Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. - Radcliffe Department of Medicine
Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Randomized Controlled Trials as Topic ... Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Chromosomal Instability, Class I Phosphatidylinositol 3-Kinases, Colorectal ...https://www.rdm.ox.ac.uk/publications/363808
Syndecan-1 Expression Is Associated with Tumor Size and EGFR Expression in Colorectal Carcinoma: A Clinicopathological Study of...
... a member of the ras family of oncogenes, is located at the chromosomal locus 12p12 and encodes a 21 kD protein (p21ras) that is ... Keywords: Syndecan-1, Expression, Colorectal cancer, Immunohistochemistry, Biomarkers Introduction. Syndecans are type I ... Sacco E, Spinelli M, Vanoni M. Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review ... Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J Natl Cancer Inst. 1998;90:675-84 ...http://www.medsci.org/v12p0092.htm
adenocarcinoma in situ of thyroid 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins c-ret / genetics. Proto-Oncogene Proteins p21(ras) / genetics ... Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion ... Proto-Oncogene Proteins B-raf; EC 18.104.22.168 / HRAS protein, human; EC 22.214.171.124 / Proto-Oncogene Proteins p21(ras); EC 126.96.36.199 / ... RET protein, human; EC 188.8.131.52 / BRAF protein, human; EC 184.108.40.206 / Proto-Oncogene Proteins B-raf; EC 220.127.116.11 / ras Proteins ...http://www.bmlsearch.com/?kwr=adenocarcinoma+in+situ+of+thyroid+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated...
... such as G-protein α subunit, Ras, nitric oxide synthase, protein kinase C, and protein kinase A ( 2, 7, 10, 16- 25). However, ... caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes, such as v-Abl and ... we evaluated the effect of inhibition of p38 MAPK on the cellular levels of p21WAF1/Cip1. Figure 3F shows that p21WAF1/Cip1 ... A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92: 9363 ...http://cancerres.aacrjournals.org/content/66/22/10805
Rhabdomyosarcoma | Cancer Genetics Web
CTLO, HAMSV, HRAS1, RASH1, p21ras, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1. -HRAS germline mutation in Costello Syndrome. 54. ... Oncogene Fusion Proteins. *Homeodomain Proteins. *FISH. *Apoptosis. *Biomarkers, Tumor. *Gene Amplification. *CDK4 ... NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1. -NRAS and Rhabdomyosarcoma. 15. HGF. 7q21.1. SF, HGFB, HPTA, F-TCF, DFNB39. -HGF and ... which inhibits protein kinase Cα-mediated activation of mitogen-activated protein kinases (MAPKs), especially p38MAPK ...http://www.cancerindex.org/geneweb/X2002.htm
Insulin‐like growth factor II messenger RNA‐binding protein‐3 is an independent prognostic factor in uterine leiomyosarcoma,...
... binding protein‐3 is an independent prognostic factor in uterine leiomyosarcoma, Histopathology" on DeepDyve, the largest ... Oncofetal protein IGF2BP3 facilitates the activity of proto‐oncogene protein eIF4E through the destabilization of EIF4E‐BP2 ... Expression of the regulatory cell cycle proteins p21, p27, p14, p16, p53, MDM2, and cyclin E in bone marrow biopsies with acute ... Uterine leiomyosarcomas: tumor size, mitotic index, and biomarkers Ki67, and Bcl‐2 identify two groups with different prognosis ...https://www.deepdyve.com/lp/wiley/insulin-like-growth-factor-ii-messenger-rna-binding-protein-3-is-an-sNH4aETuXC
2012 Oncomine Citations | Thermo Fisher Scientific - CN
Oncogene. 2012 Jul 16. , Pubmed. *Synaptotagmin-like proteins control the formation of a single apical membrane domain in ... Oncogene. 2012 Jan 16. , Pubmed. *DNA methylation biomarker candidates for early detection of colon cancer.. Yi JM, Dhir M, ... The RNA processing and modification protein, carbon catabolite repression 4, arrests the cell cycle through a p21-dependent and ... Human Mut T Homolog 1 (MTH1): A roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS.. Rai P.. Small ...https://www.thermofisher.com/cn/zh/home/life-science/cancer-research/cancer-genomics/cancer-genomics-data-analysis-compendia-bioscience/oncomine-cancer-genomics-data-analysis-library/oncomine-platform-citations/2012-oncomine-citations.html
Jun dimerization protein - Wikipedia
Broder YC, Katz S, Aronheim A (Oct 1998). "The ras recruitment system, a novel approach to the study of protein-protein ... By contrast, JDP2-knockout mice exhibit in downregulation of p53 and p21 proteins. JDP2 appears to be involved in the ... Oncogene. 22 (14): 2151-9. doi:10.1038/sj.onc.1206312. PMID 12687017. GeneCard for JDP2 Universal protein resource accession ... indicating that JDP2 may serve as a biomarker to predict the prognosis of patients with pancreatic cancer. In addition, JDP2 ...https://en.wikipedia.org/wiki/Jun_dimerization_protein
PSMD2 - Wikipedia
... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. The protein 26S proteasome non- ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 ... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... as well as with the induction of p21. In addition, patients with higher PSMD2 expression indicated a poorer prognosis and a ...https://en.wikipedia.org/wiki/PSMD2
Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma
protein protects p53 from degradation and promotes p21 activation leading to controlled cell division and enhanced apoptosis. ... Ras association (ralgds/af-6) domain family member 1 (RASSF1A), insulin-like growth factor 2 (IGF-2), and adenomatous polyposis ... P. Laurent-Puig and J. Zucman-Rossi, "Genetics of hepatocellular tumors," Oncogene, vol. 25, no. 27, pp. 3778-3786, 2006. View ... F. Yu, Z. Lu, B. Chen, P. Dong, and J. Zheng, "microRNA-150: a promising novel biomarker for hepatitis B virus-related ...https://www.hindawi.com/journals/bmri/2016/3956485/
Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. - PubMed - NCBI
Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72. doi: 10.1158/1055-9965.EPI-09-0490. Epub 2009 Sep 29. Research ... Proto-Oncogene Proteins/genetics*. *Proto-Oncogene Proteins B-raf/genetics. *Proto-Oncogene Proteins p21(ras) ... Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72. doi: 10.1158/1055-9965.EPI-09-0490. Epub 2009 Sep 29. ... A link between VDR and the RAS-mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K)-AKT pathway has ...https://www.ncbi.nlm.nih.gov/pubmed/19789368
PSMA3 - Wikipedia
"Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3". Oncogene. 34 (19): 2538-45. doi: ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (December 1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". ... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. A role of the proteasome subunit ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ...https://en.wikipedia.org/wiki/PSMA3
The Emerging Epigenetic Landscape in Melanoma | IntechOpen
Oncogene. 2008;27(4):490-498.. 147 - Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, et al. Combination ... activating protein NF1 . It was recently reported that the combined loss of NF1 and the PRC2 component SUZ12 amplifies RAS ... Medicine » Oncology » 'Human Skin Cancer, Potential Biomarkers and Therapeutic Targets', book edited by Miroslav Blumenberg, ... EZH2‐dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. ...https://www.intechopen.com/books/human-skin-cancer-potential-biomarkers-and-therapeutic-targets/the-emerging-epigenetic-landscape-in-melanoma/
PAK5 - Wikipedia
June 2014). "An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis". Human ... a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain". Oncogene. 21 (24): ... Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR (March 2012). " ... Cancer Biomarkers. 16 (2): 203-9. doi:10.3233/CBM-150557. PMID 26682509. Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, Zhang H ...https://en.wikipedia.org/wiki/PAK5
SKIL | Cancer Genetics Web
Ski‑novel protein (SnoN) is a proto‑oncogene that belongs to the Ski protein family and is involved in regulating processes ... Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia.. BMC Med Genomics. 2013; 6:27 [PubMed] Free Access to ... In both TIOSE and OVCA, SnoN siRNA decreased cell growth between 20 and 50% concurrent with increased p21 levels. In TIOSE, ... Moderate ectopic expression of GRIM-1 caused growth inhibition and sensitized cells to retinoic acid (RA)/IFN-induced cell ...http://www.cancerindex.org/geneweb/SKIL.htm
McKenzie PP, Guichard SM, Middlemas DS, Ashmun RA, Danks MK, Harris LC. Wild-type p53 can induce p21 and apoptosis in ... Mantovani F, Banks L. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 2001; 20: ... A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92: 9363 ... p21 (p21WAF1), BTG2, WIP1, and p48, by comparison with the up-regulation of these genes in the parental IMR-32 cells. This ...http://cancerres.aacrjournals.org/content/67/21/10351
Common Genetic Variation in GATA-Binding Protein 3 and Differential Susceptibility to Breast Cancer by Estrogen Receptor α...
Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas. J Pathol 1997;181:140- ... Cancer Epidemiol Biomarkers Prev November 1 2007 (16) (11) 2269-2275; DOI: 10.1158/1055-9965.EPI-07-0449 ... RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem 2001;276:42259-67. ... Oncogene 2004;23:7669-78.. OpenUrlCrossRefPubMed. *↵ Bukholm IK, Nesland JM, Karesen R, Jacobsen U, Borresen AL. ...http://cebp.aacrjournals.org/content/16/11/2269
Øystein Fodstad - Institutt for klinisk medisin
Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance NUPR1 and p21 in chemoresistance. FEBS Letters. ISSN ... Biomarkers in Medicine. ISSN 1752-0363. 12(1), s 45- 61 . doi: 10.2217/bmm-2017-0142 Vis sammendrag Although CD44 has been ... Oncogene. ISSN 0950-9232. 28(42), s 3689- 3701 . doi: 10.1038/onc.2009.229 Vis sammendrag ErbB2 has been shown to activate ... Clark, DW; Mitra, A; Fillmore, RA; Jiang, WG; Samant, RS; Fodstad, Øystein & Shevde, LA (2008). NUPR1 interacts with p53, ...https://www.med.uio.no/klinmed/personer/vit/fodstad/index.html
Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks | SpringerLink
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene 18:6635-6640 ... Kawata S, Ariumi Y, Shimotohno K (2003) p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells ... Rhodes DR, Sanda MG, Otte AP, Chinnaiyan AM, Rubin MA (2003) Multiplex biomarker approach for determining risk of prostate- ... Saris CJ, Domen J, Berns A (1991) The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative ...https://link.springer.com/article/10.1007/s10495-016-1289-3
Vitamin D-related Therapies in Prostate Cancer | SpringerLink
De Boland AR, Norman AW: Evidence for involvement of protein kinase C and cyclic adenosine 3´,5´monophosphate-dependent protein ... Modzelewski RA, Davies P, Watkins SC, Auerbach R, Ming-Jei C, Johnson CS: Isolation and identification of fresh tumor-derived ... Calcitriol induces a significant G0/G1 arrest and modulates p21Waf1/Cip1 and p27Kip1, the cyclin dependent kinase inhibitors. ... Hockenbery DM: The bcl-2 oncogene and apoptosis. Semin Immunol 4: 413-420, 1992Google Scholar ...https://link.springer.com/article/10.1023%2FA%3A1020836226594
Influence of K-ras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and...
Singh J., Kelloff G., Reddy B. S. Intermediate biomarkers of colon cancer, modulation of expression of ras oncogene by ... Protein Quantitation.. Protein measurements of the lysates used for Western blotting were performed with the DC protein assay ... ras mutations from 90 to 36 and 25%, respectively (8) . Both agents also reduced the amount of biochemically active p21 ras in ... Mutational activation of the K-ras oncogene is an important genetic alteration in colorectal neoplasia. K-ras mutations have ...http://cebp.aacrjournals.org/content/9/11/1155
IJMS | Free Full-Text | MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer? | HTML
Identification of targets of this ncRNA associated with cancer can suggest that networks of these linked to oncogenes or tumor ... and modulation of protein activity. Thus, studies of non-coding RNA (ncRNA) may contribute to the discovery of possible ... and discusses some of challenges derived from their use as potential biomarkers of tumor properties. ... biomarkers in human cancers. Considering that the response to chemotherapy can differ amongst individuals, researchers have ...http://www.mdpi.com/1422-0067/13/1/840/htm
The power and promise of "rewiring" the mitogen-activated protein kinase network in prostate cancer therapeutics | Molecular...
... and proto-oncogene products deliver their growth-eliciting stimuli through the activation of the small G protein Ras and ... kinase suppressor of Ras; MKP, MAPK phosphatase; P, phosphate groups; PAK, p21-activated kinase; PDK1, phosphatidylinositol- ... Prostate cancer specimen analysis for specific biomarkers is of cardinal importance in the field of signal transduction therapy ... The Ras subfamily consists of three functional members: H-Ras, N-Ras, and K-Ras. K-Ras is the isoform that is most frequently ...http://mct.aacrjournals.org/content/6/3/811
IJMS | Free Full-Text | Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players | HTML
... and modulating protein activities. At the end, we will also discuss recently unraveled activities of circular RNAs (circRNAs). ... mRNA translation and protein function. Dysregulation of ncRNAs contributes to the pathogenesis of a variety of cancers and ... The discovery of the first human oncogene RAS [8-10] and the first tumor suppressor Retinoblastoma (Rb) in the 1980s ... A RNA-binding protein, HuR, can recruit let-7/AGO2 to lincRNA-p21 to reduce its stability; thus, elevated HuR releases lincRNA- ...http://mdpi.com/1422-0067/14/9/18319/htm
Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
Two days later lysates were prepared and blotted directly for total canonical Ras proteins (H,N,K-Ras), active ERK, or active ... Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (Type 1) neurofibromatosis ... Oncogene. 1995;11:325-335. [PubMed]. *Klose A, Robinson N, Gewies A, Kluwe L, Kaufmann D, Buske A, et al. Two novel mutations ... Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2809821/