*  Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. | MRC Mitochondrial Biology Unit
Mitochondrial Proton-Translocating ATPases, Models, Molecular, Protein Conformation, Protein Folding. Abstract. Adenosine ... is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic ... We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining ... Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.. ...
  http://www.mrc-mbu.cam.ac.uk/publications/2468/structure-and-conformational-states-bovine-mitochondrial-atp-synthase-cryo-em
*  Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten...
Mitochondrial Proton-Translocating ATPases, Molecular Sequence Data, Neuronal Ceroid-Lipofuscinoses, Peptides, Protein ... Home Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with ... Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten ... Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten ...
  http://www.mrc-mbu.cam.ac.uk/publications/818/lysine-43-trimethylated-subunit-c-bovine-mitochondrial-atp-synthase-and-storage
*  Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase | PNAS
1999) Transient accumulation of elastic energy in proton translocating ATP synthase. FEBS Lett 449:1-6. ... 2001) Structure of bovine mitochondrial F1-ATPase with nucleotide bound to all three catalytic sites: Implications for the ... Our treatment started with the X-ray structure of bovine mitochondrial F1-ATPase (Protein Data Bank ID: 1H8E) (8), and then ... However, in the ATPase, the barrier is reduced to about 14 kcal/mol, and as shown in Fig. 3, the movement from ATP to ADP and ...
  http://www.pnas.org/content/108/51/20550
*  The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin. | MRC Mitochondrial Biology Unit
Proton-Translocating ATPases. Abstract. In the previously determined structure of mitochondrial F1-ATPase determined with ... 15 amino acids that inhibit both ATP synthesis and hydrolysis by binding to the F1 catalytic domain of F1F0-ATP synthase. In ... The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin.. ... The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin.. ...
  http://www.mrc-mbu.cam.ac.uk/publications/2687/structure-bovine-f1-atpase-complexed-peptide-antibiotic-efrapeptin
*  ATP synthase - Wikipedia
Proton and Sodium translocating F-type, V-type and A-type ATPases in OPM database The Nobel Prize in Chemistry 1997 to Paul D. ... "Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM". eLife. 4: e10180. doi:10.7554/eLife. ... However, whereas the F-ATP synthase generates ATP by utilising a proton gradient, the V-ATPase generates a proton gradient at ... The consumption of ATP by ATP-synthase pumps proton cations into the matrix. The evolution of ATP synthase is thought to have ...
  https://en.wikipedia.org/wiki/ATP_synthase
*  Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling | JGP
S2 shows a cryo-EM map of the subunit a-c-ring complex from the bovine mitochondrial ATP synthase. Fig. S3 shows alignment of ... The cytoplasmic loops of subunit a of Escherichia coli ATP synthase may participate in the proton translocating mechanism. J. ... The structure of bovine F1-ATPase in complex with its regulatory protein IF1. Nat. Struct. Biol. 10:744-750. doi:10.1038/nsb966 ... Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. eLife. 4:e10180. doi:10.7554/eLife. ...
  http://jgp.rupress.org/content/early/2016/11/04/jgp.201611679
*  Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable,...
ATP synthase (F1Fo-ATPase), and ADP/ATP translocase. AppCCl2p is shown to inhibit the ADP/ATP translocase in the mitochondrial ... which is translocated by ANT (Watanabe et al., 1985). ATP and ADP are known to inhibit PT pore opening (Halestrap et al., 1997 ... A mixed rat bone cell population was cultured on clodronate-coated or control bovine bone slices as described previously (Boyde ... Moreover, if the translocation of bisphosphonate would occur in the protonated form, the high proton gradient across the basal ...
  http://molpharm.aspetjournals.org/content/61/5/1255
*  Frontiers | Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423 | Physiology
The immunomodulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and ... The immunomodulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and ... progress to reveal the binding of Bz-423 to the mitochondrial target and discuss how subunit rotation of FoF1-ATP synthase is ... progress to reveal the binding of Bz-423 to the mitochondrial target and discuss how subunit rotation of FoF1-ATP synthase is ...
  https://www.frontiersin.org/articles/10.3389/fphys.2018.00803/full
*  Oxidative phosphorylation - Wikipedia
As protons cross the membrane through the channel in the base of ATP synthase, the FO proton-driven motor rotates. Rotation ... "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex". Science. 281 (5373): 64-71. Bibcode:1998Sci ... Becher B, Müller V (1994). "Delta mu Na+ drives the synthesis of ATP via an delta mu Na(+)-translocating F1F0-ATP synthase in ... "The cellular biology of proton-motive force generation by V-ATPases". J. Exp. Biol. 203 (Pt 1): 89-95. PMID 10600677. ...
  https://en.wikipedia.org/wiki/Oxidative_phosphorylation
*  Hyperlipid: 2013
This reduces uncoupling because there is a much lower voltage pushing protons back in to the mitochondrial matrix. This means ... Life (03) ATP synthase (1) * Life (04) On the bench top (1) ... We can now translocate GLUT4s to the cell surface and start to ... The fluorescence rises with inner mitochondrial membrane potential, delta psi. Antimycin A blocks ATPase so hyperpolarises the ... BSA (bovine serum albumin) eliminates the uncoupling as it "hoovers-up" all available FFAs.. Does this uncoupling happen in ...
  http://high-fat-nutrition.blogspot.com.br/2013/
*  Oxidative phosphorylation
As protons cross the membrane through the channel in the base of ATP synthase this causes the FO proton-driven motor to rotate. ... Iwata S, Lee JW, Okada K, et al (1998). "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex". ... Becher B, Müller V (1994). "Delta mu Na+ drives the synthesis of ATP via a delta mu Na(+)-translocating F1F0-ATP synthase in ... "The cellular biology of proton-motive force generation by V-ATPases". J. Exp. Biol. 203 (Pt 1): 89-95. PMID 10600677.. ...
  http://www.chemeurope.com/en/encyclopedia/Oxidative_phosphorylation.html
*  M5 Receptors
With pH Together, it models the traveling push for ATP synthase, and for cytosolic Ca2+ to enter the matrix [9]. Average ... the extrusion of Ca2+ generates huge amounts of protons that are sent to mitochondrial matrix leading to pH lower [13]. AR-42 ... The crystal structure of the bovine enzyme has been determined previously (8), showing that the four redox-active centers of ... Plasma membrane layer California2+-ATPase (PMCA) by extruding California2+ outdoors the cell,. Posted by techtasys , M5 ...
  http://www.techtasys.com/category/m5-receptors/
*  Fosforylacja oksydacyjna - Wikipedia, wolna encyklopedia
a b Becher B, Müller V. Delta mu Na+ drives the synthesis of ATP via a delta mu Na(+)-translocating F1F0-ATP synthase in ... a b c d Schultz B, Chan S. Structures and proton-pumping strategies of mitochondrial respiratory enzymes. „Annu Rev Biophys ... ATP synthase complex from bovine heart mitochondria: the oligomycin sensitivity conferring protein is essential for ... Nelson N, Perzov N, Cohen A, Hagai K, Padler V, Nelson H. The cellular biology of proton-motive force generation by V-ATPases ...
  https://pl.wikipedia.org/wiki/Fosforylacja_oksydacyjna
*  Proteomic changes in a childhood acute lymphoblastic leukemia cell line during the adaptation to vincristine | Boletín Médico...
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient ... The B-lineage pediatric ALL cell line CCRF-SB (ATCC CCL-120) was grown in RPMI-1640 with 10% (v/v) fetal bovine serum, 100 U/ml ... Sarcoplasmic/ endoplasmic reticulum calcium ATPase 2 P16615 Cation transporter, ion channel Homeostatic process This magnesium- ... 40 Calcium is translocated from the cytosol to the sarcoplasmic reticulum lumen by the AT2A2 protein (assigned to the ...
  http://www.elsevier.es/es-revista-boletin-medico-del-hospital-infantil-401-articulo-proteomic-changes-in-childhood-acute-S1665114617300473
*  Adenosine triphosphate - Wikipedia
Flow of protons down this potential gradient - that is, from the intermembrane space to the matrix - yields ATP by ATP synthase ... which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite ... Å resolution of F1-ATPase from bovine heart mitochondria". Nature. 370 (6491): 621-628. doi:10.1038/370621a0. PMID 8065448. ... ATP synthase then ensues exactly as in oxidative phosphorylation. Some of the ATP produced in the chloroplasts is consumed in ...
  https://en.wikipedia.org/wiki/Adenosine_triphosphate
*  Adenosine triphosphate - Wikipedia
Flow of protons down this potential gradient - that is, from the intermembrane space to the matrix - yields ATP by ATP synthase ... Abrahams, J.; Leslie, A.; Lutter, R.; Walker, J. (1994). "Structure at 2.8 Å resolution of F1-ATPase from bovine heart ... which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite ... ATP synthase then ensues exactly as in oxidative phosphorylation.[21] Some of the ATP produced in the chloroplasts is consumed ...
  https://en.m.wikipedia.org/wiki/Adenosine_triphosphate
*  Complementation of the Fo c Subunit of Escherichia coli with That of Streptococcus mutans and Properties of the Hybrid FoF1 ATP...
In vivo evidence for the role of the epsilon subunit as an inhibitor of the proton-translocating ATPase of Escherichia coli. J ... coli ATP synthase. We could not express functional S. mutans ATP synthase from the cloned ATP operon (see Fig. S1 and S2 in the ... It is localized in bacterial plasma membranes and mitochondrial inner and chloroplast thylakoid membranes. F1 has three ... using bovine serum albumin (fraction V; Sigma) as a standard. ... ATP synthase (H+-ATPase): results by combined biochemical and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3807490/?lang=en-ca
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and activity of F0F1-ATPase. Energy status of RPTC is assessed by determining the intracellular ATP content. Mitochondrial ... MitGO-ATeam is a Förster resonance energy transfer (FRET) probe in which the ε subunit of the FoF1-ATP synthase is sandwiched ... dissipation of the proton motive force, membrane potential collapse and an increase in mitochondrial matrix volume (swelling) ... Upon binding of insulin to its receptor, vesicles containing GLUT4 translocate from the cytoplasm to the plasma membrane, ...
  https://www.jove.com/visualize/abstract/22028857/changes-cardiac-substrate-transporters-metabolic-proteins-mirror
*  Fosforilasi oksidatif - Wikipedia bahasa Indonesia, ensiklopedia bebas
"Hyperthyroidism stimulates mitochondrial proton leak and ATP turnover in rat hepatocytes but does not change the overall ... Joshi S, Huang YG (1991). "ATP synthase complex from bovine heart mitochondria: the oligomycin sensitivity conferring protein ... "Delta mu Na+ drives the synthesis of ATP via a delta mu Na(+)-translocating F1F0-ATP synthase in membrane vesicles of the ... Müller V (2004). "An exceptional variability in the motor of archaeal A1A0 ATPases: from multimeric to monomeric rotors ...
  https://id.wikipedia.org/wiki/Fosforilasi_oksidatif
*  Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential | JCB
Because the mitochondrial F1FO ATP synthase is an important control point for proton flux across the inner mitochondrial ... The structure of bovine F1-ATPase complexed with the antibiotic inhibitor aurovertin B. Proc. Natl. Acad. Sci. USA. 93:6913- ... Endogenous Bcl-xL in HeLa cells resides predominantly in the cytosol as a homodimer and translocates to mitochondria via its C- ... The mitochondrial F1FO ATP synthase synthesizes ATP in the mitochondrial matrix using cytosolic ADP and phosphate as substrates ...
  http://jcb.rupress.org/content/195/2/263.long
*  Publications | Paul Scherrer Institut (PSI)
The structure of bovine mitochondrial F1-ATPase ? an example of rotational catalysis? Leslie AGW, Abrahams JP, van Raaij M, ... ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase Hilge M, Siegal G, Vuister G, Güntert P, ... Evidence for proton shuffling in a thioredoxin-like protein during catalysis Narzi D, Siu SWI, Stirnimann CU, Grimshaw JPA, ... A Type IV Translocated Legionella Cysteine Phytase Counteracts Intracellular Growth Restriction by Phytate Weber Stephen, ...
  https://www.psi.ch/lbr/publications
*  Protocols and Video Articles Authored by Hong He (Translated to Hindi)
Further study indicated that the plasma membrane Ca(2+)-ATPase (PMCA) activity was inhibited by MDA in a concentration- and ... The activation energy for the intramolecular proton-transfer reaction of bridged thiocarbonate was calculated to be 18.52 kcal ... Taurine also significantly inhibited the formation of lipofuscin-like fluorescence induced by MDA-modified bovine serum albumin ... when translocated into the nucleus, mediates signalling by activation of transcription factors such as TCF4. Mutations of the ...
  https://www.jove.com/author/Hong_He?language=Hindi
*  Equilibrative Nucleoside Transporters
The obstructing remedy comprised of 5% regular donkey serum, 2% bovine serum albumin, and 0.5% Triton X-100 in PBS. In some ... Intracellular translocation of histatins can be inhibited by low temps (19) or pretreatment of cells with proton ionophores ... Treatment of cells with a spermidine synthase inhibitor increased spermidine uptake and Hst 5 killing whereas protonophores and ... 11). Comparison with amphipathic peptides that translocated across and disrupted liposome membranes showed that Hst 5 did PP121 ...
  http://www.ovarian-cancersymptoms.com/category/equilibrative-nucleoside-transporters/
*  Adenosine triphosphate - wikidoc
This produces a proton-motive force and this drives the ATP synthase, exactly as in oxidative phosphorylation.[20] Some of the ... Abrahams J, Leslie A, Lutter R, Walker J (1994). "Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria". ... which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite ... In neutral solution, ATP is ionized and exists mostly as ATP4−, with a small proportion of ATP3−.[8] As ATP has several ...
  http://es.wikidoc.org/index.php/Adenosine_triphosphate
*  The world's most compressed sentence - Peter Horttanainen
FoF1-ATP synthase family of proteins convert the chemical energy in ATP to the electrochemical potential energy of a proton ... 1992 - Isolation of the first reported mitochondrial DNA helicase (from bovine brain)[21] ... those that translocate in a 5′-3′ direction along single-stranded DNA and those that operate with the opposite polarity. For ... including two domains that are structurally similar to the ATPase domain of the recombination protein RecA (Story and Steitz ...
  http://peterhorttanainen.com/the-worlds-most-compressed-sentence/