*  Leukop nia
A v rben kering feh rv rsejtek sz m nak k ros cs kken se. Sz mos oka lehet, gyakoriak a vegyszer rtalmak s a gy gyszermell khat sok.
  http://www.hazipatika.com/szakkifejezesek/leukopenia/665
*  北京大学医学部机构知识库(IR@PKUHSC): Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese...
Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the jaws. To clarify the clinicopathologic profile and pathogenesis of central MEC, clinicopathologic findings and follow-up data of 39 cases were collected and analyzed. There were 16 male and 23 female patients (median age, 43 y). Sixteen cases affected the maxilla, and 23 occurred in the mandible. Radiographically, most cases (32 of 39) showed a unilocular or multilocular radiolucency with bone destruction, and 7 were found with scattered calcification. The margins of the lesions were ill defined or diffused in 14 cases and relatively well defined in 25 cases. Most cases (26 of 39) were classified as low-grade MECs, whereas 13 were moderate-to-high grade. Follow-up data were available for 35 patients with a median period of 36 months. All cases were found to be primary; local recurrence occurred in 8 cases, most (75.0%) of which were low-grade tumors. Four cases showed regional lymph node ...
  http://ir.bjmu.edu.cn/handle/400002259/51375
*  Malignant Salivary Gland Tumors and Epstein-Barr Virus (EBV) Infection: A Systematic Review and Meta-analysis
Background: Salivary gland tumors are rare head and neck tumors with lymphoepithelial carcinoma (LEC) as a particularly infrequent variant. This study was an evaluation of the incidence of EBV infection in malignant salivary gland tumors with the emphasis on tumor type and geographical area. Methods: Five databases (PubMed, ScienceDirect, Scopus, Web of Science and Cochrane library) were searched for data on the prevalence of EBV in malignant salivary gland tumors. A random-effects meta-analysis was conducted with Comprehensive Meta-Analysis software version 2.0 (CMA 2.0) using the event rate (ER) for estimation of the incidence of EBV in the salivary gland tumor patients. Publication bias was lacking as assessed through funnel plot analysis with the Begg's and Egger's tests (P|0.05). Results: Out of 618 studies searched in databases, 19 reported the prevalence of EBV in malignant salivary gland ...
  http://journal.waocp.org/article_46661_5098.html
*  A Photo Essay - Mammary Analogue Secretory Carcinoma of Salivary Glands (MASC) - Pathology - Dr Sampurna Roy MD
Differential diagnosis include: (i) Mucoepidermoid carcinoma (MEC): Low-grade mucoepidermoid carcinoma consists of various cell types ( it may contain variable proportions of squamous cells, clear cells, mucocytes, oncocytes, intermediate cells, and columnar cells). MASC typically lacks p63 staining and shows diffuse S100 positivity in most cases, which would be unusual in MEC, as would papillary formations and hobnailing in the lining of the cysts. 50 % of MEC are characterized by a t(11; 19) translocation coding for a CRTC1-MAML2 fusion protein.. (ii) Low Grade Cribriform Cystadenocarcinoma (Low Grade Salivary Duct Carcinoma) : Cystadenocarcinoma may resemble cribriform ductal carcinoma in situ (DCIS) not observed in Mammary analogue secretory carcinoma. Low grade cribriform cystadenocarcinoma (LGCC) must be considered in differential diagnosis of MASC as well. Although LGCC shares with MASC strong diffuse S-100 protein expression, LGCC shows a complete intact ...
  http://www.histopathology-india.net/MASC.htm
*  Mucoepidermoid Carcinoma of the Head and Neck: Clinical Analysis of 43 Patients : Japanese Journal of Clinical Oncology - oi
Objective. It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.. Methods. This report analyzes 43 patients suffering from head and neck MEC, who were treated in our department during the period from 1989 to 2005. The relationship between clinical and pathologic characteristics and survival rate was investigated.. Results. The 5-year overall and disease-free survival rate was 62.3 and 57.2%. Multivariate analysis demonstrated that the parameters that significantly affected survival were the patient's age (P = 0.040) and treatment method (P = 0.011).. Conclusions. The patient's age and treatment method is the prognostic parameter in this study. Although complete surgical resection is the standard treatment for MEC, we should aggressively ...
  http://oxfordindex.oup.com/view/10.1093/jjco/hyn045
*  Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications.
Abstract Mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy of the upper aerodigestive tract and tracheobronchial tree, is also known for its considerable ce..
  https://www.omicsonline.org/references/molecular-heterogeneity-in-mucoepidermoid-carcinoma-conceptual-and-practical-implications-1578958.html
*  Thorotrast-associated mucoepidermoid carcinoma of the liver - UQ eSpace
Lambrianides A.L., Askew A.R. and Lefevre I. (1986) Thorotrast-associated mucoepidermoid carcinoma of the liver. British Journal of Radiology, 59 704: 791-792. ...
  https://espace.library.uq.edu.au/view/UQ:400457
*  T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors
Background: Salivary gland tumors are among malignancies that have high recurrence rate. Immune responses in salivary gland tumors have not been well elucidated. T helper type 1 (Th1) and Th2 cytokines have been reported to play a role in the outcome of head and neck cancers. Objective: To evaluate the serum levels of interferon gamma (IFN- γ), as the hallmark of Th1 cytokines, and interleukin-4 (IL-4), as the hallmark of Th2 cytokines, in patients with benign and malignant salivary gland tumors in comparison with healthy controls. Methods: Fifty patients with benign and 14 patients with malignant salivary gland tumors, as well as 23 healthy individuals were recruited. Serum levels of IFN-γ and IL-4 were measured using ELISA method. Nonparametric tests were used for data analysis. Results: Serum levels of IFN-γ and IL-4 were found not to be significantly different in patients compared to the control group (0.68 ± 0.29 vs. 1.03 ± 0.57 pg/ml, ...
  http://iji.sums.ac.ir/article_16723.html
*  Rare Cancer Support Forum • View topic - Introductory Post Walk-Through
My name is Nancy and I am 48yrs old. I have recently been diagnosed with high grade salivary gland mucoepidermoid carcinoma. I have been to a specialist at Penn Medicine for evaluation. He said this was curable .The cancer has not spread but there may be some lymph node involvement. I am to have a radical surgery in a few weeks to remove the tumor which involves the floor of my mouth, tongue and some of the neck. I will also get a neck dissection and reconstructive surgery the same day. When I left the office I actually felt relief of some kind. Except 2 days later I found out my EKG can back abnormal and I have to be cleared for surgery. I have never had any heart problems and I just had surgical biopsy 2 weeks ago and all was fine. I also made the mistake of looking up my scans and labwork results. The pet scan said there was 'minimal widespread diffuse FDG uptake through both breasts. Not suggestive of malignancy.' What if the specialist missed this or had not received ...
  http://www.rare-cancer.org/forum/viewtopic.php?f=27&t=2781&p=52107
*  Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck - Full Text View -...
Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage 0 Hypopharyngeal Cancer Stage 0 Laryngeal Cancer Stage 0 Lip and Oral Cavity Cancer Stage I Adenoid Cystic Carcinoma of the Oral Cavity Stage I Mucoepidermoid Carcinoma of the Oral Cavity Stage I Squamous Cell Carcinoma of the Hypopharynx Stage I Squamous Cell Carcinoma of the Larynx Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity Stage I Verrucous Carcinoma of the Larynx Stage I Verrucous Carcinoma of the Oral Cavity Stage II Adenoid Cystic Carcinoma of the Oral Cavity Stage II Mucoepidermoid Carcinoma of the Oral Cavity Stage II Squamous Cell Carcinoma of the Hypopharynx Stage II ...
  https://clinicaltrials.gov/ct2/show/NCT01473784?recr=Open&cond=%22Tongue+Neoplasms%22&rank=17
*  Moffitt Cancer Center: Clinical Trial 18612 | Moffitt Cancer Center
NOTE: Phase II is complete. Phase II: 1. Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors; 2. Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin. Phase III: 1. Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone. Phase II/III Secondary Objectives: 1. Compare the acute toxicities of these 2 adjuvant treatments; 2. Compare late treatment-related adverse events in patients receiving postoperativeradiation to those receiving concurrent chemoradiation; 3. Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), ...
  https://moffitt.org/clinical-trials-and-studies/clinical-trial-18612/
*  Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have...
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
  https://clinicaltrials.gov/ct2/show/NCT01220583?term=NCT+01220583&rank=1
*  L-lysine in Treating Oral Mucositis in Patients Undergoing Radiation Therapy With or Without Chemotherapy For Head and Neck...
Mucositis Oral Complications of Chemotherapy Oral Complications of Radiation Therapy Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Basal Cell Carcinoma of the Lip Recurrent Lymphoepithelioma of the Nasopharynx Recurrent Lymphoepithelioma of the Oropharynx Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage I Adenoid Cystic Carcinoma of the Oral Cavity Stage I Basal Cell Carcinoma of the Lip Stage I Lymphoepithelioma of the Nasopharynx Stage I Lymphoepithelioma of the Oropharynx Stage I Mucoepidermoid Carcinoma of the Oral Cavity Stage I Salivary Gland Cancer Stage ...
  https://clinicaltrials.gov/ct2/show/NCT01155609?cond=%22Adenoid+cystic+carcinoma%22&rank=5
*  Mucoepidermoid Carcinoma in a Minor Salivary Gland in a Child
Case Reports in Dentistry is a peer-reviewed, Open Access journal that publishes case reports in all areas of dentistry, including periodontal diseases, dental implants, oral pathology, as well as oral and maxillofacial surgery.
  https://www.hindawi.com/journals/crid/2013/615948/
*  Mucoepidermoid Carcinoma | Cancer Survivors Network
Hi Phil,. Thank you so much for your reply. Believe it or not, but I am STILL dealing with the pain. At one point, I was told I had shingles. However, the ENT surgeon took a biopsy which turned out to be "just an ulcer". I cannot touch it. It is way far back on my soft pallete. I have to use "miracle mouthwash" before I eat. Sometimes I will use it in the middle of what I am eating, too. This has been going on for 5 weeks. I have lost 50 pounds (since Dec), but honestly, the weight loss is the ONLY positive thing that has come of this nightmare called cancer. I am now 147 pounds - a weight I haven't seen since 1992 - ha! I miss eating. I miss pizza and subs the most. I can't eat pizza because it burns and is hard to chew (of course). Subs are impossible. I can only open my mouth to fit one finger in. I eat a lot of soups. I drink Boost (just started that) and Carnation Instant Breakfast. I'm going to try what you said about adding stuff to the Carnation Instant Breakfast. I have added whey ...
  https://csn.cancer.org/comment/1012916
*  Plus it
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally ...
  http://cebp.aacrjournals.org/content/18/11/2899
*  Plus it
4321 The 11q23 region is a common participant in LOH (Loss of Heterozygosity), observed in 40% of breast cancers, as well as leukemogenic translocations; in this study a search was made for motifs intrinsic to the region that promote recombinogenic events. The human mucoepidermoid carcinoma cell line, H292, was used for initial study on radiation-induced LOH. Here, 5 x 105 cells were exposed to either 4 or 8 Gy, surviving single cells expanded into colonies of 100 cells or more, the colonies isolated and regrown from single cells. 150 separate clones were analyzed in total. After expansion of the doubly picked clones, LOH analysis of chromosome 11 was performed using polymorphic markers at 6 locations both distal and proximal to 11q23 using a genetic analyzer. A total of 38 LOH events were observed within the irradiated groups. A hot spot for LOH was observed at 11q23.2 (Marker 744724) positive in 8/49 and 6/50 clones after 4 and 8 Gy exposure respectively. No LOH was observed centromeric to ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/4321
*  "Parotidectomy: a review of 112 patients treated at a teaching hospital" by Naeem Sultan Ali, Ahmad Nawaz et al.
Objective:The Purpose of this study was to analyze the clinical presentation, histopathology and complications following parotid surgery. Methods: We retrospectively reviewed the charts of 112 Patients who underwent parotidectomy from January 2000 to February 2010. Data including age, sex, clinical signs and symptoms, histology and complication were collected from medical records. Results: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors. The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%). Analysis of the correlation between fine-needle aspiration cytology and final histology revealed that fine-needle aspiration sensitivity, specificity and accuracy to 86.6%, 97.6% and 94.6% respectively. The most common complication following parotidectomy was transient facial nerve palsy (18.7%). Conclusions: Superficial parotidectomy is associated with ...
  https://ecommons.aku.edu/pakistan_fhs_mc_surg_otolaryngol_head_neck/30/
*  Salivary glands - Malignant Salivary Gland Tumors
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
  http://www.pathologyoutlines.com/topic/salivaryglandscompmalignanttumors.html
*  Postoperative radiotherapy for malignant tumors of the parotid gland
AND MATERIALS: A retrospective analysis of 166 patients with parotid gland malignancies treated in the Department of Radiotherapy at the University of Texas M. D. Anderson Cancer Center between 1965-1989 was performed. All patients were treated following surgery and did not have macroscopic disease at the time of their radiation. The most common histologies were mucoepidermoid carcinoma (28%) and adenocarcinoma (27%). Pathologic features constituting indications for postoperative radiotherapy included: inadequate margins, 104 (63%) cases; extraglandular disease extension, 82 (49%); perineural invasion 57 (34%); and nodal disease 43 (26%). Radiation was delivered through an ipsilateral field of predominantly high energy electrons in 142 patients (86%). Wedged paired 60Co fields were used to treat 19 patients. The median dose was 60 Gy, typically delivered at 2 Gy per fraction. The median follow-up time for surviving patients was 155 months. Results: ...
  http://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/97207587/PMID/9054880
*  Prognostic factors in anal squamous carcinoma: a multivariate analysis of clinical, pathological and flow cytometric parameters...
Clinical, pathological and flow cytometric parameters have been analysed by univariate and multivariate analysis to define those parameters of important prognostic influence in 235 cases of surgically treated squamous carcinoma of the anus and perianal skin. Patients had been treated by anorectal excision (166 patients) or by local excision (69). Analyses were carried out on five data sets--the two surgical subgroups, two groups distinguished by site of tumour and on all 235 patients. Univariate analysis showed many parameters to be of prognostic influence, although histological typing of tumours into the more common histological subtypes was of no prognostic value. Parameters of independent prognostic significance in multivariate analysis were those indicating depth of spread, inguinal lymph node involvement and DNA-ploidy. In this study the subdivision of the rarer types of anal canal tumour, such as mucoepidermoid carcinoma, microcystic squamous carcinoma and small cell anaplastic ...
  https://www.ndorms.ox.ac.uk/publications/532656
*  Carcinoma
Mucoepidermoid carcinoma of the lung is a rare subtype of bronchial adenoma first described 35 years ago by Smetana et al. Although initially perceived to be a slow-growing neoplasm exhibiting local but not distant spread, dissemination was later described by Ozlu et al in 1961. Widespread metastases have since been described by many authors. Of […] ...
  http://www.levelofhealth.com/category/carcinoma
*  The utility and technique for infraorbital and supraorbital nerve biopsies | IOVS | ARVO Journals
A total of 6 patients met the inclusion criteria. Five patients (83%) were female and 1 (17%) was male with the average age being 72.3, ranging from 36-90 years. Five of the 6 patients had a history of a cutaneous malignancy. All 6 patients presented with either diplopia and/or dysesthesias on the affected side. Clinical examination confirmed decreased V1 and/or V2 sensation for 5 of the 6 patients. Imaging revealed enlargement of V1, V2, and/or V3 for all of the patients.,br /, Supraorbital nerve biopsies were performed for 2 patients via a sub-brow incision onto the superior orbital rim with reflection of the periosteum that revealed the nerve. One confirmed squamous cell carcinoma and one confirmed mucoepidermoid carcinoma. The remaining 4 patients underwent infraorbital nerve biopsies via a transconjunctival fornix-based orbitotomy with subperiosteal dissection along the orbital floor followed by unroofing of the infraorbital canal. The biopsy confirmed squamous cell carcinoma for the 3 ...
  http://iovs.arvojournals.org/article.aspx?articleid=2333302
*  Could a Possible Crosstalk between AMPK and TGF-β Signaling Pathways Be a Key Player in Benign and Malignant Salivary Gland...
|b||i|Background: |/i||/b|Salivary gland tumors (SGTs) are known for their specific heterogeneity and ambiguous outcome for the affected patients. The |i|LKB1 |/i|a
  https://www.karger.com/Article/Abstract/345131