  IJERPH | Free Full-Text | Non-Chemical Stressors and Cumulative Risk Assessment: An Overview of Current Initiatives and...
Correlation between biomarkers of human exposure to genotoxins with focus on carcinogen-DNA adducts. Mutagenesis 2008, 73, 1-18 ... For decades, there have been attempts to assess total DNA damage by looking at chromosomal damage or DNA adducts in workplace ... In many cases, evaluating a general biomarker of DNA damage was done in order to identify hazardous industries in which there ... Sram, RJ; Binkova, B. Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, ...
  https://www.mdpi.com/1660-4601/8/6/2020/htm