*  Posterior reversible encephalopathy syndrome: a case following reversible cerebral vasoconstriction syndrome masquerading as...
Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic clinico-radiological diagnosis typically presenting with headache, encephalopathy and visual disturbance accompanied by a unique neuroradiological pattern of symmetrical parieto-occi
*  Small-Molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain Disease
Most loss-of-function diseases are caused by aberrant folding of important proteins. These proteins often misfold due to inherited mutations. The rare disease marble brain disease (MBD) also known as carbonic anhydrase II deficiency syndrome (CADS) can manifest in carriers of point mutations in the human carbonic anhydrase II (HCA II) gene. We have over the past 10-15 years studied the folding, misfolding and aggregation of the enzyme human carbonic anhydrase II. In summary our HCA II folding studies have shown that the protein folds via an intermediate of molten-globule type, which lacks enzyme activity and the molten globule state of HCA II is prone to aggregation. One mutation associated with MBD entails the His107Tyr (H107Y) substitution. We have demonstrated that the H107Y mutation is a remarkably destabilizing mutation influencing the folding behavior of HCA II. A mutational survey of position H107 and a neighboring conserved position E117 has been performed entailing ...
*  Germline mosaicism in X-linked periventricular nodular heterotopia | BMC Neurology | Full Text
Periventricular nodular heterotopia (PNH) is a disorder of cortical development [1]. PNH is a term used to describe the collections of neurons lining the lateral ventricles that have failed to migrate normally to form the cerebral cortex [1]. It is a clinically and genetically heterogeneous group of disorders [2]. Mutations in the filamin A gene (FLNA) result in an X-linked dominant form of this disorder [3]. Mutations in FLNA leading to protein truncation are the predominant cause of the PNH phenotype [2, 4]. Most affected females present with seizures and normal to mildly impaired cognitive function [2, 5]. FLNA-associated PNH may also be associated with other cerebral malformations as well as extra-cerebral features [6]. The condition typically results in prenatal lethality or a more severe phenotype in males although paternal transmission has been documented in the literature [2, 7-9].. Mutations in FLNA are associated with a wide spectrum of disorders including the otopalatodigital syndrome ...
*  Brain Research Trust - Wikipedia
The Brain Research Trust (also known as BRT) is a British medical research charity dedicated to the research of neurological diseases and conditions. Registered charity no. 1137560 Since its founding in 1971, the Trust has funded research totalling more than £30 million at University College London's Institute of Neurology, Queen Square, London. The Trust aims to provide a steady income to sustain and expand the vital research carried out at the Institute of Neurology, which together with the National Hospital for Neurology and Neurosurgery, is the UK's foremost centre for research into diseases of the brain and nervous system. From the more than 250 identifiable neurological conditions, the Institute's current research programme includes: Alzheimer's Disease, Brain Tumours, Multiple Sclerosis, Stroke, Parkinson's Disease, Epilepsy, Motor Neurone Disease, Migraine, Brain Trauma and Spinal Cord Regeneration. ...
*  Choroid plexus cyst - Wikipedia
Choroid plexus cysts (CPCs) are cysts that occur within choroid plexus of the brain. The brain contains pockets or spaces called ventricles with a spongy layer of cells and blood vessels called the choroid plexus. This is in the middle of the fetal brain. The choroid plexus has the important function of producing cerebrospinal fluid. The fluid produced by the cells of the choroid plexus fills the ventricles and then flows around the brain and the spinal cord to provide a cushion of fluid around these structures. CPCs can form within this structure and come from fluid trapped within this spongy layer of cells, much like a soap bubble or a blister. CPCs are often called "soft signs" or fetal ultrasound "markers" because some studies have found a weak association between CPCs and fetal chromosome abnormalities. It is believed that many adults have one or more tiny CPCs. The fetal brain may create these cysts as a normal part of ...
*  DMOZ - Health: Conditions and Diseases: Neurological Disorders: Brain Diseases: Metabolic: Sialuria
Sialic acid storage disease, also known as Salla disease, is a lysosomal storage disorder caused by defective transport of lysosomal degradation product, free sialic acid, across the lysosomal membrane. Functional consequences come only from central nervous system presenting slowly progressive mental retardation associated with ataxia and some other neurological manifestations. Affected infants present first signs of the disease already at 3 to 9 months of age as muscular hypotonia, truncal and limb ataxia, often transient nystagmus and delayed motor development. Developmental profile of SD patients is characterized by slowly progressive general handicap with motor performance more severely and earlier affected than cognitive skills. All patients are severely mentally retarded from third decade on. Life span of affected patients is close to normal.
*  Sports Medicine & Physical Activity | Links Medicus
Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football - JAMA (free). Author interview: Evaluation of Chronic Traumatic Encephalopathy in Football Players (free video). Commentaries: High Prevalence of Evidence of CTE in Brains of Deceased Football Players - JAMA Network (free) AND Brain disease CTE seen in most football players in large report - STAT News (free) AND 110 N.F.L. Brains - The New York Times (10 articles per month are free) AND Signs of brain disease in 99 percent of ex-NFL players studied: paper - Reuters (free) AND Study: CTE Found In Nearly All Donated NFL Player Brains - NPR (free). "A neuropathologist has examined the brains of 111 N.F.L. players - and 110 were found to have C.T.E., the degenerative disease linked to repeated blows to the head" (from NYT).. ...
*  The brain is a source of S100B increase during endotoxemia in the pig
BACKGROUND:. Cerebral dysfunction frequently complicates septic shock. A marker of cerebral dysfunction could be of significant value in managing sedated septic patients. Plasma S100 (S100B) proteins increase in sepsis. S100B is present not only in the brain but also in other tissues. The source of this protein has not been investigated in sepsis. Our aim in this study was to determine whether the brain is an important source of S100B in an experimental sepsis model.. METHODS:. Twenty-seven pigs were anesthetized and randomized to either infusion of endotoxin at the rate of 1 µg · kg-1 · h-1 (n = 19) or saline (n = 8). Catheters were inserted into a cervical artery and the superior sagittal sinus. Blood samples were collected from both sites and physiologic data were registered before the start of the endotoxin infusion and hourly during the experiment. After 6 h, the animals were killed and brain tissue samples were taken from the left hemisphere. S100B in ...
*  Choroid Plexus Cyst
We had a pretty scary doctors appointment yesterday afternoon. The doctor told us he saw a Choroid Plexus Cyst on the baby's brain in the ultrasound. He said this fairly common and he has seen quite a few before. He said that the cyst alone does not cause any harm and usually goes away before delivery. However, he suggested we go to a Maternal and Fetal Specialist to have a more detailed ultrasound because the cyst along with other signs could mean the baby has Trisomy 18. I know one other sign they are looking for are clinched fist which we see in the pictures of the ultrasound but during the ultrasound she had her hand open at times and waving. Trisomy 18 is a chromosome disorder where the baby has two of the 18th chromosome. This usually results in a miscarriage or death soon after birth. My doctor said he has never seen a case where the cyst turns out to be Trisomy 18 and he said with my age we are much lower risk of this happening. He said usually by the time the patient goes to the ...
*  DMOZ - Health: Conditions and Diseases: Neurological Disorders: Brain Diseases: Miller Fisher Syndrome
A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk.
*  DMOZ - Health: Conditions and Diseases: Neurological Disorders: Brain Diseases: Metabolic: Mucolipidosis Type IV
Mucolipidosis Type IV is an autosomal recessive disorder, mainly seen in Jews of Eastern European background. A cation channel disorder, characterized by severe neurological and ophthalmologic abnormalities, ML4 usually presents during the first year of life with mental retardation, corneal opacities, and delayed motor milestones. Children with ML4 typically reach a maximum developmental age of 15 months.
*  Neurologic disorder | definition of Neurologic disorder by Medical dictionary
Looking for online definition of Neurologic disorder in the Medical Dictionary? Neurologic disorder explanation free. What is Neurologic disorder? Meaning of Neurologic disorder medical term. What does Neurologic disorder mean?
*  Optic neuromyelitis syndrome in Brazilian patients | Journal of Neurology, Neurosurgery & Psychiatry
Recurrences of bouts of neurological dysfunction have almost invariably been ascribed to MS but such events also can be seen in recurrent (RDEM) and multiphasic disseminated encephalomyelitis (MDEM).6 In RDEM the first, acute bout is followed by one or more episodes that reproduce all or some of the symptoms of the original episode; this symptomatic stereotype that is quite rare in MS, can be seen in some cases of RONM.6 Our case 7 is a good illustration of this type of illness: a 55 year old Afro-Brazilian woman was treated with praziquantel for cerebral cysticercosis one year before the onset of RONM. She developed a subacute episode of TM at the T4 level and partial bilateral visual loss, with complete remission after corticotherapy. This first episode was then followed by seven episodes in the subsequent eight years, each one reproducing all or some of the symptoms of the original attack, mimicking the description of RDEM.6 Brain MRI revealed only one small periventricular lesion (Paty ...
*  Steven G. Clarke, Ph.D. | UCLA Brain Research Institute
Steven Clarke has been on the faculty of the UCLA Department of Chemistry and Biochemistry since 1978. He is currently a Distinguished Professor of Biochemistry and Director of the UCLA Cellular and Molecular Biology Training Program. He was born in Los Angeles and attended public schools in Altadena and Pasadena, California. He did his undergraduate work at Pomona College in Claremont, majoring in Chemistry and Zoology. During this time, he did undergraduate research at the UCLA Brain Research Institute with Dr. James E. Skinner and Professor Donald Lindsley on neural mechanisms of attention. He was also an NIH fellow in the laboratory of Dr. Peter Mitchell at Glynn Research Laboratories in Bodmin, England studying mitochondrial amino acid transport. He obtained his PhD in Biochemistry and Molecular Biology at Harvard University working as an NSF Fellow with Professor Guido Guidotti on membrane protein-detergent interactions and the identification of the major rat liver mitochondrial ...
*  Finger agnosia synonyms, Finger agnosia antonyms - FreeThesaurus.com
Synonyms for Finger agnosia in Free Thesaurus. Antonyms for Finger agnosia. 7 words related to agnosia: astereognosis, tactile agnosia, brain disease, brain disorder, encephalopathy, auditory agnosia, visual agnosia. What are synonyms for Finger agnosia?
*  Hypothermia for Neonatal Encephalopathy Lowers Death Rate Wi... : Neurology Today
Dr. Shankaran is continuing to study the hypothermia therapy. In a study submitted for publication that involves the same two groups of babies, MRIs tend to be more favorable for the hypothermia group, she said. Her team is also looking at variations on how best to use hypothermia. For instance, they are studying whether more time - 120 hours instead of 72 - and a lower temperature - 32 degrees instead of 33.5 - might deliver better results.. Donna Ferriero, MD, the W.H. and Marie Wattis Distinguished Professor and chair of the department of pediatrics at the University of California, San Francisco, said it is not fully understood why hypothermia therapy helps prevent brain injury in babies.. "We still don't know the true mechanism at work," she told Neurology Today. "We think we are slowing the metabolism and thus ultimately preventing cell death.". Dr. Ferriero was part of a research team that investigated the use of Cool-Cap, a brain-cooling cap that works on the same ...
*  Reye's Syndrome Symptoms, Treatment, Causes, Prognosis and Prevention on MedicineNet.com
Learn about Reye's syndrome symptoms, signs, treatment, prognosis, prevention and research. Aspirin use is a risk factor for Reye's syndrome.
*  Investigating hyponatraemia | The BMJ
scenario does not exclude the so called 'mild head injured'.. References. 1. Ammar Wakil, Jen Min Ng, and Stephen L Atkin; BMJ2011 342:d1118doi:10.1136/bmj.d1118. 2. McLellan D L, Barnes M, Eames P, Innotti F et al.. Rehabilitation after traumatic brain injury. London.BSRM, 1998. 3. Paul E Marik, Joseph Veron, Todd Trask. Management. of Head Trauma: http://chestjournal.chestpubs.org/content/122/2/699. 4. National Clinical Guidelines: Rehabilitation. following acquired brain injury, BSRM/RCP 2003. 5. Cort J H. Cerebral salt wasting. Lancet.. 1954;266:752-754. 6. Betjes M G. Hyponatraemia in acute brain disease:. the cerebral salt wasting syndrome. Eur J Intern. Med. 2002;13:9-14. ...
*  Results of four technical investigations in fifty clinically brain dead patients | SpringerLink
Fifty consecutive patients (aged 19-77 years, median 56 years) with primary cerebral diseases and the clinical signs of absent cortical and brainstem function were subjected to electroencephalography (EEG), brainstem acoustic evoked potentials (BAEP), extracranial Doppler ultrasonography (ECD) and arterial digital subtraction angiography (DSA). In the majority of cases the results of the technical tests agreed with the clinical signs and were suggestive of brain death. However, in one patient EEG revealed clear bioelectrical activity. In 6 cases, doubts existed about whether the EEG was isoelectric; in 3 of the 6 cases biological activity might have been present. In 31 of 42 patients ECD showed a typical pattern of intracranial circulatory arrest, in 9 of 42 ECD revealed a pattern suggestive of the cessation of cerebral blood flow. In four patients BAEP recordings compatible with brain death were recorded 2-3 days before ...
*  Term Life Insurance Quotes with Head or Brain Disorders
How to get approved for life insurance with head and brain disorders from migraines to head injury, and affordable term life insurance quotes.
*  Aaron Hernandez's Brain Reveals Signs Of CTE, Says Lawyer | KUNR
The brain of former New England Patriots star Aaron Hernandez showed severe signs of the degenerative brain disease chronic traumatic encephalopathy,
*  Obstetric aspects of hypoxic ischemic encephalopathy.
Hypoxic ischemic encephalopathy (HIE) describes neonatal encephalopathy that is caused by intrapartum asphyxia and it can result in the long term sequelae of cerebral palsy which is a major cause of disability. The incidence of cerebral palsy has not
*  2016 January Archive - Sai Orthocare
Fat Embolism is a complication of closed fracrures. It may lead to Respiratory distress, cerebral dysfunction and rash. It is often very difficult to diagnose.. Causes. 1. Fractures - closed fractures produce more emboli than open fractures. Long bones pelvis and ribs cause more emboli. Sternum and clavicle furnish less. Multiple fractures produce more emboli ...
*  Plus it
Microglia are critically involved not only in inflammatory and immune responses during brain diseases or trauma but also in the healthy developing brain (Paolicelli et al., 2011; Prinz et al., 2011; Chung and Barres, 2012). While microglia regulate the number of neuroblasts during developmental neurogenesis in the cerebellum, several lines of evidence suggest that microglia also regulate early steps of the adult neurogenesis (Marín-Teva et al., 2004). First, microglia eliminate dying neuroblasts within the neurogenic niche of the adult hippocampus (Sierra et al., 2010). Second, activated microglia impair the formation of new neurons in the adult hippocampus (Ekdahl et al., 2003; Monje et al., 2003). For instance, irradiation damages the proliferative niche in the adult hippocampus by activating microglia cells and triggering aberrant angiogenesis that collectively lead to sustained blockade of neurogenesis (Monje et al., 2003). Third, quiescent microglia ...
*  Phase 11-Grape Seed Extract as Anti-Oligomerization Agent in Alzheimer's Disease - Samuel Gandy
Alzheimer Disease (AD) is a progressive brain disease known generally as senile dementia. More than 4.5 million Americans have been diagnosed with AD, and this...