*  Galectins Sebagai Modulator Progresi Tumor | Moko Apt
Famili ini dikenal dengan setidaknya satu karakteristik carbohydrate recognition domain (CRD) dengan afinitas untuk beta- ... Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting ... Galectins (juga dikenal sebagai galaptins atau S-lectin) merupakan famili lektin yang terikat pada beta-galactoside. ... a , Galectins are a family of animal lectins characterized by conserved carbohydrate-recognition domains (CRDs) consisting of ...
  https://moko31.wordpress.com/2011/12/13/galectins-sebagai-modulator-progresi-tumor/
*  Galectin-1 - Wikipedia
The oxidized form is reported to have alternative functions not involving carbohydrate binding. The galectins are a family of ... Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. LGALS1 contains four exons. The galectin-1 protein is 135 ... Galectin 1 contains a single carbohydrate recognition domain through which it can bind glycans both as a monomer and as a ... Galectin-1 is thought to play a role in creating immune tolerance in pregnancy. Galectin-1 is expressed by the endometrial ...
  https://en.wikipedia.org/wiki/Galectin-1
*  Galectin-1 Antibody 11858-1-AP | Proteintech
Galectin-1 Antibody 11858-1-AP has been identified with IF, IHC, WB, ELISA. 11858-1-AP detected 15 kDa band in NIH/3T3 cells ... Galectin-1 Antibody 2 Publications. Rabbit Polyclonal, Catalog number: 11858-1-AP ... Galectins are a family of animal lectins defined by shared characteristic amino-acid sequences and affinity for β-galactose- ... Galectin-1 is a multifunctional protein that is involved in cell adhesion, migration, proliferation, apoptosis, inflammation, ...
  https://www.ptglab.com/Products/GAL1,LGALS1-Antibody-11858-1-AP.htm
*  Galectin - Wikipedia
... the length of the carbohydrate and the mode of presentation of ligand to carbohydrate recognition domain. Different galectins ... Tandem galectins include galectin-4, -6, -8, -9 and -12. The final galectin is galectin-3 which is the only galectin found in ... The galectin carbohydrate recognition domain (CRD) is constructed from beta-sheet of about 135 amino acids. The two sheets are ... Tandem galectins contain at least two distinct carbohydrate recognition domains (CRD) within one polypeptide, thus are ...
  https://en.wikipedia.org/wiki/Galectin
*  Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis | Cancer Research
Galectins are members of a large carbohydrate-binding lectins that share a highly conserved carbohydrate recognition domain ( ... Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta 1999;1473:172-85. ... Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology 1997;113:1906-15. ... Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional ...
  http://cancerres.aacrjournals.org/content/71/13/4423
*  Galectins | Sigma-Aldrich
Galectin-3C Galectin-3C is a truncated form of galectin-3 that contains the carboxy-terminus carbohydrate-binding domain. ... The only chimera galectin currently identified (galectin-3) contains one CRD connected to a non-lectin domain. The tandem- ... Galectin-3 Galectin-3, also called Mac-2, L29, CBP35 and εBP, is a chimera galectin that is expressed in tumor cells, ... Galectins occur at high concentration in a limited range of cell types, different for each galectin. Galectins bind to sugar ...
  https://www.sigmaaldrich.com/technical-documents/articles/biofiles/galectins.html
*  Patent US7416725 - Compositions and methods of using galectin-8 as an inhibitor of tumor cell ... - Google Patents
It further provides compositions and methods for modulating the expression of galectin-8, and galectin-8-like proteins, ... The present invention provides compositions that enhance or inhibit the interactions of galectin-8 and galectin-8-like proteins ... Galectin-8 is composed of two homologous (38% identity) carbohydrate recognition domains joint by a short (˜26 amino acids) ... exemplified by but not limited to antibodies to the hinge region that links the two carbohydrate recognition domains. While ...
  http://www.google.com/patents/US7416725?dq=7181427
*  Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Pathogenesis | Faculty Open Information System
... contains a conserved carbohydrate recognition domain that recognizes galactose-containing oligosaccharides. As the envelope ... We found that galectin-1 was upregulated in the lung of mice during influenza virus infection. There was a positive correlation ... Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Pathogenesis. *檢視 ... Cells treated with recombinant human galectin-1 generated lower viral yields after influenza virus infection. Galectin-1 could ...
  http://oar.npust.edu.tw/node/24567
*  Manipulating Galectin Expression in Zebrafish (Danio rerio)
... proto-type galectins, which contain one carbohydrate recognition domain (CRD) and form homodimers; (ii) chimera-type galectins ... Galectins are β-galactosyl-binding lectins with a characteristic sequence motif in their carbohydrate recognition domains (CRDs ... Galectins are β-galactosyl-binding lectins, which share primary structural homology in their carbohydrate-recognition domains ( ... Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin. Biochemical ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4600349/
*  MicroRNA profiles during galectin‑9‑induced apoptosis of pancreatic cancer cells
Galectin-9 (Gal-9) is a tandem-repeat type galectin with 2 carbohydrate-recognition domains (CRDs), and it was first identified ... Galectin‑9 (Gal‑9) is a tandem‑repeat type galectin that has recently been demonstrated to possess an anti‑proliferative effect ... Saita N, Goto E, Yamamoto T, Cho I, Tsumori K, Kohrogi H, Maruo K, Ono T, Takeya M, Kashio Y, et al: Association of galectin-9 ... Dai S, Nakagawa R, Itoh A, Murakami H, Kashio Y, Abe H, Katoh S, Kontani K, Kihara M, Zhang SL, et al: Galectin-9 induces ...
  https://www.spandidos-publications.com/ol/15/1/407
*  Frontiers | Extracellular Galectin-3 in Tumor Progression and Metastasis | Oncology
Galectin-3 presence enhances migration and/or invasion of many tumors. Galectin-3-dependent clustering of integrins promotes ... Galectin-3 presence enhances migration and/or invasion of many tumors. Galectin-3-dependent clustering of integrins promotes ... This lectin is found in the tumor stroma, suggesting a role for microenvironmental galectin-3 in tumor progression. Galectin-3 ... This lectin is found in the tumor stroma, suggesting a role for microenvironmental galectin-3 in tumor progression. Galectin-3 ...
  https://www.frontiersin.org/articles/10.3389/fonc.2014.00138/full
*  Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes | PNAS
2007) Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. ... 2003) The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity. ... 2016) Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, ... 2011) Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J Biol Chem 286:11346-11355. ...
  http://www.pnas.org/content/115/11/E2509
*  LGALS7 Human His | ProSpec
Galectin-7 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated ... polypeptide chain containing 156 amino acids (1-136 a.a.) and having a molecular mass of 17.2kDa. ... Galectins share similarities in the CRD (the carbohydrate recognition domain). Galectins are synthesized as cytosolic proteins ... Human Galectin-7 is localized in both nucleus and cytoplasm.. Description. Galectin-7 Human Recombinant fused with a 20 amino ...
  https://www.prospecbio.com/LGALS7_Human_His
*  Galectin-9 | SpringerLink
Ecalectin; Gal-9; Galectin 9; HUAT; Lectin, galactoside-binding, soluble, 9; LGALS9; LGALS9A; Tumor antigen HOM-HD-21; Urate ... transporter/channel protein Galectin-9 (gal-9) is a member of the... ... Carbohydrate-recognition domains of galectin-9 are involved in intermolecular interaction with galectin-9 itself and other ... galectin-9 n-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition ...
  https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101652
*  How a Plant Lectin Recognizes High Mannose Oligosaccharides | Plant Physiology
... galectin-3 and the carbohydrate recognition domain of galactin-3. Glycobiology 14: 817-825. ... Sharma V, Surolia A (1997) Analyses of carbohydrate recognition by legume lectins: size of the combining site loops and their ... Only 12 out of the more than 500 structures of lectins and carbohydrate-binding domains currently present in the Protein Data ... α-OMe-concanavalin A complex reveals a balance of forces involved in carbohydrate recognition. Glycobiology 9: 539-545. ...
  http://www.plantphysiol.org/content/144/4/1733.full
*  Galectin-7 (IPR030640) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... and are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. ... Structural basis for the recognition of carbohydrates by human galectin-7.. Biochemistry 37 13930-40 1998 ... they typically bind through the activity of a specific compact protein domain known as a carbohydrate-binding domain or CRD [ ...
  http://www.ebi.ac.uk/interpro/entry/IPR030640
*  Detection of galectin-3 in tear fluid at disease states and immunohistochemical and lectin histochemical analysis in human...
Based on structural analysis of the carbohydrate recognition domains, animal lectins are currently classified into five ... Inflammatory leucocytes and goblet cells found in galectin-3 containing tear fluid also expressed galectin-3. Galectin-3 ... express galectin-3 and galectin-3 reactive glycoligands in a similar pattern.21 24 The co-localisation of galectin-3 reactive ... 1996) Modulation of functional properties of galectin-3 by monoclonal antibodies binding the non-lectin domains. Biochemistry ...
  http://bjo.bmj.com/content/85/11/1336
*  Molecules | Free Full-Text | Studying the Structural Significance of Galectin Design by Playing a Modular Puzzle: Homodimer...
Engineering of variants by changing the topological display of carbohydrate recognition domains (CRDs) provides tools to ... We here illustrate its practical implementation in the case of human tandem-repeat-type galectin-8 (Gal-8). It is termed Gal-8 ... The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is ... Engineering of variants by changing the topological display of carbohydrate recognition domains (CRDs) provides tools to ...
  https://www.mdpi.com/1420-3049/22/9/1572
*  Galectin-8 - Wikipedia
Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been ... Ideo H, Seko A, Ishizuka I, Yamashita K (2004). "The N-terminal carbohydrate recognition domain of galectin-8 recognizes ... Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene. This gene encodes a member of the ... 2001). "Galectin-8: a complex sub-family of galectins (Review)". Int. J. Mol. Med. 8 (3): 245-50. doi:10.3892/ijmm.8.3.245. ...
  https://en.wikipedia.org/wiki/Galectin-8
*  Introduction to galectins | SpringerLink
Good evidence suggest roles of galectins in cancer, immunity and inflammation, and development, but a unifying picture of their ... X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution, J Biol Chem 273, 13047-52 ... Drickamer K, Two distinct classes of carbohydrate-recognition domains in animal lectins, J Biol Chem 263, 9557-60 (1988).Google ... Hughes RC, Secretion of the galectin family of mammalian carbohydrate-binding proteins, Biochim Biophys Acta 1473, 172- 85 ( ...
  https://link.springer.com/article/10.1023%2FB%3AGLYC.0000014072.34840.04
*  台桂花
2. The N-terminal tail coordinates with carbohydrate recognition domain to mediate galectin-3 induced apoptosis in T cells, ... Two Endocytic Pathways Mediated by the Carbohydrate Recognition Domain and Regulated by the Collagen-like Domain of Galectin-3 ... 6. Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and ... The inhibitory effects of a Rhamnogalacturonan I (RG-I) domain from ginseng pectin on galectin-3 and its structure-activity ...
  http://js.nenu.edu.cn/teacher/index.php?zgh=2001900080
*  Transmembrane protein 63A is a partner protein of Haemonchus contortus galectin in the regulation of goat peripheral blood...
It was reported that the C-terminal carbohydrate recognition domain (CRD) of galectin-1 and galectin-9, but not N-terminal CRD ... Specific recognition of Leishmania major poly-beta-galactosyl epitopes by galectin-9: possible implication of galectin-9 in ... Previous research suggested that T cell immunoglobulin domain and mucin domain (Tim)-3 was the receptor of galectin-9 on Th1 ... The carbohydrate-dependent binding of galectin-4 secreted by intestinal epithelial cells to the CD3 epitope is fully functional ...
  https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-0816-3
*  Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types.
... and also by the R186S mutation in the galectin-3 carbohydrate recognition domain (CRD). In M1 cells galectin-3 endocytosis ... and also by the R186S mutation in the galectin-3 carbohydrate recognition domain (CRD). In M1 cells galectin-3 endocytosis ... although the non-CRD galectin-3 domain is also involved. General significance The demonstration that galectin-3 endocytosis in ... although the non-CRD galectin-3 domain is also involved. General significance The demonstration that galectin-3 endocytosis in ...
  https://lup.lub.lu.se/search/publication/2431447
*  Lectin, Galactoside-Binding, Soluble, 4 (LGALS4) ELISA Kits
structure of galectin-4 and binding properties of the N-terminal domain carbohydrate-recognition domain (CRD)1 were further ... While the CRD2 domain of galectin-4 has a high specificity and affinity for A type-2 alpha-GalNAc structures, the CRD1 domain ... while galectin-2 (zeige LGALS2 ELISA Kits), galectin-3 (zeige LGALS3 ELISA Kits), and galectin-4 were strongly expressed. ... galectin family xgalectin-VIa , Galectin-4 , galectin-4 , lactose-binding lectin 4 , gal-4 , L-36 lactose binding protein , L- ...
  https://www.antikoerper-online.de/abstract/Lectin%2C+Galactoside-Binding%2C+Soluble%2C+4+
*  KAKEN - Research Projects | Analysis of the role of galectin family and its signaling in the host-response to infection and...
The results revealed that N-terminal CRD(carbohydrate recognition domain) of galectin-8 bound pormatrix metalloproteinase-9 ( ... galectin / immunology / infection / galectin-8 / galectin-9 / integrin / neutrophil / Jurkat / galectin-8 / galectin-9 / インテグリン ... Galectin-9 induced apoptosis of T-cell lines (Jurkat and Molt-4), but galectin-8 did not. Both of galectins mediated the cell ... Specific recognition of Leishmania major Poly-b-galactosyl epitopes by galectin-9 : Possible implication of galectin-9 in ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15570120/