*  Interaction of Caffeine and Hydration on Voice - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Other Name: Caffeine and water 2.. Drug: C3(200mg of caffeine; 1 L of water) Ingestion of 200 mg of caffeine and 1 Liter of ... Other Name: Caffeine and water 2.. Drug: C3(200mg of caffeine; 1 L of water) Ingestion of 200 mg of caffeine and 1 Liter of ... Drug: C2 (200mg of caffeine; 1/2 L of water) Drug: C3(200mg of caffeine; 1 L of water) Drug: C1 (200mg of caffeine, no water) ...
  https://clinicaltrials.gov/ct2/show/NCT01435837
*  Caffeine and Cocaine - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. Anesthetics, Local. ... Experimental: 1 Caffeine 150 mg Caffeine 150 mg. Drug: Caffeine 150 MG Across five separate testing days, subjects were ... Experimental: 4 Caffeine 300 mg Caffeine 300 mg. Drug: Caffeine 300 MG Across five separate testing days, subjects were ... Drug: Caffeine 150 MG Drug: Placebo Drug: Amphetamine Drug: Caffeine 300 MG Phase 1 Phase 2 ...
  https://clinicaltrials.gov/ct2/show/NCT00733993?recr=Open&intr=caffeine&rank=14
*  Combined Effects of Alcohol and Caffeine - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. Antimalarials. ... Drug: Alcohol + Caffeine Beverage 14 g alcohol per 180 ml total beverage combined with 60 mg caffeine per 180 ml total beverage ... Participants and research assistants will be blinded to inclusion of caffeine/caffeine-placebo in beverage, but each beverage ... The primary outcome measure is the total volume of beverage consumed during alcohol + caffeine sessions and alcohol + caffeine- ...
  https://clinicaltrials.gov/ct2/show/NCT01289561?recr=Open&intr=caffeine&rank=2
*  The Effects of Caffeine Withdrawal on Migraine - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Active Comparator: Caffeine Caffeine tablets (Recip) 100 mg, 300-800 mg. Drug: Caffeine From the point of enrollment, patients ... The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both ... Drug: Caffeine From the point of enrollment, patients will substitute their daily dietary caffeine with either placebo- or ...
  https://clinicaltrials.gov/show/NCT03022838
*  Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... The Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study is a sub-study of the main Caffeine for Apnea of Prematurity (CAP) ... Active Comparator: caffeine Drug: Caffeine citrate injection Loading dose: 20 mg/kg administered over at least 30 minutes via ... Caffeine. Caffeine citrate. Central Nervous System Stimulants. Physiological Effects of Drugs. Phosphodiesterase Inhibitors. ...
  https://clinicaltrials.gov/ct2/show/NCT01020357?term=sleep+studies+OR+polysomnogram+OR+multiple+sleep+latency+test+OR+maintenance+of+wakefulness+test&recr=Open&fund=01&rank=10
*  Effects of Neo40(TM) With Caffeine on Cycling Time Trial Performance - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Active Comparator: Nitrate supplement with caffeine Dietary Supplement: Nitrate supplement with caffeine Lozenge consisting of ... Effects of Neo40(TM) With Caffeine on Cycling Time Trial Performance. The recruitment status of this study is unknown. The ... Caffeine. Central Nervous System Stimulants. Physiological Effects of Drugs. Phosphodiesterase Inhibitors. Enzyme Inhibitors. ...
  https://clinicaltrials.gov/ct2/show/NCT01710761?recr=Open&intr=caffeine&rank=18
*  Efficacy of ONE A DAY Weightsmart Advanced Versus Caffeine and Placebo on Energy Expenditure, Thermogenesis and Perceived...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Dietary Supplement: One-A-Day Weight S.A. (Multi-Vitamins, BAY94-9350) Drug: Caffeine Drug: Placebo Phase 4 ... Caffeine. Central Nervous System Stimulants. Physiological Effects of Drugs. Phosphodiesterase Inhibitors. Enzyme Inhibitors. ... Using ephedra- or caffeine-containing products or chronic medications other than contraceptives or HRT ...
  https://clinicaltrials.gov/ct2/show/NCT00781586
*  The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA). - Full Text...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Active Comparator: Caffeine Caffeine benzoate. Drug: Caffeine Children in group one will receive caffeine benzoate 20 mg/kg i.v ... The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA). (OSA). The ... The purpose of this study is to determine whether caffeine when given in the vein, will wake children up faster and decrease ...
  https://clinicaltrials.gov/show/NCT00273754
*  Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache - Full Text View -...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Experimental: Ibuprofen + Caffeine 72 patients treated with one or two tablets of ibuprofen 400 mg + caffeine 200 mg when ... Drug: Ibuprofen plus caffeine One or two tablets of ibuprofen 400 mg + caffeine 200 mg when presenting headache. ... Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache. The safety and ...
  https://clinicaltrials.gov/ct2/show/NCT01172405?term=%22Headache%22&recr=Open&rank=8
*  Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. To Top. *For Patients and Families ... Drug: tivantinib Drug: omeprazole Drug: s-warfarin Drug: caffeine Dietary Supplement: vitamin K Drug: digoxin Drug: midazolam ... Caffeine. Warfarin. Omeprazole. Digoxin. Micronutrients. Growth Substances. Physiological Effects of Drugs. Adjuvants, ... The purpose of this study is to determine the effects of tivantinib on the pharmacokinetics of omeprazole, s-warfarin, caffein ...
  https://clinicaltrials.gov/ct2/show/NCT01517399?recr=Open&intr=%22Vitamin+K%22&rank=17
*  Caffeine citrate - Nippon Boehringer/Nobelpharma - AdisInsight
... has developed caffeine citrate (NPC 11), a purinergic P1 receptor antagonist which acts as a respiratory ... Mechanism of Action Purinergic P1 receptor antagonists * Orphan Drug Status Orphan designation is assigned by a regulatory body ... Caffeine citrate - Nippon Boehringer/Nobelpharma Alternative Names: Anhydrous caffeine - Nobelpharma/Nippon Boehringer; NPC-11 ...
  https://adisinsight.springer.com/drugs/800034778?error=cookies_not_supported&code=f526e82b-f7bc-4459-8842-c3775c99fff6
*  Effectiveness of Rehabilitation on the Recovery of Patients Post Right Stroke With Unilateral Spatial Neglect - Full Text View ...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Caffeine. Central Nervous System Stimulants. Physiological Effects of Drugs. Phosphodiesterase Inhibitors. Enzyme Inhibitors. ...
  https://clinicaltrials.gov/show/NCT00305513
*  The Effects of a Combination of Nootropic Ingredients on Cognition in Healthy Young Volunteers - Full Text View -...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. To Top ... Active Comparator: Caffeine-alone The effects of the combination will be compared to both placebo and caffeine-alone, to test ... Caffeine. Nootropic Agents. Central Nervous System Stimulants. Physiological Effects of Drugs. Phosphodiesterase Inhibitors. ... During the three test sessions the subjects will receive a capsule that contains a placebo, caffeine or a combination of ...
  https://clinicaltrials.gov/ct2/show/NCT02857829
*  Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. Anti-Inflammatory ... And the caffeine presents mechanisms that are not totally clear, but it may relieves the pain by activating of the central ... Caffeine. Dihydroergotamine. Dipyrone. Central Nervous System Stimulants. Physiological Effects of Drugs. Phosphodiesterase ... Dihydroergotamine mesylate+ dipyrone sodium + caffeine. Drug: Cefaliv® & Placebo 02 tablet of Cefaliv® + 02 tablet of ...
  https://clinicaltrials.gov/show/NCT02706015
*  Purinergic receptor - Wikipedia
There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. P2X receptors are ligand- ... Xanthines (e.g. caffeine) specifically block adenosine receptors, and are known to induce a stimulating effect to one's ... P1 receptors are preferentially activated by adenosine and P2Y receptors are preferentially more activated by ATP. P1 and P2Y ... IUPHAR GPCR Database - Adenosine receptors IUPHAR GPCR Database - P2Y receptors Purinergic Receptors at the US National Library ...
  https://en.wikipedia.org/wiki/Purinergic_receptor
*  Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of...
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Anti-Arrhythmia Agents. Antihypertensive Agents ... Excessive caffeine consumption, defined as mor than 800 mg per day. *History or clinical evidence of any disease and/or ... Caffeine. Metoprolol. Omeprazole. Efavirenz. Losartan. Chlorzoxazone. Adjuvants, Anesthesia. Hypnotics and Sedatives. Central ... Single-center, Randomized, Five-way Crossover Study to Investigate Low-dose Combinations of Caffeine, Efavirenz, Losartan, ...
  https://clinicaltrials.gov/ct2/show/NCT01187862
*  Purinergic signalling - Wikipedia
There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. Cell signalling events ... On the other hand, the adenosine-receptor antagonist caffeine reverses the anti-inflammatory effects of methotrexate. Anti- ... The purinergic signalling complex of a cell is sometimes referred to as the "purinome". Purinergic receptors, represented by ... Purinergic receptors are specific classes of membrane receptors that mediate various physiological functions such as the ...
  https://en.wikipedia.org/wiki/Purinergic_signalling
*  Adenosine receptor - Wikipedia
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ... It is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. The A2A receptor is ... Kalda A, Yu L, Oztas E, Chen JF (October 2006). "Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in ... Xanthine derivatives such as caffeine and theophylline act as non-selective antagonists at A1 and A2A receptors in both heart ...
  https://en.wikipedia.org/wiki/Adenosine_receptor
*  Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Agonists. Purinergic Agonists. Purinergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Willing to abstain from caffeine-containing products from 1 week prior to dosing until discharge from unit. ... occupies the brain's A2A receptors. Receptor occupancy will be assessed by PET scanning using a radiolabelled tracer. ... Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers. The safety and scientific validity of ...
  https://clinicaltrials.gov/ct2/show/NCT00531193
*  RCSB PDB - Ligand Summary Page
Purinergic Agents. *Purinergic Agonists. *Purinergic P1 Receptor Agonists. *Purines. *Ribonucleosides. *Sensory System Agents ... Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of ... Adenosine receptor A1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVS... yes. agonist. Adenosine receptor A2b ... Adenosine receptor A3 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYF... yes. agonist. Adenosine receptor A2a ...
  http://www.rcsb.org/pdb/ligand/ligandsummary.do?handler=biologyChemistry&hetId=ADN
*  Working memory and the homeostatic control of brain adenosine by adenosine kinase. - Semantic Scholar
However, mice that globally over-express an Adk transgene ('Adk-tg' mice) were devoid of a caffeine-like pro-cognitive profile ... This may be mechanistically linked to cortical/hippocampal N-methyl-d-aspartate receptor (NMDAR) hypofunction because the motor ... AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effects ... maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors ( ...
  https://www.semanticscholar.org/paper/Working-memory-and-the-homeostatic-control-of-brain-Singer-McGarrity/7190233510d2689eae7fc6f610d18dab1d376d7b
*  Extracellular ATP Induces a Distorted Maturation of Dendritic Cells and Inhibits Their Capacity to Initiate Th1 Responses | The...
Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T cell development and cytotoxic T lymphocyte ... Adenosine receptors antagonists 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), 8-(3-chlorostyryl)caffeine (CSC), MRS-1220, and the ... The P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release. FASEB J. 14: 2466. ... Extracellular ATP triggers IL-1β release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 159: 1451 ...
  http://www.jimmunol.org/content/166/3/1611
*  A Study of LY2216684 and Theophylline in Healthy Subjects - Full Text View - ClinicalTrials.gov
Purinergic P1 Receptor Antagonists. Purinergic Antagonists. Purinergic Agents. Neurotransmitter Agents. Anti-Infective Agents, ... Consume 5 or more cups of coffee (or other beverages of comparable caffeine content) per day, on a habitual basis, or any ... subjects unwilling to adhere to study caffeine and chocolate restrictions.. *Have used any tobacco-containing or nicotine- ...
  https://clinicaltrials.gov/ct2/show/NCT01263106
*  A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease - Full Text...
Adenosine A2 Receptor Agonists. Purinergic P1 Receptor Agonists. Purinergic Agonists. Purinergic Agents. Neurotransmitter ... Subject must abstain from any intake of foods and beverages containing a methylated xanthine derivative (i.e. caffeine, ...
  https://clinicaltrials.gov/ct2/show/NCT00862641?term=Lung+Diseases%2C+Obstructive&rank=10
*  Adenosine - DrugBank
Purinergic Agents. *Purinergic Agonists. *Purinergic P1 Receptor Agonists. *Purines. *Ribonucleosides. *Sensory System Agents ... Avoid caffeine containing foods and drinks.. References. Synthesis Reference. Giorgio Stramentinoli, Federico Gennari, 'Process ... G-protein coupled adenosine receptor activity. Specific Function. Receptor for adenosine. The activity of this receptor is ... G-protein coupled adenosine receptor activity. Specific Function. Receptor for adenosine. The activity of this receptor is ...
  https://www.drugbank.ca/drugs/DB00640