*  Oncovirus - Wikipedia
... capsid and nucleocapsid proteins. In pol, the information for the reverse transcription and integration enzymes are stored. In ... DNA oncoviruses typically impair two families of tumor suppressor proteins: tumor proteins p53 and the retinoblastoma proteins ... the HPV protein E6 binds to a cellular protein called the E6-associated protein (E6-AP, also known as UBE3A), forming a complex ... SV40 uses the same protein for inactivating Rb, LT, to inactivate p53.[39] HPV contains a protein, E7, which can bind to Rb in ...
  https://en.wikipedia.org/wiki/Tumor_viruses
*  Patent US7384738 - Retrovirus-based genomic screening - Google Patents
The resulting provirus or proteins expression from the provirus are then analyzed. ... present invention relates to the expression and screening of genomic DNA sequences encoding uncharacterized genes and proteins ... The gag gene encodes the internal structural proteins (e.g., matrix, capsid, and nucleocapsid proteins); the pol gene encodes ... protein kinases, protein phosphatases, transmembrane proteins, secreted proteins, G-protein coupled receptors). It is ...
  http://www.google.com/patents/US7384738?dq=5,966,702
*  The Scripps Research Institute - News and Views
Inside the immature virion are long Gag polyproteins, which are precursors of the structural proteins nucleocapsid, capsid, and ... Capsid proteins, for instance, assemble into the protein capsid shell that surrounds the RNA of the retrovirus and appears as a ... The capsid proteins from several different retroviruses have now been solved, and their 3-D structures are virtually identical ... According to the model, the structures of the capsid protein domains are more or less the same in the various retroviruses. The ...
  http://www.scripps.edu/newsandviews/e_20030811/onpress.html
*  Effects of Blocking Individual Maturation Cleavages in Murine Leukemia Virus Gag
The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and ... capsid (CA), and nucleocapsid (NC) proteins. We introduced mutations into MLV that inhibited cleavage at individual sites in ... HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro. Proc. Natl. Acad. Sci. USA 93:7577-7581. [ ... Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly. EMBO J. 17:1555-1568. [PubMed ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC321369/?lang=en-ca
*  ERVW-1 (Endogenous Retroviral family W, Env (C7), member 1)
genes, normally coding respectively for the matrix, capsid and nucleocapsid proteins, and for the viral enzymatic machinery, ... Among these ORFs, only two proteins seem to be produced: a Gag protein encoded on a HERV-W pseudogene, and Syncytin-1, encoded ... Protein : pattern, domain, 3D structure. UniProt/SwissProt. Q9UQF0 [function] [subcellular_location] [family_and_domains] [ ... Syncytin-1 proteins present similar fusogenic activity in heterologous cell fusion assays.. *Convergent evolution of endogenous ...
  http://atlasgeneticsoncology.org/Genes/GC_ERVW-1.html
*  UAB - School of Medicine - News - Last unknown structure of HIV-1 solved, another step in efforts to disarm the AIDS virus
The Gag polyproteins are later cut inside the maturing virus to form multiple smaller matrix, capsid and nucleocapsid proteins ... a bacterial enzyme was cutting the protein during protein expression. "We have never seen this for any other protein," Saad ... The rest of this HIV-1 envelope protein, which is docked on a gray membrane, are the structures of gp120 and gp41, shown in ... Co-authors with Saad of the article, "Solution structure and membrane interaction of the cytoplasmic tail of HIV-1 gp41 protein ...
  http://www.uab.edu/medicine/news/latest/item/1703-last-unknown-structure-of-hiv-1-solved-another-step-in-efforts-to-disarm-the-aids-virus
*  US20110142818A1 - Combination enzyme replacement and small molecule therapy for treatment of lysosomal storage diseases ...
The gag gene encodes the internal structural (matrix, capsid, and nucleocapsid) proteins; the pol gene encodes the RNA-directed ... Protein production and protein delivery US5827703A (en) * 1992-06-04. 1998-10-27. The Regents Of The University Of California. ... High mannose proteins and methods of making high mannose proteins US20020142299A1 (en) * 2001-01-09. 2002-10-03. Davidson ... Protein production and protein delivery US6022874A (en) * 1996-10-03. 2000-02-08. Vical Incorporated. Piperazine based ...
  https://patents.google.com/patent/US20110142818A1/en
*  Potyvirus - Wikipedia
The nucleocapsid contains ~2000 copies of the capsid protein. The symmetry of the nucleocapsid is helical with a pitch of 3.4 ... capsid protein (CP) and two small putative proteins known as 6K1 and 6K2. The P3 cistron also encodes a second protein-P3N-PIPO ... The capsid protein ranges between 30 and 35 kDa in weight. The VPg protein interacts with eukaryotic initiation factor 4E ( ... end a protein is covalently linked (the Vg protein). It encodes a single open reading frame (ORF) expressed as a 350kDa ...
  https://en.wikipedia.org/wiki/Potyvirus
*  HERVs in Multiple Sclerosis - From Insertion to Therapy | IntechOpen
... including the nucleocapsid, matrix, and capsid proteins. The pol gene codes for the viral replication proteins, yielding the ... HERVs proteins hold epitopes to B and T cells and molecular mimicry between viral proteins and certain autoantigens may exist, ... Both proteins bind to the PLZF protein, a transcriptional repressor of the C-MYC proto-oncogen. The inflammation and the ... as well as for the Env protein and for the accessory Rec protein [96]. This family has been related with different autoimmune ...
  https://www.intechopen.com/books/advances-in-molecular-retrovirology/hervs-in-multiple-sclerosis-from-insertion-to-therapy/
*  Feline immunodeficiency virus - Wikipedia
The Gag polyprotein is cleaved into matrix (MA), capsid (CA) and nucleocapsid (NC) proteins. Cleavage between CA and NC ... The capsid protein derived from the polyprotein Gag is assembled into a viral core (the protein shell of a virus) and the ... The bovine protein is homologous with other mammalian species and is a homogeneous 50 kDa glycoprotein with an isoelectric ... The protein is prepared in a lyophilized 1 microgram dose. Reconstitution in sterile diluent produces a solution for ...
  https://en.wikipedia.org/wiki/Feline_immunodeficiency_virus
*  VIRUSES, HERPESVIRUSES, AND THE DETECTION OF HERPESVIRUS INFECTIONS IN TORTOISES. | British Chelonia Group
The new nucleic acid associates with the capsid protein and new nucleocapsid is formed. Enveloped viruses (like herpesvirus) ... forming the capsid. The capsid protects the genome. It is also these capsid proteins which enable the virus to attach to host ... The capsid surrounding the nucleoid, is made up of 162 capsomeres. and is closely surrounded by another layer of protein known ... This requires surface capsid proteins, or envelope spikes in the case of the more complex enveloped viruses. Infection follows ...
  http://britishcheloniagroup.org.uk/testudo/v5/v5n2drury
*  The cooperative function of arginine residues in the Prototype Foamy Virus Gag C-terminus mediates viral and cellular RNA...
... present in all FV Gag proteins, is the main viral protein determinant for viral and cellular RNA encapsidation. The viral ... Unlike orthoretroviruses, the content of selected cellular RNAs in capsids of PFV vector particles was not altered by viral ... Finally, this study indicates that analogous to orthoretroviruses, Gag - nucleic acid interactions are required for FV capsid ... capsid protein Gag is the absence of Cys-His motifs, which in orthoretroviruses are irreplaceable for multitude functions ...
  https://retrovirology.biomedcentral.com/articles/10.1186/s12977-014-0087-7
*  METHODS AND COMPOSITIONS RELATING TO IMPROVED LENTIVIRAL VECTORS AND THEIR APPLICATIONS - Patent application
The gag gene encodes the internal structural (matrix, capsid and nucleocapsid) proteins; the pol gene encodes the RNA-directed ... Thus, the packaging unit of the first generation HIV-based vectors comprised all HIV-1 proteins except the envelope proteins ( ... protein G (VSV G), that of hepatitis viruses and of influenza also can be used. [0060] While VSV G protein is a desirable env ... proteins, or peptides some of which are therapeutic genes or proteins which will be used for gene therapies. F. Injectable ...
  http://www.patentsencyclopedia.com/app/20130115692
*  Anti-GAG antibody (ab100970) | Abcam
... capsid (CA) and nucleocapsid proteins. These separated Gag proteins then play roles in the early stages of infection. ... Lane 1 : PageRuler Prestained Protein Ladder (#SM0671, lot: 00052778, Fermentas); Lane 2 : HEK293 cells. Lane 3 : GAG protein ... Lane 4 : PageRuler Prestained Protein Ladder (#SM0671, lot: 00052778, Fermentas);. Lane 5 : CHO cells. Lane 6 : Gag protein ... After budding, the core matures by cleavage of Gag precursor protein into the mature core proteins, the matrix (MA), ...
  http://www.abcam.com/gag-antibody-ab100970.html
*  Zika virus - Wikipedia
The RNA genome forms a nucleocapsid along with copies of the 12-kDa capsid protein. The nucleocapsid, in turn, is enveloped ... the RNA genome encodes seven nonstructural proteins and three structural proteins. One of the structural proteins encapsulates ... This protein is the flavivirus envelope glycoprotein, that binds to the endosomal membrane of the host cell to initiate ... A positive-sense RNA genome can be directly translated into viral proteins. As in other flaviviruses, such as the similarly ...
  https://en.wikipedia.org/wiki/Zika_virus
*  News Release | Scripps Research
... the nucleocapsid is the viral genome protected by a protein coat-the capsid. This core protein plays an essential role in the ... the capsid protein. By targeting the interactions of core with itself or other proteins, we could reduce the problem of rapid ... The core protein is particularly important in the assembly of the hepatitis C nucleocapsid, an essential step in the formation ... However, as the study points out, the one HCV structural protein that has not been targeted yet is the core protein, the one ...
  https://www.scripps.edu/news-and-events/press-room/2009/030909.html
*  USMLE Microbiology Flashcards - Cram.com
HIV's capsid, core nucleocapsid, and matrix proteins are products of what structural gene? ... What protein of the HIV virus does ELISA detect to determine whether a patient is HIV positive? ... Which M-protein strain of Streptococcus pyogenes is associated with acute glomerulonephritis? ... True or false? Interferons are eukaryotic proteins that inhibit viral replication by being virus specific. ...
  http://www.cram.com/flashcards/usmle-microbiology-412278
*  Virology by Christian - Issuu
3. Capsomer is the protein subunit that makes up the capsid. 4. Nucleocapsid is composed of the capsid and genetic material. 5 ... 3. Uncoating occurs when there is either the separation of the capsid from the genome or rearrangement of the capsid proteins ... 2. Capsid is the protein coat that encloses the genetic material. ... Naked nucleocapsids are viruses with no envelopes. C. Replication 1. Adsorption is attachment of the virus to a specific ...
  https://issuu.com/christianmugabo/docs/virology
*  Jaagsiekte sheep retrovirus - Wikipedia
They are "gag" encoding the structural internal virion proteins comprising "matrix" (MA), "capsid" (CA) and "nucleocapsid"(NC ... The viral proteins are synthesized initially as large precursors and are later processed into the mature proteins by ... But JSRV is different in this aspect since its envelope glycoprotein ("env") by itself is an oncogene and this single protein ... The cellular receptor for JSRV is hyaluronidase 2 (Hyal2), a glycophosphatidylinol(GPI)-anchored protein belonging to the ...
  https://en.wikipedia.org/wiki/Jaagsiekte_sheep_retrovirus
*  Publikace - Ústav biochemie a mikrobiologie VŠCHT Praha
Functional and structural characterization of novel type of linker connecting capsid and nucleocapsid protein domains in murine ... Membrane Interactions of the Mason-Pfizer Monkey Virus Matrix Protein and Its Budding Deficient Mutants. J Mol Biol 2016, 228, ...
  https://biomikro.vscht.cz/vyzkum/publikace
*  Landmarks of the HIV genome
... shows a graphical map of the genes and proteins of HIV-1, including the breakpoints on reference ... CApsid), p7 (NucleoCapsid), and p6 proteins, by the viral protease. Gag associates with the plasma membrane, where virus ... GAG The genomic region encoding the capsid proteins (group specific antigens). The precursor is the p55 myristoylated protein, ... REGULATORY PROTEINS Tat and Rev proteins of HIV/SIV and Tax and Rex proteins of HTLVs. They modulate transcriptional and ...
  https://www.hiv.lanl.gov/content/sequence/HIV/MAP/landmark.html
*  Phosphorylation and membrane association of the Rubella virus capsid protein is important for its anti-apoptotic function -...
Cheong, Y.K., and Ng, M.L. (2011) Dephosphorylation of West Nile virus capsid protein enhances the processes of nucleocapsid ... West Nile virus capsid protein interaction with importin and HDM2 protein is regulated by protein kinase C-mediated ... Rubella virus capsid protein interacts with poly(a)-binding protein and inhibits translation. J Virol 82: 4284-4294.. *CrossRef ... Beatch, M.D., Everitt, J.C., Law, L.J., and Hobman, T.C. (2005) Interactions between rubella virus capsid and host protein p32 ...
  http://onlinelibrary.wiley.com/doi/10.1111/cmi.12272/references
*  Frontiers | Unusual Fusion Proteins of HIV-1 | Microbiology
While the majority of these fusion proteins (e.g. TNV/p28tev, p186Drev, Tat1-Rev2, Tat^8c, p17tev, or Ref) are the result of ... While the majority of these fusion proteins (e.g. TNV/p28tev, p186Drev, Tat1-Rev2, Tat^8c, p17tev, or Ref) are the result of ... The goal of this review is to provide an overview of previously described HIV-1 fusion proteins and to summarize our current ... The goal of this review is to provide an overview of previously described HIV-1 fusion proteins and to summarize our current ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.02152/full
*  Visna virus - Wikipedia
The gag gene encodes three final glycoprotein products: the capsid, the nucleocapsid, and the matrix protein which links the ... The viral tat gene encodes a 94-amino acid protein. Tat is the most enigmatic of the proteins of the visna virus. Most studies ... A few studies have proposed MHC class II, CD4 and CXCR4 proteins as possible receptors however, none of these proteins have ... Virions consist of an icosahedral capsid surrounded by an envelope derived from the host plasma membrane. Inside the capsid are ...
  https://en.wikipedia.org/wiki/Visna_virus
*  Gag-onc fusion protein - Wikipedia
... capsid and nucleocapsid of the mature virus particles. Like in HIV's replication cycle, these proteins are needed for viral ... When this type of gene is translated to a protein, the protein is called a "transforming protein". Note that since the viral ... Rous sarcoma virus Fusion protein Fusion gene Fusion transcript Chimeric gene Bcr-abl fusion protein Oncovirus Retrovirus ... a Gag-v-Onc fusion protein from the Rous sarcoma virus is useful in illustrating the dual role that the fusion protein plays in ...
  https://en.wikipedia.org/wiki/Gag-onc_fusion_protein