Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord...
Focal microinjection of tetrodotoxin (TTX), a potent voltage-gated sodium channel blocker, reduces neurological deficits and ... Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord ... Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord ... Effects of the Sodium Channel Blocker Tetrodotoxin on Acute White Matter Pathology After Experimental Contusive Spinal Cord ...http://www.jneurosci.org/content/19/14/6122
Frontiers | A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is...
Interestingly, either the presence of the voltage-dependent sodium channel blocker tetrodotoxin (TTX), or the removal of mature ... Interestingly, either the presence of the voltage-dependent sodium channel blocker tetrodotoxi... ... Either the presence of the voltage-dependent sodium channel blocker tetrodotoxin (TTX), or the removal of mature neurons, ... Neuronal Differentiation Induced by AM251 is Reversed by the Voltage-Dependent Sodium Channel Blocker Tetrodotoxin (TTX). Since ...https://www.frontiersin.org/articles/10.3389/fnins.2012.00004/full
Suppression of GABAergic Synaptic Activity in CA1 Pyramidal Neurons Exposed to the Na+-Channel Blocker Tetrodotoxin.. To ... tetrodotoxin. QX-314. N-(2,6-dimethylphenylcarbamoylmethyl) triethylammonium bromide. τd. decay-time constant.. ... 3B). α-BGT also decreased the frequency of PSCs in the presence of the glutamate receptor blockers CNQX (10 μM) and APV (50 μM ... The contribution of nAChRs present on glutamate neurons is limited because glutamate receptor blockers CNQX and APV had no ...http://jpet.aspetjournals.org/content/341/2/500
Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels | Journal of Neuroscience
In axons that were pretreated with the Na+channel blocker tetrodotoxin (TTX; 1 μm) and then injured, we found a complete ... 1999) Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal ... traumatic change in intra-axonal calcium was completely abolished by the application of the sodium channel blocker tetrodotoxin ... Louis, MO), a Na+-Ca2+exchanger blocker, was used at 50 μm(n = 6 at 25°C; n = 3 at 37°C) (Garcia et al., 1988). Calcium-free ...http://www.jneurosci.org/content/21/6/1923
... light-evoked responses were completely blocked by the Na+-channel blocker tetrodotoxin (1 μm; Fig. 2B), indicating that, like ...http://www.jneurosci.org/content/33/15/6454
All solutions used during imaging contained standard ACSF and the sodium channel blocker tetrodotoxin (1 μm). Slices received ... 2 μm tetrodotoxin citrate (TTX), and 1.5× FLIPR calcium assay kit component A (Invitrogen), pH 7.4. Cells were maintained at 37 ... striatal brain slices expressing fluorescent reporters to differentiate D1 and D2 MSNs and in the presence of tetrodotoxin to ...http://www.jneurosci.org/content/31/26/9563
Differential expression of voltage-sensitive K+ and Ca2+ currents in neurons of the honeybee olfactory pathway | Journal of...
... channel blocker tetrodotoxin (TTX, 100 nmol l-1) added. As in Fig. 3, projection neurons showed higher current amplitudes (note ... A) In the presence of tetrodotoxin (TTX) and Cd2+ in the external saline to block currents through voltage-sensitive Na+ and Ca ... To record currents through K+ channels, the standard saline was replaced with one in which tetrodotoxin (TTX, 100 nmol l-1) was ... Addition of the irreversible Ca2+ channel blocker 50 μmol l-1 CdCl2 (Cd2+) to the bath solution had little effect on K+ ...http://jeb.biologists.org/content/206/1/117
Paul Buckmaster, DVM, PhD | Stanford Medicine Profiles
In some brain regions, prolonged application of the sodium channel blocker tetrodotoxin prevents axon sprouting and posttrauma ... Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats EPILEPSIA Buckmaster, P. S. ... Tetrodotoxin-infused and vehicle-infused hippocampi displayed similar levels of hilar neuron loss. The Timm stain revealed ... The average frequency of mEPSCs of mossy cells recorded in the presence of tetrodotoxin and bicuculline was 3.2-times higher in ...https://med.stanford.edu/profiles/paul-buckmaster
Patente US6051422 - Hybrid biosensors - Google Patentes
The addition of the sodium channel blocker tetrodotoxin (TTX) resulted in qualitatively different responses from different ... single electrode impedances were monitored over time as the highly specific blocker of voltage gated Na+ channels tetrodotoxin ... that respond to a variety of ion channel blockers. However, it is to be understood that many different types of cells are ...http://www.google.es/patents/US6051422
Newts of the genus Taricha possess the sodium channel blocker tetrodotoxin (TTX), which is lethal to most predators. Garter ...http://www.nescent.org/media/NABTSymposium2010.php.html
This possibility seems unlikely, however, because prolonged infusion of the sodium channel blocker tetrodotoxin, which reduces ... 2004b) Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats. Epilepsia 45:452- ... 2000) L-type Ca2+ channel blocker inhibits mossy fiber sprouting and cognitive deficits following pilocarpine seizures in ... inhibited neural activity with tetrodotoxin (Buckmaster, 2004b), blocked protein synthesis with cycloheximide around the time ...http://www.jneurosci.org/content/29/25/8259
British Library EThOS: Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells :...
... blockers of persistent current (INaP) (ranolazine and riluzole). In addition, a specific VGSC blocker, tetrodotoxin (TTX), was ... blocker on nNav1.5 mRNA and protein expression and metastatic cell behaviours (MCBs); (2) to determine the effects of hypoxia ... Two classes of blocker were used: a) Local anaesthetics (lidocaine and procaine) and (b) ... Treatment for 24 h with INaP blockers; ranolazine and riluzole under hypoxia reduced lateral motility, transverse migration and ...http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539266
... channel blocker tetrodotoxin (TTX; 1 μm) produced cell depolarization comparable to that induced by the application of 500 μm l ... 6E). Application of the lipophilic NMDA channel blocker MK-801 (2 μm) (Wong and Kemp, 1991; Yu and Salter, 1998; Dingledine et ... The recorded currents were abolished by the bath application of the lipophilic NMDA channel blocker MK-801 (2 μm), confirming ...http://www.jneurosci.org/content/25/1/139
... as the intraocular application of the sodium channel blocker tetrodotoxin disrupts this process (Cramer and Sur, 1997a). ... 1988) Prenatal tetrodotoxin infusion blocks segregation of retinogeniculate afferents. Science 242:87-89. ... 1988) Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin. Nature 336:468-471. ...http://www.jneurosci.org/content/21/11/3871
Infantile Spasm (West Syndrome): Background, Etiology, Epidemiology
The model uses a sodium channel blocker, tetrodotoxin (TTX), that is infused into the hippocampus of rodents. This infusion has ...https://emedicine.medscape.com/article/1176431-overview
OSA | Label-free optical detection of action potential in mammalian neurons
... both were blocked by application of a Na-channel blocker, Tetrodotoxin. The observed transient change in optical path length in ... T. Narahashi, J. W. Moore, and W. R. Scott, "Tetrodotoxin blockage of sodium conductance increase in lobster giant axons," J. ... T. Narahashi, J. W. Moore, and W. R. Scott, "Tetrodotoxin blockage of sodium conductance increase in lobster giant axons," J. ... T. Narahashi, J. W. Moore, and W. R. Scott, "Tetrodotoxin blockage of sodium conductance increase in lobster giant axons," J. ...https://www.osapublishing.org/boe/abstract.cfm?URI=boe-8-8-3700
Frontiers | Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders | Physiology
... the INa blocker tetrodotoxin (100 nM) substantially reduced both atrial and ventricular AP upstroke velocity in intact adult ... 2010) observed no effect of the IKs blocker HMR1556 on membrane currents, suggesting that IKs is absent in zebrafish myocytes. ... Using patch-clamp analysis and specific ion channel blockers, the presence and function of various inward and outwardly ... T blockers on zebrafish AP configuration has not yet been investigated, and the functional relevance of ICa,T in zebrafish ...https://www.frontiersin.org/articles/10.3389/fphys.2012.00255/full
Repositorio da Producao Cientifica e Intelectual da Unicamp: Effect of Tityus serrulatus scorpion venom on the rabbit isolated...
6 The sodium channel blocker tetrodotoxin (TTX; 1 mu M) abolished the relaxations of the rabbit isolated corpus cavernosum ... Tetrodotoxin (1 mu M) also promptly reversed the response to the venom when infused during the relaxation phase. 7 The bioassay ... Similarly, the Kt channel blocker tetraethylammonium (TEA; 10 mu M) had no effect on the venom-induced relaxations. 5 Capsaicin ...http://repositorio.unicamp.br/jspui/handle/REPOSIP/63987
Both components were eliminated by the voltage-gated Na+ and Ca2+ channel blockers tetrodotoxin (TTX) and cadmium, respectively ... Consistent with our earlier findings, the HCN-channel blocker ZD7288 (50 μm) had no effect on the amplitude of the third ... By contrast, a mixture of pharmacological blockers of D1-type and D2-type dopamine receptors (SCH23390 plus SKF82566 plus ... both of which were blocked by the HCN channel blocker ZD7288 (50 μm; C). D, E, Population perievent spike histograms of average ...http://www.jneurosci.org/content/34/25/8557
JCI - Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders
... and voltage dependence and can also be defined by their sensitivity to the voltage-gated sodium-channel blocker tetrodotoxin ( ... Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc. Natl. Acad. Sci. U. S. A. 93:1108-1112 ... This is in contrast with Nav1.8, which is also present within DRG neurons but is fairly resistant to tetrodotoxin. Nav1.7 ... PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP- ...https://www.jci.org/articles/view/33297
Vivianne Tawfik, MD, PhD | Stanford Medicine Profiles
The glutamate release was still evoked in the presence of the Na channel blocker tetrodotoxin, but was eliminated with the ...https://med.stanford.edu/profiles/vivianne-tawfik
The sodium channel blocker tetrodotoxin (TTX), at 1 μm, completely eliminated the nicotine-induced current spikes when exposure ... Tetrodotoxin (TTX) blocked the action potentials but not the inward currents. α-Bungarotoxin blocked both, consistent with the ...http://www.jneurosci.org/content/17/15/5798
Frontiers | Early hypersynchrony in juvenile PINK1−/− motor cortex is rescued by antidromic stimulation | Frontiers in Systems...
The voltage-sensitive sodium channel blocker tetrodotoxin (TTX, 1 µM) or the calcium channels blocker Cd2+ (200 µM) blocked all ... cortico-subthalamic connection by recording antidromic spikes in M1 pyramidal neurons in the continuous presence of blockers of ...https://www.frontiersin.org/articles/10.3389/fnsys.2014.00095/full
Frontiers | Developmental Profile of Ion Channel Specializations in the Avian Nucleus Magnocellularis | Frontiers in Cellular...
Isolated KV currents were recorded in the presence of the NaV blocker tetrodotoxin (TTX, 1 μM) and isolated NaV currents were ... DTx is a potent and selective blocker of KV1.1 and KV1.2-containing K+LVA channels. Bath application of Flx, the K+HVA channel ... Flx is a potent KV3.1-containing K+HVA channel blocker. Scale bar values are 2000 pA/20 ms. Data obtained during drug ... Dendrotoxin (DTx, 0.1 μM), a potent blocker of Kv1.1, Kv1.2-containing K+LVA channels, was bath applied to characterize the ...https://www.frontiersin.org/articles/10.3389/fncel.2016.00080/full
Frontiers | Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticity | Frontiers in Cellular...
... that the impairment of synaptic activity by preventing action potential firing with the sodium channel blocker tetrodotoxin ( ...https://www.frontiersin.org/articles/10.3389/fncel.2014.00300/full