Patent US6867589 - Method for detecting hydrocarbons from NMR data - Google Patents
A method for detecting hydrocarbons in a fluid sample includes deriving a difference measurement from a first nuclear magnetic resonance measurement and a second nuclear magnetic resonance measurement, wherein the first nuclear magnetic resonance measurement and the second nuclear magnetic resonance measurement have difference values in an acquisition parameter such that molecular diffusion affects the first nuclear magnetic resonance measurement and the second nuclear magnetic resonance measurement to a different extent; and determining a presence of hydrocarbons from the difference measurement.http://www.google.com/patents/US6867589?dq=6,563,928
IJMS | Free Full-Text | Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran...
Four new (1-4), along with six known (5-10) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The new compounds were structurally elucidated through spectroscopic analysis including UV (Ultraviolet Spectrum), IR (Infrared Spectrum), 1H-NMR (1Hydrogen-Nuclear Magnetic Resonance), 13C-NMR (13Carbon-Nuclear Magnetic Resonance), DEPT (Distortionless Enhancement by Polarization Transfer), 1H-1H COSY (1H-1H Correlation Spectroscopy), HSQC (Heteronuclear Single Quantum Coherence), HMBC (Heteronuclear Multiple Bond Correlation), NOESY (Nuclear Overhauser Enhancement Spectroscopy) and HR-MS (High Resolution Mass Specttrum) and their absolute configurations were proposed by comparison of NOESY spectra and specific optical rotations with those of known compounds and biosynthesis grounds. Compound 2 is the first sesquiterpene alkaloid isolated from ...http://www.mdpi.com/1422-0067/16/5/9119
Patent US6369567 - Nuclear magnetic resonance method and apparatus for determining pore ... - Google Patents
A method for determining a pore characteristic of a substance includes the following steps: subjecting the substance to a substantially uniform static magnetic field; applying a magnetic pulse sequence to the substance, the pulse sequence being selected to produce nuclear magnetic resonance signals that are responsive to internal magnetic field inhomogeneities in the pore structure of the substance, and detecting, as measurement signals, nuclear magnetic resonance signals from the substance; applying a reference magnetic pulse sequence to the substance, the reference pulse sequence being selected to produce nuclear magnetic resonance signals that are substantially unresponsive to internal magnetic field inhomogeneities in the pore structure of the substance, and detecting, as reference measurement signals, nuclear ...http://www.google.com/patents/US6369567?dq=6,993,661
Explicit calculation of nuclear magnetic resonance relaxation rates in small pores to elucidate molecular scale fluid dynamics ...
Nuclear magnetic resonance (NMR) spin-lattice (T−1 1 ) and spin-spin (T−1 2 ) relaxation rate mea- surements can act as e ective non-destructive probes of the nano-scale dynamics of 1H spins in porous media. In particular, fast- eld-cycling T−1 1 dispersion measurements contain information on the dynamics of di using spins over time scales spanning many orders of magnitude. Previously- published experimental T−1 1 dispersions from a plaster paste, synthetic saponite, mortar and oil- bearing shale are re-analysed using a model and associated theory which describe the relaxation rate contributions due to the interaction between spins ensembles in quasi-two-dimensional (Q2D) pores. Application of the model yields physically-meaningful di usion correlation times for all systems. In particular, the surface di usion correlation time and the surface desorption time take similar values for each system suggesting that surface ...http://epubs.surrey.ac.uk/813679/
High-resolution magic angle spinning proton (HRMAS 1H) magnetic resonance spectroscopy produces well-resolved spectra of metabolites from intact tissue specimens. Here we report the results of a preliminary study of 19 human brain tumors obtained by applying this method. Among these 19 cases were 2 low-grade astrocytomas, 1 anaplastic astrocytoma, 8 glioblastomas, 6 meningiomas, and 2 schwannomas. In addition, autopsy human brain tissues from two subjects without any known neurological diseases were used as normal controls. The HRMAS 1H magnetic resonance spectroscopy measurements were performed at 2°C on a 400-MHz NMR spectrometer with a HRMAS speed of 2.5 kHz. From these HRMAS 1H MR ...http://cancerres.aacrjournals.org/content/58/9/1825
Centre for Magnetic Resonance Investigations - Wikipedia
The Kingston Upon Hull Centre for Magnetic Resonance Investigations (CMRI), which opened in 1992, is a magnetic resonance imaging centre located in the city of Kingston upon Hull (Hull) in the East Riding of Yorkshire, England, UK. It is situated in the grounds of the Hull Royal Infirmary hospital in the centre of the city. The centre carries out both cancer research studies, under the auspices of the University of Hull, and clinical scanning, under the auspices of the local NHS trust, Hull and East Yorkshire Hospitals. The centre currently has three MRI scanners; two 1.5 tesla scanners owned by the NHS (a Philips Intera and a GE Signa) and a 3.0 tesla MR 750 GE Signa scanner owned by the University which was installed in January 2009 (one of the first 3.0 tesla whole-body capable systems in Europe). The medical research is carried out under the Directorship of Professor Lindsay W. Turnbull, ...https://en.wikipedia.org/wiki/Centre_for_Magnetic_Resonance_Investigations
Polymerization of a divalent/tetravalent metal-storing atom-mimicking dendrimer | Science Advances
Supplementary material for this article is available at http://advances.sciencemag.org/cgi/content/full/2/12/e1601414/DC1. fig. S1. Molecular models of DPA G4 and linker molecule.. fig. S2. 1H NMR spectrum (400 MHz, CDCl3, 302 K) of 2.. fig. S3. 13C NMR spectrum (100 MHz, CDCl3, 302 K) of 2.. fig. S4. 1H NMR spectrum (400 MHz, CDCl3, 302 K) of 3.. fig. S5. 13C NMR spectrum (100 MHz, CDCl3, 302 K) of 3.. fig. S6. 1H NMR spectrum (400 MHz, CDCl3, 302 K) of 4.. fig. S7. 13C NMR spectrum (100 MHz, CDCl3, 302 K) of 4.. fig. S8. 1H NMR spectrum (400 MHz, CDCl3, 302 K) of 5.. fig. S9. 13C NMR spectrum (100 MHz, CDCl3, 302 K) of 5.. fig. S10. 1H NMR spectrum (400 MHz, CDCl3, 302 K) of 6.. fig. S11. 13C NMR spectrum (100 MHz, CDCl3, 302 K) of 6.. fig. S12. 1H NMR spectrum (400 MHz, CDCl3, 303 K) of 7.. fig. S13. 13C NMR spectrum (100 MHz, CDCl3, 303 K) of 7.. fig. S14. 1H NMR spectrum (400 MHz, dehydrated CDCl3, 303 K) of 8.. fig. S15. 13C NMR spectrum (100 MHz, CDCl3, 302 K) of 8 ...http://advances.sciencemag.org/content/2/12/e1601414/tab-figures-data
NMR Spectroscopy: Basic Principles, Concepts and Applications in Chemistry, 3rd Edition | NMR Spectroscopy / MRI / Imaging |...
Preface XV. 1 Introduction 1. 1.1 Literature 8. 1.2 Units and Constants 9. References 10. Part I Basic Principles and Applications 11. 2 The Physical Basis of the Nuclear Magnetic Resonance Experiment.. Part I 13. 2.1 The Quantum Mechanical Model for the Isolated Proton 13. 2.2 Classical Description of the NMR Experiment 16. 2.3 Experimental Verification of Quantized Angular Momentum and of the Resonance Equation 17. 2.4 The NMR Experiment on Compact Matter and the Principle of the NMR Spectrometer 19. 2.4.1 How to Measure an NMR Spectrum 19. 2.5 Magnetic Properties of Nuclei beyond the Proton 25. References 27. 3 The Proton Magnetic Resonance Spectra of Organic Molecules - Chemical Shift and Spin-Spin Coupling 29. 3.1 The Chemical Shift 29. 3.1.1 Chemical Shift Measurements 32. 3.1.2 Integration of the Spectrum 35. 3.1.3 Structural Dependence of the Resonance Frequency - A ...https://www.wiley.com/en-us/NMR+Spectroscopy%3A+Basic+Principles%2C+Concepts+and+Applications+in+Chemistry%2C+3rd+Edition-p-9783527674770
Local Ordering at Mobile Sites in Proteins from Nuclear Magnetic Resonance Relaxation: the Role of Site Symmetry
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.http://pubmedcentralcanada.ca/pmcc/articles/PMC4837759/
High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid - WestminsterResearch
1. One- and two-dimensional (correlated shift spectroscopy) high resolution proton n.m.r. spectra of human cerebrospinal fluid (CSF) are reported. The merits of water suppression by freeze drying or irradiation, and spectral simplification by spin-echo methods, are discussed. 2. Well-resolved resonances for a range of low molecular weight metabolites such as lactate, 3-d-hydroxybutyrate, alanine, acetate, citrate, glucose, valine and formate were observed. Resonances for glutamine were observed only from freeze dried samples. Concentrations determined by n.m.r. were in reasonable agreement with those from conventional methods. 3. The n.m.r. spectra of CSF were related to the clinical conditions of the subjects. No resonances for citrate were present in spectra of CSF from subjects (three infants) with bacterial meningitis; high lactate and lowered glucose levels were observed. Strong ...http://westminsterresearch.wmin.ac.uk/14091/
Patent US6084408 - Methods for acquisition and processing of nuclear magnetic resonance signals ... - Google Patents
A method for determining intrinsic transverse relaxation time of a first mobile phase in a porous medium using nuclear magnetic resonance measurement sequences. The sequences are measured at first and second wait times. At least two different interecho spacing times are used for each wait time. The first and second wait time are selected to provide different magnetization recoveries of the first phase, and are selected to be longer than the longitudinal relaxation time of a second mobile phase. For the measurements made at the first interecho spacing time, components of signals in the measurements corresponding to the first phase are separated from components corresponding to the second mobile phase by determining differences between the signals measured at the first and at the second wait times. The step of separating is performed for each of the interecho spacing times. An apparent transverse relaxation time of the first mobile phase is ...http://www.google.com/patents/US6084408?dq=456322
Wiley: NMR Spectroscopy: Basic Principles, Concepts and Applications in Chemistry, 3rd Edition - Harald Gunther
Preface XV. 1 Introduction 1. 1.1 Literature 8. 1.2 Units and Constants 9. References 10. Part I Basic Principles and Applications 11. 2 The Physical Basis of the Nuclear Magnetic Resonance Experiment.. Part I 13. 2.1 The Quantum Mechanical Model for the Isolated Proton 13. 2.2 Classical Description of the NMR Experiment 16. 2.3 Experimental Verification of Quantized Angular Momentum and of the Resonance Equation 17. 2.4 The NMR Experiment on Compact Matter and the Principle of the NMR Spectrometer 19. 2.4.1 How to Measure an NMR Spectrum 19. 2.5 Magnetic Properties of Nuclei beyond the Proton 25. References 27. 3 The Proton Magnetic Resonance Spectra of Organic Molecules - Chemical Shift and Spin-Spin Coupling 29. 3.1 The Chemical Shift 29. 3.1.1 Chemical Shift Measurements 32. 3.1.2 Integration of the Spectrum 35. 3.1.3 Structural Dependence of the Resonance Frequency - A ...http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527330003.html?filter=TEXTBOOK
Wiley: NMR Spectroscopy: Basic Principles, Concepts and Applications in Chemistry, 3rd Edition - Harald Gunther
Preface XV. 1 Introduction 1. 1.1 Literature 8. 1.2 Units and Constants 9. References 10. Part I Basic Principles and Applications 11. 2 The Physical Basis of the Nuclear Magnetic Resonance Experiment.. Part I 13. 2.1 The Quantum Mechanical Model for the Isolated Proton 13. 2.2 Classical Description of the NMR Experiment 16. 2.3 Experimental Verification of Quantized Angular Momentum and of the Resonance Equation 17. 2.4 The NMR Experiment on Compact Matter and the Principle of the NMR Spectrometer 19. 2.4.1 How to Measure an NMR Spectrum 19. 2.5 Magnetic Properties of Nuclei beyond the Proton 25. References 27. 3 The Proton Magnetic Resonance Spectra of Organic Molecules - Chemical Shift and Spin-Spin Coupling 29. 3.1 The Chemical Shift 29. 3.1.1 Chemical Shift Measurements 32. 3.1.2 Integration of the Spectrum 35. 3.1.3 Structural Dependence of the Resonance Frequency - A ...http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527674772.html
Human cardiac 31P magnetic resonance spectroscopy at 7 Tesla. - Radcliffe Department of Medicine
PURPOSE: Phosphorus magnetic resonance spectroscopy ((31)P-MRS) affords unique insight into cardiac energetics but has a low intrinsic signal-to-noise ratio (SNR) in humans. Theory predicts an increased (31)P-MRS SNR at 7T, offering exciting possibilities to better investigate cardiac metabolism. We therefore compare the performance of human cardiac (31)P-MRS at 7T to 3T, and measure T1s for (31)P metabolites at 7T. METHODS: Matched (31)P-MRS data were acquired at 3T and 7T, on nine normal volunteers. A novel Look-Locker CSI acquisition and fitting approach was used to measure T1s on six normal volunteers. RESULTS: T1s in the heart at 7T were: phosphocreatine (PCr) 3.05 ± 0.41s, γ-ATP 1.82 ± 0.09s, α-ATP 1.39 ± 0.09s, β-ATP 1.02 ± 0.17s and 2,3-DPG (2,3-diphosphoglycerate) 3.05 ± 0.41s (N = 6). In the field comparison (N = 9), PCr SNR increased 2.8× at 7T ...https://www.rdm.ox.ac.uk/publications/420913
Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study
Aims/hypothesis. It is increasingly evident that the brain is another site of diabetic end-organ damage. The pathogenesis has not been fully explained, but seems to involve an interplay between aberrant glucose metabolism and vascular changes. Vascular changes, such as deficits in cerebral blood flow, could compromise cerebral energy metabolism. We ... read more therefore examined cerebral metabolism in streptozotocin-diabetic rats in vivo by means of localised 31P and 1H magnetic resonance spectroscopy. Methods. Rats were examined 2 weeks and 4 and 8 months after diabetes induction. A non-diabetic group was examined at baseline and after 8 months. Results. In 31P spectra the phosphocreatine:ATP, phosphocreatine:inorganic phosphate and ATP:inorganic phosphate ratios and intracellular pH in diabetic rats were similar to controls at all time points. In 1H spectra a lactate resonance was detected as frequently in controls as in ...https://dspace.library.uu.nl/handle/1874/3642
Secondary structure of neutrophil-activating peptide-2 determined by 1H-nuclear magnetic resonance spectroscopy | Biochemical...
Neutrophil-activating protein-2 (NAP-2) is a 72 residue protein demonstrating a range of proinflammatory activities. The solution structure of monomeric NAP-2 has been investigated by two-dimensional 1H-n.m.r. spectroscopy. Sequence-specific proton resonance assignments have been made and secondary structural elements have been identified on the basis of nuclear Overhauser data, coupling constants and amide hydrogen/deuteron exchange. The NAP-2 monomer consists of a triple-stranded anti-parallel beta-sheet arranged in a 'Greek key' and a C-terminal helix (residues 59-70) and is very similar to that found in the n.m.r. solution conformation of dimeric interleukin-8 and the crystal structure of tetrameric bovine platelet factor-4. Results are discussed in terms of heparin binding and neutrophil-activation properties of NAP-2. ...http://www.biochemj.org/content/304/2/371
Nuclear magnetic resonance spectroscopy of excised human hearts | Heart
Background-Phosphorus nuclear magnetic resonance spectroscopy has been proposed as a method of studying the metabolism of the myocardium in patients. Little is known about 31P nuclear magnetic resonance spectroscopy of diseased human hearts.. Methods-Two donor hearts meeting the requirements for heart transplantation and 11 diseased hearts were removed during a transplantation procedure and were studied in a horizontal 2·35 T superconducting magnet. Spectra were obtained at 0°C about 30 minutes after the excision. The areas of the inorganic phosphate peak (Pi) and of the phosphocreatine peak (PCr) were summed and expressed as a ratio with respect to the area of the β ATP peak.. Results-The ratio (Pi + Pcr)/β ATP was found to be significantly lower in five hearts with a myocardial infarct (0·77 (0·18)) than in hearts with dilated cardiomyopathy (1·25 (0·29)) and in ...http://heart.bmj.com/content/68/9/272
Interpretation Of Proton Nmr Spectra - 28 images - Chemistry Assignment Of 13c Nmr Spectra To Structural, Nuclear Magnetic...
Interpretation Of Proton Nmr Spectra - 28 images - Chemistry Assignment Of 13c Nmr Spectra To Structural, Benchtop Nmr On Ibuprofen Molecules, How To Interpret Proton Nmr Spectra Thespectroscopy, Image Gallery Nmr Spectrum, Organic Spectroscopy International 1h Nmrhttp://www.waitingforchange.us/interpretation-of-proton-nmr-spectra.html
Intracellular acidosis during and after cerebral ischemia: in vivo nuclear magnetic resonance study of hyperglycemia in cats. |...
In vivo 31P nuclear magnetic resonance spectroscopy was used to monitor the time course of intracellular pH in cat cerebral cortex subjected to global cerebral ischemia under control and hyperglycemic pretreatment conditions. Transient (16 minutes) global cerebral ischemia was induced in 14 cats using an inflatable cervical cuff combined with systemic arterial hypotension. Six cats were pretreated with infusion of 1.5 g/kg glucose prior to ischemia. Relative concentrations of high-energy phosphate metabolites and intracellular pH were continuously monitored before, during, and for 2 hours after cerebral reperfusion. During ischemia, intracellular pH fell to the same level and followed a similar time course in both groups. However, during initial reperfusion in the hyperglycemic group, there was a severe further decline (p less than 0.003) in intracellular pH. We suggest that the increased neurologic deficit and mortality found in hyperglycemic ...http://stroke.ahajournals.org/content/18/5/919
Bioenergetic Measurements in Children with Bipolar Disorder: A Pilot 31P Magnetic Resonance Spectroscopy Study
Background Research exploring Bipolar Disorder (BD) phenotypes and mitochondrial dysfunction, particularly in younger subjects, has been insufficient to date. Previous studies have found abnormal cerebral pH levels in adults with BD, which may be directly linked to abnormal mitochondrial activity. To date no such studies have been reported in children with BD. Methods Phosphorus Magnetic Resonance Spectroscopy (31P MRS) was used to determine pH, phopshocreatine (PCr) and inorganic phosphate (Pi) levels in 8 subjects with BD and 8 healthy comparison subjects (HCS) ages 11 to 20 years old. Results There was no significant difference in pH between the patients and HCS. However, frontal pH values for patients with BD increased with age, contrary to studies of HCS and the pH values in the frontal lobe correlated negatively with the YMRS values. Global Pi was significantly lower in subjects with BD compared ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054536
Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by 13C Nuclear Magnetic Resonance Spectroscopy:...
Subjects. NMR studies were performed with eight healthy volunteers (four males and four females; aged 29 ± 6; mean ± SD) at rest after a 12 hr overnight fasting. Informed written consent was obtained from all subjects after the aims and potential risks were explained to them. The protocol was approved by the Yale University School of Medicine Human Investigation Committee.. NMR acquisition. NMR data were acquired on a 2.1 T whole body (1 m bore) magnet connected to a modified Bruker AVANCE spectrometer (Bruker Instruments, Billerica, MA). Subjects remained supine in the magnet with the head lying on top of a home-built radio-frequency NMR probe, consisting of one13C circular coil (8.5 cm diameter) and two 1H quadrature coils for1H acquisitions and decoupling. After tuning, acquisition of scout images, shimming with the FASTERMAP procedure ...http://www.jneurosci.org/content/22/5/1523.long
In-pore exchange and diffusion of carbonate solvent mixtures in nanoporous carbon (Journal Article) | DOE PAGES
High resolution magic angle spinning (HRMAS) 1H NMR spectroscopy has been used to resolve different surface and in-pore solvent environments of ethylene carbonate (EC) and dimethyl carbonate (DMC) mixtures absorbed within nanoporous carbon (NPC). Two dimensional (2D) 1H HRMAS NMR exchange measurements revealed that the inhomogeneous broadened in-pore resonances have pore-to-pore exchange rates on the millisecond timescale. Pulsed-field gradient (PFG) NMR diffusometry revealed the in-pore self-diffusion constants for both EC and DMC were reduced by up to a factor of five with respect to the diffusion in the non-absorbed solvent mixtures. ...https://www.osti.gov/pages/biblio/1257785-pore-exchange-diffusion-carbonate-solvent-mixtures-nanoporous-carbon
Diagnostic Value of Breast Proton Magnetic Resonance Spectroscopy at 1.5T in Different Histopathological Types
The Scientific World Journal is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journal's Editorial Board as well as its Table of Contents are divided into 81 subject areas that are covered within the journal's scope.https://www.hindawi.com/journals/tswj/2012/508295/
Resolution of individual lipids in mixed phospholipid membranes and specific lipid-cytochrome c interactions by magic-angle...
A model of the inner mitochondrial membrane was constructed with dioleoyphosphatidylcholine (PC), dioleoylphosphatidylethanolamine (PE), and cardiolipin (CL) at a PC:PE:CL molar ratio of 2:2:1, and the interaction of the peripheral membrane protein cytochrome c with this mixed membrane has been investigated by static and magic-angle spinning (MAS) solid-state 31P NMR. The static 31P NMR spectrum of the three-component membrane is a typical broad powder pattern for phospholipids in a bilayer structure, and is a result of three overlapping spectra of each individual phospholipid component in the mixed membrane, with an average effective chemical shift anisotropy of approximately 41 ppm. Using magic-angle spinning NMR methods, three resolved resonances are observed in the narrowed MAS 31P NMR spectrum, each of which has been assigned to each lipid component in the mixed membrane. This allows the investigation ...https://www.neuroscience.ox.ac.uk/publications/422128
Human cardiac <sup>31</sup>P magnetic resonance spectroscopy at 3T with a receive array: Is single-loop or dual...