Comparison of paired human nasal and bronchial airway epithelial cell responses to rhinovirus infection and IL-13 treatment |...
Our data suggest that nasal epithelial cells could serve as a surrogate to bronchial epithelial cells in future studies aimed ... Nasal and bronchial airway epithelial cells taken from the same patient were cultured under submerged and air-liquid interface ... In the absence of IL-13 treatment, nasal and bronchial cells showed a similar IP-10 response in both ALI and submerged cultures ... The goal of the present study is to test whether nasal epithelial cells have similar antiviral and inflammatory responses to IL ...https://clintransmed.springeropen.com/articles/10.1186/s40169-018-0189-2
On Rhinoviruses and bronchial epithelial cells:. Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured ... The study looked at cultured primary bronchial epithelial cells (PBEC) in patients with the common cold rhinovirus RV16, which ... Rhinoviruses (more than 100 known serotypes):. v Rhinoviruses are transmitted through the respiratory route and replicate in ... bronchial epithelial cells. Duits LA, Nibbering PH, van Strijen E, Vos JB, Mannesse-Lazeroms SP, van Sterkenburg MA, Hiemstra ...https://web.stanford.edu/group/virus/picorna/2004flynn/Picornaviridae2.htm
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Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. ... Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains. ... Rhinovirus and dsRNA induce RIG-I-like receptors and expression of interferon β and λ1 in human bronchial smooth muscle cells. ... Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=24131248
Incarceration as a key variable in racial disparities of asthma prevalence
The researchers studied the immune response to infection with a rhinovirus in cultures of bronchial epithelial cells... ...http://connection.ebscohost.com/c/articles/52038906/incarceration-as-key-variable-racial-disparities-asthma-prevalence
Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma | Thorax
Rhinovirus induction of the CXC chemokine epithelial-neutrophil activating peptide-78 in bronchial epithelium. J Infect Dis2003 ... a recent in vitro study showed that rhinovirus infection induces bronchial epithelial neutrophil chemokine CXCL5 and CXCL8 ... 5 in therapeutic bronchial lavage in patients in status asthmatics,22 and in sputum,6 lavage fluid and bronchial tissue of ... All evaluable bronchial biopsy specimens from each patient were included and the average for each patient was used in the ...http://thorax.bmj.com/content/62/6/475
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201 ... Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol 2010 ... In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human ... When the bronchial mucosa is sampled 6 h post-allergen challenge, myeloid DCs (CD1c+ HLA-DR+) are increased, but pDC numbers ...http://erj.ersjournals.com/content/43/1/264
Ellen F Foxman, MD, PhD > Laboratory Medicine | Yale School of...
Micrograph of human bronchial epithelial cells, seven hours after exposure to rhinovirus 1B. Rhinovirus infection of airway ... epithelial cells results in accumulation of double stranded RNA (dsRNA; blue) during viral genome replication. Cells are also ... cool ambient temperature permits growth of the common cold virus by diminishing antiviral responses of airway epithelial cells ...https://medicine.yale.edu/labmed/sections/virology/ellen_foxman.profile
Pharmacologic Therapies for Severe Asthma | SpringerLink
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005;201( ... NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation. Cell ... Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013;368(15):1398-407.PubMedPubMedCentral ... The roles of phytochemicals in bronchial asthma. Molecules. 2010;15(10):6810-34.PubMedCrossRefGoogle Scholar ...https://link.springer.com/chapter/10.1007%2F978-981-10-1998-2_6
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Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. ... Rhinovirus-Induced Airway Disease: A Model to Understand the Antiviral and Th2 Epithelial Immune Dysregulation in Childhood ... Rhinoviruses in the pathogenesis of asthma: the bronchial epithelium as a major disease target. ... Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_reviews&from_uid=15781584
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... antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus. ... Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in ... Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection. ... High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=22766097
Evaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a model
Rhinovirus induction of the CXC chemokine epithelial-neutrophil activating peptide-78 in bronchial epithelium Donninger H.; ... Rhinovirus serotype 16 (RV16) was used to infect primary bronchial epithelial cells and a cell line ... ... Epithelial-neutrophil activating peptide-78 (ENA-78) induces neutrophil migration, an early response to viral infection. ...http://scholar.sun.ac.za/handle/10019.1/11998
Dr. Lisa Parker BSc MRes PhD - Staff and Student List - Infection, Immunity & Cardiovascular Disease - The University of...
... of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial ... the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy. , 44(1), 20-28. ... Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol. , 86(12), 6595-6604. ... 2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma ...https://www.sheffield.ac.uk/iicd/profiles/parker
Widdicombe JH[au] - PubMed - NCBI
In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human ... Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in ... Resistance of differentiated human airway epithelium to infection by rhinovirus.. Lopez-Souza N, Dolganov G, Dubin R, Sachs LA ... Quantitative real-time PCR for rhinovirus, and its use in determining the relationship between TCID50 and the number of viral ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Widdicombe+JH%5Bau%5D&dispmax=50
Respiratory syncytial virus and asthma: still no final answer | Thorax
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005;201: ... Wheezing rhinovirus illnesses in early life predict asthma development in high risk children. Am J Respir Crit Care Med 2008: ... Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 2005;116:571-7. ... those in which human rhinovirus was identified, were associated with asthma later in life. It is plausible to speculate that ...http://thorax.bmj.com/content/65/12/1033
Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed
... of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to Rhinovirus in primary bronchial epithelial ... J. L. Devalia, R. J. Sapsford, D. R. Cundell, C. Rusznak, A. M. Campbell, and R. J. Davies, "Human bronchial epithelial cell ... A. T. Hastie, K. B. Everts, S.-K. Cho et al., "IL-1 beta release from cultured bronchial epithelial cells and bronchoalveolar ... R. N. Bauer, L. E. Brighton, L. Mueller et al., "Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic ...https://www.hindawi.com/journals/jir/2015/828264/ref/
Monica Spiteri - Keele University
IFN-gamma regulation of ICAM-1 receptors in bronchial epithelial cells: soluble ICAM-1 release inhibits human rhinovirus ... Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1. ... A biological model to explain the association between human rhinovirus respiratory infections and bronchial asthma. Monaldi ... Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis. Eur Respir J, vol. 41(3), 683-694. link, doi ...https://www.keele.ac.uk/istm/staff/monicaspiteri/
Systems, Models and Methods for Identifying and Evaluating Skin-Active Agents Effective for Treating Dandruff/Seborrheic...
Human Bronchial Epithelial Cells treated with rhinovirus-13; hKC = human keratinocytes Example 4  This example ...http://www.patentsencyclopedia.com/app/20120258074
MRC IMPACT PhD projects - University of Birmingham
Rhinovirus induces interleukin 33 (IL33) release from bronchial epithelial cells which activates a range of inflammatory cells ... loci have been associated with exacerbation risk we hypothesise that these variants can modulate bronchial epithelial cell ... Rhinovirus is a major cause of exacerbations; however the contribution of host genetics and molecular mechanisms underlying ... This project will use a combination of cell and molecular biology, immunology and genetics to investigate epithelial cell - ...https://www.birmingham.ac.uk/schools/mds-graduate-school/scholarships/mrc-impact/programme.aspx
JoVE Author Search: Bertics PJ
Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection.. Abstract ... Rhinovirus Stimulation of Macrophage Signaling and Mediator Production. 6/01/2008. 5/31/2009. NIH. R33: Exploratory/ ...http://labindex.jove.com/author/Bertics-PJ
Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected,...
... and bronchial epithelial cells (HBEC). The mediators IL-6, IL-8, prostaglandin E2 and cAMP production were assayed by ELISA and ... Rhinovirus (RV) infections are responsible for half of all COPD exacerbations. The mechanism by which exacerbations occur ... Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005, 201 ... Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial ...https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-14-127
IFN-γ-inducible protein of 10 kDa upregulates the effector functions of eosinophils through β2integrin and CXCR3 | Respiratory...
Eosinophils play an important role in the pathogenesis of bronchial asthma and its exacerbation. Recent reports suggest the ... Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection. Clin Exp ... RV infection induces bronchial epithelial cells to produce IP-10 in vitro and in vivo . Monocytic cells also play an ... Experimental rhinovirus 16 infection increases intercellular adhesion molecule-1 expression in bronchial epithelium of ...https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-12-138
ASMscience | Defensins and Other Anti
Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells. FEMS Immunol. Med. ... The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. J. ... Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect. Immun. 67:3121- ... Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. AIDS 17:F39-F48.. ...http://www.asmscience.org/content/book/10.1128/9781555817619.chap2
The exact cell function of CDHR3 is not known, but the protein is found in human lung, bronchial epithelium, and cultured ... but not in a variety of epithelial and transformed cell lines (e.g. HeLa cells). In silico comparison of gene expression ... A new cell receptor for rhinovirus. Rhinovirus is the most frequent cause of the common cold, and the virus itself is quite ... Rhinovirus was detected in one patient, and enterovirus D68 in two patients; all others were negative for potential etiologic ...http://www.virology.ws/tag/rhinovirus/
a1-Antitrypsin reduces rhinovirus infection in primary human air | COPD
Brushed bronchial epithelial cells from normal subjects and patients diagnosed with COPD were cultured at air-liquid interface ... A1AT-mediated reduction of viral load was not accompanied by increased epithelial antiviral gene expression or by inhibiting ... We determined whether α1-antitrypsin (A1AT) reduces HRV-16 infection in CS-exposed primary human airway epithelial cells. ... Keywords: α1-antitrypsin, rhinovirus, COPD, cigarette smoke, ICAM-1 ...https://www.dovepress.com/alpha1-antitrypsin-reduces-rhinovirus-infection-in-primary-human-airwa-peer-reviewed-article-COPD
Ellen F Foxman, MD, PhD > Laboratory Medicine | Yale School of...
Micrograph of human bronchial epithelial cells, seven hours after exposure to rhinovirus 1B. Rhinovirus infection of airway ... Basic science projects focus on defense against rhinovirus by airway epithelial cells. Rhinovirus is the virus most commonly ... Recently published work has focused on understanding innate immune defense against human rhinovirus. Rhinovirus is the most ... found that mouse airway epithelial cells and human epithelial cells employed different defense mechanisms to block rhinovirus ...http://labmed.yale.edu/faculty/ellen_foxman-2.profile