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*  RGL3 (ral guanine nucleotide dissociation stimulator like 3)
... ral guanine nucleotide dissociation stimulator like 3), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... intracellular small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding ... intracellular small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding ...
  http://atlasgeneticsoncology.org/Genes/GC_RGL3.html
*  Pressure-induced local unfolding of the Ras binding domain of RalGDS - Publikationsserver der Universität Regensburg
ral Guanine Nucleotide Exchange Factor/metabolism. MESH. ras Proteins/metabolism. MESH. Dewey-Dezimal-Klassifikation:. 500 ... 1H 2D NMR spectroscopy a unique equilibrium unfolding intermediate I in the Ras binding domain of the Ral guanine nucleotide ... Pressure-induced local unfolding of the Ras binding domain of RalGDS. Nature structural biology 7 (7), S. 547-550. ... dissociation stimulator (Ral GDS). It is characterized by a local melting of specific structural elements near hydrophobic ...
  https://epub.uni-regensburg.de/16571/
*  Ras Oncoproteins Transfer from Melanoma Cells to T Cells and Modulate Their Effector Functions | The Journal of Immunology
In T cells, a set of adaptors link TCR signaling to the two guanine nucleotide exchange factors RasGRP1 and Sos1 (26), which ... The CD3+ T cell-enriched PBMCs were activated by plate-bound OKT3 mAbs (2 μg/ml) and soluble anti-CD28 mAbs (1 μg/ml; BD ... Ral, and Arf). It is thus reasonable to assume that, likewise, lymphocytes acquire many proteins in vivo from cancer cells ... which controls the activation of the guanine nucleotide exchange factor, RasGRP1. The authors also show that inhibition of ...
  http://www.jimmunol.org/content/189/9/4361.full
*  Vesicle tethering complexes in membrane traffic | Journal of Cell Science
... possess guanine-nucleotide-exchange factor (GEF) activity towards Rabs. Yeast contains 11 Rab proteins, whereas humans have at ... This binding appears to be independent of other factors, since it occurs even when the COPII vesicles are formed from purified ... Moskalenko, S., Henry, D. O., Rosse, C., Mirey, G., Camonis, J. H. and White, M. A. ( 2002). The exocyst is a Ral effector ... Wang, W., Sacher, M. and Ferro-Novick, S. ( 2000). TRAPP stimulates guanine nucleotide exchange on Ypt1p. J. Cell Biol. 151, ...
  http://jcs.biologists.org/content/115/13/2627.full
*  Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity | BMC Evolutionary Biology |...
We furthermore demonstrate that these three Rap1 isoforms exhibit distinct affinities for the Ras-binding domain of RalGDS. ... indicating that their conformations resemble that of active GTP-bound Rap1. ... Indeed, all retrogene-encoded GTPases have an increased GTP/GDP binding ratio in vivo, ... These receptors regulate the activity of guanine nucleotide exchange factors (GEFs), resulting in GTP-binding of Rap1, or ...
  https://0-bmcevolbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2148-10-55
*  SMART: RasGEF domain annotation
Crystal structure of the CDC25 Domain from Ral-specific Guanine-nucleotide Exchange Factor RalGPS1a. ... Binding / catalysis: protein-binding, Ras-binding, guanine nucleotide exchange activity towards Ras ... It has been suggested that a key event in growth factor-induced p21Ras activation by the guanine nucleotide exchange factor Sos ... The latter proteins are known as guanine-nucleotide exchange (or releasing) factors (GEFs or GRFs) (or also as guanine- ...
  http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=RasGEF&BLAST=DUMMY
*  Cancers | Free Full-Text | Genetic Interactions of STAT3 and Anticancer Drug Development | HTML
... epidermal growth factor receptor, and reduction-oxidation pathways; and molecular mechanisms that modulate therapeutic ... Binding of Ras with GTP is facilitated by guanine nucleotide exchange factors (GEFs) via catalysis of the release of GDP and is ... Goi, T.; Shipitsin, M.; Lu, Z.; Foster, D.A.; Klinz, S.G.; Feig, L.A. An EGF receptor/Ral-GTPase signaling cascade regulates c- ... Rossman, K.L.; Der, C.J.; Sondek, J. GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. ...
  http://mdpi.com/2072-6694/6/1/494/htm
*  The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity | JCB
Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases. J ... and active Rap was precipitated with a GST fusion protein of the Ras-binding domain of Ral guanine nucleotide dissociation ... guanine nucleotide exchange factor. NPC. nuclear pore complex. OA. okadaic acid. RA. Ras association. REM. Ras exchange motif. ... This activation cycle is regulated by guanine nucleotide exchange factors (GEFs), which induce dissociation of the bound ...
  http://jcb.rupress.org/content/193/6/1009
*  Growth factors can activate ATF2 via a two‐step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of...
Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway. Mol Cell Biol, 20, 8480-8488. ... bound Ral. Beads were washed extensively, and collected Ral was detected by immunoblotting with HA antibody. (B) Insulin‐ and ... mutant of the Ral exchange factor Rlf (Wolthuis et al., 1997). In line with the role of Ral in growth factor‐induced activation ... Wolthuis RM and Bos JL (1999) Ras caught in another affair: the exchange factors for Ral. Curr Opin Genet Dev, 9, 112-117. ...
  http://emboj.embopress.org/content/21/14/3782
*  RAB5 ELISA & Assay Kits
RAB Interacting Factor ELISA Kits * RAB Guanine Nucleotide Exchange Factor (GEF) 1 ELISA Kits ... Ral GEF with PH Domain and SH3 Binding Motif 1 ELISA Kits ... Ral GEF with PH Domain and SH3 Binding Motif 2 ELISA Kits ... small GTP-binding protein rab5 , GTP-binding protein (rab5) ... Rabaptin, RAB GTPase Binding Effector Protein 2 ELISA Kits * ...
  https://www.antikoerper-online.de/smooth-muscle-cell-migration-pathway-102/rab5-elisa-kit-10753/
*  KRAS - Wikipedia
KRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class (such as SOS1), which forces the release of ... Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a ... Kiyono M, Kato J, Kataoka T, Kaziro Y, Satoh T (September 2000). "Stimulation of Ras guanine nucleotide exchange activity of ... bound nucleotide (GDP). Subsequently, KRAS binds GTP present in the cytosol and the GEF is released from ras-GTP. Other members ...
  https://en.wikipedia.org/wiki/KRAS
*  Reactome | NRAS [plasma membrane]
Guanine nucleotide exchange on RAL (Homo sapiens) * Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens) * p21 RAS:GTP [ ... RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens) * p21 RAS:GDP [plasma membrane] (Homo sapiens) * RAS [ ... Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens) * IGF1R signaling cascade (Homo sapiens) * IRS ... RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens) * p21 RAS:GDP [plasma membrane] (Homo ...
  https://reactome.org/content/detail/R-HSA-62725
*  C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH? | Journal of Cell Science
... regulate actin assembly by serving as guanine nucleotide exchange factors (GEFs) for CDC42 (Hussain et al., 2001) and binding ... Yamaguchi, A., Urano, T., Goi, T. and Feig, L. A. (1997). An Eps homology (EH) domain protein that binds to the Ral-GTPase ... guanine nucleotide exchange factors for Rho, proline-rich regions and ubiquitin interaction motifs (reviewed in Polo et al., ... Nucleotide-binding. All mammalian C-terminal EHD proteins contain a putative P-loop motif, an ATP/GTP-binding site found in Ras ...
  http://jcs.biologists.org/content/118/18/4093
*  Gentaur Molecular :Arbor \ Dissociation Reagent, 5ML \ X017-5ML
RALGDS KIAA1308 RGF] Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) ... CDC42] Cell division control protein 42 homolog (G25K GTP-binding protein). [Gdi1 Rabgdia] Rab GDP dissociation inhibitor alpha ... Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein). [Gdi2 Gdi3] Rab GDP dissociation ... TGFB1 TGFB] Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]. Bibliography :. No ...
  http://www.antibody-antibodies.com/product_det.php?id=1473265&supplier=search&name=Dissociation%20Reagent,%205ML
*  List of MeSH codes (D08) - Wikipedia
... ral gtp-binding proteins MeSH D08.811.277.040.330.300.400.462 --- ran gtp-binding protein MeSH D08.811.277.040.330.300.400.475 ... factor ixa MeSH D08.811.277.656.300.760.315 --- factor xa MeSH D08.811.277.656.300.760.320 --- factor xia MeSH D08.811.277.656. ... cyclic-nucleotide phosphodiesterase MeSH D08.811.277.352.640.160 --- 2',3'-cyclic-nucleotide phosphodiesterases MeSH D08.811. ... exchanging atpase MeSH D08.811.277.040.050 --- apyrase MeSH D08.811.277.040.330 --- gtp phosphohydrolases MeSH D08.811.277.040. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Ras- and Mitogen-activated Protein Kinase Kinase-dependent and -independent Pathways in p21Cip1/Waf1 Induction by Fibroblast...
... including guanine-nucleotide exchange factors Rho, its homologue Rac1, and Ral, have been characterized in Ras-mediated ... Ras protein is an important mediator of growth factor signals (reviewed in Ref. 1 ). Its activation to GTP-bound form is ... platelet-derived growth factor; FGF, fibroblast growth factor; NGF, nerve growth factor; TGF-ß, transforming growth factor-ß; ... We show here that fibroblast growth factor-2 (FGF-2), platelet-derived growth factor (PDGF), and transforming growth factor-ß1 ...
  http://cgd.aacrjournals.org/cgi/content/full/10/9/621
*  A Morphogenesis Checkpoint Monitors the Actin Cytoskeleton in Yeast | JCB
... catalyzed by the guanine nucleotide exchange factor Cdc24p (Fig. 1) (Pringle et al., 1995). In a manner that is poorly ... The drug Lat-A binds to monomeric actin and prevents actin polymerization (Ayscough et al., 1997). Drubin and co-workers have ... RAL Sia, * HA Herald, * DJ Lew. (1996) Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol ... 4 A and Ayscough et al., 1997). We synchronized wild-type and swe1Δ cells in G1 using α-factor and then washed out the α-factor ...
  http://jcb.rupress.org/content/142/6/1487
*  NewEast Biosciences
Ligand-bound GPCRs, in turn, function as guanine nucleotide exchange factors catalyzing the exchange of GDP bound on the Gα ... Ral RalB Ras RheB RhoA Sar1 NFE2L2 His-tag Vimentin Purified Proteins. ... Briefly, the anti-active Gαo monoclonal antibody will specifically bind to active Gαo protein. This antibody/Gαo complex will ... NewEast Biosciences Gαo Activation Assay Kit is based on the monoclonal antibody specifically recognizing the active GTP-bound ...
  http://www.neweastbio.com/GqAssay.do
*  AUREMOL-RFAC-3D, combination of R-factors and their use for automated quality assessment of protein solution structures -...
... from Staphylococcus carnosus and on the Ras-binding domain (RBD) of the Ral guanine-nucleotide dissociation stimulation factor ... ral Guanine Nucleotide Exchange Factor/chemistry. MESH. Dewey-Dezimal-Klassifikation:. 500 Naturwissenschaften und Mathematik ... In addition, we present a novel direct R-factors based measure that correlates an R-factors as defined in this paper to the ... To enhance the reliability of the calculated R-factors the method is also generalized to calculate combined R-factors from a ...
  https://epub.uni-regensburg.de/16533/
*  Gα<sub>z</sub>...
Ligand-bound GPCRs, in turn, function as guanine nucleotide exchange factors catalyzing the exchange of GDP bound on the Ga ... Ral RalB Ras RheB RhoA Sar1 NFE2L2 His-tag Vimentin Purified Proteins. ... Briefly, the anti-active Gαz monoclonal antibody will specifically bind to active Gαz protein. This antibody/Gαz complex will ... NewEast Biosciences Gαz Activation Assay Kit is based on the monoclonal antibody specifically recognizing the active GTP-bound ...
  http://www.neweastbio.com/GzAssay.do
*  humchr07.txt
HUMAN 609527 Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) ( ... Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) ( ... HUMAN 179550 Ras-related protein Ral-A precursor [RAL] RAMP3 7p12-p13 O60896 RAMP3_HUMAN 605155 Receptor activity-modifying ... Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) [ARHGEF5L] ARHGEF5 7q21-q22 ...
  https://www.uniprot.org/docs/humchr07
*  NewEast Biosciences
Ligand-bound GPCRs, in turn, function as guanine nucleotide exchange factors catalyzing the exchange of GDP bound on the Gα ... Ral RalB Ras RheB RhoA Sar1 NFE2L2 His-tag Vimentin Purified Proteins. ... The bound active Gα13 will then be pulled down by protein A/G agarose. The precipitated active Gα13 will be detected by ... 1. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal ...
  http://www.neweastbio.com/G13Assay.do
*  NewEast Biosciences
Ligand-bound GPCRs, in turn, function as guanine nucleotide exchange factors catalyzing the exchange of GDP bound on the Gα ... Ral RalB Ras RheB RhoA Sar1 NFE2L2 His-tag Vimentin Purified Proteins. ... The bound active Gαs will then be pulled down by protein A/G agarose. The precipitated active Gαs will be detected by ... NewEast Biosciences Gαs Activation Assay Kit is based on the monoclonal antibody specifically recognizing the active GTP-bound ...
  http://www.neweastbio.com/GsAssay.do
*  anti-Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) Antibodies</span>
anti-RalA Binding Protein 1 Antibodies * anti-Ral Guanine Nucleotide Dissociation Stimulator-Like 3 Antibodies ... Rap guanine nucleotide exchange factor (GEF) 4 , rap guanine nucleotide exchange factor 4 , rap guanine nucleotide exchange ... RAP guanine-nucleotide-exchange factor (GEF) 4 , cAMP-regulated guanine nucleotide exchange factor II , exchange factor ... anti-Rap Guanine Nucleotide Exchange Factor (GEF) 6 Antibodies * anti-Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 ...
  http://www.antibodies-online.com/hormone-transport-pathway-38/rapgef4-antibody-27748/
*  Regulation of Rap2 in B lymphocytes - UBC Library Open Collections
RasGRP is a guanine-nucleotide exchange factor (GNEF) that activates Ras by triggering the displacement of GDP from Ras in ... Rapl cannot bind to all of the subset of Ras effectors. In addition, Rapl has its own subset of effectors that includes Ral-GEF ... A Rap guanine Nucleotide Exchange Factor Enriched Highly in the Basal Ganglia. Proceedings from the National Academy of ... PDZGEF1, a Guanine Nucleotide Exchange Factor Specific for Rapl and Rap2. Journal of Biological Chemistry. 274:38125-38130. de ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/831/items/1.0090517