*  Faculty for Chemistry and Pharmacy LMU Munich - Prof. Dr. Anja Hoffmann-Röder
Synthesis of carbohydrates, peptides and glycokonjugates. *Tumor-associated carbohydrate antigens and cancer vaccines ... "Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen-Friedenreich Antigen and a ... "Perfluoroalkylated amphiphilic MUC1 glycopeptide antigens as tools for cancer immunotherapy", Chem. Commun. 2011, 47, 382-384. ...
  http://www.cup.uni-muenchen.de/de/departments/chemie/personen/prof-dr-anja-hoffmann-roeder/
*  KAKEN - Research Projects | Molecular mechanisms for maintenance of the integrity of nervous tissues by glycosphingolipids ...
Presentation] Regulatory mechanisms of malignant phenotypes of human cancers by tumor-associated carbohydrate antigens in the ... Journal Article] Trimeric Tn antigen on Syndecan-1 binds to integrins and enhances cancer metastasis via dynamic changes of ... Presentation] Involvement of complex carbohydrates in the cancer phenotypes and therapeutic application.2012. *. Author(s). K. ... Presentation] Expression and roles of gangliosides GD1α GM1b in human cancer cell lines2016. *. Author(s). Robiul Hasan Bhuiyan ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23110008/
*  CA50 - AM09238PU-N | acris-antibodies.com
... a carcinoma associated carbohydrate antigen, has been found to be elevated in the blood of patients with colorectal cancer and ... CA50 has been evaluated in various studies for use as a tumor marker for cancer diagnosis. Results showed that CA50 was ... Cancer antigen 50 (CA50), a carcinoma associated carbohydrate antigen, has been found to be elevated in the blood of patients ... Antigens. *Proteins & Growth Factors. *Control Peptides. *Synthetic Peptides. Lysates (see all»). *Lysates (Overexpressed) ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/ca50-am09238pu-n.htm
*  Oncotarget | Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in...
... a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects ... a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects ... A mimic of tumor rejection antigen-associated carbohydrates mediates an antitumor cellular response. Cancer Res. 2004; 64:2162- ... Hakomori S. Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines. ...
  http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21959&path%5B%5D=69621
*  Frontiers | Carbohydrate-Mimetic Peptides for Pan Anti-Tumor Responses | Immunology
... carbohydrate mimetic peptides in vaccine design strategies to induce responses to pan-glycan antigens expressed on cancer cells ... consequences of mimicking tumor associated carbohydrate antigens and the notion of reverse engineering to develop carbohydrate ... the biological consequences of mimicking tumor associated carbohydrate antigens and the notion of reverse engineering to ... Here, we discuss our experience in bringing a tumor-associated carbohydrate mimetic peptide to the clinic. Emphasis is placed ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00308/full
*  Clinical Studies of Vaccines Targeting Breast Cancer | Clinical Cancer Research
Hakamori S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res., 52: 257-331, 1989. ... Breast Cancer Antigen-specific Vaccines. The discovery of T-cell recognition and lysis of human tumors subsequently led to the ... hTERT is a common, nearly universal, tumor antigen and is expressed in more than 85% of all human cancers (57) . Some of the ... Vonderheide R. H. Telomerase as a universal tumor-associated antigen for cancer immunotherapy. Oncogene, 21: 674-679, 2002. ...
  http://clincancerres.aacrjournals.org/content/9/9/3222
*  CEA levels in serum and BAL in patients suffering from lung cancer | SpringerLink
CEA is synthesized by epithelial and tumor cells. In this study, CEA... ... is a tumor marker belonging to the immunoglobulin gene superfamily of adhesion molecules. ... Superiority of tissue polypeptiode antigene to carcinoembryonic antigen and carbohydrate antigenic determinant 19.9.Cancer 1987 ... Demonstration at tumor specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques.J ...
  https://link.springer.com/article/10.1007%2FBF02698043
*  Frontiers | Molecular Recognition of Gangliosides and Their Potential for Cancer Immunotherapies | Immunology
... it is known as an onco-fetal antigen. Gangliosides perform important functions through carbohydrate-specific interactions with ... Human healthy tissue is deficient in NeuGc, but since this molecule is expressed in tumors and in human fetal tissues, it is ... Human healthy tissue is deficient in NeuGc, but since this molecule is expressed in tumors and in human fetal tissues, ... Through both mechanisms, tumor-associated gangliosides may affect malignant progression, which makes them attractive targets ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00325/full
*  Immunization with Mimotopes Prevents Growth of Carcinoembryonic Antigen-Positive Tumors in BALB/c Mice | Clinical Cancer...
Peptide mimicry of adenocarcinoma-associated carbohydrate antigens. Hybridoma 1997;16:3-10. ... Jager D, Jager E, Knuth A. Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer. J ... Cancer Therapy: Preclinical Immunization with Mimotopes Prevents Growth of Carcinoembryonic Antigen-Positive Tumors in BALB/c ... Induction of IgG antibodies against the GD2 carbohydrate tumor antigen by vaccination with peptide mimotopes. Eur J Immunol ...
  http://clincancerres.aacrjournals.org/content/13/21/6501
*  Apoptosis Induction of Human Lung Cancer Cell Line in Multicellular Heterospheroids with Humanized Antiganglioside GM2...
Hakomori S. Possible functions of tumour-associated carbohydrate antigens. Curr. Opin. Immunol., 3: 646-653, 1991. ... GM2 is expected to be an ideal antigen for specific immunotherapy of human cancers with either vaccination or MAbs. ... Ragupathi G. Carbohydrate antigens as targets for active specific immunotherapy. Cancer Immunol. Immunother., 43: 152-157, 1996 ... Cancer Research Online ISSN: 1538-7445. Cancer Research Print ISSN: 0008-5472. Journal of Cancer Research ISSN: 0099-7013. ...
  http://cancerres.aacrjournals.org/content/59/20/5323
*  Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
... cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and ... all of them are directed against protein antigens. Although a long list of tumor-associated carbohydrate antigens has been ... Immunotherapies of cancers exploit the fact that tumor cells often expressed antigen molecules on their surface that can be ... S. K. Singh, I. D. Clarke, M. Terasaki et al., "Identification of a cancer stem cell in human brain tumors," Cancer Research, ...
  https://www.hindawi.com/journals/jir/2017/5604891/
*  Pilot Study of a Heptavalent Vaccine-Keyhole Limpet Hemocyanin Conjugate plus QS21 in Patients with Epithelial Ovarian,...
Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: serous and mucinous tumors ... Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene. Int J Cancer 2002;98:737-40. ... Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens. Clin Cancer Res 1998;4: ... Ovarian cancers express a rich array of cell surface antigens. These include carbohydrate epitopes, such as GM2, Globo-H, Lewis ...
  http://clincancerres.aacrjournals.org/content/13/14/4170
*  Local team makes first prostate cancer candidate vaccine - Taipei Times
... according to the results of research conducted by an Academia Sinica team on carbohydrate-based vaccines. ... It may soon be possible to innoculate against prostate cancer, ... The RM2 antigen, a tumor-associated carbohydrate antigen, is ... Antigens are foreign substances that stimulate immunoligical responses.. The team said that cell surfaces are coated with sugar ... This could help advance the development of early cancer detection tools and anti-bacterial or anti-cancer vaccines, according ...
  http://www.taipeitimes.com/News/front/archives/2013/08/11/2003569417
*  Cancers | Free Full-Text | C-type Lectin Receptors for Tumor Eradication: Future Directions
... which bind carbohydrate structures and internalize antigens upon recognition. Intracellular routing of antigen through CLR ... Profound research has been done on targeting specific tumor antigens to CLR using either antibodies or the natural ligands such ... enhances loading and presentation of antigen through MHC class I and II, inducing antigen-specific CD4+ and CD8+ T-cell ... on the current data showing the potency of CLR-targeting and discuss improvements that can be achieved to enhance anti-tumor ...
  http://www.mdpi.com/2072-6694/3/3/3169
*  The Witebsky Center :: Kate Rittenhouse-Olson
... the case of carbohydrate tumor associated antigens the patient may be tolerant to their tumor associated carbohydrate antigen, ... IgG Immune response to Tumor-Associated Carbohydrate Antigens (TF, Tn, alphaGal) in Patients with Breast Cancer: Impact of ... Joseph Barchi of NCI and involves the same carbohydrate tumor associated antigen, Thomsen Friedenreich antigen (TF-Ag). We feel ... antigen bearing tumors" (K R Olson, principle inventor of JAA-F11 monoclonal antibody), and "Carbohydrate Antigen-Nanoparticle ...
  http://www.smbs.buffalo.edu/wcmpi/Faculty/rittenhouseolson.html
*  UC Irvine - Faculty Profile System
... associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates. Cancer Research. 2004. 64(14): 4987- ... BenMohamed L. Identification of Asymptomatic Antigens by Probing Whole Herpes Simplex Virus Type 1 and Type 2 Open Reading ... Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Q? Capsids. Yin Z, Comellas-Aragones M, Chowdhury ... Cancer Immunology and Immunotherapy. 2009. 58(2): 187-200.. 32. Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL & ...
  https://www.faculty.uci.edu/profile.cfm?faculty_id=5696
*  Cancer immunotherapy - Wikipedia
... known as tumour-associated antigens (TAAs); they are often proteins or other macromolecules (e.g. carbohydrates). Active ... In cancer treatment they aid cancer antigen targeting. The only approved cellular cancer therapy based on dendritic cells is ... Nivolumab is approved to treat melanoma, lung cancer, kidney cancer, bladder cancer, head and neck cancer, and Hodgkin's ... Those that bind to tumor antigens treat cancer. Cell surface receptors are common targets for antibody therapies and include ...
  https://en.wikipedia.org/wiki/Cancer_immunotherapy
*  Thomsen-Friedenreich antigen - Wikipedia
Yu, Lu-Gang (2007). "The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression". Glycoconjugate Journal. 24 ... represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven ... Tumor restriction of Thomsen-Friedenreich antigen may therefore be determined either by the protein backbone or by the beta- ... In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c mice ...
  https://en.wikipedia.org/wiki/Thomsen%E2%80%93Friedenreich_antigen
*  Tumor M2-PK - Wikipedia
... carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 724 in the diagnosis of gastrointestinal cancer". ... Tumor M2-PK is also useful to diagnose lung cancer and better than SCC and NSE tumor markers. With renal cell carcinoma (RCC), ... The combination of Tumor M2-PK with the appropriate classical tumor marker, such as CEA for bowel cancer, CA 19-9 for ... Tumor M2-PK can be elevated in many tumor types, rather than being an organ-specific tumor marker such as PSA. Increased stool ...
  https://en.wikipedia.org/wiki/Tumor_M2-PK
*  Sialyl-Lewis X - Wikipedia
Sialyl Lewis x is being used in studies to fight tumors and cancer cell growth. It has been shown that there is frequent ... Sialyl Lewis X is also one of the most important blood group antigens and is displayed on the terminus of glycolipids that are ... Sialyl LewisX, also known as sialyl LeX or SLeX, is a tetrasaccharide carbohydrate with the sequence Neu5Acα2-3Galβ1-4[Fucα1-3] ... Sialyl Lewis x is an inflammation-associated antigen on liver cells. It becomes over expressed on diseased liver cells and can ...
  https://en.wikipedia.org/wiki/Sialyl-Lewis_X
*  Immunofluorescence - Wikipedia
Intact antibodies can also be too large to dye cancer cells in vivo. Their size results in slow tumor penetration and long ... Carbohydrate sequence specificity of the mouse monoclonal antibodies that recognize crossreacting antigens on LOS and human ... Staining procedures can apply to both fixed antigen in the cytoplasm or to cell surface antigens on live cells, called " ... Likewise, an antigen can also be conjugated to the antibody with a fluorescent probe in a technique called fluorescent antigen ...
  https://en.wikipedia.org/wiki/Immunofluorescence
*  CVac - Wikipedia
The antigen in this case is MUC1, known to be overexpressed on a variety of cancer cells and in CVac MUC1 is conjugated to the ... WO application 1995018145, Vasso Apostolopoulos, "Conjugates of human mucin and a carbohydrate polymer and their use in cancer ... cells involves exposing those cells to disease antigens in order to get the immune system to properly recognise the antigen and ... "Fraunhofer IZI received manufacturing authorization for tumor vaccine CVac". Fraunhofer IZI press release. 28 October 2011. ...
  https://en.wikipedia.org/wiki/CVac
*  Poly N-acetyllactosamine substitutions on N- and not O-oligosaccharides or Thomsen-Friedenreich antigen facilitate lung...
Yu, L.G.: The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression. Glycoconj. J. 24, 411-420 (2007). doi: ... Hakomori, S.: Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res. 56, 5309-5318 ... 3 exhibit differential recognition of sialylated glycans and blood group antigens. J. Biol. Chem. 283, 10109-10123 (2008). doi: ... The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res. ...
  https://rd.springer.com/article/10.1007/s10719-008-9194-9
*  1 - Binary option broker ladder
... nonlineage-specific tumor antigens such as the human MAGE-3 in humans and the murine P1A antigens that are expressed in cancer ... binady A carbohydrate molecule with three to seven carbon atoms (and the corresponding number of hydrogen and oxygen binary ... Anti-CD52 mAb Campath-1 (CD52) is an antigen expressed on most mature lymphocytes and on some lymphocyte precursors. ... Cancer Res. ) Follow these steps to start Query Analyzer and connect with the AdventureWorks sample database: 1. ...
  http://forexsignalhere.com/binary-option-broker-ladder.html
*  C57BL/6 Origin Harlan Laboratories
Cancer Res. 32, 1129-1132. Whitmire CE, Salerno RA, Rabstein LS, Heubner RJ, Turner HC (1971) RNA tumour-virus antigen ... Virus-genome specified common antigens detected by complement fixation in mouse tumours induced by 3-methylcholanthrene. J. ... High simple carbohydrate diet for five months induced hyperglycaemia, hyperinsulinaemia and hypercholesterolaemia and non- ... Whitmire CE, Salerno RA (1972) RNA tumour virus antigen and tumour induction by various doses of 3methylcholanthrene in various ...
  http://spotidoc.com/doc/20606/c57bl-6-origin-harlan-laboratories