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*  Recombinant Human GRB2 protein (ab116430) | Abcam
Ab116430 is a full length protein produced in Escherichia coli and has been validated in WB, ELISA, SDS-PAGE, MS. Abcam… ... Epidermal growth factor receptor binding protein GRB2. *GRB 2. *Grb2. *GRB2 adapter protein ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. ...
  http://www.abcam.com/recombinant-human-grb2-protein-ab116430.html
*  Gentaur Molecular :GenWay \ Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2 SH3 adapter GRB2; Protein Ash \...
Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash \ 10-288-22538F for more molecular products just contact us ... TGFB1 TGFB] Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]. [PDGFRA PDGFR2 ... GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2). [IGF1 IBP1] ... SH3 adapter GRB2; Protein Ash Related products : Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter ...
  http://www.antibody-antibodies.com/product1881261-search-Growth_factor_receptor_bound_protein_2___Adapter_protein_GRB2
*  "Coupling of the proto-oncogene product c-Cbl to the epidermal growth f" by Herman Meisner and Michael P. Czech
... that contains numerous PXXP motifs in its COOH-terminal region and constitutively binds the SH3-containing adaptor protein Grb2 ... Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 ... Immunoprecipitates of Cbl from lysates of these cells contain Grb2 in the basal state, while EGF stimulation causes co- ... These results indicate that autophosphorylated EGF receptors associate with the SH2 domain of Grb2, which is complexed through ...
  https://escholarship.umassmed.edu/oapubs/805/
*  Adaptive Hypersensitivity to Estrogen | Clinical Cancer Research
Shc binds to the adaptor proteins Grb2 and Sos, which results in activation of Ras, Raf, Mek, and MAPK (15) . ... The adaptor protein Shc represents a key modulator of tyrosine kinase-activated peptide hormone receptors (13, 14) . As an ... physically associates with the adaptor protein Shc, and induces its phosphorylation. In turn, Shc binds Grb2 and Sos, which ... MAPK pathway activation by Shc requires Shc association with adapter protein Grb2 and then further association with Sos. By ...
  http://clincancerres.aacrjournals.org/content/10/1/337s.long
*  The Role of Grb2 in Cancer and Peptides as Grb2 Antagonists | BenthamScience
... peptide, signaling pathways.. Abstract:Background: Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein, ... Grb2 protein introduction, Grb2 protein involvement in cancer, and the role of peptides as Grb2 antagonists. First, Grb2 and ... Grb2 protein introduction, Grb2 protein involvement in cancer, and the role of peptides as Grb2 antagonists. First, Grb2 and ... Background: Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein, which was originally discovered to ...
  http://www.eurekaselect.com/157760
*  Anti-MUC1/episialin Antibody, clone 214D4 | 05-652
Can bind to GRB2 adapter protein.. SIZE: 1255 amino acids; 122072 Da SUBUNIT: The cleaved form (only the isoform 1) of MUC1 ... The average density of O-glycosylated sites within repeat peptides varies with cell differentiation from about 50% in lactation ... Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding-protein (PEBP) family that modulates ... The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. ...
  http://www.merckmillipore.com/INTL/en/product/Anti-MUC1/episialin-Antibody-clone-214D4,MM_NF-05-652
*  Frank Otto Gombert - Rapid Identification of Ph... | ACS Network
... the SH2 domain of the adapter protein Grb2 predominantly selected beads with the sequence Y*ENDP, whereas the C-terminal SH2 ... containing peptide library. 6.4 +ù 105 individual peptides of nine amino acids in length (EPX6Y*X19X7X19X7X6) were each ... Phosphopeptide interaction of a given SH2 domain was monitored by binding of fluorescein isothiocyanate-labeled antibodies ... Recombinant SH2 domains, expressed as glutathione S-transferase (GST) fusion proteins, were incubated with a phosphotyrosine (Y ...
  https://communities.acs.org/docs/DOC-44000
*  Signal transducing adaptor protein - Wikipedia
... adaptor protein GAB2 - GRB2-associated binding protein 2 Wikipedia:MeSH D12.776#MeSH D12.776.157.057 --- adaptor proteins.2C ... phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins ... GRB2-related adaptor protein GRAP2 - GRB2-related adaptor protein 2 LDLRAP1 - low-density lipoprotein receptor adaptor protein ... phosphoinositide-3-kinase adaptor protein 1 SH2B1 - SH2B adaptor protein 1 SH2B2 - SH2B adaptor protein 2 SH2B3 - SH2B adaptor ...
  https://en.wikipedia.org/wiki/Signal_transducing_adaptor_protein
*  FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve...
... and a C-terminal tail containing multiple binding sites for the SH2 domains of the adapter protein Grb2 and the protein ... 10 μl of the peptide containing the FRS2α binding site of FGFR1 inhibited the binding of the PTB domains of both FRS2 proteins ... Numb is a protein involved in asymmetric cell division inDrosophila melanogaster. It binds to the adapter protein Lnx through ... FRS2 proteins bind to similar regions on FGFR1 via their PTB domains. (A) Binding of FRS2 proteins to deletion mutants of FGFR1 ...
  https://mcb.asm.org/content/20/3/979?ijkey=83748833d6a9bbede69449e685ae7e3e484d000f&keytype2=tf_ipsecsha
*  PTPRA - Wikipedia
... a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo". EMBO J. 13 (13): 3020-32. PMC 395191 . PMID 7518772. Zheng ... Ohagi S, Nishi M, Steiner DF (1991). "Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide)". ... a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo". EMBO J. 13 (13): 3020-32. PMC 395191 . PMID 7518772. den ... den Hertog J, Hunter T (1996). "Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the ...
  https://en.wikipedia.org/wiki/PTPRA
*  Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor...
HD-PTP binds the EGFR adaptor Grb2, via the PRR [55]. The importance of HD-PTP for MVB sorting is highlighted by its necessity ... domain binds at the CHMP4-binding pocket in the Bro1 domain [54,62], while the STAM2 SH3 domain binds to a peptide motif within ... Hrs-binding protein, STAM (signal transducing adaptor molecule) and EAST 1 (EGFR-associated protein with SH3 and TAM domain 1 ... Key binding sites are shown in yellow. HD-PTP binding to EGFR may occur via Grb2, but other modes of interaction are possible ...
  http://www.biochemsoctrans.org/content/early/2018/09/05/BST20170443
*  EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1 | Journal of Cell Science
Binding of SHP2 SH2 domains to phosphotyrosines on various RTKs or on adaptor proteins such as GRB2-associated binding protein- ... 1994). Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived ... Lysates were prepared and assayed for total protein as described above, and 500 μg of protein was incubated with protein G ... Given that SHP2 binding to phosphotyrosine-containing proteins through its N-terminal SH2 domains stabilizes an active SHP2 ...
  http://jcs.biologists.org/content/128/21/3898
*  anti-Homo sapiens (Human) Phospho-EGFR (Y1068) Antibody - Cusabio
The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. ... epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and ... A synthesized peptide derived from human Phospho-EGFR (Y1068). Species Reactivity. Human. ... The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. ...
  https://www.cusabio.com/Recombinant_Antibodies/Phospho-EGFR--Y1068--Antibody-12921430.html
*  CD94/NKG2 - Wikipedia
Ligand binding enables interaction between receptor and ITAM-bearing adaptor protein DAP12 (ITAM, Immunoreceptor tyrosine-based ... Src or Jak kinases phosphorylate DAP10, which can then associate with p85 subunit of PI(3)K or adaptor molecule Grb2. This ... but they present mainly peptides derived from the signal peptides of MHC class I. Therefore NK cells can indirectly monitor the ... NKG2D binds MHC class I homologues MICA (MHC class I polypeptide-related sequence A), MICB and ULBP (UL-16 binding protein) in ...
  https://en.wikipedia.org/wiki/CD94/NKG2
*  anti-GRB2 antibody | GRB2 Monoclonal Antibody (Clone 5G3-E7-F11)-NP 002077.1
GRB2 Monoclonal Antibody (Clone 5G3-E7-F11)-NP_002077.1 (MBS475234) product datasheet at MyBioSource, Primary Antibodies. ... GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3; Growth factor receptor bound protein 2; Growth factor receptor bound protein 3 ... Peptide. Rec./Purified Protein. Custom ELISA Kit. Custom Protein. Custom Antibody. Antibody Matched Pairs. Antibody Peptide ... UniProt Protein Name Growth factor receptor-bound protein 2 UniProt Synonym Protein Names Adapter protein GRB2; Protein Ash; ...
  https://www.mybiosource.com/prods/Antibody/Monoclonal/GRB2/datasheet.php?products_id=475234
*  Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis | The Journal of Immunology
This binding was decreased by coincubation of LP17, a TREM-1-derived peptide known to bind to the TREM-1 ligand (14). The ... The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat ... pathway involving ZAP70 and SYK and the ensuing recruitment and tyrosine phosphorylation of adaptor molecules such as GRB2; the ... 1G). TREM-1 signals through its association with DAP12, an ITAM-containing adaptor protein. Because the formation of CARD9- ...
  http://www.jimmunol.org/content/188/11/5585.long
*  The Clinical Proteomic Technologies for Cancer | Details for Growth Factor Receptor-Bound Protein 2 Peptide 1
... highly characterized monoclonal antibodies to human proteins associated with cancer. ... Epidermal Growth Factor Receptor-Binding; Protein GRB2; Growth Factor Receptor Bound Protein 3; Adapter Protein GRB2 ... CPTC-GRB2-1 peptide ELISA. Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note ... NCKAP2; Protein Ash; ASH; SH2/SH3 Adapter GRB2; EGFRBP-GRB2; Grb3-3; HT027; MST084; MSTP084; Abundant SRC Homology; ...
  https://antibodies.cancer.gov/detail/CPTC-GRB2-1
*  RCSB PDB for 1AZE
Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin. ... Show Detailed Protein Feature View for P62993/1AZE SOS B 10 Drosophila melanogaster Fragment: BINDING SITE IN H-SOS, PEPTIDE ... GRB2 A 56 Homo sapiens Fragment: N-TERMINAL SH3 DOMAIN, RESIDUES 1 - 55 Mutation: Y7V, C32S Gene Name(s): GRB2 Gene View ASH ... Classification: COMPLEX (ADAPTOR PROTEIN / PEPTIDE) * Deposited: 1997-11-17 Released: 1999-05-18 ...
  http://www.rcsb.org/pdb/explore/biologyAndChemistry.do?structureId=1AZE
*  Tyrosine kinase - Wikipedia
An adapter protein such as Grb2 will bind to phosphate-tyrosine residues under the influence of receptor protein kinases. This ... Also very common among protein tyrosine kinases are two peptide sequences. There are over 100 3D structures of tyrosine kinases ... One of the factors is a molecule that is bound reversibly by a protein, called a ligand. A number of receptor tyrosine kinases ... Protein tyrosine kinase plays a role in this task, too. A protein tyrosine kinase called pp125 is likely at hand in the ...
  https://en.wikipedia.org/wiki/Tyrosine_kinase
*  A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 89:693-702. [ ... the COOH terminus of FRS2 are phosphorylated by activated FGFR or NGF receptors and serve to recruit the adaptor protein Grb2 ( ... FGFs are peptide growth factors playing critical roles in various cellular processes including cell proliferation, ... Gab2 was cloned as an SHP2 interacting protein and binds to many of the same proteins as Gab1. It functions in many cellular ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2171408/?lang=en-ca
*  Plus it
... the adaptor molecule Grb2-associated binding protein 1, and the polyoma middle T antigen, also contain pYXXM sites for PI3K ... GO-201 is a cell-penetrating peptide that contains the CQC sequence and binds directly to the MUC1-C cytoplasmic domain, thus ... interacts directly with the SH2 domain of the Grb2 adapter protein (21, 22). The MUC1-C/Grb2 complex associates with the Ras ... Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. Cancer Res 1995;55:4000-3. ...
  http://mct.aacrjournals.org/content/10/5/806
*  KEGG PATHWAY: ErbB signaling pathway - Rattus norvegicus (rat)
Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the ... The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB ... These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ... Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ...
  http://www.genome.jp/kegg-bin/show_pathway?rno04012
*  anti-GAB2 antibody, Internal | GeneTex
GRB2-associated binding protein 2) for WB. Anti-GAB2 pAb (GTX89031) is tested in Human samples. 100% Ab-Assurance. ... GRB2-associated binding protein 2. Background. Adapter protein which acts downstream of several membrane receptors including ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ... GRB2-associated binding protein 2, GAB2, Grb2associated binder2, GRB2associated binding protein 2, KIAA0571, Grb2-associated ...
  http://www.genetex.com/GAB2-antibody-Internal-GTX89031.html
*  GRB2 - Wikipedia
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell ... The SH2 domain of Grb2 binds to phosphorylated tyrosine-containing peptides on receptors or scaffold proteins with a preference ... The Grb2 protein page on The SH2 Website GeneCards entry for Grb2 Human Protein Resource Database entry for Grb2 Grb2 ... In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal ...
  https://en.wikipedia.org/wiki/GRB2
*  February | 2013 | PKA Inhibitors
... one more adaptor protein implicated in RTK signaling.. In this situation,no Grb2 modulation in response for the pharmacological ... and HER2 peptide combine was used as being a stimulating antigen.HIV peptide mix was utilised being a detrimental manage,as ... 31 By reversibly binding to issue Xa, rivaroxaban inhibits human no cost Xa, prothrombinase, and thrombin-bound Xa activity ... Figure 2C demonstrates a time program experiment where Grb7 protein and Akt phos. Posted on February 25, 2013. by admin ...
  https://pkainhibitors.com/2013/02