Peripheral mucoepidermoid tumour of the lung. | Thorax
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center's RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...http://thorax.bmj.com/content/46/1/65
Neoplasm of head and neck (Concept Id: C0278996) - MedGen - NCBI
A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.https://www.ncbi.nlm.nih.gov/medgen?LinkName=pubmed_medgen&from_uid=18364504
A v rben kering feh rv rsejtek sz m nak k ros cs kken se. Sz mos oka lehet, gyakoriak a vegyszer rtalmak s a gy gyszermell khat sok.http://www.hazipatika.com/szakkifejezesek/leukopenia/665
北京大学医学部机构知识库(IR@PKUHSC): Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese...
Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the jaws. To clarify the clinicopathologic profile and pathogenesis of central MEC, clinicopathologic findings and follow-up data of 39 cases were collected and analyzed. There were 16 male and 23 female patients (median age, 43 y). Sixteen cases affected the maxilla, and 23 occurred in the mandible. Radiographically, most cases (32 of 39) showed a unilocular or multilocular radiolucency with bone destruction, and 7 were found with scattered calcification. The margins of the lesions were ill defined or diffused in 14 cases and relatively well defined in 25 cases. Most cases (26 of 39) were classified as low-grade MECs, whereas 13 were moderate-to-high grade. Follow-up data were available for 35 patients with a median period of 36 months. All cases were found to be primary; local recurrence occurred in 8 cases, most (75.0%) of which were low-grade tumors. Four cases showed regional lymph node ...http://ir.bjmu.edu.cn/handle/400002259/51375
Mucoepidermoid carcinoma - Wikipedia
Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac and thyroid. Mucicarmine staining is one stain used by pathologist for detection. Occurs in adults, with peak incidence from 20-40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research. Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors. This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells. Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the ...https://en.wikipedia.org/wiki/Mucoepidermoid_carcinoma
Malignant Salivary Gland Tumors and Epstein-Barr Virus (EBV) Infection: A Systematic Review and Meta-analysis
Background: Salivary gland tumors are rare head and neck tumors with lymphoepithelial carcinoma (LEC) as a particularly infrequent variant. This study was an evaluation of the incidence of EBV infection in malignant salivary gland tumors with the emphasis on tumor type and geographical area. Methods: Five databases (PubMed, ScienceDirect, Scopus, Web of Science and Cochrane library) were searched for data on the prevalence of EBV in malignant salivary gland tumors. A random-effects meta-analysis was conducted with Comprehensive Meta-Analysis software version 2.0 (CMA 2.0) using the event rate (ER) for estimation of the incidence of EBV in the salivary gland tumor patients. Publication bias was lacking as assessed through funnel plot analysis with the Begg's and Egger's tests (P|0.05). Results: Out of 618 studies searched in databases, 19 reported the prevalence of EBV in malignant salivary gland ...http://journal.waocp.org/article_46661_5098.html
A Photo Essay - Mammary Analogue Secretory Carcinoma of Salivary Glands (MASC) - Pathology - Dr Sampurna Roy MD
Differential diagnosis include: (i) Mucoepidermoid carcinoma (MEC): Low-grade mucoepidermoid carcinoma consists of various cell types ( it may contain variable proportions of squamous cells, clear cells, mucocytes, oncocytes, intermediate cells, and columnar cells). MASC typically lacks p63 staining and shows diffuse S100 positivity in most cases, which would be unusual in MEC, as would papillary formations and hobnailing in the lining of the cysts. 50 % of MEC are characterized by a t(11; 19) translocation coding for a CRTC1-MAML2 fusion protein.. (ii) Low Grade Cribriform Cystadenocarcinoma (Low Grade Salivary Duct Carcinoma) : Cystadenocarcinoma may resemble cribriform ductal carcinoma in situ (DCIS) not observed in Mammary analogue secretory carcinoma. Low grade cribriform cystadenocarcinoma (LGCC) must be considered in differential diagnosis of MASC as well. Although LGCC shares with MASC strong diffuse S-100 protein expression, LGCC shows a complete intact ...http://www.histopathology-india.net/MASC.htm
Prognostic Factors Identified in Mucoepidermoid Carcinoma - MPR
Diagnosis of low- or intermediate-grade tumors is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma (MEC) of the salivary glands, while advanced disease stage and perineural invasion are the most significant indicators of poor prognosis.http://www.empr.com/medical-news/prognostic-factors-identified-in-mucoepidermoid-carcinoma/article/254217/
Mucoepidermoid Carcinoma of the Head and Neck: Clinical Analysis of 43 Patients : Japanese Journal of Clinical Oncology - oi
Objective. It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.. Methods. This report analyzes 43 patients suffering from head and neck MEC, who were treated in our department during the period from 1989 to 2005. The relationship between clinical and pathologic characteristics and survival rate was investigated.. Results. The 5-year overall and disease-free survival rate was 62.3 and 57.2%. Multivariate analysis demonstrated that the parameters that significantly affected survival were the patient's age (P = 0.040) and treatment method (P = 0.011).. Conclusions. The patient's age and treatment method is the prognostic parameter in this study. Although complete surgical resection is the standard treatment for MEC, we should aggressively ...http://oxfordindex.oup.com/view/10.1093/jjco/hyn045
Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications.
Abstract Mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy of the upper aerodigestive tract and tracheobronchial tree, is also known for its considerable ce..https://www.omicsonline.org/references/molecular-heterogeneity-in-mucoepidermoid-carcinoma-conceptual-and-practical-implications-1578958.html
Cavitary mucoepidermoid carcinoma of lung with metastases in s...
Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature.: Mucoepidermoihttps://www.mysciencework.com/publication/show/cavitary-mucoepidermoid-carcinoma-lung-metastases-skeletal-muscles-presenting-features-case-report-review-literature-28e15a64
Bronchial mucoepidermoid carcinoma after allogeneic bone marrow transplantation. | Journal of Clinical Pathology
A 16 year old man underwent an allogeneic bone marrow transplantation (BMT) from an HLA identical sibling donor for acute lymphoblastic leukaemia in 1984. He developed chronic graft versus host disease involving the skin and kidneys. At day 400 after BMT his condition was complicated by obstructive airways disease, which was partially responsive to azathioprine and steroids. Five years after withdrawal of immunosuppressive treatment he developed dyspnoea and decreased pulmonary function test results, and steroid treatment was resumed. Fibrobronchoscopy revealed the presence of a mucoepidermoid carcinoma in the left main bronchus. After surgical laser resection, there was gradual clinical and functional improvement. There was no evidence of recurrence one year after surgery.. ...http://jcp.bmj.com/content/50/11/969
Thorotrast-associated mucoepidermoid carcinoma of the liver - UQ eSpace
Lambrianides A.L., Askew A.R. and Lefevre I. (1986) Thorotrast-associated mucoepidermoid carcinoma of the liver. British Journal of Radiology, 59 704: 791-792. ...https://espace.library.uq.edu.au/view/UQ:400457
Rare Cancer Support Forum • View topic - Introductory Post Walk-Through
My name is Nancy and I am 48yrs old. I have recently been diagnosed with high grade salivary gland mucoepidermoid carcinoma. I have been to a specialist at Penn Medicine for evaluation. He said this was curable .The cancer has not spread but there may be some lymph node involvement. I am to have a radical surgery in a few weeks to remove the tumor which involves the floor of my mouth, tongue and some of the neck. I will also get a neck dissection and reconstructive surgery the same day. When I left the office I actually felt relief of some kind. Except 2 days later I found out my EKG can back abnormal and I have to be cleared for surgery. I have never had any heart problems and I just had surgical biopsy 2 weeks ago and all was fine. I also made the mistake of looking up my scans and labwork results. The pet scan said there was 'minimal widespread diffuse FDG uptake through both breasts. Not suggestive of malignancy.' What if the specialist missed this or had not received ...http://www.rare-cancer.org/forum/viewtopic.php?f=27&t=2781&p=52107
Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck - Full Text View -...
Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage 0 Hypopharyngeal Cancer Stage 0 Laryngeal Cancer Stage 0 Lip and Oral Cavity Cancer Stage I Adenoid Cystic Carcinoma of the Oral Cavity Stage I Mucoepidermoid Carcinoma of the Oral Cavity Stage I Squamous Cell Carcinoma of the Hypopharynx Stage I Squamous Cell Carcinoma of the Larynx Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity Stage I Verrucous Carcinoma of the Larynx Stage I Verrucous Carcinoma of the Oral Cavity Stage II Adenoid Cystic Carcinoma of the Oral Cavity Stage II Mucoepidermoid Carcinoma of the Oral Cavity Stage II Squamous Cell Carcinoma of the Hypopharynx Stage II ...https://clinicaltrials.gov/ct2/show/NCT01473784?recr=Open&cond=%22Tongue+Neoplasms%22&rank=17
Moffitt Cancer Center: Clinical Trial 18612 | Moffitt Cancer Center
NOTE: Phase II is complete. Phase II: 1. Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors; 2. Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin. Phase III: 1. Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone. Phase II/III Secondary Objectives: 1. Compare the acute toxicities of these 2 adjuvant treatments; 2. Compare late treatment-related adverse events in patients receiving postoperativeradiation to those receiving concurrent chemoradiation; 3. Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), ...https://moffitt.org/clinical-trials-and-studies/clinical-trial-18612/
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have...
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...https://clinicaltrials.gov/ct2/show/NCT01220583?term=NCT+01220583&rank=1
Malignant salivary gland tumours (staging) | Radiology Reference Article | Radiopaedia.org
Malignant salivary gland tumours are staged using the TNM staging system: T: Tumour Tx: primary tumour cannot be assessed T0: no evidence of primary tumour T1 less than or equal to 2 cm in maximal diameter no extra-parenchymal extension T2...https://radiopaedia.org/articles/malignant-salivary-gland-tumours-staging-1
Mucoepidermoid Carcinoma in a Minor Salivary Gland in a Child
Case Reports in Dentistry is a peer-reviewed, Open Access journal that publishes case reports in all areas of dentistry, including periodontal diseases, dental implants, oral pathology, as well as oral and maxillofacial surgery.https://www.hindawi.com/journals/crid/2013/615948/
Mucoepidermoid Carcinoma | Cancer Survivors Network
Hi Phil,. Thank you so much for your reply. Believe it or not, but I am STILL dealing with the pain. At one point, I was told I had shingles. However, the ENT surgeon took a biopsy which turned out to be "just an ulcer". I cannot touch it. It is way far back on my soft pallete. I have to use "miracle mouthwash" before I eat. Sometimes I will use it in the middle of what I am eating, too. This has been going on for 5 weeks. I have lost 50 pounds (since Dec), but honestly, the weight loss is the ONLY positive thing that has come of this nightmare called cancer. I am now 147 pounds - a weight I haven't seen since 1992 - ha! I miss eating. I miss pizza and subs the most. I can't eat pizza because it burns and is hard to chew (of course). Subs are impossible. I can only open my mouth to fit one finger in. I eat a lot of soups. I drink Boost (just started that) and Carnation Instant Breakfast. I'm going to try what you said about adding stuff to the Carnation Instant Breakfast. I have added whey ...https://csn.cancer.org/comment/1012916
4321 The 11q23 region is a common participant in LOH (Loss of Heterozygosity), observed in 40% of breast cancers, as well as leukemogenic translocations; in this study a search was made for motifs intrinsic to the region that promote recombinogenic events. The human mucoepidermoid carcinoma cell line, H292, was used for initial study on radiation-induced LOH. Here, 5 x 105 cells were exposed to either 4 or 8 Gy, surviving single cells expanded into colonies of 100 cells or more, the colonies isolated and regrown from single cells. 150 separate clones were analyzed in total. After expansion of the doubly picked clones, LOH analysis of chromosome 11 was performed using polymorphic markers at 6 locations both distal and proximal to 11q23 using a genetic analyzer. A total of 38 LOH events were observed within the irradiated groups. A hot spot for LOH was observed at 11q23.2 (Marker 744724) positive in 8/49 and 6/50 clones after 4 and 8 Gy exposure respectively. No LOH was observed centromeric to ...http://cancerres.aacrjournals.org/content/68/9_Supplement/4321
Postoperative radiotherapy for malignant tumors of the parotid gland
AND MATERIALS: A retrospective analysis of 166 patients with parotid gland malignancies treated in the Department of Radiotherapy at the University of Texas M. D. Anderson Cancer Center between 1965-1989 was performed. All patients were treated following surgery and did not have macroscopic disease at the time of their radiation. The most common histologies were mucoepidermoid carcinoma (28%) and adenocarcinoma (27%). Pathologic features constituting indications for postoperative radiotherapy included: inadequate margins, 104 (63%) cases; extraglandular disease extension, 82 (49%); perineural invasion 57 (34%); and nodal disease 43 (26%). Radiation was delivered through an ipsilateral field of predominantly high energy electrons in 142 patients (86%). Wedged paired 60Co fields were used to treat 19 patients. The median dose was 60 Gy, typically delivered at 2 Gy per fraction. The median follow-up time for surviving patients was 155 months. Results: ...http://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/97207587/PMID/9054880
Prognostic factors in anal squamous carcinoma: a multivariate analysis of clinical, pathological and flow cytometric parameters...
Clinical, pathological and flow cytometric parameters have been analysed by univariate and multivariate analysis to define those parameters of important prognostic influence in 235 cases of surgically treated squamous carcinoma of the anus and perianal skin. Patients had been treated by anorectal excision (166 patients) or by local excision (69). Analyses were carried out on five data sets--the two surgical subgroups, two groups distinguished by site of tumour and on all 235 patients. Univariate analysis showed many parameters to be of prognostic influence, although histological typing of tumours into the more common histological subtypes was of no prognostic value. Parameters of independent prognostic significance in multivariate analysis were those indicating depth of spread, inguinal lymph node involvement and DNA-ploidy. In this study the subdivision of the rarer types of anal canal tumour, such as mucoepidermoid carcinoma, microcystic squamous carcinoma and small cell anaplastic ...https://www.ndorms.ox.ac.uk/publications/532656
Mucoepidermoid carcinoma of the lung is a rare subtype of bronchial adenoma first described 35 years ago by Smetana et al. Although initially perceived to be a slow-growing neoplasm exhibiting local but not distant spread, dissemination was later described by Ozlu et al in 1961. Widespread metastases have since been described by many authors. Of […] ...http://www.levelofhealth.com/category/carcinoma
Tap1 - BET-bromodomain inhibition research
History: Cryptotanshinone (CT) is a biologically active compound from the root of that has been reported to induce apoptosis in various malignancy cell lines; but it has not yet been fully explored in human mucoepidermoid carcinoma (MEC). of MC-3 cells results in anti-proliferative and apoptotic activities in MC-3 and it is accompanied by a decrease in phosphorylation and dimerization of transmission transducer and activators of transcription 3 (STAT3). CT decreased the expression levels of myeloid cell leukemia-1 (Mcl-1) and surviving whereas Bcl-xL expression was not changed. CT obviously regulates survivin proteins in a transcriptional alters and level Mcl-1 through proteasome-dependent proteins degradation. Furthermore CT-induced apoptotic cell loss of life in YD-15 another individual MEC cell series was from the inhibition BMS-650032 of STAT3 phosphorylation. Bottom line: These data claim that CT BMS-650032 is actually a great apoptotic inducer through adjustment of STAT3 signaling in ...http://healthandwellnesssource.org/tag/tap1/