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*  Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. - Radcliffe Department of Medicine
Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Randomized Controlled Trials as Topic ... Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Chromosomal Instability, Class I Phosphatidylinositol 3-Kinases, Colorectal ...
  https://www.rdm.ox.ac.uk/publications/363808
*  Syndecan-1 Expression Is Associated with Tumor Size and EGFR Expression in Colorectal Carcinoma: A Clinicopathological Study of...
... a member of the ras family of oncogenes, is located at the chromosomal locus 12p12 and encodes a 21 kD protein (p21ras) that is ... Keywords: Syndecan-1, Expression, Colorectal cancer, Immunohistochemistry, Biomarkers Introduction. Syndecans are type I ... Sacco E, Spinelli M, Vanoni M. Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review ... Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J Natl Cancer Inst. 1998;90:675-84 ...
  http://www.medsci.org/v12p0092.htm
*  adenocarcinoma in situ of thyroid 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins c-ret / genetics. Proto-Oncogene Proteins p21(ras) / genetics ... Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion ... Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); EC 3.6.5.2 / ... RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins ...
  http://www.bmlsearch.com/?kwr=adenocarcinoma+in+situ+of+thyroid+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated...
... such as G-protein α subunit, Ras, nitric oxide synthase, protein kinase C, and protein kinase A ( 2, 7, 10, 16- 25). However, ... caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes, such as v-Abl and ... we evaluated the effect of inhibition of p38 MAPK on the cellular levels of p21WAF1/Cip1. Figure 3F shows that p21WAF1/Cip1 ... A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92: 9363 ...
  http://cancerres.aacrjournals.org/content/66/22/10805
*  Insulin‐like growth factor II messenger RNA‐binding protein‐3 is an independent prognostic factor in uterine leiomyosarcoma,...
... binding protein‐3 is an independent prognostic factor in uterine leiomyosarcoma, Histopathology" on DeepDyve, the largest ... Oncofetal protein IGF2BP3 facilitates the activity of proto‐oncogene protein eIF4E through the destabilization of EIF4E‐BP2 ... Expression of the regulatory cell cycle proteins p21, p27, p14, p16, p53, MDM2, and cyclin E in bone marrow biopsies with acute ... Uterine leiomyosarcomas: tumor size, mitotic index, and biomarkers Ki67, and Bcl‐2 identify two groups with different prognosis ...
  https://www.deepdyve.com/lp/wiley/insulin-like-growth-factor-ii-messenger-rna-binding-protein-3-is-an-sNH4aETuXC
*  Rhabdomyosarcoma | Cancer Genetics Web
CTLO, HAMSV, HRAS1, RASH1, p21ras, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1. -HRAS germline mutation in Costello Syndrome. 54. ... Oncogene Fusion Proteins. *Homeodomain Proteins. *FISH. *Apoptosis. *Biomarkers, Tumor. *Gene Amplification. *CDK4 ... NS6, CMNS, NCMS, ALPS4, N-ras, NRAS1. -NRAS and Rhabdomyosarcoma. 15. HGF. 7q21.1. SF, HGFB, HPTA, F-TCF, DFNB39. -HGF and ... which inhibits protein kinase Cα-mediated activation of mitogen-activated protein kinases (MAPKs), especially p38MAPK ...
  http://www.cancerindex.org/geneweb/X2002.htm
*  Jun dimerization protein - Wikipedia
Broder YC, Katz S, Aronheim A (Oct 1998). "The ras recruitment system, a novel approach to the study of protein-protein ... By contrast, JDP2-knockout mice exhibit in downregulation of p53 and p21 proteins. JDP2 appears to be involved in the ... Oncogene. 22 (14): 2151-9. doi:10.1038/sj.onc.1206312. PMID 12687017. GeneCard for JDP2 Universal protein resource accession ... indicating that JDP2 may serve as a biomarker to predict the prognosis of patients with pancreatic cancer. In addition, JDP2 ...
  https://en.wikipedia.org/wiki/Jun_dimerization_protein
*  2012 Oncomine Citations | Thermo Fisher Scientific - CN
Oncogene. 2012 Jul 16. , Pubmed. *Synaptotagmin-like proteins control the formation of a single apical membrane domain in ... Oncogene. 2012 Jan 16. , Pubmed. *DNA methylation biomarker candidates for early detection of colon cancer.. Yi JM, Dhir M, ... The RNA processing and modification protein, carbon catabolite repression 4, arrests the cell cycle through a p21-dependent and ... Human Mut T Homolog 1 (MTH1): A roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS.. Rai P.. Small ...
  https://www.thermofisher.com/cn/zh/home/life-science/cancer-research/cancer-genomics/cancer-genomics-data-analysis-compendia-bioscience/oncomine-cancer-genomics-data-analysis-library/oncomine-platform-citations/2012-oncomine-citations.html
*  Silencing of TGIF attenuates the tumorigenicity of A549 cells in vitro and in vivo | SpringerLink
Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995;81:323-30.CrossRefPubMedGoogle Scholar ... and p21 was markedly increased in the A549-shTGIF cells compared with the A549-shcon cells. A lower level of β-Catenin protein ... Oncogene. 1995;11:211-9.PubMedGoogle Scholar ... International Society of Oncology and BioMarkers (ISOBM) 2016. ... Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression. J Biomed Sci. 2008;15:333-42.CrossRefPubMedGoogle ...
  https://link.springer.com/article/10.1007/s13277-016-5222-8
*  Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma
protein protects p53 from degradation and promotes p21 activation leading to controlled cell division and enhanced apoptosis. ... Ras association (ralgds/af-6) domain family member 1 (RASSF1A), insulin-like growth factor 2 (IGF-2), and adenomatous polyposis ... P. Laurent-Puig and J. Zucman-Rossi, "Genetics of hepatocellular tumors," Oncogene, vol. 25, no. 27, pp. 3778-3786, 2006. View ... F. Yu, Z. Lu, B. Chen, P. Dong, and J. Zheng, "microRNA-150: a promising novel biomarker for hepatitis B virus-related ...
  https://www.hindawi.com/journals/bmri/2016/3956485/
*  Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. - PubMed - NCBI
Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72. doi: 10.1158/1055-9965.EPI-09-0490. Epub 2009 Sep 29. Research ... Proto-Oncogene Proteins/genetics*. *Proto-Oncogene Proteins B-raf/genetics. *Proto-Oncogene Proteins p21(ras) ... Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72. doi: 10.1158/1055-9965.EPI-09-0490. Epub 2009 Sep 29. ... A link between VDR and the RAS-mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K)-AKT pathway has ...
  https://www.ncbi.nlm.nih.gov/pubmed/19789368
*  Immunogenic cell death modalities and their impact on cancer treatment | SpringerLink
Oncogene 23:2825-2837. doi: 10.1038/sj.onc.1207528 PubMedCrossRefGoogle Scholar ... Gonzalez-Polo RA, Boya P, Pauleau AL et al (2005) The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic ... Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB (2001) BH3-only proteins that bind pro-survival Bcl-2 family members ... and p21(CIP1), but not p16(INK4a). Mol Cell 14:501-513. doi: 10.1016/S1097-2765(04)00256-4 PubMedCrossRefGoogle Scholar ...
  https://link.springer.com/article/10.1007%2Fs10495-008-0303-9
*  PSMD2 - Wikipedia
... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. The protein 26S proteasome non- ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 ... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... as well as with the induction of p21. In addition, patients with higher PSMD2 expression indicated a poorer prognosis and a ...
  https://en.wikipedia.org/wiki/PSMD2
*  Full text] Centrosome - a promising anti-cancer target | BTT
Several drugs/compounds against centrosomal proteins have shown promising results. Other drugs have higher toxicity with modest ... because there are important oncogenic and tumor suppressor proteins that are localized in this organelle and drive centrosome ... Hundreds of proteins found in the centrosome exert a variety of roles, including microtubule dynamics, nucleation, and ... The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene. 2010; ...
  https://www.dovepress.com/centrosome-ndash-a-promising-anti-cancer-target-peer-reviewed-fulltext-article-BTT
*  The Emerging Epigenetic Landscape in Melanoma | IntechOpen
Oncogene. 2008;27(4):490-498.. 147 - Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, et al. Combination ... activating protein NF1 [123]. It was recently reported that the combined loss of NF1 and the PRC2 component SUZ12 amplifies RAS ... Medicine » Oncology » 'Human Skin Cancer, Potential Biomarkers and Therapeutic Targets', book edited by Miroslav Blumenberg, ... EZH2‐dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. ...
  https://www.intechopen.com/books/human-skin-cancer-potential-biomarkers-and-therapeutic-targets/the-emerging-epigenetic-landscape-in-melanoma/
*  SKIL | Cancer Genetics Web
Ski‑novel protein (SnoN) is a proto‑oncogene that belongs to the Ski protein family and is involved in regulating processes ... Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia.. BMC Med Genomics. 2013; 6:27 [PubMed] Free Access to ... In both TIOSE and OVCA, SnoN siRNA decreased cell growth between 20 and 50% concurrent with increased p21 levels. In TIOSE, ... Moderate ectopic expression of GRIM-1 caused growth inhibition and sensitized cells to retinoic acid (RA)/IFN-induced cell ...
  http://www.cancerindex.org/geneweb/SKIL.htm
*  PSMA3 - Wikipedia
"Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3". Oncogene. 34 (19): 2538-45. doi: ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (December 1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". ... predominantly exhibit circulating proteasomes which can be applied as clinical biomarkers. A role of the proteasome subunit ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ...
  https://en.wikipedia.org/wiki/PSMA3
*  Plus it
McKenzie PP, Guichard SM, Middlemas DS, Ashmun RA, Danks MK, Harris LC. Wild-type p53 can induce p21 and apoptosis in ... Mantovani F, Banks L. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 2001; 20: ... A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92: 9363 ... p21 (p21WAF1), BTG2, WIP1, and p48, by comparison with the up-regulation of these genes in the parental IMR-32 cells. This ...
  http://cancerres.aacrjournals.org/content/67/21/10351
*  Common Genetic Variation in GATA-Binding Protein 3 and Differential Susceptibility to Breast Cancer by Estrogen Receptor α...
Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas. J Pathol 1997;181:140- ... Cancer Epidemiol Biomarkers Prev November 1 2007 (16) (11) 2269-2275; DOI: 10.1158/1055-9965.EPI-07-0449 ... RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem 2001;276:42259-67. ... Oncogene 2004;23:7669-78.. OpenUrlCrossRefPubMed. *↵ Bukholm IK, Nesland JM, Karesen R, Jacobsen U, Borresen AL. ...
  http://cebp.aacrjournals.org/content/16/11/2269
*  Øystein Fodstad - Institutt for klinisk medisin
Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance NUPR1 and p21 in chemoresistance. FEBS Letters. ISSN ... Biomarkers in Medicine. ISSN 1752-0363. 12(1), s 45- 61 . doi: 10.2217/bmm-2017-0142 Vis sammendrag Although CD44 has been ... Oncogene. ISSN 0950-9232. 28(42), s 3689- 3701 . doi: 10.1038/onc.2009.229 Vis sammendrag ErbB2 has been shown to activate ... Clark, DW; Mitra, A; Fillmore, RA; Jiang, WG; Samant, RS; Fodstad, Øystein & Shevde, LA (2008). NUPR1 interacts with p53, ...
  https://www.med.uio.no/klinmed/personer/vit/fodstad/index.html
*  PAK5 - Wikipedia
June 2014). "An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis". Human ... a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain". Oncogene. 21 (24): ... Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR (March 2012). " ... Cancer Biomarkers. 16 (2): 203-9. doi:10.3233/CBM-150557. PMID 26682509. Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, Zhang H ...
  https://en.wikipedia.org/wiki/PAK5
*  Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks | SpringerLink
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene 18:6635-6640 ... Kawata S, Ariumi Y, Shimotohno K (2003) p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells ... Rhodes DR, Sanda MG, Otte AP, Chinnaiyan AM, Rubin MA (2003) Multiplex biomarker approach for determining risk of prostate- ... Saris CJ, Domen J, Berns A (1991) The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative ...
  https://link.springer.com/article/10.1007/s10495-016-1289-3
*  KRAS - Wikipedia
The gene product was first found as a p21 GTPase.[6][7] Like other members of the ras subfamily, the KRAS protein is a GTPase ... This proto-oncogene is a Kirsten ras oncogene homolog from the mammalian ras gene family. A single amino acid substitution, and ... Cancer Biomarkers. 1 (2-3): 177-82. PMID 17192038.. ... 1jah: H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5 ... KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene ...
  https://en.wikipedia.org/wiki/KRAS
*  Vitamin D-related Therapies in Prostate Cancer | SpringerLink
De Boland AR, Norman AW: Evidence for involvement of protein kinase C and cyclic adenosine 3´,5´monophosphate-dependent protein ... Modzelewski RA, Davies P, Watkins SC, Auerbach R, Ming-Jei C, Johnson CS: Isolation and identification of fresh tumor-derived ... Calcitriol induces a significant G0/G1 arrest and modulates p21Waf1/Cip1 and p27Kip1, the cyclin dependent kinase inhibitors. ... Hockenbery DM: The bcl-2 oncogene and apoptosis. Semin Immunol 4: 413-420, 1992Google Scholar ...
  https://link.springer.com/article/10.1023%2FA%3A1020836226594
*  Alan Cantor, MD, PhD | Boston Children's Hospital
Zhukov TA, Johanson RA, Cantor AB, Clark RA, Tockman MS. Discovery of distinct protein profiles specific for lung tumors and ... Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene. 2002 Dec ... Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2004 Jul; 13(7):1185-91. View ... Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse ...
  http://www.childrenshospital.org/directory/physicians/c/alan-cantor