*  Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal...
105 cells per ml. Granulocyte/macrophage colony-stimulating factor (rboGM-CSF expressed in CHO cells using a previously defined ... bone marrow derived hematopoietic progenitor cells during bovine neonatal pancytopenia through in vitro culture of bone marrow ... We describe here a pilot study on the utility of bone marrow hematopoietic progenitor cell (BM-HPC) cultures to assess the ... Muiya P, Logan-Henfrey L, Naessens J: Expression of antigens on haemopoietic progenitor cells in bovine bone marrow. Vet ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-599
*  The TH1 Lymphokine Interferon-γ is a Potent Upregulator of Dendritic Cells with Phagocytic Capacity in GM-CSF Supplemented Bone...
... macrophages and granulocytes are descendants of a hematopoietic progenitor cell that originates in the bone marrow1. Thus, bone ... Dendritic cells from mouse bone marrow: in vitro differentiation using low doses of recombinant granulocyte-macrophage colony- ... macrophages and granulocytes are descendants of a hematopoietic progenitor cell that originates in the bone marrow1. Thus, bone ... Dendritic Cell Cutaneous Leishmaniasis Mouse Bone Marrow Bone Marrow Culture Phagocytic Capacity These keywords were added by ...
  https://rd.springer.com/chapter/10.1007/978-1-4757-9966-8_37
*  JCI - The stem cell niches in bone
... cell development. CMP, common myeloid progenitor; CLP, common lymphoid progenitor; GMP, granulocyte/macrophage progenitor; MKEP ... Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures. Blood. 87:518-524. View this ... Hematopoiesis of bone cells and marrow stromal cells. In the bone marrow HSCs reside either next to osteoblasts on the ... Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell. 109: ...
  https://www.jci.org/articles/view/JCI28568
*  Steven Hancock, MD | Stanford Medicine Profiles
... on the in vitro response of human bone marrow progenitor cells to irradiation. Light density nonadherent mononuclear cells were ... granulocyte colony-forming units, and granulocyte-macrophage colony-forming units as compared to cultures that did not contain ... The effect of recombinant human stem cell factor (SCF) on the response of human fetal bone marrow progenitor cells to ... STEM-CELL FACTOR ENHANCES THE SURVIVAL OF IRRADIATED HUMAN BONE-MARROW MAINTAINED IN SCID MICE STEM CELLS Leigh, B. R., Webb, S ...
  https://med.stanford.edu/profiles/steven-hancock?tab=research-and-scholarship
*  US5470569A - Recombinant colony stimulating factor-1 - Google Patents
... variety of tissues to stimulate the growth and development of bone marrow progenitor cells into granulocytes and/or macrophages ... which macrophages are produced by in vitro culture of bone marrow or other suitable preparations treated with CSF-1. These ... For the bone marrow stimulation assay, which measures biological activity of the protein, bone marrow cells from Balb/C mice ... In addition, a murine factor called IL-3 induces colonies from murine bone marrow cells which contain all these cell types plus ...
  https://patents.google.com/patent/US5470569
*  Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. - PubMed - NCBI
It appears to do so by protecting both hematopoietic progenitor cells directly and the bone marrow stem cell niche through its ... In vitro assays showed that CS enhanced the colony-forming ability of both granulocyte macrophage colony forming unit (GM-CFU) ... and osteogenic cells from bone marrow preparations and promoted the differentiation of bone marrow mesenchymal stromal cells ... CS effects on BM cells in vitro. (A) CS enhanced the survival of GM-CFUs from BM cells. BM cells were harvested from the tibia ...
  https://www.ncbi.nlm.nih.gov/pubmed/18367634
*  In Vivo 4-1BB Deficiency in Myeloid Cells Enhances Peripheral T Cell Proliferation by Increasing IL-15 | The Journal of...
... and granulocyte-macrophage progenitors and that 4-1BBL signaling inhibited the differentiation of myeloid progenitors into DC ... bone marrow. CBA. cytometric bead array. CD62L. L-selectin. Cl2MDP. clodronate. DC. dendritic cell. InLN. inguinal lymph node. ... Because in vitro 4-1BB signaling of activated T cells routinely enhances the multiplication of T cells and stimulates their ... Alternatively, cytotoxic CD8+ T cells may suppress NK cell expansion as NK cells are known to do the same for CD8+ T cells (39 ...
  http://www.jimmunol.org/content/194/4/1580
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... we performed bone marrow transplantation of transduced Mpl(-/-) bone marrow cells into Mpl(-/-) mice. We show that restoration ... Ectopic HOXC6 expression also induced strong myeloid differentiation and expansion of granulocyte-macrophage progenitors/common ... We have identified HOXC6 as a factor that enhances competitive repopulation capacity in vivo and colony formation in vitro. ... accompanied by bone neo-formation and marrow fibrosis. Gene-corrected Mpl(-/-) cells had increased long-term repopulating ...
  https://www.jove.com/visualize?author=Dirk+Heckl
*  PI3K-dependent ERK is involved in GM-CSF-mediated activation of progenitor cells in a neovascularisation model
Palabras clave : co-culture model; endothelial progenitor cell; extracellular signal-regulated kinase; granulocyte-macrophage ... on rat endothelial progenitor cell (EPC) biology. EPCs were isolated from rat bone marrow and experiments were carried out to ... to determine the effect of GM-CSF on EPC angiogenesis in vitro. EPC proliferation and viability, migration, and vasculogenesis ... ZHAO, Wei y YANG, Xiang-Hong. PI3K-dependent ERK is involved in GM-CSF-mediated activation of progenitor cells in a ...
  http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0038-23532010000300016&lng=es&nrm=iso&tlng=en
*  Growth Factors in the Treatment of HIV Disease | SpringerLink
Steinberg, H. N., Crumpacker, C. S., and Chatis, P. A., 1991, In vitro suppression of normal human bone marrow progenitor cells ... Effect of granulocyte-macrophage colony-stimulating factor on rat alveolar macrophage anticryptococcal activity in vitro, J. ... Absent or rare HIV infection of bone marrow stem/progenitor cells in vivo, J. Virol. 65:1985-1990.PubMedGoogle Scholar ... Macrophage-active colony-stimulating factors enhance human immunodeficiency virus type 1 infection in bone marrow stem cells, ...
  https://link.springer.com/chapter/10.1007/978-1-4899-0191-0_27
*  US5945337A - Method for culturing CD34+ cells in a serum-free medium - Google Patents
... cells purified from normal bone marrow, peripheral blood of patients treated with cytokines, and umbilical cord blood is ... used to stimulate proliferation and differentiation of mid-progenitor cells are interleukin-3 and granulocyte-macrophage colony ... cells that are tainted with tumor cells, either of bone marrow or metastatic origin, are placed into in vitro culture in the ... cultivating a mixed human bone marrow cell population, containing CD34+ cells and non-CD34+ cells in the population, in a serum ...
  https://patents.google.com/patent/US5945337
*  Stanley Schrier | Stanford Medicine Profiles
We identify a recurrent loss of granulocyte-macrophage progenitors (GMPs) in the bone marrow of low risk MDS patients that can ... Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age PROCEEDINGS OF THE NATIONAL ... Blocking calreticulin on low risk MDS myeloid progenitors rescues them from phagocytosis in vitro. However, in the high-risk ... Evaluation of bone marrow plasma cell infiltration and presence of myeloma associated end organ damage could be clinically ...
  https://med.stanford.edu/profiles/stanley-schrier
*  Steven Goodman | Stanford Medicine Profiles
Bone marrow granulocyte and macrophage colony-forming units (CFU-GM) were assayed in vitro for dose response to 4- ... Pharmacodynamic analysis of individual patient bone marrow progenitor cell sensitivity did not reveal any correlation with age ... Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder that can be treated with bone marrow ... EFFICACY OF IMMUNE GLOBULIN IN PREVENTING COMPLICATIONS OF BONE-MARROW TRANSPLANTATION - A METAANALYSIS BONE MARROW ...
  https://med.stanford.edu/profiles/steven-goodman
*  The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor...
... granulocyte colony-stimulating factor (G-CSF), CSF-1, granulocyte macrophage (GM) CSF stem cell factor (SCF), and IL-6. FL and ... progenitor cells. FL alone was a weak growth stimulator of CD34+ BM cells, but synergistically and directly enhanced colony ... CD71+ BM cells. Thus, FL potently stimulates the growth of primitive and more committed human BM progenitor cells. ... subset of the CD34+ progenitors, as 4.5-fold more colonies were formed by CD34+CD71- cells in response to FL + IL-3 + SCF than ...
  https://www.rdm.ox.ac.uk/publications/573533
*  Cancer Stem Cells-Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells | Cancer Research
... bone marrow samples is encouraging in that patients in blast crisis all exhibited an expansion of the granulocyte-macrophage ... In addition, it is thought that stem cells may divide symmetrically to form two progenitor cells, which could lead to stem cell ... Several in vitro assays have been used to identify stem cells, including sphere assays, serial colony-forming unit (CFU) assays ... or an asymmetrical self-renewing cell division, resulting in one stem cell and one more differentiated progenitor cell. ...
  http://cancerres.aacrjournals.org/content/66/19/9339
*  CFU-DL - Wikipedia
... other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow ... Reid CD, Stackpoole A, Meager A, Tikerpae J (October 1992). "Interactions of tumor necrosis factor with granulocyte-macrophage ... CFU-DL is a colony forming unit that gives rise to Langerhans cells. ...
  https://en.wikipedia.org/wiki/CFU-DL
*  GPR84 - Wikipedia
... in the bone marrow) that arise from dysregulated production of myeloid progenitor cells in the bone marrow. Ly6G + MDSCs in Lal ... GPR84 is normally expressed at low levels in myeloid cells and can be induced in vitro by stimulating macrophage or microglial ... GPR84 was also upregulated on both macrophages and neutrophyl granulocytes after LPS stimulation. Not only LPS challenge but ... There was also a GPR84 downregulation in dentritic cell derived from FcRgamma chain KO mice. In microglial cells, the GPR84 ...
  https://en.wikipedia.org/wiki/GPR84
*  IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis | The Journal of Immunology
... eosinophils in vitro in which bone marrow cells were cultured in SCF and Flt3L for the first 4 d to expand the progenitor cells ... granulocyte-macrophage progenitor. ILC2. type 2 innate lymphoid cell. KO. knockout. SCF. stem cell factor. WT. wild-type.. ... Bone marrow cells were counted, and 5 × 106 cells were used for staining. Cells were washed with PBS and stained with 0.25 μl ... Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J. Immunol. 187: 5795- ...
  http://www.jimmunol.org/content/197/9/3445
*  Modeling Bone Marrow Progenitor Cell Differentiation and Susceptibility to HIV-1 Infection | MedCrave
... and recombinant human granulocyte-macrophage-colony stimulating factor (rhGM-CSF, 2 ng/ml; eBioscience, San Diego, CA). The ... Steinberg HN, Crumpacker CS, Chatis PA (1991) In vitro suppression of normal human bone marrow progenitor cells by human ... has strongly suggested that these cells are differentiating towards macrophages.. TF-1 cells, similar to bone marrow progenitor ... ancestral hematopoietic progenitor cells, as well as more mature hematopoietic progenitors and bone marrow progenitor stromal ...
  http://googlescholar.medcraveonline.com/scholars/article_fulltext/195
*  Articles Added on January 26, 2013
Although bone marrow (BM) inflammatory cells are the main source of eosinophil-basophil (Eo/B) differentiation-inducing ... Toll-like receptor-mediated eosinophil-basophil differentiation: autocrine signalling by granulocyte-macrophage colony- ... Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro ... ... mediated signalling in BM progenitors. Having previously demonstrated ... ...
  http://www.biomedsearch.com/added/20130126.html
*  BCR-ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment | Clinical...
CMP, common myeloid progenitor; GMP, granulocyte macrophage progenitor; LT-HSC, long-term hematopoietic stem cell; MPP, ... This article combines mathematical modeling with recent clinical observations of progenitor cell kinetics in the bone marrow to ... Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro . Blood 2002;99 ... evaluated the dynamics of several different subpopulations of progenitor cells (granulocyte-macrophage progenitors ...
  http://clincancerres.aacrjournals.org/content/17/21/6812
*  Judith C. Gasson | Department of Biological Chemistry, UCLA
... blood cell progenitor cells and the stroma cells necessary for their proliferation and differentiation in the bone marrow. ... In the mid-1980s she and her collaborators purified the human Granulocyte-Macrophage Colony-Stimulating-Factor (GM-CSF) and ... Her current activities are focused upon in vitro model systems that are designed to better understand the interactions between ... Gasson was instrumental in purifying for the first time a hormone-like substance that increases the speed of bone marrow cell ...
  http://www.biolchem.ucla.edu/node/119
*  Hematopoietic Stem and Progenitor Cells Can Be Enriched by Implanting Biomaterial into Spatium Intermusculare
Figure 4: Hematopoietic stem and progenitor cells (HSPCs) in the migrating cells (MCs) originated in the bone marrow (BM). (a) ... colony-forming-unit-granulocyte, macrophage: GFU-GM, and colony-forming-unit-granulocyte, erythroid, macrophage, megakaryocyte ... In Vitro CFU Assay. MCs and BM cells were suspended in 2% FBS containing DMEM and then mixed with methylcellulose-based ... H. Kawada and M. Ogawa, "Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle," Blood, vol. 98, no. ...
  https://www.hindawi.com/journals/bmri/2015/398642/
*  Preclinical Pharmacologic Basis for Clinical Use of rhIL-11 as an Effective Platelet-Support Agent | Cancer Network | The...
purified bone marrow CD34+ cells (ie, early progenitor cells).. The in vitro megakaryocytopoietic effects of rhIL-11 in human ( ... progenitor cells, including multipotential progenitor cells (CFU-GEMM. [colony-forming. unit granulocyte-erythroid-macrophage- ... progenitor cells from murine bone marrow.[13] In combination with. IL-3 or stem-cell factor, rhIL-11 has been shown to ... primate bone marrow stromal cell line, called PU-34. IL-11 mediates. its effects on bone marrow megakaryocytes through direct ...
  http://www.cancernetwork.com/review-article/preclinical-pharmacologic-basis-clinical-use-rhil-11-effective-platelet-support-agent
*  ORBi: Browsing ORBi
CXCR4 axis in the interactions between MSC and hematopoietic stem/progenitor cells (HSPC) was studied. Human bone marrow MSC ... granulocyte macrophage-colony stimulating factor as well as monocyte-chemoattractant protein-1. Altogether, human MSC support ... Mesenchymal stem cells (MSC) have the ability to support and maintain hematopoiesis in vitro. However, mechanisms implicated in ... In multivariate analysis, bone marrow involvement, the presence of effusions, and high aaIPI were all associated with high ...
  http://orbi.ulg.ac.be/browse?type=journal&value=European+Journal+of+Haematology