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*  Primed to Understand Fibrinogen in Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
Fibrinogen gamma′ chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway. Br J Haematol. 2007; ... chain containing a unique 20-amino acid sequence at the C terminus. Between 8% and 15% of circulating fibrinogen in healthy ... to-total fibrinogen ratio7-11 suggests that γA/γ′ fibrinogen is not simply a biomarker for increased total fibrinogen. Together ... fibrinogen versus γA/γA fibrinogen.30 Accordingly, γA/γ′ fibrinogen may be increased to downregulate inflammation-induced ...
  http://atvb.ahajournals.org/content/36/1/4
*  Immune physiologic D/C Flashcards by Lorne Runge | Brainscape
The carboxy terminus is similar to fibrinogen. Binds to syndecan. Multiple disulfide bonds and glycosylation sites. The C form ...
  https://www.brainscape.com/flashcards/immune-physiologic-d-c-2484247/packs/4392200
*  FGL1 Gene - GeneCards | FGL1 Protein | FGL1 Antibody
Fibrinogen Like 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen ... Liver fibrinogen-related protein 1 (FGL1_HUMAN). *cDNA FLJ75986, highly similar to Homo sapiens fibrinogen-like 1 (FGL1), ... FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Basal Laminar Drusen and ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=FGL1
*  fgl1, fibrinogen-like 1 - Creative Biogene
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen ... FGL1; fibrinogen-like 1; fibrinogen-like protein 1; HFREP 1; FGL 1; FGL1_HUMAN; Fibrinogen like 1; Fibrinogen like protein 1; ... Hepatocyte derived fibrinogen related protein 1; Hepatocyte-derived fibrinogen-related protein 1; HFREP-1; HFREP1; HP 041; HP- ... 041; HP041; LFIRE 1; LFIRE-1; LFIRE1; Liver fibrinogen related protein 1; Liver fibrinogen-related protein 1; MFIRE 1; ...
  https://www.creative-biogene.com/symbolsearch_fgl1.html
*  Fibrinogen alpha chain - Wikipedia
Alternative splicing results in two isoforms that vary in the carboxy-terminus. Fibrinogen alpha chain has been shown to ... Fibrinogen Fibrinogen gamma chain GRCh38: Ensembl release 89: ENSG00000171560 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and ... Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha ...
  https://en.wikipedia.org/wiki/Fibrinogen_alpha_chain
*  Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial...
... sequences at the carboxy terminus and the middle section of the 2 Aα chains of fibrinogen17 are able to bind to endothelial ... at 1 μmol/L fibrinogen, to 171±18% at 2 μmol/L fibrinogen, and to 210±20% at 4 μmol/L fibrinogen (ANOVA, P,0.05; n=4). After ... of basal levels at 0.3 μmol/L fibrinogen, to 112±8% at 1 μmol/L fibrinogen, to 109±10% at 2 μmol/L fibrinogen, and to 94±4% at ... The role of fibrinogen as a bridging ligand was attributed to binding of the γ117-133 sequence of the fibrinogen D domain to ...
  http://atvb.ahajournals.org/content/20/3/652
*  FGL1 - Wikipedia
FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved ... Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like ... Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the ... "Entrez Gene: FGL1 fibrinogen-like 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure ...
  https://en.wikipedia.org/wiki/FGL1
*  Point-of-Care Testing of Hemostasis in Cardiac Surgery | Thrombosis Journal | Full Text
Thrombin cleaves the amide bond at the carboxy-terminus of the arginine residue, because the bond structurally resembles the ... The substrate used in the electrogenic assay has an amide linkage that mimics the thrombin-cleaved amide linkage in fibrinogen ... platelet counts and fibrinogen levels. So, Sonoclot TP is able to investigate platelet function in patients undergoing cardiac ... thrombin-cleaved amide linkage in fibrinogen. This reaction produces an electroactive compound which is detected ...
  https://thrombosisjournal.biomedcentral.com/articles/10.1186/1477-9560-1-1
*  FGL2 - Wikipedia
The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a ... The protein exists as both a Type II transmembrane protein (with the carboxy terminus on the extracellular side of the plasma ... Fibrinogen-like protein 2, also known as FGL2, is a protein which in humans is encoded by the FGL2 gene. FGL2 is a 439 amino ... 2005). "Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection". J. Immunol ...
  https://en.wikipedia.org/wiki/FGL2
*  COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Patent application
The paxillin binding sequence (PBS) on GIT1 is found at the carboxy-terminus of the protein and has been shown to prevent ... Additionally, cells expressing αIIb:β3 or αIIb-Robo4:β3 were plated on fibronectin and fibrinogen, and Rac-GTP levels were ... To clarify which Lim domain is required for binding to Robo4, serial deletions were made from the carboxy terminus of paxillin ... As described previously, cells expressing αIIb-Robo4:β3 displayed a decrease in cell area when plated on fibrinogen, but this ...
  http://www.patentsencyclopedia.com/app/20100222401
*  Hybridoma Center
Ndonwi M, Girard TJ, Broze GJ Jr. The carboxy-terminus of TFPI alpha is required for its interaction with factor V and Va. J. ... Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation. Proc. Natl ...
  https://pathology.wustl.edu/research/core-facilities/hybridoma-center/
*  A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial...
Introduction of a synthetic peptide corresponding to the C terminus of the Gi3 alpha subunit into permeabilized CD8 cells ... C-terminus DEFINITION: The intracellular carboxy-terminus or tail of the vasopressin-2 receptor (V2R). See diagram. ... fibrinogen and other coagulation factors, complement components, immunoglobulins, enzyme inhibitors, precursors of substances ... The peptides corresponded to a part of the G proteins called the C-terminus (the tail end of the protein). Each G protein had a ...
  http://www.ndif.org/articles/22-A_Heterotrimeric_G_Protein_of_the_Gi_Family_is_Required_for_cAMPtriggered_Trafficking_of_Aquaporin_2_in_Kidney_Epithelial_Cells/body
*  Proteases in angiogenesis - Wikipedia
The hemopexin like domain in the carboxy terminus of MMP-2 is able to block this interaction of active MMP-2 and integrin αvβ3 ... For example, MMP-3, 7, 8, 12 and 13 can cleave fibrinogen. MMP activity is one of the earliest and most sustained processes ... Lastly, endorepellin is a recently described inhibitor of angiogenesis derived from the carboxy terminus of perlecan. Nanomolar ... Mongiat, M (2003). "Endorepellin, a novel inhibitor of angiogenesis derived from the carboxyl terminus of perlecan". J. Biol. ...
  https://en.wikipedia.org/wiki/Proteases_in_angiogenesis
*  ICAM-1 - Wikipedia
... and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein's ... and fibrinogen. These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to ... ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, ...
  https://en.wikipedia.org/wiki/ICAM-1
*  Patent US6887473 - Inhibition of angiogenesis in disease states with an anti-αvβ3 monoclonal ... - Google Patents
COOH refers to the free carboxy group present at the carboxy terminus of a polypeptide. In keeping with standard polypeptide ... wherein said antibody preferentially inhibits fibrinogen binding to αvβ3 compared to fibrinogen binding to αIIbβ3. ... The unprotected linear peptide with free amino and carboxy termini so obtained is converted to its corresponding cyclic peptide ... herein by formulae whose left and right orientation is in the conventional direction of amino-terminus to carboxy-terminus. ...
  http://www.google.com.au/patents/US6887473
*  Human Angiopoietin 2 peptide (ab172727) | Abcam
18 amino acids near the carboxy terminus of Human ANGPT2.. Associated products. ... The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor. ...
  http://www.abcam.com/human-angiopoietin-2-peptide-ab172727.html
*  US6103888A - Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity - Google Patents
... fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated ... The sequence derived from Edman degradation is found at the carboxy-terminus of the protein beginning at amino acid position ... Prothrombinase converts prothrombin (factor II) to thrombin (IIa). Thrombin generates fibrin monomers from fibrinogen. Because ... CAP18 includes a short peptide, usually present at its carboxy-terminus, referred to as the reactive nitrogen inhibitory ...
  https://patents.google.com/patent/US6103888
*  Undergraduate Research Symposium Abstracts from Biology 2006 A-K
A multi-step cloning strategy was used to add the HA coding sequence to the carboxy terminus of the human gene already cloned ... As the concentration of Fibrinogen increased the absorbance of the B7 cells at 485 nm increased. Beyond 50 g/mL of Fibrinogen ... Fibrinogen was used as the ECM. Serum-starved cells were labeled with Calcein AM and readings were taken at an absorbance of ... into pUAST, an in vivo and in vitro Drosophila expression vector, (pUAST-Hsrt-HA). Despite abundant similarity, the carboxy ...
  http://www1.udel.edu/chem/white/HHMI2/Symp06/BiolAbst06A-K.html
*  New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins | JEM
TM is a complex membrane protein with a lectin-like domain from the amino terminus, six epidermal growth factor (EGF)-like ... but also blocks the ability of thrombin to clot fibrinogen and participate in platelet and endothelial cell activation (25). An ... this class of enzymes removes carboxy terminal arginine and lysine residues. It was originally thought that this enzyme's major ...
  http://jem.rupress.org/content/196/5/561
*  Method of Measuring Amyloid-Beta Peptides - Patent application
For example, Aβ(1-43) is an Aβ species or variant, whose amino terminus begin at amino acid number 1 and carboxy terminus ends ... Because plasma is serum plus the clotting protein fibrinogen, the term "plasma" is used broadly herein to encompass "serum." [ ... Aβ whose carboxy termini extend beyond amino acid 40; but it may also detect AD whose amino termini do not extend to amino acid ... shown above and whose carboxy-terminus ends at different amino acid number, such as Aβ(1-39), Aβ(1-40), Aβ(1-41), and Aβ(1-42 ...
  http://www.patentsencyclopedia.com/app/20090123952
*  US5719041A - DNA encoding ecotin homologs - Google Patents
USA 82:5132 1985!). Solid phase synthesis begins at the carboxy-terminus of the putative peptide by coupling a protected amino ... Factor Xa activates prothrombin to thrombin which cleaves fibrinogen to fibrin and ultimately results in the formation of a ... ID NO:8) and corresponded to the amino terminus of ecotin.. FIG. 6. Determination of the molecular weight of the ecotin •FXa ... For insoluble carriers, those which react with the carboxy group of the C-terminal amino acid to form a bond which is readily ...
  https://patents.google.com/patent/US5719041?oq=patent%3A5992892
*  Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
MMP-23 has a unique carboxy terminal domain rich in cysteine and an immunoglobulin-like domain after the C terminus of the ... Casein, fibrinogen and fibronectin. MMP-26. Collagen type IV and gelatin. Casein. α1-antitrypsin. ... Typically in MMPs, carboxy-terminal end is linked to hemopexin domain with linker peptide called 'hinge region'. Hemopexin ... specifically three-fourths from the N-terminus. In that way they are making characteristic ¼ and ¾ fragments. Beyond the ...
  https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
*  WikiGenes - leucine - (2R)-2-amino-4-methyl-pentanoic acid
... and a carboxy terminus with high homology to cyclophilin [39]. ... renal amyloidosis associated with a mutant fibrinogen alpha- ...
  http://www.wikigenes.org/e/chem/e/439524.html
*  Experimental Evolution: Foot-and-Mouth Disease Virus - Immunology and Evolution of Infectious Disease - NCBI Bookshelf
12.3). In serotype C, the carboxyl terminus of VP1 also contributes to this site, and in serotype O, the EF loop of VP2 is ... A second discontinuous epitope occurs in serotype O. The GH loop and the carboxy-terminal (COOH) end of VP1 jointly form the ... fibrinogen, and type I collagen (Fox et al. 1989). All field isolates of FMDV have the conserved RGD motif needed for ... However, in serotype C, the GH loop and the carboxy-terminal end of VP1 form independent, continuous epitopes. The high ...
  https://www.ncbi.nlm.nih.gov/books/NBK2393/
*  Analytical Enzyme Factor Xa | Sigma-Aldrich
Further hydrolysis of a small glycopeptide from the carboxy-terminus of the heavy chain yields factor Xaβ, which has equal ... Activation of factor X involves the hydrolysis of a 9.5 KDa peptide from the amino terminus of the heavy chain of the zymogen. ... Fibrinogen & Fibrin * Luciferase * BioUltra Proteins * Cell Signaling Enzymes, Proteins and Peptides * Enzyme Reagents ...
  https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/factor-xa.html