*  Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design |...
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design. ... Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design ... Correction to: Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified Through Structure- ... Our previous modeling and biological studies showed that an ethyl ester is optimal at the C2 substitution of the pyrrole, ...
  http://molpharm.aspetjournals.org/content/89/2/287
*  Pyrroles - A Novel Synthetic Method For Pyrrole Derivatives From Nitrodienes | 66638
Pyrrole nucleus is one of the most important heterocycles abundantly found in bioactive natural molecules, forming the ... 1,2,5-Trisubstituted pyrroles display interesting biological properties, such as anti-inflammatory, antipsychotic, spasmolytic ... Pyrroles - A novel synthetic method for pyrrole derivatives from nitrodienes. 6th World Congress on Medicinal Chemistry and ... The electronic properties of pyrrole are important in the context of conducting polymers, where poly-pyrroles have found many ...
  https://www.omicsonline.org/proceedings/pyrroles--a-novel-synthetic-method-for-pyrrole-derivatives-from-nitrodienes-66638.html
*  subject:(Pyrroles) - OATD
"A study of pyrroles in biological materials. - ." 1938. Doctoral Dissertation, McGill University. Accessed March 25, 2018. http ... A study of pyrroles in biological materials. - . [Internet] [Doctoral dissertation]. McGill University; 1938. [cited 2018 Mar ... In the gradual unravelling of the complexities of biological materials, it has become apparent that the pyrrole group of ... In the gradual unravelling of the complexities of biological materials, it has become apparent that the pyrrole group of ...
  https://oatd.org/oatd/search?q=subject%3A%28Pyrroles%29&pagesize=30
*  Difference between revisions of "OpenSourceMalaria:GSK Arylpyrrole Series" - OpenWetWare
Scifinder Search: 2,4,5-alkyl-1-aryl-pyrrole: 77552 hits, 905 biological studies: WO 2011127333 (A2) ... TCMDC Aryl pyrrole core InChi Key: LNROIXNEIZSESG-UHFFFAOYSA-N. * TCMDC Aryl pyrrole core InChi Key: LNROIXNEIZSESG-UHFFFAOYSA- ... Pyrrole core acid to amide: Amide Synthesis. Other known incidences of these molecules/this series. According to this paper, ... A number of these compounds and intermediates are available for biological testing from by request (contact information on the ...
  https://openwetware.org/wiki/?title=OpenSourceMalaria:GSK_Arylpyrrole_Series&diff=708788&oldid=597172
*  Difference between revisions of "OpenSourceMalaria:GSK Arylpyrrole Series" - OpenWetWare
Scifinder Search: 2,4,5-alkyl-1-aryl-pyrrole: 77552 hits, 905 biological studies: WO 2011127333 (A2) ... A number of these compounds and intermediates are available for biological testing from Todd group by request. ...
  https://openwetware.org/wiki/?title=OpenSourceMalaria:GSK_Arylpyrrole_Series&diff=565683&oldid=565682
*  Difference between revisions of "OpenSourceMalaria:GSK Arylpyrrole Series" - OpenWetWare
Scifinder Search: 2,4,5-alkyl-1-aryl-pyrrole: 77552 hits, 905 biological studies: WO 2011127333 (A2) ... Pyrrole core acid to amide: Amide Synthesis. Other known incidences of these molecules/this series. Related compounds are known ... A number of these compounds and intermediates are available for biological testing from Todd group by request. If you would ... The [1] side chain would target ester isosteres (see TCMDC-123812) but with greater biological stability. ...
  https://openwetware.org/wiki/?title=OpenSourceMalaria:GSK_Arylpyrrole_Series&diff=prev&oldid=597163
*  Pyrrole - Wikipedia
ISBN 1-57259-153-6. . Walsh, C. T., Garneau-Tsodikova, S. & Howard-Jones, A. R. Biological formation of pyrroles: Nature's ... Pyrrole aus Azinen" [Synthesis of pyrrole derivatives: pyrrole from diethyl succinyl succinate, pyrrole from azines]. Berichte ... In contrast, substituted pyrroles (including protected pyrroles) have been used in a broad range of transformations. Pyrroles ... Pyrrole is also weakly acidic at the N-H position, with a pKa of 17.5. Pyrrole was first detected by F. F. Runge in 1834, as a ...
  https://en.wikipedia.org/wiki/Pyrrole
*  Prodigiosin - Wikipedia
Walsh, C. T., Garneau-Tsodikova, S. & Howard-Jones, A. R. Biological formation of pyrroles: Nature's logic and enzymatic ... The biosynthesis of Prodigiosin involves the convergent coupling of three pyrrole type rings (labeled A, B, and C in figure 1) ... Oxidation of the resulting ring yields the final pyrrole ring C. Finally, these two pieces are stitched together in a ... Prodigiosin has recently received renewed attention for its wide range of biological activities, including activities as ...
  https://en.wikipedia.org/wiki/Prodigiosin
*  Double and#946;-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole
Bando T, Sugiyama H (2006) Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides ... 2013) Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/ ... Open circles denote pyrrole subunits, and filled (black) circles represent imidazoles in the simplified structure above. Dp=N, ... John WT, Eldon EB, Milan M, Dervan PB (1996) Extension of Sequence-Specific Recognition in the Minor Groove of DNA by Pyrrole- ...
  https://www.omicsonline.org/open-access/double-alanine-substitutions-incorporated-in-12ring-pyrroleimidazolepolyamides-for-lengthened-dna-minor-groove-recognition-2379-1764-1000175.php?aid=71916
*  Therapeutic Effect of Lecithinized Superoxide Dismutase against Colitis | Journal of Pharmacology and Experimental Therapeutics
2008) Applicability of new spin trap agent, 2-diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-oxide, in biological system ... LPS was from List Biological Laboratories Inc. (Campbell, CA). Alexa Fluor 488 goat anti-rabbit immunoglobulin G was purchased ...
  http://jpet.aspetjournals.org/content/328/1/152.long
*  Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders -...
Buu-Hoi et al., "Thiophen derivatives of potential biological interest. Part IV. Tuberculostatic thiophen compounds" J. Chem. ... Synthesis of 2-(8Z,11Z-heptadecadlenyl)pyrrole (Scheme 3). *Step 1: A Mixture of pyrrole (2.0 g, 29.8 mmol) 8Z,11Z- ... In order to generate 2-alkylated pyrroles, pyrrole was acylated using zinc powder to afford 2-acylpyrroles. The 2-acylpyrroles ... In this paper, the authors disclosed the synthesis of 2-alkylated pyrroles and 3-alkylated pyrroles. The intermediates were ...
  http://www.freepatentsonline.com/9814694.html
*  A comparative study of the biological properties of Australian elapid venoms.
4-substituted 3-hydroxy-1h-pyrrole-2,5-dione deriv.... 16307769 - Isolation of a new l-amino acid oxidase from crotalus ... 4. The data show that information on venom biological properties can be used for differentiation of many species of Australian ... The non-procoagulant Australian venoms exhibited biological properties similar to other elapid venoms, while the procoagulant ...
  http://www.biomedsearch.com/nih/comparative-study-biological-properties-Australian/1981349.html
*  Gold(3+) bromide 2-oxo-2H-pyrrol-5-olate - 1,3-bis(2-methyl-2-butanyl)-2,3-didehydro-1H-3λ<sup>5</sup>-imidazole (1:2:1:1) |...
... bromide 2-oxo-2H-pyrrol-5-olate - 1,3-bis(2-methyl-2-butanyl)-2,3-didehydro-1H-3λ,sup>5. ... Biological Properties. Chemical Reactions. Chemical Safety Data. Drugs or Compounds in Development. Imaging Agents. ... o-2H-pyrrol-5-olat --1,3-bis(2-methyl-. 2-butanyl)-2,3-dide. hydro-1H-3λ5-imidazol (1:2:1:1) [German] [ACD/IUPAC Name] ... oxo-2H-pyrrol-5-ola. te - 1,3-bis(2-meth. yl-2-butanyl)-2,3-d. idehydro-1H-3λ5. -imidazole (1:2:1:1) [ACD/IUPAC Name] ...
  http://www.chemspider.com/Chemical-Structure.23558984.html?rid=f5bd117b-b00a-4936-9831-989970987f0f
*  Plus it
In the current study we provide the first documentation of the biological activity of members in this novel pyrrole carboxamide ... which was a positive ratio that was 40-fold less than that seen with the pyrrole carboxamide library. Furthermore, the pyrrole ... The pyrrole carboxamide library contained 41 building blocks for the R3 position; these included aliphatic as well as aromatic ... Arnold D, Foster C, Huryn D, Lazo J, Johnston P, and Wipf P (2007) Synthesis and biological activity of a focused library of ...
  http://jpet.aspetjournals.org/content/322/3/940
*  Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate
Nakvasina, Biological Membranes: Structural Organization, Functions, Modification by Physical and Chemical Agents, Voronezh ... Protein kinase inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1Н-pyrrol-2,5-dione (MI-1) (Figure 1) has been ... Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate. Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar ... Figure 1: 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1Н-pyrrol-2,5-dione (MI-1): structural formula. ...
  https://www.hindawi.com/journals/tswj/2016/2145753/
*  malaria research community | The Synaptic Leap
Here is a summary of the biological data obtained for the aryl pyrroles to date:. The team have been looking for patterns in ... First Set of Biological Results from the Third Round of Compounds. Published by Alice Williamson ... In late September, the commercial compounds, plus some of the synthetic targets (and analogues) were sent away for biological ... Read more about First Set of Biological Results from the Third Round of Compounds ...
  http://www.thesynapticleap.org/malaria/posts?page=1
*  Publications - Latvijas Organiskās sintēzes institūts
Structure, reactivity, biological applications and future perspectives . Химия гетероцикл.соед. 2002 (11), 1617-1618. ... Andersons A.; Simonyan S.; Lukevics E. Pyrrole-pyridine interconversions on the tungsten catalyst . Latvian J. Chem. 2002(2), ... Veretennikova N.; Skorova A.; Jansone D.; Lukevics E.; Leite L.; Melikyan G. Computer analysis of the biological activity of 2- ... Veretennikova N.; Skorova A.; Jansone D.; Lukevics E.; Leite L.; Melikyan G. Computer analysis of the biological activity of 4- ...
  http://www.osi.lv/en/publications/?op&gads=2002&pg=3&print=1
*  Faculty Full Profile
Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives†. Org. ...
  http://vidyasagar.ac.in/Faculty/Profile/Print?fac_u_id=Fac-CHEM-164
*  Hantzsch pyrrole synthesis - Wikipedia
Pyrroles are found in a variety of natural products with biological activity, so the synthesis of substituted pyrroles has ... 3-dicarbonylated pyrroles can be synthesized by a version of the Hantzsch Pyrrole Synthesis. These pyrroles are particularly ... Alternative methods for synthesizing pyrroles exist, such as the Knorr Pyrrole Synthesis and Paal-Knorr Synthesis. Below is one ... which also have biological significance. A library of substituted pyrrole analogs can be quickly produced by using continuous ...
  https://en.wikipedia.org/wiki/Hantzsch_pyrrole_synthesis
*  Leveraging domain information to restructure biological prediction | BMC Bioinformatics | Full Text
... represents aromatic single bonds as in the C-N bond in pyrrole. ... Biological activity prediction of glycogen synthase kinase-3β ... The biological activities have been discretized as binary values: highly active and weakly active, with a cut-off value of 100 ... Experimental results for biological activity prediction of glycogen synthase kinase-3 β inhibitors. The categorical attributes ... The use of domain information in biological problems has notable effects. There is an abundance of prior work in the field of ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-12-S10-S22
*  The analgesic and anti-inflammatory profile of (±)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619) |...
D.J. Finney,Statistical Methods in Biological Assay, Hafner Publishing Co., New York 1964.Google Scholar ... The analgesic and anti-inflammatory profile of (±)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619). ... pyrrole-1-carboxylic acid (RS-37619),Fedn Proc. 38, 440 (1979).Google Scholar ...
  https://link.springer.com/article/10.1007/BF01965079
*  Marine Drugs | Free Full-Text | Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the ...
... pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good ... Gu, X.-H.; Wan, X.-Z.; Jiang, B. Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole ... A general synthesis of 2,5-bis(3′-indolyl)pyrroles 1a-e is shown in Scheme 1. N-methyl indoles 16a-e were transformed into 1,4- ... 3.1.4. General Procedure for the Preparation of Pyrroles (1a-e). Butanediones 17a-e (2 mmol) was refluxed under N2 for 4 h with ...
  http://www.mdpi.com/1660-3397/11/3/643/htm
*  Patent US6333051 - Nanogel networks and biological agent compositions thereof - Google Patents
1994, 5:647), ethyl 4-[[N-[3-bis(octadecylcarbamoyl)-2-oxapropylcarbonyl]glycinamido]pyrrole-2-carboxamido]-4-pyrrole-2- ... Biological. Any property of biological agent or biological agent. property:. composition that affects the action of this ... The term "biological property" as used herein refers to any property of a biological agent or biological agent composition that ... The libraries of biological agent compositions can be also screened using direct measurement of the biological agent biological ...
  http://www.google.com.au/patents/US6333051
*  Patent US5126442 - Advanced glycosylation endproducts and associated methods - Google Patents
The biological sample is reacted with a known amount of the 1-alkyl-2-formyl-3,4-diglycosyl-pyrrole and then the amount of ... 4-diglycosyl-pyrroles of the present invention can also be utilized to quantitate the amount of protein in a biological sample ... 4 diglycosyl-pyrrole (G-AFGP) and the 1-alkyl-2-formyl-3,4-diglycosyl-pyrrole derived from xylose and 6-aminohexanoic acid is ... These alpha-hydroxyl-pyrroles act as alkylating agents; their electrophilic site is a hydroxymethyl group attached to C3 or C4 ...
  http://www.google.com/patents/US5126442?dq=5,838,906