Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint ...

Weston A, Poirier MC (2005). "Carcinogen-DNA Adduct Formation and DNA Repair.". In Wexler P (ed.). Encyclopedia of Toxicology. ... DNA adducts are researched in laboratory settings. A typical experimental design for studying DNA adducts is to induce them ... These carcinogens end up forming adducts when reacted with DNA, with those being called pyridyl oxobutyl (POB) adducts. Further ... forming DNA adducts, and inducing double-strand breaks (DSBs). In regards to DNA adduct formation, this analysis was conducted ...

Dive into the research topics of NMR solution structures of stereoisomeric covalent polycyclic aromatic carcinogen-DNA adducts ... NMR solution structures of stereoisomeric covalent polycyclic aromatic carcinogen-DNA adducts: Principles, patterns, and ... NMR solution structures of stereoisomeric covalent polycyclic aromatic carcinogen-DNA adducts: Principles, patterns, and ... NMR solution structures of stereoisomeric covalent polycyclic aromatic carcinogen-DNA adducts: Principles, patterns, and ...

Bulky carcinogen-DNA adducts commonly cause replicative polymerases to stall, leading to a switch to bypass polymerases. We ... N2 - Bulky carcinogen-DNA adducts commonly cause replicative polymerases to stall, leading to a switch to bypass polymerases. ... AB - Bulky carcinogen-DNA adducts commonly cause replicative polymerases to stall, leading to a switch to bypass polymerases. ... abstract = "Bulky carcinogen-DNA adducts commonly cause replicative polymerases to stall, leading to a switch to bypass ...

Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 ... DNA polymerase IV (Dpo4): modeling and dynamics studies. ... food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA ... Bulky carcinogen-DNA adducts commonly cause replicative polymerases to ... Bulky carcinogen-DNA adducts commonly cause ... suggesting that the PhIP adduct enhances incorporation of these mismatches. Finally, bulky C8-dG adducts, situated in the major ...

NIOSH-Grant; Cancer; Pyrenes; Cell-cultures; Carcinogens; DNA-adducts; Metabolic-study; Mammalian-cells; Iron-oxides ... The effects of particles on the metabolism of benzo(a)pyrene (50328) (BaP) and on the formation of BaP-DNA adducts were ... Results also indicated that Fe2O3 enhanced the formation of total DNA adduct in the hamster tracheal epithelial cells. The ... author suggests that enhanced BaP metabolism and DNA adduct formation by Fe2O3 particles results from an increased uptake of ...

Carcinogen-DNA Adducts in Cultures of Rat and Human Hepatocytes.. 1992. 2. NTP technical report on the carcinogenesis bioassay ...

MTHFR polymorphisms, folate intake and carcinogen DNA adducts in the lung. [PMID 22706675] Folic acid supplementation, MTHFR ... Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide ... PMID 21347786] DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the ... Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. ...

Polyaromatic hydrocarbons and nicotine-derived nitrosamine ketone (NNK) are known to cause DNA damage by forming DNA adducts in ... Exposure to carcinogens. Tobacco smoke contains more than 300 harmful substances with at least 40 known potent carcinogens. ... The silicate type of asbestos fiber is an important carcinogen. Asbestos exposure has been shown to be strongly associated with ... This difference may be due to differences in DNA repair mechanisms. Although still considered controversial, it is well known ...

... polymorphisms in specific genes can modulate the formation of DNA-carcinogen adducts (Ketelslegers et al., 2006) which favors ... All of these gene groups need to be considered when analyzing the efficiency of reactive metabolite generation, DNA-adduct ... DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1 and mEH Cancer Epidemiol ... Interindividual variations in DNA adduct levels assessed by analysis of multiple genetic polymorphism in smokers. Cancer ...

Kato, S., Bowman, E. D., Harrington, A. M., Blomeke, B., and Shields, P. G. Human lung carcinogen-DNA adduct levels mediated by ... Rimbach, G., Guo, Q., Akiyama, T., Matsugo, S., Moini, H., Virgili, F., and Packer, L. Ferric nitrilotriacetate induced DNA and ... effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with ...

Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Optional) PAR-19- ... "adducts". The carcinogen-induced DNA-, RNA-, and protein adducts contribute to tumor emergence and are highly relevant markers ... DNA adducts have been most widely studied with regard to their roles in cancer initiation. DNA adducts, if not correctly ... For example, adductomic studies may aim to identify the patterns of DNA adducts along the sequence of genomic DNA, to ...

NNN have been shown to cause DNA adducts associated with tumours in rodents and are classified as probable human carcinogens by ... known human carcinogens) or 2A (probable human carcinogens) or group 2B (possible human carcinogens). Group 3 chemicals (not ... DNA adduct formation from tobacco-specific N-nitrosamines. Mutation Research1999;424:127-42. ... However, BDE is not a group 1 IARC carcinogen, and it is possible that the potency factor calculated for BDE by the Cal/EPA, ...

J. K. Wiencke, K. T. Kelsey, A. Varkonyi et al., "Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen ... N. Li, X. Jia, C. Y. O. Chen et al., "Almond consumption reduces oxidative DNA damage and lipid peroxidation in male smokers," ... T. Nunoshiba and B. Demple, "Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide," Cancer ... Cigarette smokers continuously inhale thousands of carcinogens and free radicals. It is estimated that about 1017 oxidant ...

DNA adduct formation, as a measure DNA carcinogen exposure, is increased in FAP versus controls (43-45). Furthermore, the ... DNA adducts, detected by 32P-postlabelling, in DNA treated in vitro with bile from patients with familial adenomatous polyposis ... DNA adducts, detected by 32P-postlabelling, in the foregut of patients with familial adenomatous polyposis and in unaffected ... DNA adducts detected by 32P-postlabelling, in the intestine of rats given bile from patients with familial adenomatous ...

NA is currently classified by the International Agency for Research on Cancer (IARC) as a Class 2B Carcinogen. There is direct ... the types and abundances of NA-DNA adducts in circulating leukocytes will at least partly reflect adduct formation in the lung ... The objective of this study is to identify and quantify NA-DNA adducts in mouse lung as well as mouse and human blood to enable ... In Aim 1, I will Identify and quantitate NA-DNA adducts formed in wild-type (WT) mice following NA inhalation exposure, with ...

... vitro studies have reported that this molecule is able to reduce the formation of DNA adducts by several genotoxic carcinogens ... activating DNA repair enzymes [2] and phase-II enzymes involved in carcinogen detoxification. Furthermore, coffee modulates the ... Moreover, it would seem that diterpenes can promote the elimination of carcinogens and improve antioxidant status. ... including DNA repair, proliferation, apoptosis, intra- and extracellular signaling, and adhesion, among others [47]. Ethnicity ...

Professor of Chemistry Ashis Basu described his research projects on DNA damage, DNA-covalent adducts of carcinogens, and the ... Barton, a recipient of the prestigious Priestly Medal, spoke on electron transfer through DNA. Dr. Barton was also a ... Her talk led to interesting discussions on the electron transport mechanism and how DNA-mediated electron transport plays an ... Professor Michael Purugganan from New York University described his collaboration with Professor Kumar on DNA-mediated electron ...

Polyaromatic hydrocarbons and nicotine-derived nitrosamine ketone (NNK) are known to cause DNA damage by forming DNA adducts in ... Exposure to carcinogens. Tobacco smoke contains more than 300 harmful substances with at least 40 known potent carcinogens. ... The silicate type of asbestos fiber is an important carcinogen. Asbestos exposure has been shown to be strongly associated with ... This difference may be due to differences in DNA repair mechanisms. Although still considered controversial, it is well known ...

Wu J., Gu L., Wang H., Geacintov N. E., Li G. M. Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis.. Mol ... This complex is believed to act as a DNA damage sensor and to participate in the recognition and repair of aberrant DNA ... It has been proposed that CPT cytotoxicity relies on the collision of the DNA replication fork with topoI-DNA complexes during ... Holm C., Covey J. M., Kerrigan D., Pommier Y. Differential requirement of DNA replication for the cytotoxicity of DNA ...

These effects are mediated through its ability to induce apoptosis, inhibit DNA-carcinogen adduct formation, and suppress free- ... In contrast, in undifferentiated cells insulin and IGF-I stimulated a large increase of [3H]thymidine incorporation into DNA ... Numerous studies have indicated that I3C also has a strong hepatoprotective activity against various carcinogens. Initial ... decreased carcinogen activation by inhibition of phase I enzymes, and slowed tumor growth and induction of apoptosis. ...

Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct ... They inflict DNA damage, increasing the risk of cancer-causing cellular mutation.25 *They stimulate metastasis (cancer cell ... Cyclooxygenase-2-mediated DNA damage. J Biol Chem. 2005 Aug 5;280(31):28337-46. ... Polaprezinc, a gastroprotective agent: attenuation of monochloramine-evoked gastric DNA fragmentation. J Gastroenterol. 1999;34 ...

DNA adduct: the binding of an environmental chemical with DNA, causing DNA damage; sometimes used as biomarkers of effect in ... DMBA serves as a model carcinogen for the class of PAHs (polycyclic aromatic hydrocarbons), which include many carcinogens; ... Epigenetic: modifications to the structure of the DNA, but not the DNA sequence, that result in changes in gene function (the ... DNA (deoxyribonucleic acid): the molecule inside the cell that carries genetic information and is passed on from one generation ...

DNA adducts levels were significantly lower in pipe or cigar smokers than in cigarette smokers. In multivariate analysis, ... Cytochrome P-450-1A (CYP1A) is a major pathway activating carcinogens from tobacco smoke. Our primary aim was to compare CYP1A2 ... Nitrosamine and benzo[a]pyrene DNA adducts were measured in lymphocytes. CYP1A2 activity was greater (p,0.0001) in cigarette ...

Micronuclei and Carcinogen DNA Adducts as Intermediate End Points in Nutrient Intervention Trial of Precancerous Lesions in the ...

Myron Mehlman to testify that MTBE causes adducts to form on DNA and is a probable human carcinogen. Judge Scheindlin found ... The expert relied on the peer reviewed MTBE-DNA Adducts study, as well as numerous studies allegedly showing exposure to MTBE ...

Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o. -anisidine and 2-nitroanisole ... follow from adducts generated by their metabolite N. -(2-methoxyphenyl)hydroxylamine with deoxyguanosine in DNA. Marie ... Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o. -anisidine and 2-nitroanisole ... follow from adducts generated by their metabolite N. -(2-methoxyphenyl)hydroxylamine with deoxyguanosine in DNA. Marie ...