*  Bulky DNA adducts and lung cancer risk: a prospective study in EPIC investigation | Cancer Research
Leukocyte DNA adducts were analysed blindly using the 32P DNA postlabelling technique. The intensity of adduct patterns was ... Bulky DNA adducts and lung cancer risk: a prospective study in EPIC investigation. Marco Peluso, Armelle Munnia, Domenico Palli ... Our large prospective study suggests that the presence of bulky 32P-postlabelling DNA adducts in the WBC of non-smokers may ... Therefore, we have measured bulky 32P-postlabelling DNA adducts in a case-control study nested in a large prospective ...
  http://cancerres.aacrjournals.org/content/65/9_Supplement/512.2
*  Abstract IA18: The post-transcriptional response to bulky-adduct DNA damage | Cancer Research
Abstract IA18: The post-transcriptional response to bulky-adduct DNA damage Message Subject (Your Name) has forwarded a page to ... For example, we have shown that following treatment with agents that cause bulky-adduct DNA damage, such a platinum-based ... Abstract IA18: The post-transcriptional response to bulky-adduct DNA damage. Anne E. Willis ... The post-transcriptional response to bulky-adduct DNA damage. [abstract]. In: Proceedings of the AACR Special Conference on ...
  http://cancerres.aacrjournals.org/content/77/6_Supplement/IA18
*  September 2012 - Volume 23 - Issue 5S : Epidemiology
O-012: Bulky DNA Adducts in Cord Blood, Maternal Diet and Birth Weight in a European Prospective Mother-Child Study (NEWGENERIS ... E-013: Follow-up Investigation in Oxidative DNA Damage and Lipid Peroxidation 3 Years after Hebei Spirit Oil Spill. Noh, Su ...
  https://journals.lww.com/epidem/toc/2012/09001
*  Current Projects: Geography | Damon Runyon
Replicative helicase bypass of bulky DNA adducts?' with Johannes C. Walter, PhD VIEW PROJECT. ... Mechanism of DNA processing during non-homologous end joining' with Johannes C. Walter, PhD, and Joseph L. Loparo, PhD VIEW ... DNA methylation stochasticity in pediatric pre-B cell acute lymphoblastic leukemia' with Andrew P. Feinberg, MD VIEW PROJECT. ... Global analysis of DNA break repair by single-cell sequencing' with Jay A. Shendure, MD, PhD VIEW PROJECT. ...
  https://www.damonrunyon.org/our-impact/current-projects/geography/HI
*  Mutagenicity and antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet...
However, the protective activity of HK is not general and varies with the type of DNA damage-inducing agent used. ... The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA ... bulky stable and depurinating DNA adducts are formed [33, 34]. Insufficient removal of these DNA adducts prior to replication ... The exo-epoxide form of AFB1 binds to DNA to form the predominant 8,9-dihydro- 8-(N7-guanyl)-9-hydroxy AFB1 adduct, leading to ...
  https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-203
*  Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model
... which is similar to what occurs with other bulky DNA adducts, such as benzo(a)pyrene diol epoxide-dG adducts and cyclobutane ... A) Chemical structures of MC, MC-mono-dG, and ICL dG-MC-dG DNA adducts. (B) The DNA sequence of the 61-bp DNA fragment ... In order to obtain definitive UvrABC-DNA adduct interactions 61-bp DNA fragments containing a site-specific MC-mono-dG adduct ( ... kink in the DNA helix (17). Similar to the ICL dG-MC-dG adduct, it has been shown that an MC-mono-dG adduct does not induce DNA ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2978355/
*  CHRNA5 | Cancer Genetics Web
Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations.. Int J Cancer. 2013; ... polycyclic aromatic hydrocarbon-DNA adduct levels, (iii) TP53 mutations and (iv) susceptibility to lung cancer. ... were associated with differential levels of genetic alterations measured as the levels of hydrophobic DNA adducts in the ... The two most frequent haplotypes were associated with the risk of developing lung cancer and with smoking-related DNA ...
  http://www.cancerindex.org/geneweb/CHRNA5.htm
*  Inter Research » MEPS » v205 » p195-206
Regardless of the exposure dose of B[a]P, several bulky DNA adducts were induced in the typical PAH diagonal radioactive zone. ... Induction and elimination of bulky benzo[a]pyrene-related DNA adducts and 8 oxodGuo in mussels Mytilus galloprovincialis ... DNA repair during depuration differed among the B[a]P-induced DNA adducts. B[a]P exposure had no effect on gill 8-oxodGuo ... KEY WORDS: B[a]P · Mussel · DNA adducts · 8-oxodGuo · DNA repair ...
  http://www.int-res.com/abstracts/meps/v205/p195-206/
*  Suse Broyde
Probing for DNA damage with beta-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human ... Effect of ring size on conformations of aromatic amine-DNA adducts: the aniline-C8 guanine adduct resides in the B-DNA major ... temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.. J Biol ... Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.. ...
  https://as.nyu.edu/faculty/suse-broyde.html
*  Polycyclic aromatic hydrocarbon - Wikipedia
... forming bulky complexes called DNA adducts that can be stable or unstable. Stable adducts may lead to DNA replication errors, ... Henkler, F; Stolpmann, K; Luch, Andreas (2012). "Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular ... This enzyme then metabolically processes the PAHs to quinone metabolites that bind to DNA in reactive adducts that remove ... Baird, W. M.; Hooven, L. A.; Mahadevan, B. (1 February 2015). "Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and ...
  https://en.wikipedia.org/wiki/Polycyclic_aromatic_hydrocarbon
*  IJERPH | Free Full-Text | Biomarkers of Induced Active and Passive Smoking Damage | HTML
Levels of DNA adducts measured in many tissues of smokers are significantly higher than in non-smokers. While some studies have ... In order to establish whether smoking-related DNA adducts are biomarkers of tobacco smoke exposure and/or its carcinogenic ... activity we summarized all data that associated tobacco smoke exposure and smoking-related DNA adducts both in controls and/or ... demonstrated an association between carcinogenic DNA adducts and cancer in current smokers, no association has been observed in ...
  http://www.mdpi.com/1660-4601/6/3/874/htm
*  Epigenetic Modifications of Nucleotide Excision Repair Genes in Oral Squamous Cell Carcinoma | OMICS International
Genotoxic exposure to tobacco carcinogens resulting in DNA damage is an important mechanism of oral squamous cell carcinoma ( ... Nucleotide Excision Repair (NER) pathway removes bulky DNA adducts, generated from tobacco exposure thereby playing a major ... 2002) The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk. Carcinogenesis 23: ... Since effective DNA repair is at backbone of cancer free survival and a DNA repair system may be modulated in effectiveness by ...
  https://www.omicsonline.org/open-access/spectrophotometric-determination-of-nifedipine-and-nicardipine-in-theirpharmaceutical-preparations-2469-9764-1000103.php?aid=62308
*  Plus it
Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of ... a presence of bulky DNA adducts.. Finally, the origin of such a genotoxic signature remains to be elucidated. We can ... expression of four base excision DNA repair genes, markers of oxidative DNA damage (29), or 4-hydroxynonenal protein adducts, a ... HNF1α protein recognizes specific palindromic nucleotide DNA sequences and interacts with DNA as either a homodimer or a ...
  http://diabetes.diabetesjournals.org/content/59/7/1836
*  rs1048943 - SNPedia
PMID 24084248] The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in ... Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide ... metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race. ... PMID 19267064] [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of ...
  https://snpedia.com/index.php/Rs1048943
*  rs1042522 - SNPedia
PMID 24084248] The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in ... Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between ... PMID 21029772] Genomic DNA extraction from whole blood stored from 15- to 30-years at -20 degrees C by rapid phenol-chloroform ... PMID 28351583] Candidate apoptotic and DNA repair gene approach confirms involvement of ERCC1, ERCC5, TP53 and MDM2 in ...
  https://snpedia.com/index.php/Rs1042522
*  rs1799814 - SNPedia
... haplotype are associated with bulky DNA adduct levels in human leukocytes [PMID 23175176. ] Variation in PAH-related DNA adduct ...
  https://snpedia.com/index.php/Rs1799814
*  XPC (gene) - Wikipedia
XPC is involved in the recognition of bulky DNA adducts in nucleotide excision repair. It is located on chromosome 3. This gene ... If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage may increase mutations due to error-prone ... Bernstein C, Prasad AR, Nfonsam V, Bernstein H. (2013). DNA Damage, DNA Repair and Cancer, New Research Directions in DNA ... www.intechopen.com/books/new-research-directions-in-dna-repair/dna-damage-dna-repair-and-cancer Harper JW, Elledge SJ (2007). " ...
  https://en.wikipedia.org/wiki/XPC_(gene)
*  Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional...
Bulky DNA adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study ( ... Therefore, a better exposure biomarker would have been benzo[a]pyrene DNA adducts as opposed to 1-OHP. Fourthly, the FV pattern ... In a European study involving 229 mothers and 612 newborns [27], DNA adduct levels in cord blood were negatively correlated ... DNA, and, proteins [24]. As a biomarker of oxidative DNA damage, urinary 8-OH-dG levels were nearly 2× higher in the exposed ...
  https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0028-5
*  Environmental Toxins and Breast Cancer on Long Island. I. Polycyclic Aromatic Hydrocarbon DNA Adducts | Cancer Epidemiology,...
PAH are bulky carcinogens, and elevated levels of PAH-DNA adducts have been observed in lung cancer cases (32) . Furthermore, ... This lack of an association between adduct levels and the major sources of PAH adducts suggest perhaps that the adducts are ... I. Polycyclic Aromatic Hydrocarbon DNA Adducts. Marilie D. Gammon, Regina M. Santella, Alfred I. Neugut, Sybil M. Eng, Susan L. ... I. Polycyclic Aromatic Hydrocarbon DNA Adducts. Marilie D. Gammon, Regina M. Santella, Alfred I. Neugut, Sybil M. Eng, Susan L. ...
  http://cebp.aacrjournals.org/content/11/8/677
*  Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study | Environmental...
Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ ... DNA and hemoglobin adducts could be instrumental in identifying susceptible populations at greater risk from high levels of ... DNA: deoxyribonucleic acid; IARC: International Agency for Research on Cancer; ICD-O-3: International Classification of ... 3-butadiene epoxy metabolites on DNA is the mechanism inducing carcinogenicity. 1,3-butadiene is metabolically activated to ...
  https://ehjournal.biomedcentral.com/articles/10.1186/s12940-016-0154-8
*  Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth...
Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ ... Expression of these DNA damage responsive genes seem to be affected by PM2.5 exposure in a time dependent manner. It is ... These pathways play a central role in the response to DNA damage and may be important in the potential of PM2.5 to induce ... Some processes were altered in both sexes for long- (e.g. DNA damage) or short-term exposure (e.g. olfactory signaling). For ...
  https://ehjournal.biomedcentral.com/articles/10.1186/s12940-017-0264-y
*  Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. - PubMed - NCBI
A) Unrepaired DNA damage and repair intermediates such as bulky DNA adducts, ribonucleotides or abasic sites can poison Top2 ... phosphotyrosine adduct derived from poisoned Top2 leaving DNA ends with a 5′-phosphate, which facilitates DNA end joining ... Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.. Schellenberg MJ1, Perera L1, Strom CN2, Waters ... D) Comparison of Ca2+ (green Ca2+ ion, orange DNA) (PDB entry 5INQ), and Mg2+ (magenta Mg2+ ion, yellow DNA) (PDB entry 4GZ1) ...
  https://www.ncbi.nlm.nih.gov/pubmed/27060144
*  XRCC1 Polymorphisms and Cancer Risk: A Meta-analysis of 38 Case-Control Studies | Cancer Epidemiology, Biomarkers & Prevention
DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study. Int J Cancer ... Pastorelli R, Cerri A, Mezzetti M, Consonni E, Airoldi L. Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human ... XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res 1999;59:2557-61. ... Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. ...
  http://cebp.aacrjournals.org/content/14/7/1810.long
*  Nucleotide excision repair - Wikipedia
UV DNA damage results in bulky DNA adducts - these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the ... and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only ... subsequent repair proteins are then recruited to the damaged DNA to verify presence of DNA damage, excise the damaged DNA ... This allows DNA polymerases implicated in repair (δ, ε and/or κ) to copy the undamaged strand via translocation. DNA ligase I ...
  https://en.wikipedia.org/wiki/Nucleotide_excision_repair
*  Biological Activities and Potential Oral Applications of N-Acetylcysteine: Progress and Prospects
... including the levels of bulky DNA adducts and 8-hydroxy-2′-deoxyguanosine in bronchoalveolar lavage cells, as well as the ... S. De Flora, A. Izzotti, F. D'Agostini, and R. M. Balansky, "Mechanisms of N-acetylcysteine in the prevention of DNA damage and ... G. Nocca, V. D'Antò, C. Desiderio et al., "N-Acetyl cysteine directed detoxification of 2-hydroxyethyl methacrylate by adduct ... Excessive oxidative stress results in oxidative modification of proteins, lipids, DNA, and subsequent cell death [13]. This ...
  https://www.hindawi.com/journals/omcl/2018/2835787/