*  Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride | SpringerLink
Detection of mutant p21 proteins in serum may be a us ... Mutations inras oncogenes and expression of their encoded p21 ... protein products are believed to play an important role in carcinogenesis in humans. ... Oncogene proteins as biomarkers in the molecular epidemiology of occupational carcinogenesis: the example of the ras oncogene ... Mutations inras oncogenes and expression of their encoded p21 protein products are believed to play an important role in ...
  https://link.springer.com/article/10.1007%2FBF01830248
*  Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. - Radcliffe Department of Medicine
Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Randomized Controlled Trials as Topic ... Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Chromosomal Instability, Class I Phosphatidylinositol 3-Kinases, Colorectal ...
  https://www.rdm.ox.ac.uk/publications/363808
*  Syndecan-1 Expression Is Associated with Tumor Size and EGFR Expression in Colorectal Carcinoma: A Clinicopathological Study of...
... a member of the ras family of oncogenes, is located at the chromosomal locus 12p12 and encodes a 21 kD protein (p21ras) that is ... Keywords: Syndecan-1, Expression, Colorectal cancer, Immunohistochemistry, Biomarkers Introduction. Syndecans are type I ... Sacco E, Spinelli M, Vanoni M. Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review ... Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J Natl Cancer Inst. 1998;90:675-84 ...
  http://www.medsci.org/v12p0092.htm
*  adenocarcinoma in situ of thyroid 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins c-ret / genetics. Proto-Oncogene Proteins p21(ras) / genetics ... Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion ... Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); EC 3.6.5.2 / ... RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins ...
  http://www.bmlsearch.com/?kwr=adenocarcinoma+in+situ+of+thyroid+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Rhabdomyosarcoma | Cancer Genetics Web
CTLO, HAMSV, HRAS1, RASH1, p21ras, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1. -HRAS germline mutation in Costello Syndrome. 54. ... Oncogene Fusion Proteins. *Homeodomain Proteins. *FISH. *Apoptosis. *Biomarkers, Tumor. *Gene Amplification. *CDK4 ... NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1. -NRAS and Rhabdomyosarcoma. 15. HGF. 7q21.1. SF, HGFB, HPTA, F-TCF, DFNB39. -HGF and ... which inhibits protein kinase Cα-mediated activation of mitogen-activated protein kinases (MAPKs), especially p38MAPK ...
  http://www.cancerindex.org/geneweb/X2002.htm
*  Jun dimerization protein - Wikipedia
Broder YC, Katz S, Aronheim A (Oct 1998). "The ras recruitment system, a novel approach to the study of protein-protein ... By contrast, JDP2-knockout mice exhibit in downregulation of p53 and p21 proteins. JDP2 appears to be involved in the ... Oncogene. 22 (14): 2151-9. doi:10.1038/sj.onc.1206312. PMID 12687017. GeneCard for JDP2 Universal protein resource accession ... indicating that JDP2 may serve as a biomarker to predict the prognosis of patients with pancreatic cancer. In addition, JDP2 ...
  https://en.wikipedia.org/wiki/Jun_dimerization_protein
*  The Emerging Epigenetic Landscape in Melanoma | IntechOpen
Oncogene. 2008;27(4):490-498.. 147 - Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, et al. Combination ... activating protein NF1 [123]. It was recently reported that the combined loss of NF1 and the PRC2 component SUZ12 amplifies RAS ... Medicine » Oncology » 'Human Skin Cancer, Potential Biomarkers and Therapeutic Targets', book edited by Miroslav Blumenberg, ... EZH2‐dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. ...
  https://www.intechopen.com/books/human-skin-cancer-potential-biomarkers-and-therapeutic-targets/the-emerging-epigenetic-landscape-in-melanoma/
*  SKIL | Cancer Genetics Web
Ski‑novel protein (SnoN) is a proto‑oncogene that belongs to the Ski protein family and is involved in regulating processes ... Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia.. BMC Med Genomics. 2013; 6:27 [PubMed] Free Access to ... In both TIOSE and OVCA, SnoN siRNA decreased cell growth between 20 and 50% concurrent with increased p21 levels. In TIOSE, ... Moderate ectopic expression of GRIM-1 caused growth inhibition and sensitized cells to retinoic acid (RA)/IFN-induced cell ...
  http://www.cancerindex.org/geneweb/SKIL.htm
*  PSMD2 - Wikipedia
... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. The protein 26S proteasome non- ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 ... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... as well as with the induction of p21. In addition, patients with higher PSMD2 expression indicated a poorer prognosis and a ...
  https://en.wikipedia.org/wiki/PSMD2
*  Plus it
McKenzie PP, Guichard SM, Middlemas DS, Ashmun RA, Danks MK, Harris LC. Wild-type p53 can induce p21 and apoptosis in ... Mantovani F, Banks L. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 2001; 20: ... A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92: 9363 ... p21 (p21WAF1), BTG2, WIP1, and p48, by comparison with the up-regulation of these genes in the parental IMR-32 cells. This ...
  http://cancerres.aacrjournals.org/content/67/21/10351
*  Common Genetic Variation in GATA-Binding Protein 3 and Differential Susceptibility to Breast Cancer by Estrogen Receptor α...
Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas. J Pathol 1997;181:140- ... Cancer Epidemiol Biomarkers Prev November 1 2007 (16) (11) 2269-2275; DOI: 10.1158/1055-9965.EPI-07-0449 ... RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem 2001;276:42259-67. ... Oncogene 2004;23:7669-78.. OpenUrlCrossRefPubMed. *↵ Bukholm IK, Nesland JM, Karesen R, Jacobsen U, Borresen AL. ...
  http://cebp.aacrjournals.org/content/16/11/2269
*  PSMA3 - Wikipedia
"Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3". Oncogene. 34 (19): 2538-45. doi: ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (December 1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". ... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. A role of the proteasome subunit ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ...
  https://en.wikipedia.org/wiki/PSMA3
*  Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks | SpringerLink
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene 18:6635-6640 ... Kawata S, Ariumi Y, Shimotohno K (2003) p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells ... Rhodes DR, Sanda MG, Otte AP, Chinnaiyan AM, Rubin MA (2003) Multiplex biomarker approach for determining risk of prostate- ... Saris CJ, Domen J, Berns A (1991) The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative ...
  https://link.springer.com/article/10.1007/s10495-016-1289-3
*  Vitamin D-related Therapies in Prostate Cancer | SpringerLink
De Boland AR, Norman AW: Evidence for involvement of protein kinase C and cyclic adenosine 3´,5´monophosphate-dependent protein ... Modzelewski RA, Davies P, Watkins SC, Auerbach R, Ming-Jei C, Johnson CS: Isolation and identification of fresh tumor-derived ... Calcitriol induces a significant G0/G1 arrest and modulates p21Waf1/Cip1 and p27Kip1, the cyclin dependent kinase inhibitors. ... Hockenbery DM: The bcl-2 oncogene and apoptosis. Semin Immunol 4: 413-420, 1992Google Scholar ...
  https://link.springer.com/article/10.1023%2FA%3A1020836226594
*  PAK5 - Wikipedia
June 2014). "An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis". Human ... a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain". Oncogene. 21 (24): ... Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR (March 2012). " ... Cancer Biomarkers. 16 (2): 203-9. doi:10.3233/CBM-150557. PMID 26682509. Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, Zhang H ...
  https://en.wikipedia.org/wiki/PAK5
*  Influence of K-ras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and...
Singh J., Kelloff G., Reddy B. S. Intermediate biomarkers of colon cancer, modulation of expression of ras oncogene by ... Protein Quantitation.. Protein measurements of the lysates used for Western blotting were performed with the DC protein assay ... ras mutations from 90 to 36 and 25%, respectively (8) . Both agents also reduced the amount of biochemically active p21 ras in ... Mutational activation of the K-ras oncogene is an important genetic alteration in colorectal neoplasia. K-ras mutations have ...
  http://cebp.aacrjournals.org/content/9/11/1155
*  IJMS | Free Full-Text | MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer? | HTML
Identification of targets of this ncRNA associated with cancer can suggest that networks of these linked to oncogenes or tumor ... and modulation of protein activity. Thus, studies of non-coding RNA (ncRNA) may contribute to the discovery of possible ... and discusses some of challenges derived from their use as potential biomarkers of tumor properties. ... biomarkers in human cancers. Considering that the response to chemotherapy can differ amongst individuals, researchers have ...
  http://www.mdpi.com/1422-0067/13/1/840/htm
*  The power and promise of "rewiring" the mitogen-activated protein kinase network in prostate cancer therapeutics | Molecular...
... and proto-oncogene products deliver their growth-eliciting stimuli through the activation of the small G protein Ras and ... kinase suppressor of Ras; MKP, MAPK phosphatase; P, phosphate groups; PAK, p21-activated kinase; PDK1, phosphatidylinositol- ... Prostate cancer specimen analysis for specific biomarkers is of cardinal importance in the field of signal transduction therapy ... The Ras subfamily consists of three functional members: H-Ras, N-Ras, and K-Ras. K-Ras is the isoform that is most frequently ...
  http://mct.aacrjournals.org/content/6/3/811
*  IJMS | Free Full-Text | Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players | HTML
... and modulating protein activities. At the end, we will also discuss recently unraveled activities of circular RNAs (circRNAs). ... mRNA translation and protein function. Dysregulation of ncRNAs contributes to the pathogenesis of a variety of cancers and ... The discovery of the first human oncogene RAS [8-10] and the first tumor suppressor Retinoblastoma (Rb) in the 1980s ... A RNA-binding protein, HuR, can recruit let-7/AGO2 to lincRNA-p21 to reduce its stability; thus, elevated HuR releases lincRNA- ...
  http://mdpi.com/1422-0067/14/9/18319/htm
*  β-catenin regulates c-Myc and CDKN1A expression in breast cancer cells
Protein expression of β-catenin, c-Myc and p21 in MDA-MB-231 cells analyzed by Western blot after β-catenin siRNA transfection ... v-myc avian myelocytomatosis viral oncogene homolog. CTNNB1. Catenin (cadherin-associated protein), beta 1. FBS. fetal bovine ... Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature ... Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4529819/
*  Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
Two days later lysates were prepared and blotted directly for total canonical Ras proteins (H,N,K-Ras), active ERK, or active ... Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (Type 1) neurofibromatosis ... Oncogene. 1995;11:325-335. [PubMed]. *Klose A, Robinson N, Gewies A, Kluwe L, Kaufmann D, Buske A, et al. Two novel mutations ... Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2809821/
*  BioModels Database
RAS p21 PROTEIN ACTIVATOR 1; RASA1. Model name. Publication. Status. Birtwistle2007_ErbB_Signalling (BIOMD0000000175). Ligand- ... V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1; RAF1. Model name. Publication. Status. ... Nayak2015 - Blood Coagulation Network - Predicting the Effects of Various Therapies on Biomarkers (BIOMD0000000611). Using a ... Proctor2010 - UCHL1 Protein Aggregation (BIOMD0000000293). Modelling the role of UCH-L1 on protein aggregatio [...]. ...
  https://www.ebi.ac.uk/biomodels-main/diseases
*  ERK2 is Essential for the Growth of Human Epithelioid Malignant Mesotheliomas
mitogen-activated protein kinase kinase. PAK7. P21 (CDKNIA)-Activated Kinase 7. qRT-PCR. quantitative Real Time PCR. RPS6KA2. ... Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin. Oncogene. 2009;28:1485-95. [PMC free ... Inhibition of PI3K and MEK: it is all about combinations and biomarkers. Clin Cancer Res. 2009;15:4518-20. [PubMed] ... Activator-Protein-1. BCL2LI. BCL2-Like 1. BMP5. Bone Morphogenic Protein 5. CASP1. Caspase 1. EGF. Epidermal Growth Factor. ERK ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3071888/?lang=en-ca
*  Frontiers | Skin Tumors Rb(eing) Uncovered | Oncology
The existence of a retinoblastoma family of proteins pRb, p107 and p130 and their potential unique and overlapping functions as ... The existence of a retinoblastoma family of proteins pRb, p107 and p130 and their potential unique and overlapping functions as ... Weinberg RA. The retinoblastoma protein and cell cycle control. Cell (1995) 81(3):323-30. doi:10.1016/0092-8674(95)90385-2 ... p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia. Oncogene (2013). doi:10.1038/onc.2013.417 ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00307/full
*  MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer using miR-21 - Patent #...
Pawelczyk, T. et al., "Expression in Escherichia coli and Simple Purification of Human Fhit Protein," Protein Expr. Purlf., Apr ... Croce, C. M., "Oncogenes and Cancer," The New England Journal of Medicine, Jan. 2008, pp. 502-511, vol. 358, No. 5. cited by ... Johnson, S. M. et al., "RAS is Regulated by the let-7 MicroRNA Family," Cell, Mar. 2005, pp. 635-647, vol. 120. cited by ... Iliopoulos, D. et al., "Fragile Genes as Biomarkers: Epigenetic Control of WWOX and FHIT in Lung, Breast and Bladder Cancer," ...
  http://www.patentgenius.com/patent/8361710.html