*  CTNNA2 - Catenin alpha-2 - Pongo abelii (Sumatran orangutan) - CTNNA2 gene & protein
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
  http://www.uniprot.org/uniprot/Q5R416
*  CTNNA1 - Catenin alpha-1 - Homo sapiens (Human) - CTNNA1 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ...
  http://www.uniprot.org/uniprot/E5RJP7
*  Catenin Family Genes Are Not Commonly Mutated in Hereditary Diffuse Gastric Cancer | Cancer Epidemiology, Biomarkers &...
Background: Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene (CDH1). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non-CDH1 families.. Methods: Affected individuals from 22 CDH1 mutation-negative families were screened for germline mutations in four catenin genes: CTNNA1, CTNNB1, JUP, and CTNND1. Catenins interact closely with E-cadherin molecules in cells, and are therefore logical candidate genes for mutation screening in HDGC families.. Results: No nonsynonymous variants were seen in CTNNA1, CTNNB1, or CTNND1; only JUP contained nonsynonymous variants, of which only two rare variants were ...
  http://cebp.aacrjournals.org/content/early/2012/11/14/1055-9965.EPI-12-1110.long
*  Catenin - Wikipedia
Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. A-catenin can bind to β-catenin and can also bind actin. B-catenin binds the cytoplasmic domain of some cadherins. Additional catenins such as γ-catenin and δ-catenin have been identified. The name ...
  https://en.wikipedia.org/wiki/Catenin
*  αE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion | JCB
In vitro studies with purified proteins showed that αE-catenin is an allosteric protein in which the monomer binds the cadherin-catenin complex and homodimer preferentially binds actin filaments and inhibits Arp2/3 complex-mediated actin polymerization (Drees et al., 2005; Yamada et al., 2005). These results intimated roles for αE-catenin in the regulation of actin-based membrane dynamics in addition to and perhaps independent of αE-catenin roles in cell-cell adhesion. In this study, we tested key predictions of these in vitro results in ...
  http://jcb.rupress.org/content/189/2/339
*  Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart | Journal of Cell Science
The increased penetrance, earlier onset, and increased severity of the cardiac phenotype in αMHC/Ecad mice suggests that the epithelial cadherin may further perturb the transmission of the contractile force across the intercalated disc structure. In contrast to chick N-cadherin, the less similar E-cadherin is more likely to interfere with adherens junction organization by intercalating into the cadherin zipper, thus disrupting the normal homogeneous clustering of N-cadherin/catenin complexes ( Fig. 9). Mouse and chicken N-cadherin are nearly identical in the cytoplasmic and transmembrane domains; therefore, we predict normal interaction(s) with the submembranous myofibril ...
  http://jcs.biologists.org/content/115/8/1623
*  Anti-CTNNA1/Alpha 1 Catenin Picoband™ Antibody
Polyclonal antibody for ALPHA 1 CATENIN/CTNNA1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. ALPHA 1 CATENIN/CTNNA1 information: Molecular Weight: 100071 MW; Subcellular Localization: Isoform 1: Cytoplasm,
  https://www.bosterbio.com/anti-ctnna1-picoband-trade-antibody-pb9137.html
*  anti-beta Catenin antibody [1F3] | GeneTex
beta Catenin antibody [1F3] (catenin (cadherin-associated protein), beta 1, 88kDa) for IHC-P, WB. Anti-beta Catenin mAb (GTX84650) is tested in Human, Monkey samples. 100% Ab-Assurance.
  http://www.genetex.com/beta-Catenin-antibody-1F3-GTX84650.html
*  anti-beta Catenin (phospho Thr41/Ser45) antibody | GeneTex
beta Catenin (phospho Thr41/Ser45) antibody (catenin (cadherin-associated protein), beta 1, 88kDa) for WB. Anti-beta Catenin (phospho Thr41/Ser45) pAb (GTX50180) is tested in Human samples. 100% Ab-Assurance.
  http://www.genetex.com/beta-Catenin-phospho-Thr41Ser45-antibody-GTX50180.html
*  KEGG PATHWAY: Adherens junction - Homo sapiens (human)
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by ...
  http://www.genome.jp/kegg-bin/show_pathway?131081650219559/hsa04520.args
*  KEGG PATHWAY: Adherens junction - Homo sapiens (human)
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by ...
  http://www.genome.jp/kegg-bin/show_pathway?133837803022751/hsa04520.args
*  Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells | Journal of Cell Science
We show in this paper that this can indeed occur, in a cell culture system in which Wg signaling can be controlled and its response be measured over time. We found two contrasting effects: Wg initially lowers the amount of the cadherin-catenin complex at cell-cell contacts, most probably by reducing the Arm pool interacting with E-cadherin, but later, Wg signaling leads to elevated DE-cadherin transcription. This later increase in DE cadherin may titrate the pool of Arm available for Wg signaling and therefore attenuate the transcriptional response to Wg. We have shown by metabolic labeling experiments that the reduction in E-cadherin levels was caused by a ...
  http://jcs.biologists.org/content/119/12/2425
*  Methylation of CTNNA1 promoter: frequent but not an adverse prognostic factor in acute myeloid leukemia. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Xing-xing Chen, Jiang Lin, Jun Qian, Wei Qian, Jing Yang, Ji-chun Ma, Zhao-qun Deng, Cui An, Chun-yan Tang, Zhen Qian, Qing Liu].
  https://www.sigmaaldrich.com/catalog/papers/24685333
*  CTNNA3 Antibody (892 24D2S) [Alexa Fluor® 405] (NBP1-97719AF405): Novus Biologicals
Mouse Monoclonal Anti-CTNNA3 Antibody (892_24D2S) [Alexa Fluor® 405]. Validated: WB, Flow, ICC/IF, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
  https://www.novusbio.com/products/ctnna3-antibody-892_24d2s_nbp1-97719af405
*  OriGene - CTNNB1 (NM 001098209) Human ORF cDNA Clone
CTNNB1 - CTNNB1 (GFP-tagged) - Human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 2 available for purchase from OriGene - Your Gene Company.
  http://www.origene.com/Human_ORF_Clone/RG212056.aspx
*  Integrin α3β1-dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts | JCB
TGF-β1 has been previously reported to promote tyrosine phosphorylation of β-catenin (Tian and Phillips, 2002), although the specific site of phosphorylation and its functional significance in TGF-β1 signaling has been unknown. Our finding of integrin-dependent tyrosine phosphorylation of Y654-β-catenin is important because phosphorylation of β-catenin at Y654 is known to promote both dissociation of β-catenin from E-cadherin and stabilization of β-catenin ...
  http://jcb.rupress.org/content/184/2/309
*  British Library EThOS: The molecular mechanism of cadherin-mediated adhesion
My work examines the role of a conserved tryptophan residue, Trp2, in the adhesive domain of cadherins that has been shown to be essential for their adhesive function. Structural studies have shown Trp2 to be integrated into its own cadherin domain, integrated into the domain an opposing cadherin molecule, or freed from the domain and exposed to solvent. Until now, the physiological relevance of these structures has been controversial. Using conformation specific antibodies I show that Trp2 integrates into the domain fold of its own cadherin molecule in physiological conditions, but that this integration is not stable owing to structural constraints imposed by calcium binding to the cadherin. This raises the ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603783
*  M-cadherin-inhibited phosphorylation of ß-catenin augments differentiation of mouse myoblasts.
β-Catenin is essential for muscle development because it regulates both cadherin-mediated cell-cell adhesion and canonical Wingless and Int1 (Wnt) signaling. The phosphorylation of β-catenin by glycogen synthase kinase-3β (GSK-3β) at serine31/37/
  http://www.biomedsearch.com/nih/M-cadherin-inhibited-phosphorylation-catenin/23138569.html
*  Alpha-catulin ELISA Kits | Biocompare.com
Compare Alpha-catulin ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
  https://www.biocompare.com/pfu/110627/soids/2-45835/Assay_Kit/ELISA_Alpha-catulin
*  Vinculin Is Part of the Cadherin-Catenin Junctional Complex: Complex Formation between ...
In this study, we addressed the following questions. First, why are vinculin and α-catenin, two structural proteins related in sequence, differentially recruited to cell-matrix and cell-cell contacts? Second, is vinculin, a recognized major component of cell-matrix contacts, also part of the cell-cell junctional complex?. The recruitment of intact vinculin to focal adhesions is mainly attributed to its rather high affinity for talin, a protein exclusively seen in cell-matrix contacts (Burridge and Connell, 1983; Drenckhahn et al., 1988). As had been described earlier (Bendori et al., 1989; Menkel et al., 1994) and was confirmed in this study (not shown), the isolated vinculin tail domain, when introduced into host cells by either transfection or microinjection, targets primarily to microfilament bundles and to focal adhesions. In contrast, the transfected ...
  http://jcb.rupress.org/content/141/3/755
*  δ-catenin interacts directly with the juxtamembrane re | Open-i
δ-catenin interacts directly with the juxtamembrane region of cadherins in the yeast two-hybrid system. (A) Interaction of δ-catenin with various cadherin fr
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2132907_JCB9808088.f7&req=4
*  Catenin alpha 2 Research Products: Novus Biologicals
Catenin alpha 2 products available through Novus Biologicals. Browse our Catenin alpha 2 product catalog backed by our Guarantee+.
  https://www.novusbio.com/common-name/catenin-alpha-2
*  Vav1 interacts with β-catenin in lung epithelial cance | Open-i
Vav1 interacts with β-catenin in lung epithelial cancer cell linesa. Vav1 protein expression in pulmonary and lymphoid cell lines. Total cell extracts were ana
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4385868_oncotarget-06-2524-g007&req=4
*  Absence of β-catenin does not affect spontaneous or gl | Open-i
Absence of β-catenin does not affect spontaneous or glucocorticoid-induced death of thymocytes. (a) Percentage of surviving thymocytes gated on CD45.1+ (WT don
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211763_20031615f5&req=4
*  Gene Expression sub-cluster 25
The canonical WNT-β-catenin pathway is essential for self-renewal, growth and survival of AML stem/blast progenitor cells (BPCs). Deregulated WNT signaling inhibits degradation of β-catenin, causing increased nuclear translocation and co-factor activity of β-catenin with the transcriptional regulator TCF4/LEF1 in AML BPCs. Here, we determined the pre-clinical anti-AML activity of the ...
  http://www.biomedsearch.com/cluster/10/Gene-Expression/sub-25.html