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*  Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. | MRC Mitochondrial Biology Unit
Mitochondrial Proton-Translocating ATPases, Models, Molecular, Protein Conformation, Protein Folding. Abstract. Adenosine ... is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic ... We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining ... Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.. ...
  http://www.mrc-mbu.cam.ac.uk/publications/2468/structure-and-conformational-states-bovine-mitochondrial-atp-synthase-cryo-em
*  Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten...
Mitochondrial Proton-Translocating ATPases, Molecular Sequence Data, Neuronal Ceroid-Lipofuscinoses, Peptides, Protein ... Home Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with ... Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten ... Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten ...
  http://www.mrc-mbu.cam.ac.uk/publications/818/lysine-43-trimethylated-subunit-c-bovine-mitochondrial-atp-synthase-and-storage
*  Molecular Structure, Function, and Assembly of the ATP Synthases | Springer for Research & Development
ATPase, FoFrATPase) has been the subject of intensive IDvestigations in many laboratories. The major reason for this lies in ... Subunit Arrangement in Bovine Mitochondrial H+-ATPASE Saroj Joshi, Robert Burrows. Pages 163-172 ... A H+-Translocating ATP Synthase in an Extremely Halophilic Archaebacterium Yasuo Mukohata, Manabu Yoshida, Masaharu Isoyama, ... The Fo Sector and Proton Motive Coupling. * Front Matter Pages 149-149 ...
  https://rd.springer.com/book/10.1007%2F978-1-4613-0593-4
*  Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria | PNAS
The most important inference from the presence of the c8-ring in bovine F-ATP synthase, is that eight protons are translocated ... F-ATPase of Drosophila melanogaster Forms 53-Picosiemen (53-pS) Channels Responsible for Mitochondrial Ca2+-induced Ca2+ ... Almost all ATP in respiring cells is made by the membrane bound enzyme F-ATPase (F-ATP synthase). In the F-ATPase in the inner ... Fo-driven Rotation in the ATP Synthase Direction against the Force of F1 ATPase in the FoF1 ATP Synthase ...
  http://www.pnas.org/content/107/39/16823
*  Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase | PNAS
1999) Transient accumulation of elastic energy in proton translocating ATP synthase. FEBS Lett 449:1-6. ... 2001) Structure of bovine mitochondrial F1-ATPase with nucleotide bound to all three catalytic sites: Implications for the ... Our treatment started with the X-ray structure of bovine mitochondrial F1-ATPase (Protein Data Bank ID: 1H8E) (8), and then ... However, in the ATPase, the barrier is reduced to about 14 kcal/mol, and as shown in Fig. 3, the movement from ATP to ADP and ...
  http://www.pnas.org/content/108/51/20550
*  TCDB » SEARCH
H+ transport and ATP synthesis may therefore be coupled mechanically. The F1 portion of the bovine mitochondrial F-type ATPase ... The structure of the membrane integral rotor ring of the proton translocating F(1)F(0)-ATPase synthase from spinach ... synthesizing ATP when protons or Na+ flow through the 'ATP synthase' down the proton electrochemical gradient (the 'proton ... 2007). The coupling ion in the methanoarchaeal ATP synthases: H+ vs. Na+ in the A(1)A(o) ATP synthase from the archaeon ...
  http://www.tcdb.org/search/result.php?tc=3.A.2
*  ATP synthase - Wikipedia
Proton and Sodium translocating F-type, V-type and A-type ATPases in OPM database The Nobel Prize in Chemistry 1997 to Paul D. ... "Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM". eLife. 4: e10180. doi:10.7554/eLife. ... However, whereas the F-ATP synthase generates ATP by utilising a proton gradient, the V-ATPase generates a proton gradient at ... The consumption of ATP by ATP-synthase pumps proton cations into the matrix. The evolution of ATP synthase is thought to have ...
  https://en.wikipedia.org/wiki/ATP_synthase
*  ATP Synthase
"ATP synthase" down the proton electrochemical gradient (the "proton motive force" or pmf). V-type ATPases may pump 2-3 H+ per ... It is the F1 unit of ATP Synthase from bovine mitochondria. This tutorial will lead you through the structure of ATP Synthase ... "proton half-channels". The proton-translocating region of ATP synthase is formed by subunit a and c-subunit oligomer. There are ... This "tube" through ATP Synthase provides a tunnel through the membrane. The protons are pumped from the mitochondrial matrix, ...
  http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2005/Carlson/chime/YFPright.html
*  The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin. | MRC Mitochondrial Biology Unit
Proton-Translocating ATPases. Abstract. In the previously determined structure of mitochondrial F1-ATPase determined with ... 15 amino acids that inhibit both ATP synthesis and hydrolysis by binding to the F1 catalytic domain of F1F0-ATP synthase. In ... The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin.. ... The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin.. ...
  http://www.mrc-mbu.cam.ac.uk/publications/2687/structure-bovine-f1-atpase-complexed-peptide-antibiotic-efrapeptin
*  Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling | JGP
S2 shows a cryo-EM map of the subunit a-c-ring complex from the bovine mitochondrial ATP synthase. Fig. S3 shows alignment of ... The cytoplasmic loops of subunit a of Escherichia coli ATP synthase may participate in the proton translocating mechanism. J. ... The structure of bovine F1-ATPase in complex with its regulatory protein IF1. Nat. Struct. Biol. 10:744-750. doi:10.1038/nsb966 ... Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. eLife. 4:e10180. doi:10.7554/eLife. ...
  http://jgp.rupress.org/content/early/2016/11/04/jgp.201611679
*  Oxidative phosphorylation - Wikipedia
As protons cross the membrane through the channel in the base of ATP synthase, the FO proton-driven motor rotates. Rotation ... "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex". Science. 281 (5373): 64-71. Bibcode:1998Sci ... Becher B, Müller V (1994). "Delta mu Na+ drives the synthesis of ATP via an delta mu Na(+)-translocating F1F0-ATP synthase in ... "The cellular biology of proton-motive force generation by V-ATPases". J. Exp. Biol. 203 (Pt 1): 89-95. PMID 10600677. ...
  https://en.wikipedia.org/wiki/Oxidative_phosphorylation
*  Comparison of the H+/ATP ratios of the H+-ATP synthases from yeast and from chloroplast | PNAS
2000) Stoichiometry of energy coupling by proton-translocating ATPases: A history of variability. J Bioenerg Biomembr 32:493- ... 1999) Energy-dependent transformation of the catalytic activities of the mitochondrial F0 x F1-ATP synthase. FEBS Lett 448:123- ... 1994) Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. Nature 370:621-628. ... 2009) Structure of the c14 rotor ring of the proton translocating chloroplast ATP synthase. J Biol Chem 284:18228-18235. ...
  http://www.pnas.org/content/109/28/11150
*  Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable,...
ATP synthase (F1Fo-ATPase), and ADP/ATP translocase. AppCCl2p is shown to inhibit the ADP/ATP translocase in the mitochondrial ... which is translocated by ANT (Watanabe et al., 1985). ATP and ADP are known to inhibit PT pore opening (Halestrap et al., 1997 ... A mixed rat bone cell population was cultured on clodronate-coated or control bovine bone slices as described previously (Boyde ... Moreover, if the translocation of bisphosphonate would occur in the protonated form, the high proton gradient across the basal ...
  http://molpharm.aspetjournals.org/content/61/5/1255
*  Elastic coupling power stroke mechanism of the F1-ATPase molecular motor | PNAS
2009) The structure of the membrane extrinsic region of bovine ATP synthase. Proc Natl Acad Sci USA 106:21597-21601. ... Since each c-subunit in the c-ring translocates one proton across the membrane, the organism-dependent variation of the c8-16- ... 2000) Structure of bovine mitochondrial F1-ATPase inhibited by Mg2+ ADP and aluminium fluoride. Structure 8:567-573. ... 2015) Fo-driven rotation in the ATP synthase direction against the force of F1 ATPase in the FoF1 ATP synthase. J Biol Chem 290 ...
  https://www.pnas.org/content/115/22/5750
*  Hyperlipid: Protons (29) Uncoupling with fatty acids
The fluorescence rises with inner mitochondrial membrane potential, delta psi. Antimycin A blocks ATPase so hyperpolarises the ... Life (03) ATP synthase (1) * Life (04) On the bench top (1) ... BSA (bovine serum albumin) eliminates the uncoupling as it " ... Charge is translocated only in step 3 when the LCFA anion returns without the H+.. All nice and simple, compared to how complex ... Protons (30) Uncoupling and metabolic rate in insulin resistance (1) * Protons (31) insulin induced theromgenesis in the Pima ( ...
  http://high-fat-nutrition.blogspot.com/2013/11/protons-29-uncoupling-with-fatty-acids.html
*  Oxidative phosphorylation
As protons cross the membrane through the channel in the base of ATP synthase this causes the FO proton-driven motor to rotate. ... Iwata S, Lee JW, Okada K, et al (1998). "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex". ... Becher B, Müller V (1994). "Delta mu Na+ drives the synthesis of ATP via a delta mu Na(+)-translocating F1F0-ATP synthase in ... "The cellular biology of proton-motive force generation by V-ATPases". J. Exp. Biol. 203 (Pt 1): 89-95. PMID 10600677.. ...
  http://www.chemeurope.com/en/encyclopedia/Oxidative_phosphorylation.html
*  Alteration of renal respiratory Complex-III during experimental type-1 diabetes | BMC Endocrine Disorders | Full Text
In addition, the renal F0F1-ATPase activity and ATP levels were increased during diabetes. In summary, these findings show for ... Mitochondrial complex activity assays, blue native gel electrophoresis (BN-PAGE), Complex III immunoprecipitation, and an ATP ... mitochondrial damage, and organ injury. Thus, one goal of this study was to determine the status of mitochondrial respiratory ... Inactivation of mitochondrial respiratory complexes or alteration of their critical subunits can lead to generation of ...
  https://bmcendocrdisord.biomedcentral.com/articles/10.1186/1472-6823-9-2
*  Frontiers | Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423 | Physiology
The immunomodulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and ... The immunomodulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and ... progress to reveal the binding of Bz-423 to the mitochondrial target and discuss how subunit rotation of FoF1-ATP synthase is ... progress to reveal the binding of Bz-423 to the mitochondrial target and discuss how subunit rotation of FoF1-ATP synthase is ...
  https://www.frontiersin.org/articles/10.3389/fphys.2018.00803/full
*  Adenosine triphosphate - Wikipedia
Flow of protons down this potential gradient - that is, from the intermembrane space to the matrix - yields ATP by ATP synthase ... which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite ... Å resolution of F1-ATPase from bovine heart mitochondria". Nature. 370 (6491): 621-628. doi:10.1038/370621a0. PMID 8065448. ... ATP synthase then ensues exactly as in oxidative phosphorylation. Some of the ATP produced in the chloroplasts is consumed in ...
  https://en.wikipedia.org/wiki/Adenosine_triphosphate
*  Hyperlipid: 2013
This reduces uncoupling because there is a much lower voltage pushing protons back in to the mitochondrial matrix. This means ... Life (03) ATP synthase (1) * Life (04) On the bench top (1) ... We can now translocate GLUT4s to the cell surface and start to ... The fluorescence rises with inner mitochondrial membrane potential, delta psi. Antimycin A blocks ATPase so hyperpolarises the ... BSA (bovine serum albumin) eliminates the uncoupling as it "hoovers-up" all available FFAs.. Does this uncoupling happen in ...
  http://high-fat-nutrition.blogspot.com.br/2013/
*  M5 Receptors
With pH Together, it models the traveling push for ATP synthase, and for cytosolic Ca2+ to enter the matrix [9]. Average ... the extrusion of Ca2+ generates huge amounts of protons that are sent to mitochondrial matrix leading to pH lower [13]. AR-42 ... The crystal structure of the bovine enzyme has been determined previously (8), showing that the four redox-active centers of ... Plasma membrane layer California2+-ATPase (PMCA) by extruding California2+ outdoors the cell,. Posted by techtasys , M5 ...
  http://www.techtasys.com/category/m5-receptors/
*  Proteomic changes in a childhood acute lymphoblastic leukemia cell line during the adaptation to vincristine | Boletín Médico...
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient ... The B-lineage pediatric ALL cell line CCRF-SB (ATCC CCL-120) was grown in RPMI-1640 with 10% (v/v) fetal bovine serum, 100 U/ml ... Sarcoplasmic/ endoplasmic reticulum calcium ATPase 2 P16615 Cation transporter, ion channel Homeostatic process This magnesium- ... 40 Calcium is translocated from the cytosol to the sarcoplasmic reticulum lumen by the AT2A2 protein (assigned to the ...
  http://www.elsevier.es/es-revista-boletin-medico-del-hospital-infantil-401-articulo-proteomic-changes-in-childhood-acute-S1665114617300473
*  Frontiers | Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies | Endocrinology
ATP synthase), which condenses ADP + Pi to form ATP while pumping protons back into the matrix. Matrix ATP is then exchanged ... The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes. Mol Cell Biol (2010) ... Molecular cloning and nucleotide sequence of DNA of mitochondrial cytochrome P-450(11 beta) of bovine adrenal cortex. J Biochem ... repeatedly shown that the oxidative phosphorylation complexes associate in supercomplexes of the three proton-translocating ...
  https://www.frontiersin.org/articles/10.3389/fendo.2016.00106/full
*  Fosforylacja oksydacyjna - Wikipedia, wolna encyklopedia
a b Becher B, Müller V. Delta mu Na+ drives the synthesis of ATP via a delta mu Na(+)-translocating F1F0-ATP synthase in ... a b c d Schultz B, Chan S. Structures and proton-pumping strategies of mitochondrial respiratory enzymes. „Annu Rev Biophys ... ATP synthase complex from bovine heart mitochondria: the oligomycin sensitivity conferring protein is essential for ... Nelson N, Perzov N, Cohen A, Hagai K, Padler V, Nelson H. The cellular biology of proton-motive force generation by V-ATPases ...
  https://pl.wikipedia.org/wiki/Fosforylacja_oksydacyjna
*  Adenosine triphosphate - Wikipedia
Flow of protons down this potential gradient - that is, from the intermembrane space to the matrix - yields ATP by ATP synthase ... Abrahams, J.; Leslie, A.; Lutter, R.; Walker, J. (1994). "Structure at 2.8 Å resolution of F1-ATPase from bovine heart ... which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite ... ATP synthase then ensues exactly as in oxidative phosphorylation.[21] Some of the ATP produced in the chloroplasts is consumed ...
  https://en.m.wikipedia.org/wiki/Adenosine_triphosphate