*  A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis. MeSH ... Anti-Anxiety Effect (0) see Anti-Anxiety Agents. Anti-Arrhythmia Agents (153) • Agents used for the treatment or prevention of ... Adrenergic alpha-Antagonists (65) • Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the ... Antithyroid Effect (0) see Antithyroid Agents. Antitreponemal Agents (1) • Agents used to treat infections with bacteria of the ...
  https://druginfo.nlm.nih.gov/drugportal/drug/categories
*  CSIRO PUBLISHING | Reproduction, Fertility and Development
Tumour necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by ... Impact of TNF-blocking agents on male sperm characteristics and pregnancy outcomes in fathers exposed to TNF-blocking agents at ... promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist. Eur. J. ... However, at concentrations of 100 and 200 µg mL-1, etanercept can block, in a significant way, the toxic effects of TNF-α (500 ...
  http://www.publish.csiro.au/RD/RD16090
*  Patente US7544696 - Spermicidal and/or antifungal composition and methods of using the same - Google Patentes
Method for Determining Direct Effect of an Agent on Sperm Motility. The direct effect of an agent on sperm motility was ... The compounds of the invention may be used in human contraception in males, either by reversibly blocking spermatogenesis or in ... analogs have been actively investigated as compounds which effectively block spermatogenesis. However, GNRH analogs interfere ... Some general cellular toxicants such as anticancer agents and alkylating agents affect spermatogenesis, but are obviously not ...
  http://www.google.es/patents/US7544696?dq=flatulence
*  Male contraceptive - Wikipedia
It effectively blocks the production of sperm by the testes, and lacks the adverse effects of previously researched hormonal ... Kjaergaard N, Kjaergaard B, Lauritsen JG; Kjaergaard; Lauritsen (June 1988). "Prazosin, an adrenergic blocking agent inadequate ... March 2002). "Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats". Asian Journal of Andrology. 4 ... Another way is blocking retionic receptors themselves, although it can also have serious side effects. Adjudin, a non-toxic ...
  https://en.wikipedia.org/wiki/Male_contraceptive
*  Regulation of expression of PI3Kβ protein in tumors - Universita' Degli Studi di Torino
... or side effects of treatment with such an agent.. Furthermore, this invention pertains to uses of novel agents identified by ... 7a). Histological analysis of the testes of homozygous mice revealed empty seminiferous tubules and a block in spermatogenesis ... 7. The blocking solution is removed by decanting and the wells are washed once with PBS. Anti-BrdU-POD:solution (1:200 dilution ... For example, an agent identified as described herein (e.g., a modulating agent, a small molecule pharmacological inhibitor, a ...
  http://www.freepatentsonline.com/8105796.html
*  Patent US20050045183 - Methods and devices for occluding body lumens and/or for delivering ... - Google Patents
... spermicidal agents, spermatogenesis inhibitors, antimicrobials, antibiotics, antifungals, chemotherapeutic agents, biologics, ... In such applications, the substance disposed on or in the device may comprise an agent that causes a therapeutic effect in the ... antimetabolites and other agents that block cancer cell growth by interfering with certain cell functions, usually DNA ... However, direct placement of quinacrine into the fallopian tube in combination with or as part of a lumen blocking implantable ...
  http://www.google.com/patents/US20050045183?dq=5,889,522
*  Androgen - Wikipedia
A Brdu analysis showed that excess testosterone did not increase this blocking effect against social isolation; that is, the ... or agents which block androgens from accessing their receptor: antiandrogens. ... Spermatogenesis[edit]. During puberty, androgen, LH and follicle stimulating hormone (FSH) production increase and the sex ... Androgen effects[edit]. The androgens function as paracrine hormones required by the Sertoli cells to support sperm production ...
  https://en.wikipedia.org/wiki/Androgen
*  Probucol Reduces Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats
A higher or lower dose of probucol may affect the effect of probucol on testicular spermatogenesis. Consequently, further ... After blocking with 5% nonfat milk solution, the membrane was incubated with anti-E-selectin antibody or anti-β-actin antibody ... Next, testicular tissues were dehydrated in an ethanol series and embedded in paraffin block. Section was cut into 5 μm ... Scavenging reactive oxygen species agents have been shown to be effective to protect against ischemia-reperfusion injury [17-19 ...
  https://www.hindawi.com/journals/omcl/2017/5424097/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an ... During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential ... The post-meiotic phenotype of a mutant of such a protein could be obscured through an earlier developmental block, or the ... Triclosan is a broad-spectrum antibacterial agent that is present in many consumer products and has been found to be a ...
  https://www.jove.com/visualize/abstract/22511966/sirt2-ablation-has-no-effect-on-tubulin-acetylation-brain-cholesterol
*  Pharmacology of bicalutamide - Wikipedia
Bicalutamide more than blocks the effects of the increased testosterone levels that it induces in men, which is evidenced by ... Although bicalutamide alone would appear to have minimal detrimental effect on spermatogenesis and male fertility, other ... and instead exclusively mediates its antiandrogen effects by blocking androgen binding and subsequent receptor activation at ... Antigonadotropic agents like high-dose CPA, high-dose androgens (e.g., testosterone esters), and GnRH antagonists (though ...
  https://en.wikipedia.org/wiki/Pharmacology_of_bicalutamide
*  Opportunity for Pharmaceutical Intervention in Lung Cancer: Selective Inhibition of JAK1/2 to Eliminate EMT-Derived Mesenchymal...
Cellular effects of the illustrated pathways are color-coded purple. Included in the map are the JAK-STAT pathway, on the top, ... B) Blocking signal transduction pathways, such as MAPK, that relay EMT-initiating signals to the nucleus. (C) Targeting cells ... Ioannidis, S., Lamb, M. L., Wang, T., Almeida, L., Block, M. H., Davies, A. M., … Zinda, M. (2011). Discovery of 5-Chloro- N 2 ... Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo. Molecular ...
  https://www.jyi.org/2016-november/2017/2/13/opportunity-for-pharmaceutical-intervention-in-lung-cancer-selective-inhibition-of-jak12-to-eliminate-emt-derived-mesenchymal-cells
*  Adjudin - Wikipedia
"A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose ... The oral dose effective for contraception is so high that there have been side effects in the muscles and liver. Coupling an ... As shown in mature male rats, the agent induces reversible germ cell loss from the seminiferous epithelium by disrupting cell ... which acts by blocking the production of sperm in the testes, but without affecting testosterone production. It is an analogue ...
  https://en.wikipedia.org/wiki/Adjudin
*  Domperidone - Wikipedia
Effects may be seen within 24 hours or may not been seen for 3 or 4 days. The maximum effect occurs after 2 or 3 weeks of ... It blocks dopamine receptors in the anterior pituitary gland increasing release of prolactin which in turn increases lactation ... The drug provides relief from nausea by blocking receptors at the chemoreceptor trigger zone (a location in the nervous system ... Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation ( ...
  https://en.wikipedia.org/wiki/Domperidone
*  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia
... of very low dose glucocorticoid to reduce adrenal androgen production and any of various agents to block the androgen effects ... Blocking the effects and conversions of estrogens will allow use of lower doses of glucocorticoids with less risk of ... in which case excessive adrenal testosterone may reduce testicular production as well as spermatogenesis. Nearly all mammals ... It is possible to reduce the effects of androgens on the body by blocking the receptors with an antiandrogen such as flutamide ...
  https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency
*  ERCC1 - Wikipedia
Interstrand crosslinks block the progression of DNA replication, and structures at blocked DNA replication forks provide ... Mammalian cells with mutant ERCC1-XPF are moderately more sensitive than normal cells to agents (such as ionizing radiation) ... These polymorphisms may have differential effects on platinum and mitomycin damage. ERCC1 protein expression is reduced or ... "DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in ...
  https://en.wikipedia.org/wiki/ERCC1
*  Actin - Wikipedia
This has the effect of impeding the addition or exchange of new G-actin subunits. Depolymerization is encouraged as the (-) ... Some infectious agents use actin, especially cytoplasmic actin, in their life cycle. Two basic forms are present in bacteria: ... Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, ... The crystallization of F-actin was possible due to the use of a rhodamine conjugate that impedes polymerization by blocking the ...
  https://en.wikipedia.org/wiki/Actin