*  Frontiers | Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction | Frontiers in Aging...
Alterations in mitochondrial dynamics may be involved in the pathophysiology of prevalent neurodegenerative conditions. ... Alterations in mitochondrial dynamics may be involved in the pathophysiology of prevalent neurodegenerative conditions. ... Here we review selected findings in the field of mitochondrial dynamics and their relevance for neurodegeneration and ... Here we review selected findings in the field of mitochondrial dynamics and their relevance for neurodegeneration and ...
  https://www.frontiersin.org/articles/10.3389/fnagi.2015.00101/full
*  British Library EThOS: PGC1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
PGC1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity Author: Dabrowska, Aleksandra Franciszka ... However, the precise regulatory role of PGC1α in the control of mitochondrial dynamics (MD) and neurotoxicity is still unknown ... PGC1α exerts its neuroprotective effects by promoting mitochondrial biogenesis (MB) and functioning. ... Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.676829
*  FASEB > Science Research Conferences >...
Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging May 21 - May 26, 2017. West Palm Beach, Florida 20-Apr-2017 ...
  http://faseb.org/Science-Research-Conferences/Calendar.aspx
*  Gerald S Shadel, PhD > Yale Cancer Center | Yale School of...
Keynote Speaker: Mitochondrial Biogenesis and Dynamics in Health, Disease and AgingFASEB (2015) ... "Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging.". Education & Training. PhD. Texas A & M University (1991) ... Video describing recent publication in CELL on mitochondrial deafness. *Yale study: how mitochondrial DNA defects cause ... of gene expression in human mitochondria and delineating signaling pathways that regulate mitochondrial function and biogenesis ...
  http://yalecancercenter.org/research/people/gerald_shadel.profile
*  Transcriptional regulation | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ...
  http://embor.embopress.org/content/9/7/612.share
*  Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [Mus musculus (house mouse)] - Gene - NCBI
Title: PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid. ... Mitochondrial biogenesis, organism-specific biosystem (from REACTOME) Mitochondrial biogenesis, organism-specific biosystem ... enhanced mitochondrial biogenesis and improved antioxidant defense in the striatum of BACHD mice Title: Enhanced mitochondrial ... Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME) Transcriptional activation ...
  https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=18204786
*  Possible Hepatotoxicity of Doxidan® | Annals of Internal Medicine | American College of Physicians
Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by ...
  http://annals.org/aim/article-abstract/690152/possible-hepatotoxicity-doxidan
*  Mitochondrial Signaling in Health and Disease | Taylor & Francis Group
Mitochondrial biogenesis and dynamics. *Mitochondrial signaling. *Apoptosis and autophagy. *Pharmacology signaling. *Epigenetic ... Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration. ByAntonio Zorzano, Jessica ... Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration. ByAntonio Zorzano, Jessica ... Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration. ByAntonio Zorzano, Jessica ...
  https://www.taylorfrancis.com/books/e/9781439880036
*  Protocols and Video Articles Authored by Matthew C. Kostek (Translated to Norwegian)
Skeletal muscle oxidative capacity and the expression of proteins regulating mitochondrial biogenesis and dynamics are ... while their effect on mitochondrial content, biogenesis and dynamics is not well understood. The purposes of this study were to ... IL-6 Regulation on Skeletal Muscle Mitochondrial Remodeling During Cancer Cachexia in the ApcMin/+ Mouse Skeletal Muscle. 2012 ... to determine if exercise training can attenuate mitochondrial dysfunction and the induction of proteolytic pathways during IL-6 ...
  https://www.jove.com/author/Matthew+C._Kostek?language=Norwegian
*  Muscle remodeling in relation to blood supply: implications for seasonal changes in mitochondrial enzymes | Journal of...
In the present study we examined the impact of erythrocyte dynamics on muscle mitochondrial biogenesis. First, we induced an ... Hood, D. A. (2001). Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J. Appl. Physiol. 90,1137 -1157. ... Scarpulla, R. C. (2002). Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim. Biophys. Acta 1576 ... Collectively, these studies assessed the impact of perfusion on muscle mitochondrial biogenesis. ...
  http://jeb.biologists.org/content/208/3/515
*  Are cancer and ageing different sides of the same coin? | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ... Recent evidence supports an important role for mitochondrial reactive oxygen species (ROS) in cell lifespan and senescence, and ... The expression of the mitochondrial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase NOX1 is increased in tumour ...
  http://embor.embopress.org/content/9/3/234
*  A multiplicity of cell death pathways | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ... Bcl‐XL−/− neurons exhibit an elevated and unstable mitochondrial transmembrane potential (Δm) as well as an increase in ... The predominant localization of Bcl‐XL in the normal mouse brain is on the inner mitochondrial membrane, where it might ... Bax−/−Bak−/− cells are resistant to the induction of apoptosis through the intrinsic (mitochondrial) pathway, which suggests ...
  http://embor.embopress.org/content/8/9/829
*  Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ... which integrates the different death pathways at the mitochondrial checkpoint of apoptosis. At the mitochondrial membrane tBid ... After cerebral ischaemia, mitochondrial dysfunction can ensue as a result of oxidative stress, energy failure and the ... Dimers of tBid and Bax form pores in the outer mitochondrial membrane, thereby releasing cytochrome c (Cytc) or apoptosis‐ ...
  http://embor.embopress.org/content/8/2/129
*  Death on the slopes | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ... Suen DF, Norris KL, Youle RJ (2008) Mitochondrial dynamics and apoptosis. Genes Dev 22: 1577-1590. ... Although much is known about mitochondrial dynamics, metabolism and cell death, we are just beginning to understand the ... This report highlights presentations on the connections between cell death and mitochondrial dynamics, metabolism and cancer, ...
  http://embor.embopress.org/content/10/8/827
*  Protein quality control-linking the unfolded protein response to disease | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ... D. Cyr (Chapel Hill, NC, USA) presented studies on CFTR biogenesis that identify Hsp70/CHIP and RMA1/Derlin1 as E3 ubiquitin ... A basic knowledge of ER structural dynamics and microdomain assembly are required to understand the UPR, as well as to identify ... identification of the components that control ER ultrastructure and the introduction of methods to study ER protein dynamics ...
  http://embor.embopress.org/content/10/11/1206
*  MHC molecules lead many lives | EMBO Reports
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction Janet M. Shaw, Dennis R. Winge ...
  http://embor.embopress.org/content/10/1/30
*  IJMS | Free Full-Text | Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics
... mitochondrial biogenesis and dynamics is also regulated by melatonin. In most cases, melatonin reduces mitochondrial fission ... Mitochondrial dynamics exhibit an oscillatory pattern which matches the melatonin circadian secretory rhythm in pinealeocytes ... melatonin maintains the optimal mitochondrial membrane potential and preserves mitochondrial functions. In addition, ... This is probably achieved by an active transportation via mitochondrial melatonin transporter(s). Melatonin protects ...
  http://www.mdpi.com/1422-0067/17/12/2124
*  Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated Interventions
Mitochondrial Dynamics and Autophagy. Mitochondrial dynamics are also involved in another form of cell death known as autophagy ... placing particular emphasis on the pathways of mitochondrial biogenesis and mitochondrial dynamics, and the therapeutic value ... with the focus on those related to stimulating mitochondrial biogenesis.. 2. Mitochondrial Biogenesis. Skeletal muscle is a ... to induce mitochondrial proliferation, confirming the importance of NRF-1 in PGC-1. -driven mitochondrial biogenesis [29]. ...
  https://www.hindawi.com/journals/jdr/2012/642038/
*  Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats | SpringerLink
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type ... Sánchez-Alcázar JA, Ault JG, Khodjakov A, Schneider E (2000) Increased mitochondrial cytochrome c levels and mitochondrial ... Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes. Mol Cell ... Eskelinen EL (2006) Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Asp Med. doi: 10.1016/j.mam.2006.08. ...
  https://link.springer.com/article/10.1007/s12035-017-0622-3
*  Mitochondrial Regulation | Springer for Research & Development
In this volume expert researchers in the field detail the many methods for further research into regulation of mitochondrial ... discussing how these interactions influence the dynamics of mitochondrial structure and biogenesis. Written in the highly ... biogenesis cellular components mitochondrial function mitochondrial regulation mitochondrial structure quantitative assessment ... PCR Based Determination of Mitochondrial DNA Copy Number in Multiple Species John P. Rooney, Ian T. Ryde, Laurie H. Sanders, ...
  https://rd.springer.com/book/10.1007/978-1-4939-1875-1
*  Probing the Cardiac PGC-1 Regulatory Cascade - Daniel Kelly
Dorn 2nd, Gerald W; Vega, Rick B; Kelly, Daniel P (2015) Mitochondrial biogenesis and dynamics in the developing and diseased ... explore the potential role of PGC-1 coactivators in the control of mitochondrial dynamics (fusion, fission, biogenesis);and (4 ... Vega, Rick B; Horton, Julie L; Kelly, Daniel P (2015) Maintaining ancient organelles: mitochondrial biogenesis and maturation. ... 2016) Mitochondrial protein hyperacetylation in the failing heart. JCI Insight 2: Gong, Guohua; Song, Moshi; Csordas, Gyorgy et ...
  http://grantome.com/grant/NIH/R01-HL058493-15
*  Επιστημονικές Δημοσιεύσεις
Nikoletopoulou V. and Tavernarakis N. (2014) Mitochondrial biogenesis and dynamics in neurodegeneration: A causative ... Palikaras K. and Tavernarakis N. (2014) Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis ... Ploumi C., Daskalaki I. and Tavernarakis N. (2017) Mitochondrial biogenesis and clearance: a balancing act. FEBS Journal, 284: ... Palikaras K., Lionaki E. and Tavernarakis N. (2015) Coordination of mitophagy and mitochondrial biogenesis during ageing in ...
  http://tavernarakislab.gr/publications/223.html
*  HO-EET Regulation of Adipocyte- Vascular Interactions - Nader Abraham
2016) PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid. ...
  http://grantome.com/grant/NIH/P01-HL034300-29-6733
*  Mass Spectrometry Core - Houli Jiang
2016) PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid. ...
  http://grantome.com/grant/NIH/P01-HL034300-29-6735
*  CECAD: Publications 2008
CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis ... Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. Nov;19(11): ... Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease. Nat Rev Genet. Sep;9(9 ... Strong purifying selection in transmission of mammalian mitochondrial DNA. PLoS Biol. Jan;6(1):e10 ...
  http://www.cecad.uni-koeln.de/index.php?id=155&type=0