*  RGL3 (ral guanine nucleotide dissociation stimulator like 3)
... ral guanine nucleotide dissociation stimulator like 3), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... intracellular small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding ... intracellular small GTPase mediated signal transduction Ral guanyl-nucleotide exchange factor activity Ras GTPase binding ...
  http://atlasgeneticsoncology.org/Genes/GC_RGL3.html
*  Plus it
... binds to Ral guanine nucleotide exchange factors (RalGEFs) that activate RalGTPase. RalBP1, one of the Ral GTP-binding proteins ... C, COOH terminus; N, NH2 terminus; NBD1 and NBD2, nucleotide-binding domains 1 and 2 of CFTR; PDZ1 and PDZ2, PDZ domain 1 and 2 ... 1). Direct binding studies have demonstrated that the COOH terminus of CFTR binds to PDZ domain 1 of NHERF1 and NHERF2 with ... Ezrin binding changes the confirmation of NHERF1, resulting in the activation of PDZ domain 2 for binding to the COOH termini ...
  http://ajprenal.physiology.org/content/291/6/F1113
*  RASSF9 - Wikipedia
"Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf". Biochemistry. 37 ... Hofer F, Fields S, Schneider C, Martin GS (November 1994). "Activated Ras interacts with the Ral guanine nucleotide ... not all RA domains bind RasGTP it is a primary Ras-binding site. PAM Peptidyl-glycine alpha-amidating monooxygenase precursor ( ... Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S (December 1998). "Solution structure of the Ras-binding domain of ...
  https://en.wikipedia.org/wiki/RASSF9
*  SMART: RA domain annotation
STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 ... RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES. 3ddc. Crystal Structure of NORE1A in Complex ... A GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR OF RAL PROTEIN. 1rax. RA-DOMAIN OF RAL GUANOSINE-NUCLEOTIDE DISSOCIATION ... that has been previously shown to regulate guanine nucleotide exchange on another member of the Ras protein family, Ral. The ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=RA&BLAST=DUMMY
*  Pressure-induced local unfolding of the Ras binding domain of RalGDS - Publikationsserver der Universität Regensburg
ral Guanine Nucleotide Exchange Factor/metabolism. MESH. ras Proteins/metabolism. MESH. Dewey-Dezimal-Klassifikation:. 500 ... 1H 2D NMR spectroscopy a unique equilibrium unfolding intermediate I in the Ras binding domain of the Ral guanine nucleotide ... Pressure-induced local unfolding of the Ras binding domain of RalGDS. Nature structural biology 7 (7), S. 547-550. ... dissociation stimulator (Ral GDS). It is characterized by a local melting of specific structural elements near hydrophobic ...
  https://epub.uni-regensburg.de/16571/
*  PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.
... and Ral guanine nucleotide exchange factors (Ral-GEFs). Previous work has demonstrated that epidermal growth factor (EGF) ... Ras proteins transduce extracellular signals to intracellular signaling pathways by binding to and promoting the activation of ... PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.. Domenii publicaţii > Biologie + ... activates Ral-GEFs, at least in part, by a Ras-mediated redistribution of the GEFs to their target, Ral-GTPases, in the plasma ...
  http://ad-astra.ro/2002/04/06/pdk1-mediates-growth-factor-induced-ral-gef-activation-by-a-kinase-independent-mechanism/
*  Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic...
Ras with the putative effector molecules Raf kinase and Ralguanine nucleotide exchange factor. J Biol Chem, 271, 6794-6800. ... The affinities of binding of anti‐RAS scFvs to antigen were measured by binding kinetics in the BIAcore (Figure 6). The Kds of ... RAS is a membrane‐bound GTP/GDP‐binding G protein that serves as a molecular switch, converting signal transduction from the ... bound to immunotubes. Anti‐RAS‐bound phage were rescued and amplified in Escherichia coli TG1. The scFv DNA fragments were ...
  http://emboj.embopress.org/content/22/5/1025
*  KEGG PATHWAY: Ras signaling pathway - Homo sapiens (human)
The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins ( ... Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound ... and Ral guanine nucleotide-dissociation stimulator (RALGDS).. Reference pathway. Reference pathway (KO). -----, Set ...
  http://www.genome.jp/kegg-bin/show_pathway?hsa04014+5594+5869
*  RALA - Wikipedia
... a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral". The Journal of Biological Chemistry. 275 ( ... "Identification and characterization of a calmodulin-binding domain in Ral-A, a Ras-related GTP-binding protein purified from ... "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Molecular and ... "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Molecular and ...
  https://en.wikipedia.org/wiki/RALA
*  The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc42 | The Journal of Immunology
p130Cas regulates the activity of AND-34, a novel Ral, Rap1 and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275: ... AND-34 binds by its GDP exchange factor domain to the C terminus of HEF1, a region of HEF1 previously implicated in apoptotic, ... In a study in which GTPase-bound 32P-labeled guanine nucleotides were assessed in transfected Cos cells, AND-34 had GDP ... GDP exchange factor; BCR, B cell receptor; SDF, stromal cell-derived factor; HEK, human embryonic kidney; MSCV, murine stem ...
  http://www.jimmunol.org/content/170/2/969?ijkey=5e163188919689daab370c4d49dd15de6a53e605&keytype2=tf_ipsecsha
*  List of MeSH codes (D12.644) - Wikipedia
... ral guanine nucleotide exchange factor MeSH D12.644.360.325.300.700 --- ras guanine nucleotide exchange factors MeSH D12.644. ... rab5 gtp-binding proteins MeSH D12.644.360.525.450 --- ral gtp-binding proteins MeSH D12.644.360.525.462 --- ran gtp-binding ... guanine nucleotide dissociation inhibitors MeSH D12.644.360.325.300 --- guanine nucleotide exchange factors MeSH D12.644. ... 360.325.300.200 --- eukaryotic initiation factor-2b MeSH D12.644.360.325.300.300 --- guanine nucleotide-releasing factor 2 MeSH ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
*  RRAS - Wikipedia
Tian X, Feig LA (2001). "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors ... Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a ... Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and ... Spaargaren M, Bischoff JR (1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative ...
  https://en.wikipedia.org/wiki/RRAS
*  nCounter® PanCancer Pathways Panel
The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins ( ... Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound ... and Ral guanine nucleotide-dissociation stimulator (RALGDS). ... The binding of growth factors to their receptor tyrosine kinase ... T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling ...
  http://genomax.com.my/index.php/featured-products/130-ncounter-pancancer-pathways-panel
*  Small GTPase - Wikipedia
... while GTP exchange is catalyzed by guanine nucleotide exchange factors (GEFs). Activation of a GEF typically activates its ... A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The ... Ral, Rit, Rap, Rheb, and Rad. Miro is a recent contributor to the superfamily. Each subfamily shares the common core G domain, ... which provides essential GTPase and nucleotide exchange activity. The surrounding sequence helps determine the functional ...
  https://en.wikipedia.org/wiki/Small_GTPase
*  G-protein signaling - Regulation of CDC42 activity Pathway Map - PrimePCR | Life Science | Bio-Rad
The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. The Journal of ... Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. The Journal of ... The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. The Journal of ... Guanine nucleotide exchange factors (GEFs) are essential for CDC42 activation. They promote the exchange of GDP for GTP to ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/g-protein-signaling-regulation-cdc42-activity
*  human Rgl3 protein Summary Report | CureHunter
... a potential binding partner for Rap-family small G-proteins and profilin II; amino acid sequence in first source ... GTP-Binding Protein Regulators*Guanine Nucleotide Exchange Factors: 309*ral Guanine Nucleotide Exchange Factor: 31*human Rgl3 ... GTP-Binding Protein Regulators*Guanine Nucleotide Exchange Factors: 309*ral Guanine Nucleotide Exchange Factor: 31*human Rgl3 ... GTP-Binding Protein Regulators*Guanine Nucleotide Exchange Factors: 309*ral Guanine Nucleotide Exchange Factor: 31*human Rgl3 ...
  http://www.curehunter.com/public/keywordSummaryC521670-human-Rgl3-protein.do
*  RAS Pathway v2.0 - National Cancer Institute
Ral guanine nucleotide dissociation stimulator RGDS, RGF, RalGEF. RAPGEF1. Rap guanine nucleotide exchange factor (GEF) 1. C3G ... ral guanine nucleotide dissociation stimulator-like 3. [none]. RHEB. Ras Homolog Enriched In Brain, GTP-binding protein Rheb. ... ral guanine nucleotide dissociation stimulator-like 1. RGL. RGL2. ral guanine nucleotide dissociation stimulator-like 2. HKE1.5 ... Rap guanine nucleotide exchange factor (GEF) 2. CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP. ...
  https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2
*  List of MeSH codes (D12.776.476) - Wikipedia
... ral guanine nucleotide exchange factor MeSH D12.776.476.325.300.700 -- ras guanine nucleotide exchange factors MeSH D12.776. ... adp-ribosylation factor 1 MeSH D12.776.476.525.400.025 -- rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp- ... eukaryotic initiation factor-2b MeSH D12.776.476.325.300.300 -- guanine nucleotide-releasing factor 2 MeSH D12.776.476.325. ... binding protein MeSH D12.776.476.525.400.100 -- rab3 gtp-binding proteins MeSH D12.776.476.525.400.100.100 -- rab3a gtp-binding ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)
*  Regulation of Rap2 in B lymphocytes - UBC Library Open Collections
RasGRP is a guanine-nucleotide exchange factor (GNEF) that activates Ras by triggering the displacement of GDP from Ras in ... Rapl cannot bind to all of the subset of Ras effectors. In addition, Rapl has its own subset of effectors that includes Ral-GEF ... A Rap guanine Nucleotide Exchange Factor Enriched Highly in the Basal Ganglia. Proceedings from the National Academy of ... PDZGEF1, a Guanine Nucleotide Exchange Factor Specific for Rapl and Rap2. Journal of Biological Chemistry. 274:38125-38130. de ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/831/items/1.0090517
*  Cyclic AMP Raises Intracellular Ca2+ in Human Megakaryocytes Independent of Protein Kinase A | Arteriosclerosis, Thrombosis,...
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998; 396: 474-477. ... precipitated with glutathione S-transferase-coupled Rap binding domain of guanine nucleotide dissociation stimulator for Ral- ... binding of GTPγS to Rap1 has been suggested to be related to SERCA3b activity.10,11 Because the guanine nucleotide exchange ... et al13 described that the small GTPase Rap1 is activated by cAMP via cAMP-sensitive guanine nucleotide exchange factors (cAMP ...
  http://atvb.ahajournals.org/content/22/1/179
*  G-protein signaling Regulation of CDC42 activity
The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. The Journal of ... Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. The Journal of ... Guanine nucleotide exchange factors (GEFs) are essential for CDC42 activation. They promote the exchange of GDP for GTP to ... The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins. ...
  http://pathwaymaps.com/maps/389/
*  1ywy - TOPSAN
... guanine exchange nucleotide factor) 12 (PDB id: 1x86), pleckstrin (PDB id: 1zm0) and other PH domains. A superposition of ... The C-terminal part of the PH domain has been implicated in G-protein binding (Touhara 1994) while the β loops have been ... PA2021 and Ral-A is shown in Fig. 1. With the exception of the first β-strand in Ral-A, all other secondary structure elements ... Figure 1. Stereo-view in ribbon diagram showing the superposition of PA2021 (Pdb id: 1ywy) and Ral-A (Pdb id: 1zc3). ...
  http://proteins.burnham.org/Proteins/NESGC/1ywy
*  RAPGEF2 - Wikipedia
... and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting ... Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a ... Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. RAPGEF2 is a cyclic AMP ... "Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2". Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin ...
  https://en.wikipedia.org/wiki/RAPGEF2
*  EXOC2 - Wikipedia
... a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion ... 2003). "Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site". J. Biol. Chem. 278 (19): 17053 ... 2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743-8. doi:10.1074 ... 2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73-8. doi: ...
  https://en.wikipedia.org/wiki/EXOC2