*  RGL3 (ral guanine nucleotide dissociation stimulator like 3)
... ral guanine nucleotide dissociation stimulator like 3), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... intracellular small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding ... intracellular small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding ...
  http://atlasgeneticsoncology.org/Genes/GC_RGL3.html
*  Pressure-induced local unfolding of the Ras binding domain of RalGDS - Publikationsserver der Universität Regensburg
ral Guanine Nucleotide Exchange Factor/metabolism. MESH. ras Proteins/metabolism. MESH. Dewey-Dezimal-Klassifikation:. 500 ... 1H 2D NMR spectroscopy a unique equilibrium unfolding intermediate I in the Ras binding domain of the Ral guanine nucleotide ... Pressure-induced local unfolding of the Ras binding domain of RalGDS. Nature structural biology 7 (7), S. 547-550. ... dissociation stimulator (Ral GDS). It is characterized by a local melting of specific structural elements near hydrophobic ...
  https://epub.uni-regensburg.de/16571/
*  Plus it
... binds to Ral guanine nucleotide exchange factors (RalGEFs) that activate RalGTPase. RalBP1, one of the Ral GTP-binding proteins ... C, COOH terminus; N, NH2 terminus; NBD1 and NBD2, nucleotide-binding domains 1 and 2 of CFTR; PDZ1 and PDZ2, PDZ domain 1 and 2 ... 1). Direct binding studies have demonstrated that the COOH terminus of CFTR binds to PDZ domain 1 of NHERF1 and NHERF2 with ... Ezrin binding changes the confirmation of NHERF1, resulting in the activation of PDZ domain 2 for binding to the COOH termini ...
  http://ajprenal.physiology.org/content/291/6/F1113
*  RASSF9 - Wikipedia
"Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf". Biochemistry. 37 ... Hofer F, Fields S, Schneider C, Martin GS (November 1994). "Activated Ras interacts with the Ral guanine nucleotide ... not all RA domains bind RasGTP it is a primary Ras-binding site. PAM Peptidyl-glycine alpha-amidating monooxygenase precursor ( ... Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S (December 1998). "Solution structure of the Ras-binding domain of ...
  https://en.wikipedia.org/wiki/RASSF9
*  SMART: RA domain annotation
STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 ... RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES. 3ddc. Crystal Structure of NORE1A in Complex ... A GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR OF RAL PROTEIN. 1rax. RA-DOMAIN OF RAL GUANOSINE-NUCLEOTIDE DISSOCIATION ... that has been previously shown to regulate guanine nucleotide exchange on another member of the Ras protein family, Ral. The ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=RA&BLAST=DUMMY
*  RALA - Ras-related protein Ral-A precursor - Homo sapiens (Human) - RALA gene & protein
Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the ... "Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.". ... Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange ... GTP-binding, Nucleotide-binding. Enzyme and pathway databases. Reactome - a knowledgebase of biological pathways and processes ...
  http://www.uniprot.org/uniprot/P11233
*  PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.
... and Ral guanine nucleotide exchange factors (Ral-GEFs). Previous work has demonstrated that epidermal growth factor (EGF) ... Ras proteins transduce extracellular signals to intracellular signaling pathways by binding to and promoting the activation of ... PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.. Domenii publicaţii > Biologie + ... activates Ral-GEFs, at least in part, by a Ras-mediated redistribution of the GEFs to their target, Ral-GTPases, in the plasma ...
  http://ad-astra.ro/2002/04/06/pdk1-mediates-growth-factor-induced-ral-gef-activation-by-a-kinase-independent-mechanism/
*  Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic...
Ras with the putative effector molecules Raf kinase and Ralguanine nucleotide exchange factor. J Biol Chem, 271, 6794-6800. ... The affinities of binding of anti‐RAS scFvs to antigen were measured by binding kinetics in the BIAcore (Figure 6). The Kds of ... RAS is a membrane‐bound GTP/GDP‐binding G protein that serves as a molecular switch, converting signal transduction from the ... bound to immunotubes. Anti‐RAS‐bound phage were rescued and amplified in Escherichia coli TG1. The scFv DNA fragments were ...
  http://emboj.embopress.org/content/22/5/1025
*  KEGG PATHWAY: Ras signaling pathway - Homo sapiens (human)
The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins ( ... Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound ... and Ral guanine nucleotide-dissociation stimulator (RALGDS).. Reference pathway. Reference pathway (KO). -----, Set ...
  http://www.genome.jp/kegg-bin/show_pathway?hsa04014+5594+5869
*  RALA - Wikipedia
... a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral". The Journal of Biological Chemistry. 275 ( ... "Identification and characterization of a calmodulin-binding domain in Ral-A, a Ras-related GTP-binding protein purified from ... "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Molecular and ... "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Molecular and ...
  https://en.wikipedia.org/wiki/RALA
*  List of MeSH codes (D12.644) - Wikipedia
... ral guanine nucleotide exchange factor MeSH D12.644.360.325.300.700 --- ras guanine nucleotide exchange factors MeSH D12.644. ... rab5 gtp-binding proteins MeSH D12.644.360.525.450 --- ral gtp-binding proteins MeSH D12.644.360.525.462 --- ran gtp-binding ... guanine nucleotide dissociation inhibitors MeSH D12.644.360.325.300 --- guanine nucleotide exchange factors MeSH D12.644. ... 360.325.300.200 --- eukaryotic initiation factor-2b MeSH D12.644.360.325.300.300 --- guanine nucleotide-releasing factor 2 MeSH ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
*  RRAS - Wikipedia
Tian X, Feig LA (2001). "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors ... Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a ... Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and ... Spaargaren M, Bischoff JR (1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative ...
  https://en.wikipedia.org/wiki/RRAS
*  The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis...
Recently, expression and post-translational modification of Ras guanine nucleotide releasing factor 1 (RasGRF1) was found to ... which catalyze the exchange of GDP on inactive GTPase for GTP. The binding of GTP to Ras superfamily GTPases leads to a ... phosphoinositide 3-kinase and Ral GTPases [9, 11]. The related but distinct family of Rho GTPases (including Rac, Cdc42 and Rho ... The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar2785
*  The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc42 | The Journal of Immunology
p130Cas regulates the activity of AND-34, a novel Ral, Rap1 and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275: ... AND-34 binds by its GDP exchange factor domain to the C terminus of HEF1, a region of HEF1 previously implicated in apoptotic, ... In a study in which GTPase-bound 32P-labeled guanine nucleotides were assessed in transfected Cos cells, AND-34 had GDP ... GDP exchange factor; BCR, B cell receptor; SDF, stromal cell-derived factor; HEK, human embryonic kidney; MSCV, murine stem ...
  http://www.jimmunol.org/content/170/2/969?ijkey=5e163188919689daab370c4d49dd15de6a53e605&keytype2=tf_ipsecsha
*  Small GTPase - Wikipedia
... while GTP exchange is catalyzed by guanine nucleotide exchange factors (GEFs). Activation of a GEF typically activates its ... A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The ... Ral, Rit, Rap, Rheb, and Rad. Miro is a recent contributor to the superfamily. Each subfamily shares the common core G domain, ... which provides essential GTPase and nucleotide exchange activity. The surrounding sequence helps determine the functional ...
  https://en.wikipedia.org/wiki/Small_GTPase
*  nCounter® PanCancer Pathways Panel
The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins ( ... Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound ... and Ral guanine nucleotide-dissociation stimulator (RALGDS). ... The binding of growth factors to their receptor tyrosine kinase ... T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling ...
  http://genomax.com.my/index.php/featured-products/130-ncounter-pancancer-pathways-panel
*  List of MeSH codes (D12.776.476) - Wikipedia
... ral guanine nucleotide exchange factor MeSH D12.776.476.325.300.700 -- ras guanine nucleotide exchange factors MeSH D12.776. ... adp-ribosylation factor 1 MeSH D12.776.476.525.400.025 -- rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp- ... eukaryotic initiation factor-2b MeSH D12.776.476.325.300.300 -- guanine nucleotide-releasing factor 2 MeSH D12.776.476.325. ... binding protein MeSH D12.776.476.525.400.100 -- rab3 gtp-binding proteins MeSH D12.776.476.525.400.100.100 -- rab3a gtp-binding ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)
*  human Rgl3 protein Summary Report | CureHunter
... a potential binding partner for Rap-family small G-proteins and profilin II; amino acid sequence in first source ... GTP-Binding Protein Regulators*Guanine Nucleotide Exchange Factors: 309*ral Guanine Nucleotide Exchange Factor: 31*human Rgl3 ... GTP-Binding Protein Regulators*Guanine Nucleotide Exchange Factors: 309*ral Guanine Nucleotide Exchange Factor: 31*human Rgl3 ... GTP-Binding Protein Regulators*Guanine Nucleotide Exchange Factors: 309*ral Guanine Nucleotide Exchange Factor: 31*human Rgl3 ...
  http://www.curehunter.com/public/keywordSummaryC521670-human-Rgl3-protein.do
*  RAS Pathway v2.0 - National Cancer Institute
Ral guanine nucleotide dissociation stimulator RGDS, RGF, RalGEF. RAPGEF1. Rap guanine nucleotide exchange factor (GEF) 1. C3G ... ral guanine nucleotide dissociation stimulator-like 3. [none]. RHEB. Ras Homolog Enriched In Brain, GTP-binding protein Rheb. ... ral guanine nucleotide dissociation stimulator-like 1. RGL. RGL2. ral guanine nucleotide dissociation stimulator-like 2. HKE1.5 ... Rap guanine nucleotide exchange factor (GEF) 2. CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP. ...
  https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2
*  G-protein signaling - Regulation of CDC42 activity Pathway Map - PrimePCR | Life Science | Bio-Rad
The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. The Journal of ... Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. The Journal of ... The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. The Journal of ... Guanine nucleotide exchange factors (GEFs) are essential for CDC42 activation. They promote the exchange of GDP for GTP to ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/g-protein-signaling-regulation-cdc42-activity
*  RAPGEF2 - Wikipedia
... and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting ... Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a ... Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. RAPGEF2 is a cyclic AMP ... "Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2". Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin ...
  https://en.wikipedia.org/wiki/RAPGEF2
*  EXOC2 - Wikipedia
... a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion ... 2003). "Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site". J. Biol. Chem. 278 (19): 17053 ... 2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743-8. doi:10.1074 ... 2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73-8. doi: ...
  https://en.wikipedia.org/wiki/EXOC2
*  RASD1 protein (Latimeria chalumnae) - STRING interaction network
Rap guanine nucleotide exchange factor (GEF) 1. 0.632. LRRK1. RASD1. ENSLACP00000020408. ENSLACP00000002754. Leucine-rich ... Ral GEF with PH domain and SH3 binding motif 1 (229 aa) ... this does not necessarily mean they are physically binding each ... Rap guanine nucleotide exchange factor (GEF) 1. 0.647. LRRK2. RASD1. ENSLACP00000013544. ENSLACP00000002754. Leucine-rich ...
  https://string-db.org/network/7897.ENSLACP00000002754
*  Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control of plant growth and development...
"Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control of plant growth and development ... nine nucleotide dissociation inhibitor; GEP-guanine nucleotide. exchange protein; GFP-green fluorescent protein; Ins(1,4,5) ... RalBP1-Ral-binding protein 1; RalGDS-Ral GDP dissocia-. tion stimulator; RIC protein-Rop-interacting CRIB motif-con- ... Actin-Depolymerizing Factor Mediates Rac/Rop GTPase-Regulated Pollen Tube Growth. Chen, C.Y.H.; Cheung, A.Y.; Wu, H.M. ...
  https://www.deepdyve.com/lp/springer_journal/superfamily-of-monomeric-gtp-binding-proteins-in-plants-1-role-of-rop-bJUCGEA0QQ