*  Threonine - Wikipedia
Enzymes involved in a typical biosynthesis of threonine include: aspartokinase β-aspartate semialdehyde dehydrogenase ... homoserine dehydrogenase homoserine kinase threonine synthase. Threonine is metabolized in two ways: In many animals it is ... In humans the gene for threonine dehydrogenase is an inactive pseudogene, so threonine it is converted to α-ketobutyrate. The ... "dl-Threonine". Organic Syntheses. 20: 101. ; Collective Volume, 3, p. 813 . Threonine biosynthesis CID 205 CID 6288. ...
  https://en.wikipedia.org/wiki/Threonine
*  Homoserine dehydrogenase - Wikipedia
Mammals lack the enzymes involved in the aspartate metabolic pathway, including homoserine dehydrogenase. As lysine, threonine ... "Lysine and threonine biosynthesis in sorghum seeds: characterisation of aspartate kinase and homoserine dehydrogenase ... Homoserine is an intermediate in the biosynthesis of threonine, isoleucine, and methionine. The enzyme can be found in a ... Other names in common use include HSDH, and HSD. Homoserine dehydrogenase catalyses the third step in the aspartate pathway; ...
  https://en.wikipedia.org/wiki/Homoserine_dehydrogenase
*  hom - Homoserine dehydrogenase - Mycobacterium leprae (strain TN) - hom gene & protein
Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis, Methionine biosynthesis, Threonine ... It always involves more than one amino acid and includes all residues involved in nucleotide-binding.,p>,a href='/help/np_bind ... Homoserine dehydrogenase (hom). This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is ... Threonine synthase (thrC). This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid ...
  http://www.uniprot.org/uniprot/P46806
*  On the origin and evolution of biosynthetic pathways: integrating microarray data with structure and organization of the Common...
... or homoserine by homoserine dehydrogenase (HD, encoded by hom). Homoserine can be then channeled towards threonine and/or ... In addition to ask, asd and hom genes, the other two genes involved in threonine biosynthesis (thrB and thrC) are scattered on ... The asd genes were not included in Figure 2, since just one copy of this gene was retrieved from the 58 proteobacteria. The ... Patte JC: Biosynthesis of threonine and lysine. In Escherichia coli and Salmonella typhimurium. Edited by: Neidhardt FC. ASM ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-S1-S12
*  KEGG SSDB Best Search Result: mmu:67956
fsy:FsymDg_3859 homoserine kinase K00872 391 104 ( -) 30 0.467 45 -, 1 gan:UMN179_00306 lipopolysaccharide biosynthesis protei ... cbab:SMCB_0269 NTP pyrophosphohydrolase including oxida 211 103 ( -) 29 0.317 82 -, 1 cmb:CSW64_11555 pyruvate dehydrogenase ... plh:VT85_14280 Serine/threonine-protein kinase pkn1 597 103 ( 1) 29 0.324 71 -, 2 ssg:Selsp_0804 DEAD/DEAH box helicase domain ... vfl:AL536_18645 malate dehydrogenase K00024 310 103 ( -) 29 0.344 90 -, 1 vil:CFK37_11750 peptide chain release factor 3 K02837 ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=mmu:67956
*  Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli | BMC Genomics | Full...
Other associations that were conserved included that with the gdh gene (encoding glutamate dehydrogenase) and the citBZ-icd ... L-homoserine + ATP , = , O-phosphohomoserine + ADP O-phosphohomoserine + H2O , = , threonine + P. ilvA: threonine , = , 2- ... The citB-citZ-idh operon has been shown to be essential for glutamate biosynthesis in S. mutans[24]. ... Glu dehydrogenase (gdh; [31, 32]), 3-hydroxybutyrate dehydrogenase (bdh[33, 34]), high affinity (HA) and low affinity (LA) ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-191
*  Metabolism of halophilic archaea | SpringerLink
Enzyme genes for threonine biosynthesis from l-aspartate semialdehyde via l-homoserine and O-phospho-l-homoserine are present ... Proline might be synthesized via 1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.2) and proline dehydrogenase (EC 1.5.99.8, ... 2008), because current knowledge of enzyme variants, domain rearrangements, and enzyme substrate specifities has been included ... haloarchaea might synthesize homocysteine from homoserine via O-acetyl-l-homoserine (but not via O-succinyl-l-homoserine). This ...
  https://link.springer.com/article/10.1007%2Fs00792-008-0138-x
*  期刊界 All Journals 搜尽天下杂志 传播学术成果 专业期刊搜
Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: Redirecting carbon ... has been achieved by amplification of genes which encode feedback resistant aspartokinase and homoserine dehydrogenase ( ... The lack of a direct link between macrophytes and higher trophic levels is due to the faunal composition, including a lack of ... Abstract Threonine and lysine are two of the economically most important essential amino acids. They are produced industrially ...
  http://biosci.alljournals.cn/search.aspx?subject=biological_science&major=&orderby=referenced&field=key_word&q=carbon+flow&encoding=utf8
*  Protocols and Video Articles Authored by Feng Geng
The accomplishment of pathway from homoserine to PDO is achieved by protein engineering of glutamate dehydrogenase (GDH) and ... Only 10 laboratory steps mediate the conversion of diisopropyl squarate to (+/-)-hypnophilin (8). Key reactions include a ... we present a de novo route for the biosynthesis of PDO from sugar, which may overcome the mentioned limitations by expanding ... calmodulin-dependent serine/threonine protein phosphatase. In this study, we demonstrate that extracellular CnB was effectively ...
  https://www.jove.com/author/Feng_Geng
*  METHODS FOR TREATING OR PREVENTING VASCULAR GRAFT FAILURE - Patent application
These enzymes include galactokinase (EC 2.7.1.6); mevalonate kinase (EC 2.7.1.36); homoserine kinase (EC 2.7.1.39); L- ... These enzymes include protein kinase (histidine kinase) (EC 2.7.1.37); [pyruvate dehydrogenase (lipoamide)] kinasc (EC 2.7.1.99 ... 0112] 1) Alanine (A), Serine (S), Threonine (T); [0113] 2) Aspartic Acid (D), Glutamic Acid (E); [0114] 3) Asparagine (N), ... 0088] A new approach to inhibit both activation of the p38MAPK-MK2-HSPB1 pathway and the biosynthesis of inflammatory cytokines ...
  http://www.patentsencyclopedia.com/app/20130115256
*  KEGG SSDB Best Search Result: dpo:Dpse GA28780
sct:SCAT_5726 Putative serine/threonine protein kinase 391 104 ( -) 30 0.500 36 -, 1 scy:SCATT_57260 putative serine/threonine ... lagg:B0E33_05625 ubiquinone biosynthesis protein 353 103 ( -) 29 0.321 78 -, 1 lap:ACP90_22195 ubiquinone biosynthesis protein ... vap:Vapar_3831 succinate-semialdehyde dehydrogenase (NA K15515 479 107 ( -) 30 0.306 108 -, 1 aka:TKWG_02680 long-chain-fatty- ... hlc:CHINAEXTREME05555 O-acetyl-L-homoserine sulfhydrola K01740 473 101 ( -) 29 0.364 66 -, 1 kna:B0W47_02730 glutamate-- ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=dpo:Dpse_GA28780
*  Amino acid synthesis - Wikipedia
The biosynthesis of threonine is regulated via allosteric regulation of its precursor, homoserine, by structurally altering the ... threonine and methionine. There are two bifunctional aspartokinase/homoserine dehydrogenases, ThrA and MetL, in addition to a ... The feedback inhibition of GS is due to a cumulative feedback due to several metabolites including L-tryptophan, L-histidine, ... High levels of threonine result in low levels of homoserine synthesis. The synthesis of aspartate kinase (AK), which catalyzes ...
  https://en.wikipedia.org/wiki/Amino_acid_synthesis
*  Methionine - Wikipedia
This step is shared with threonine biosynthesis. In most organisms, an acetyl group is used to activate the homoserine. This ... Aspartokinase Aspartate-semialdehyde dehydrogenase Homoserine dehydrogenase Homoserine O-transsuccinylase Cystathionine-γ- ... In the mitochondrial genome of several organisms, including metazoa and yeast, the codon AUA also encodes for methionine. In ... Homoserine is the branching point with the threonine pathway, where instead it is isomerised after activating the termainal ...
  https://en.wikipedia.org/wiki/Methionine
*  Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesis | Molecular Systems Biology
... threonine or l‐allo‐threonine contained 30 U ml−1 yeast alcohol dehydrogenase. Assays with 4HT contained 500 U ml−1 yeast ... Hama H, Kayahara T, Tsuda M, Tsuchiya T (1991) Inhibition of homoserine dehydrogenase I by L‐serine in Escherichia coli. J ... threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis. FEBS Lett 318: 125-128. ... In such cases, further genetic changes, including gene duplications, insertions or deletions, and point mutations, can result ...
  http://msb.embopress.org/content/6/1/436
*  Strand-specific transcriptomes of Enterohemorrhagic Escherichia coli in response to interactions with ground beef microbiota:...
... including NO [58, 59]. These RNSs can interact with and damage numerous targets, including tyrosine residues, thiols and ... dehydrogenase, GlpA, was also repressed in O2621765 (Table 1). Under anaerobic conditions, G3P dehydrogenase GlpA converts G3P ... methionine biosynthesis, transport or regulation (metBELQNR), biosynthesis of glutamate (gltD), lysine (lysA), and arginine ( ... Characterization of a luxI/luxR-type quorum sensing system and N-acyl-homoserine lactone-dependent regulation of exo-enzyme and ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3957-2
*  Network Portal - Gene BSU00090
threonine synthase (RefSeq). 42, 192. BSU32260. hom. homoserine dehydrogenase (RefSeq). 42, 192. ... 2-deoxy-D-gluconate 3-dehydrogenase (RefSeq). 150, 168. BSU22750. ubiE. ubiquinone/menaquinone biosynthesis methyltransferase ( ... These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its ... IMP dehydrogenase/GMP reductase. cog/ cog. GMP reductase activity. go/ molecular_function. IMP dehydrogenase activity. go/ ...
  http://networks.systemsbiology.net/bsu/gene/BSU00090
*  Morpheein - Wikipedia
Ogilvie, JW; Vickers, LP; Clark, RB; Jones, MM (1975). "Aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12 ( ... "Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate ... In light of the discovery of morpheeins, however, this definition could be expanded to include mutations that shift an ... Saeki, Y; Ito, S; Shizuta, Y; Hayaishi, O; Kagamiyama, H; Wada, H (1977). "Subunit structure of biodegradative threonine ...
  https://en.wikipedia.org/wiki/Morpheein
*  Transcription profile of Trichophyton rubrum conidia grown on keratin reveals the induction of an adhesin-like protein gene...
Internal control probes were included in addition to the functional genes of T. rubrum. The arrays were washed according to the ... which is characterized by a 188-amino acid serine/threonine/proline-rich N-terminus followed by a large, variable, six-amino ... These targets may be involved in the establishment and maintenance of fungal infection, and they may include genes that ... The modulated genes were related to the dormancy, survival and germination of conidia, including genes involved in the ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2567-8
*  KEGG SSDB Best Search Result: mhi:Mhar 2265
miu:ABE85_05935 homoserine dehydrogenase K00003 352 109 ( 9) 31 0.327 110 -, 2 mop:Mesop_6218 S-adenosylmethionine synthetase ... aer:AERYTH_14590 cobalamin biosynthesis protein CobQ K02232 504 105 ( -) 30 0.347 98 -, 1 bbag:E1O_09910 peptidase M23B K06194 ... mrb:Mrub_1066 diguanylate cyclase and serine/threonine 609 104 ( -) 30 0.353 51 -, 1 mre:K649_04975 diguanylate cyclase and ... rmu:RMDY18_03680 Zn-dependent hydrolase including glyox 322 112 ( -) 31 0.320 103 -, 1 rpe:RPE_0024 gamma-glutamyltransferase ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=mhi:Mhar_2265
*  Transporter Classification Database - Wikipedia
Family 2.A.76 The Resistance to Homoserine/Threonine (RhtB) Family 2.A.77 The Cadmium Resistance (CadD) Family 2.A.78 The ... Family 3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family Bacteriorhodopsin-like proteins including rhodopsin (see ... Family 1.A.104 The Proposed Flagellar Biosynthesis Na+ Channel, FlaH (FlaH) Family 1.A.105 The Mixed Lineage Kinase Domain-like ... and succinate dehydrogenase. See electron transport chain. 3.D.1 The H+ or Na+-translocating NADH Dehydrogenase ("complex I") ...
  https://en.wikipedia.org/wiki/Transporter_Classification_Database
*  KEGG SSDB Best Search Result: sbh:SBI 07687
myc:NF90_16440 homoserine dehydrogenase K00003 434 111 ( 6) 31 0.304 148 -, 2 mys:NF92_16435 homoserine dehydrogenase K00003 ... ccr:CC_3106 threonine aldolase 369 111 ( 9) 31 0.302 106 -, 3 ccs:CCNA_03204 alanine racemase 402 111 ( 9) 31 0.302 106 -, 3 ... ngg:RG540_PA16680 Lipopolysaccharide biosynthesis prote 356 108 ( -) 30 0.306 98 -, 1 npe:Natpe_0818 Lhr-like helicase K03724 ... smeg:C770_GR4Chr3240 Acetyltransferase, including N-ace 195 102 ( -) 29 0.308 107 -, 1 smel:SM2011_c03774 Putative ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=sbh:SBI_07687
*  Production of (S)-2-aminobutyric acid and (S)-2-aminobutanol in Saccharomyces cerevisiae | Microbial Cell Factories | Full Text
... l-threonine by l-threonine deaminase and a NADH-regeneration system based on l-leucine dehydrogenase and formate dehydrogenase ... l-homoserine, and O-phospho-l-homoserine [29]. It is known that l-threonine inhibits aspartate kinase activity in S. cerevisiae ... an enzyme involved in threonine biosynthesis in yeast, elevated (S)-2-aminobutyric acid biosynthesis to above 0.49 mg/L in ... Yeasts that did not express the pathway enzymes were included as control. b EcGDH' for the second step of the pathway was ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0667-z
*  Biological Synthesis of Difunctional Hexanes and Pentanes from Carbohydrate Feedstocks - Patent application
0278] Other alcohol dehydrogenases include but are not limited to adhA or adhB (from Z. mobilis), butanol dehydrogenase (from ... Enzymes involves in the lysine biosynthesis include (Lehninger, A. L., D. L. Nelson, and M. M. Cox. 2000. Lehninger Principles ... homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methyl-malonyl-CoA mutase. [0207] As ... In the pathways that belong to the diaminopimelate group, lysine is produced from aspartate (along with methionine, threonine ...
  http://www.patentsencyclopedia.com/app/20130017593
*  PRODUCTION OF 1,4 BUTANEDIOL IN A MICROORGANISM - MICROBIA, INC.
The method includes: (a) conversion of L-glutamate to L-glutamate 5- phosphate; (b) conversion of L-glutamate 5 -phosphate to L ... In certain cases where the oxidoreductase is a wild-type homoserine dehydrogenase negatively regulated by threonine or another ... including certain homoserine dehydrogenases [EC 1.1.1.3] represented by the Genbank GI numbers in FIGURE IB and the ... Pro line biosynthesis in many bacteria is subject to feedback inhibition of ProB, the gene encoding glutamate 5-kinase. ...
  http://www.sumobrain.com/patents/wipo/Production-14-butanediol-in-microorganism/WO2010085731.html
*  Microorganisms Comprising Enzymes Express with Low Gamma-Elimination Activity - Patent application
... branch point between methionine and threonine/isoleucine biosynthesis lies at the level of phosphohomoserine. Homoserine is ... homoserine dehydrogenase/aspartokinase, 1786183), preferably with reduced feed-back sensitivity, metL (homoserine dehydrogenase ... Methods used to transform microorganisms are well known, including homologous recombination. [0035]It is known that plant ... homoserine by a sequence of three reactions. Homoserine can subsequently enter the threonine/isoleucine or methionine ...
  http://www.patentsencyclopedia.com/app/20080286840