*  Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors | Circulation
Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol. 1990;30:535-560. ... Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors. Am J Med. 1989; ... Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors. Ulrich Laufs, Vito La Fata, Jorge Plutzky, ... Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors. Ulrich Laufs, Vito La Fata, Jorge Plutzky ...
  http://circ.ahajournals.org/content/97/12/1129
*  SA RS04780 - AureoWiki
MetabolismFatty acid and phospholipid metabolismBiosynthesisputative hydroxymethylglutaryl-CoA synthase (TIGR00748; EC 2.3.3.10 ... hydroxymethylglutaryl-CoA synthase (TIGR01835; EC 2.3.3.10; HMM-score: 32.4) MetabolismFatty acid and phospholipid metabolism ... hydroxymethylglutaryl-CoA synthase (TIGR01833; EC 2.3.3.10; HMM-score: 18.2) Cellular processesCellular processesSporulation ... HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal (PF01154; HMM-score: 19.1) ...
  http://aureowiki.med.uni-greifswald.de/SA_RS04780
*  SAOUHSC 02860 - AureoWiki
MetabolismFatty acid and phospholipid metabolismBiosynthesisputative hydroxymethylglutaryl-CoA synthase (TIGR00748; EC 2.3.3.10 ... hydroxymethylglutaryl-CoA synthase (TIGR01835; EC 2.3.3.10; HMM-score: 531.4) hydroxymethylglutaryl-CoA synthase (TIGR01833; EC ... and IsoprenoidsIsoprenoidsArchaeal lipids Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) IsoprenoidsIsoprenoid Biosynthesis ... Hydroxymethylglutaryl-coenzyme A synthase C terminal (PF08540; HMM-score: 96.8) HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme ...
  http://aureowiki.med.uni-greifswald.de/SAOUHSC_02860
*  Molecules | Free Full-Text | Characterization, Function, and Transcriptional Profiling Analysis of 3-Hydroxy-3-methylglutaryl...
... enzymes in the mevalonate pathway as it catalyzes the condensation of acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA. ... 3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is one of the rate-limiting ... a gene encoding hydroxymethylglutaryl-CoA synthase from Ganoderma lucidum (Ling-zhi) in ganoderic acid biosynthesis pathway. ... As a major rate-limiting enzyme in the terpenoid biosynthesis, HMGS converts acetoacetyl-CoA into HMGS-CoA in the MVA pathway. ...
  http://www.mdpi.com/1420-3049/22/10/1706/htm
*  Hydroxymethylglutaryl-CoA synthase - Wikipedia
HMG-CoA). It is the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in ... In molecular biology, Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the ... hydroxymethylglutaryl coenzyme A synthase, and hydroxymethylglutaryl coenzyme A-condensing enzyme. HMG-CoA synthase contains an ... 3-hydroxy-3-methylglutaryl-coenzyme A synthase, beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, acetoacetyl ...
  https://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase
*  hmgr-1 - 3-hydroxy-3-methylglutaryl coenzyme A reductase - Caenorhabditis elegans - hmgr-1 gene & protein
... hydroxymethylglutaryl-CoA reductase (NADPH) activity, isoprenoid biosynthetic process, sterol biosynthetic process ... Hydroxymethylglutaryl-CoA synthase (hmgs-1). *3-hydroxy-3-methylglutaryl coenzyme A reductase (hmgr-1) ... mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis. ... IPR023074. HMG_CoA_Rdtase_cat_sf. IPR023076. HMG_CoA_Rdtase_CS. IPR004554. HMG_CoA_Rdtase_eu_arc. IPR023282. HMG_CoA_Rdtase_N. ...
  http://www.uniprot.org/uniprot/Q19207
*  Recombinant Human HMGCS2 protein (ab114900) | Abcam
Hydroxymethylglutaryl CoA synthase. *Hydroxymethylglutaryl CoA synthase mitochondrial. *Hydroxymethylglutaryl-CoA synthase. * ... Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. ... This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. ... Defects in HMGCS2 are the cause of HMG-CoA synthase deficiency (HMGCS deficiency) [MIM:605911]; also known as deficiency of ...
  http://www.abcam.com/recombinant-human-hmgcs2-protein-ab114900.html
*  重组人HMGCS1蛋白(ab114524)| Abcam中国
HMG-CoA synthase. *HMGCS. *HMGCS1. *Hydroxymethylglutaryl CoA synthase, cytoplasmic. *Hydroxymethylglutaryl-CoA synthase ... Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. ... This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. ...
  http://www.abcam.cn/recombinant-human-hmgcs1-protein-ab114524.html
*  Most recent papers with the keyword squalene | Read by QxMD
... a key precursor of triterpenoid biosynthesis. In the present study, T. wilfordii squalene synthase (TwSQS) was cloned followed ... determined that FaNES1 directed to the ER via fusion to the transmembrane domain of squalene synthase or hydroxymethylglutaryl ... CoA reductase displayed significant improvements in terms of transcript levels, protein accumulation, and volatile production ... Squalene synthase of Alisma orientale catalyzes farnesyl diphosphate (FPP) to form squalene, which is the key regulatory enzyme ...
  https://www.readbyqxmd.com/keyword/52905
*  The genome of the basal agaricomycete Xanthophyllomyces dendrorhous provides insights into the organization of its acetyl-CoA...
CoA-related pathways. The two major acetyl-Co A derived biosynthesis pathways in X. dendrorhous are terpenoid and fatty acid ... Hydroxymethylglutaryl-CoA synthase. XDEN_03265. 59% Cr.n.; 57% Rh.t.. HMG1 ... Figure 4A shows the biosynthesis pathway to these fatty acids catalyzed by type I FAS. The synthesis starts with the acetyl CoA ... geranylgeranyl pyrophosphate synthase [19] and farnesyl pyrophosphate synthase [20] have been cloned before from X. dendrorhous ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1380-0
*  KEGG SSDB Best Search Result: dmo:Dmoj GI19680
nev:NTE_01316 hydroxymethylglutaryl-CoA synthase K01641 466 100 ( -) 29 0.309 94 -, 1 pace:A6070_00500 DNA gyrase subunit B ... strm:M444_20220 menaquinone biosynthesis protein K11782 287 102 ( -) 29 0.354 99 -, 1 svu:B1H20_20895 menaquinone biosynthesis ... att:AMQ28_08310 N-acetylglutamate synthase K14682 450 107 ( -) 30 0.323 93 ,-, 1 bif:N288_00245 16S rRNA methyltransferase ... sso:SSO2306 Cobalamin biosynthesis precorrin-3 methylas K05934 250 133 ( -) 36 0.337 95 ,-, 1 ssoa:SULA_0114 cobalt-precorrin- ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=dmo:Dmoj_GI19680
*  Indian Patents. 256966:'A COMPOUND OF FORMLAR (I)'
"HMG-CoA synthase inhibitor" as used herein, unless otherwise stated, refers to a compound which inhibits the biosynthesis of ... hydroxymethylglutaryl-coenzyme A from acetyl-coenzyme A and acetoacetyl-coenzyme A, catalyzed by the enzyme HMG-CoA synthase. ... especially HMG-CoA reductase inhibitors and HMG-CoA synthase inhibitors, HMG-CoA reductase gene expression inhibitors, CETP ... Any HMG-CoA synthase inhibitor may be used as the second compound in the combination therapy aspect of this invention. The term ...
  http://www.allindianpatents.com/patents/256966-a-compound-of-formlar-i
*  KEGG PATHWAY: sui00900
Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]. SSUJS14_1612 3-hydroxy-3-methylglutaryl CoA synthase [KO:K01641] [EC:2.3 ... Terpenoid backbone biosynthesis - Streptococcus suis JS14. Description. Terpenoids, also known as isoprenoids, are a large ... hydroxymethylglutaryl-CoA reductase [KO:K00054] [EC:1.1.1.88]. SSUJS14_0275 mevalonate kinase [KO:K00869] [EC:2.7.1.36] ... geranylgeranyl pyrophosphate synthase [KO:K13789] [EC:2.5.1.29 2.5.1.10 2.5.1.1] ...
  http://www.genome.jp/dbget-bin/www_bget?pathway+sui00900
*  KEGG PATHWAY: efu00900
hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]. HMPREF0351_11072 acetyl-CoA acetyltransferase [KO:K00054] [EC:1.1 ... Terpenoid backbone biosynthesis - Enterococcus faecium DO. Description. Terpenoids, also known as isoprenoids, are a large ... dxs; 1-deoxy-D-xylulose-5-phosphate synthase [KO:K01662] [EC:2.2.1.7] ...
  http://www.genome.jp/dbget-bin/www_bget?pathway+efu00900
*  Light-dependent regulation of carotenoid biosynthesis in plants
IPP is synthesized from 3 molecules of acetyl CoA by the enzyme hydroxymethyl glutaryl CoA reductase (HMGR). IPP molecules ... Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-D-xyhilose 5-phosphate synthase. Plant 122: ... Modulation of carotenoid biosynthesis during tomata fruit ripening through phytochrome regulation of phytoene synthase activity ... Biosynthesis of carotenoids in plants. Until the 1960's, research in carotenoid biosynthesis had been centered on ...
  http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202009000200001&lng=es&nrm=iso&tlng=en
*  KEGG SSDB Best Search Result: mhi:Mhar 2265
vfl:AL536_05245 hydroxymethylglutaryl-CoA lyase K01640 309 101 ( -) 29 0.309 97 -, 1 vma:VAB18032_27591 hypothetical protein ... aer:AERYTH_14590 cobalamin biosynthesis protein CobQ K02232 504 105 ( -) 30 0.347 98 -, 1 bbag:E1O_09910 peptidase M23B K06194 ... rir:BN877_I2896 cobyric acid synthase K02232 485 107 ( 5) 30 0.311 122 -, 2 rpj:N234_33745 hypothetical protein 699 107 ( 7) 30 ... chn:A605_13620 phenylacetate-CoA ligase K01912 437 103 ( -) 29 0.320 153 -, 1 coa:DR71_735 glycine oxidase ThiO K03153 403 103 ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=mhi:Mhar_2265
*  Peroxisome Proliferator-Activated Receptor Alpha Target Genes
... α null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression," FEBS Letters, vol. 475, no. 3 ... regulates bile acid biosynthesis," Journal of Biological Chemistry, vol. 275, no. 37, pp. 28947-28953, 2000. View at Google ... Additionally, synthesis of ketone bodies via mitochondrial HMG-CoA synthase (Hmgcs2) and HMG-CoA lyase (Hmgcl) is governed by [ ... "Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene ...
  https://www.hindawi.com/journals/ppar/2010/612089/
*  The Toxoplasma Blog: December 2010
Lovastatin and compactin, both inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase in the mevalonate pathway, ... Sterol biosynthesis inhibitors, however, have a demonstrated anti-Toxoplasma effect. In this study, we examined the host ... Parasite growth was also suppressed by squalestatin, an inhibitor of squalene synthase, despite mevalonate producing isoprenoid ... New insights into the apicoplast fatty acid biosynthesis pathway and some novel roles of the apicoplast in vaccine development ...
  http://toxoplasmaparasite.blogspot.com/2010/12/
*  SACOL1355 - AureoWiki
hydroxymethylglutaryl-CoA synthase [1] (data from MRSA252). ⊟Localization[edit source , edit]. *PSORTb: Cytoplasmic*Cytoplasmic ... pyridoxal biosynthesis lyase PdxS [1] (data from MRSA252). SACOL0914. FeS assembly ATPase SufC [1] (data from MRSA252). ... succinyl-CoA synthetase subunit beta [1] (data from MRSA252). SACOL0626. (thiD1). phosphomethylpyrimidine kinase [1] (data from ...
  http://aureowiki.med.uni-greifswald.de/SACOL1355
*  KEGG PATHWAY: mfu00900
putative hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]. LILAB_29495 hydroxymethylglutaryl-CoA synthase [KO: ... Terpenoid backbone biosynthesis - Myxococcus fulvus. Description. Terpenoids, also known as isoprenoids, are a large class of ... geranylgeranyl diphosphate synthase [KO:K13789] [EC:2.5.1.29 2.5.1.10 2.5.1.1] ... 1-deoxy-D-xylulose-5-phosphate synthase [KO:K01662] [EC:2.2.1.7] ... of solanesyl and decaprenyl diphosphate synthases in mice and ...
  http://www.genome.jp/dbget-bin/www_bget?pathway+mfu00900
*  Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes | BMC Genomics | Full Text
Genes involved in cholesterol biosynthesis on the other hand, such as those encoding lanosterol synthase (Lss), sterol-C4- ... hydroxymethylglutaryl-CoA reductase), a gene targeted by drugs such as statins for lowering cholesterol. The fold change ... and hydroxyacyl-CoA dehydrogenases (Hadhb, Hadhsc). (B) Genes down-regulated in the liver cholesterol biosynthesis pathway. ... and 3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1) were down-regulated (Figure 3B). In this pathway, besides those ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-12-432
*  SAUSA300 2240 - AureoWiki
hydroxymethylglutaryl-CoA synthase [1] (data from MRSA252). ⊟Localization[edit source , edit]. *PSORTb: Cytoplasmic*Cytoplasmic ... MetabolismPurines, pyrimidines, nucleosides, and nucleotidesPyrimidine ribonucleotide biosynthesisdihydroorotase, ... acetyl-CoA carboxylase biotin carboxylase subunit [1] (data from MRSA252). SAUSA300_1657. (ackA). acetate kinase [1] (data from ... carbamoyl phosphate synthase large subunit [1] (data from MRSA252). SAUSA300_2477. (cidC). pyruvate oxidase [1] (data from ...
  http://aureowiki.med.uni-greifswald.de/SAUSA300_2240
*  KEGG SSDB Best Search Result: vap:Vapar 1945
avd:AvCA6_49510 hydroxymethylglutaryl-CoA lyase K01640 300 106 ( 4) 30 0.317 104 -, 2 avl:AvCA_49510 hydroxymethylglutaryl-CoA ... rsm:CMR15_11564 chorismate synthase K01736 366 103 ( -) 29 0.307 88 -, 1 rxy:Rxyl_2368 short chain enoyl-CoA hydratase K01715 ... ster:AOA14_17005 thiamine biosynthesis protein ApbE K03734 315 113 ( -) 32 0.355 124 -, 1 adk:Alide2_1628 Methylcrotonoyl-CoA ... 0293 hydroxymethylglutaryl-CoA reductase, d K00054 429 103 ( -) 29 0.323 96 -, 1 dts:BI380_23315 hydroxymethylglutaryl-CoA ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=vap:Vapar_1945
*  Human Metabolome Database: Showing metabocard for TG(16:1(9Z)/18:1(9Z)/20:4(5Z,8Z,11Z,14Z)) (HMDB0005441)
Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase ... De Novo Triacylglycerol Biosynthesis TG(16:1(9Z)/18:1(9Z)/20:4(5Z,8Z,11Z,14Z)). Not Available. ... Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Gene Name: ... Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by ...
  http://www.hmdb.ca/metabolites/HMDB05441