*  Plus it
... binding affinity to soluble recombinant antigen as well as cell surface CD30 was measured. Binding affinity to recombinant CD30 ... Results: The binding of MDX-1401 to CD30 antigen was identical to fucose-containing parental anti-CD30 antibody (MDX-060). In ... Although the anti-CD30 antibody with an N297Q mutation bound well to CD30+ cells, this antibody failed to bind to FcγRIIIa- ... Identical antigen-binding properties of fucosylated and nonfucosylated anti-CD30 antibodies. To determine whether ...
  http://clincancerres.aacrjournals.org/content/15/10/3376
*  WikiGenes - TNFRSF8 - tumor necrosis factor receptor superfamily...
Bispecific monoclonal antibodies (Bi-mAbs) were designed that bound to a Hodgkin's tumor-associated antigen (CD30) on the tumor ... Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. Hargreaves, P.G., Al-Shamkhani, A. ... Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30 [24]. ... The TRAF-binding domain of CD30 was mapped to the COOH-terminal 36 amino acid residues, which contained two independent binding ...
  https://www.wikigenes.org/e/gene/e/943.html
*  CD30-positive malignant lymphomas: time for a change of management? | Haematologica
Upon binding to the target antigen, brentuximab vedotin is internalized and subsequently degraded within the lysosomal ... 4 the CD30 antigen has attracted substantial scientific interest. Initially termed Ki-1, this antigen was clustered as CD30 ... The CD30 antigen was subsequently also detected in mediastinal B-cell lymphoma, immunoblastic lymphoma, adult T-cell lymphoma ... The diagnostic significance of the CD30 (Ki-1) antigen. Histopathology. 1990;16(4):409-13. ...
  http://www.haematologica.org/content/98/8/1165
*  Chemically linked Fab - Wikipedia
Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell ... Two chemically linked fragments antigen-binding form an artificial antibody that binds to two different antigens, making it a ... They are fragments antigen-binding (Fab or Fab') of two different monoclonal antibodies and are linked by chemical means like a ... antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen-dependent and antigen- ...
  https://en.wikipedia.org/wiki/Chemically_linked_Fab
*  Engineering AAV-2 Targeting Vectors: A New Insertion Site and scFv Driven Vectors - Kölner UniversitätsPublikationsServer
... were able to effectively transduce HeLa cells and to bind an anti-idiotypic antibody homologue to the recognized antigen ... dass die mit anti-CD30 scFV erhaltenen Ergebnisse nicht spezifisch für den anti-CD30 scFv sind. Vergleicht man Studien, die ... These observations led to generation of an anti-CD30 scFv fused to the N-terminus of a GFP molecule that was fused to the N- ... Substitution of the anti-CD30 scFv by an anti-CEA scFv or an anti-CA19 scFv revealed that the results observed with the anti- ...
  http://kups.ub.uni-koeln.de/2690/
*  CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Mouse Monoclonal Antibody [Clone SPM121 ] IHC, IF, FC - Buy...
CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody, Mouse Monoclonal Antibody [Clone SPM121 ] validated in IHC, IF ... Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, ... CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature ... In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also ...
  http://www.abgent.com/products/AH12690-CD30--TNFRSF8-Hodgkin-Reed-Sternberg-Cell-Marker-Antibody
*  CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide
... , Mouse Monoclonal Antibody [Clone Ki-1/ ... Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, ... CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature ... CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology ...
  http://www.abgent.com/products/AH12693-CD30--TNFRSF8-Hodgkin-Reed-Sternberg-Cell-Marker-Antibody-Without-BSA-and-Azide
*  US Patent # 9,102,736. Multispecific deimmunized CD3-binders - Patents.com
The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically ... binding to human CD3 and an Ig-derived second binding domain. Furthermore, ... CD30, CD44v6, Wue-1, Plasma Cell Antigen (see WO 01/47953), (membrane-bound) IgE, Melanoma Chondroitin Sulfate Proteoglycan ( ... Also particularly comprised by said definition is the binding of an antigen-interaction-site to antigens such as antigens of ...
  http://patents.com/us-9102736.html
*  Competitive binding assay. Clone R24.1 and clone R23.1 | Open-i
Clone R24.1 and clone R23.1 mabs did not block the binding of anti-CD30 (BerH2 antibody) to KMH2 cells. ... The antigen recognized by the clone R23.1 mab and clone R24.1 mab does not share epitopes with CD30 cluster regions A, B, or C ... or C of the CD30 molecule, to bind to KMH2 cells (Figure 5). Similarly, none of the anti-CD30 antibodies blocked the binding of ... or C of the CD30 molecule, to bind to KMH2 cells (Figure 5). Similarly, none of the anti-CD30 antibodies blocked the binding of ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2267462_1476-4598-7-12-5&req=4
*  Frontiers | Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds | Immunology
Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit effector ... Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit effector ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00038/full
*  Application # 2018/0142210. MODIFIED STEM CELLS AND USES THEREOF - Patents.com
2), OX40, CD30, CD40, lymphocyte function-associated antigen-1 (LFA-1), CD2, CD7, LIGHT, NKG2C, B7-H3, and a ligand that ... The tag cassette can bind an exogenous cognate binding molecule (ExoCBM) or an endogenous cognate binding molecule (EndoCBM). ... or other binding partner) is capable of specifically binding where the binding property can be used to detect, enrich for, ... or eliminated by binding to cognate binding molecule antibodies that specifically bind a tag cassette (e.g., anti-tag ...
  http://patents.com/us-20180142210.html
*  HABP4 - Wikipedia
1992). "Cellular localizations and processing of the two molecular forms of the Hodgkin-associated Ki-1 (CD30) antigen. The ... Intracellular hyaluronan-binding protein 4 is a protein that in humans is encoded by the HABP4 gene. GRCh38: Ensembl release 89 ... 2005). "MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57". FEBS Lett. 579 ( ... "Entrez Gene: HABP4 hyaluronan binding protein 4". Rohde D, Hansen H, Hafner M, et al. ( ...
  https://en.wikipedia.org/wiki/HABP4
*  EXBIO Antibodies Product Data Sheet
Franke AC, Jung D, Ellis TM: Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies ... CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. ... The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, ... The mouse monoclonal antibody Ber-H8 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein ...
  http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000641/7/6/datasheet-1P-153-T100.html?format=html
*  Patent US20070042017 - Medical device with coating that promotes endothelial cell adherence and ... - Google Patents
... growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to ... bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The ... CD30, stem cell antigen-1 (Sca-1), stem cell factor (SCF or c-Kit ligand), CD133 antigen, VE-cadherin, P1H12, TEK, CD31, Ang-1 ... The endothelial cell, 2.01, is bound via a cell surface antigen, 2.02, to an antibody, 2.03, which in turn is bound, covalently ...
  http://www.google.ca/patents/US20070042017
*  Anti-CD30 [Ki-3]
Lymphocyte activation antigen CD30 Immunogen: Human CD30.. Specificity: The antibody binds to CD30.. Application Notes: The ... CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with ... Anti-CD30 [Ki-3]. Clone Number: Ki-3. Description: Recombinant monoclonal antibody to CD30. Manufactured using AbAb's ... Incubation of CD30 positive L540 cells with Ki-3 antibody weakly enhances release of soluble CD30 (in contrast to Ki-4, Ab00475 ...
  http://absoluteantibody.com/ab/Anti-CD30-Ki-3/
*  Construction and application of bispecific antibody HER2xCD3 - Patent application
... binding capability against surface antigens of tumor cells, comprising HER2, CD20, CD30 or CD133; and (b) a single-chain unit ... 0015] The bispecific antibody is an antibody in which two antigen binding sites in one antibody molecule can bind to two ... the tumor antigen epitope HER2; the light chain binds to the heavy chain through a disulfide bond; and the heavy chain binds to ... binding capability against a surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability ...
  http://www.patentsencyclopedia.com/app/20160145339
*  Plus it
Staining of CD30, IL-6, and IL-2R was observed in the diagnostic lymph node biopsy specimens (Fig. 3A-C) and was mainly ... Nonspecific binding sites were blocked by incubation with 10% nonimmune goat serum. Primary antibodies were added to tissue ... After rinsing with water, the tissue was subjected to antigen retrieval with heated 1 mmol/L EDTA, pH 8.0, and rinsed well with ... Costaining staining of cHL tumor sections with IL-2R and IL-6 followed by CD30 revealed staining of IL-6 in sCD30+ HRS cells. ...
  http://clincancerres.aacrjournals.org/content/19/24/6812
*  US Patent # 9,901,647. Conjugates comprising cell-binding agents and cytotoxic agents - Patents.com
... the cell-binding agent is an antigen-binding portion of a monoclonal antibody, sharing sequences critical for antigen-binding ... CD30, CD33, CD36, CD37, CD38, CD40, CD44, CD52, CD55, CD56, CD59, CD70, CD79, CD80. CD81, CD103, CD105, CD134, CD137, CD138, ... The term "cell binding agent" as used herein refers to a compound that can bind a cell (e.g., on a cell-surface ligand) or bind ... includes a family of proteins as cell binding agents that specifically bind desired targets. As is well known, antibodies bind ...
  http://patents.com/us-9901647.html
*  Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites - Immunomedics,...
... the HLA-DR antigen to which L243 binds, CD66 antigens, i.e. CD66a-d or a combination thereof. The CD66 antigens consist of five ... CD30, Ia, A3, A33, Ep-CAM, KS-1, Le(y), S100, PSA (prostate-specific antigen), tenascin, folate receptor, Thomas-Friedenreich ... The multispecific composite may bind to different epitopes of the same antigen, or alternatively may bind to two different ... having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a ...
  http://www.freepatentsonline.com/8889835.html
*  Mechanisms of Resistance to Antibody-Drug Conjugates | Molecular Cancer Therapeutics
Decreased cell-surface antigen reduces antibody binding, whereas elevated drug transporters such as MDR1 and MRP1 reduce ... three of these Karpas-299-35R clones also showed significant down-regulation of CD30 antigen (25). In this case, no full length ... First, target antigen downregulation can prevent proper binding and/or internalization into cells. Following internalization, ... ADCs are modular biotherapeutics composed of antibody, linker, and payload (3). The antibody is designed to bind antigens that ...
  http://mct.aacrjournals.org/content/15/12/2825?utm_source=jan4spot&utm_medium=carousel&utm_campaign=0408
*  IJMS | Free Full-Text | Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies | HTML
Bispecific antibodies that can simultaneously bind to cell surface antigens and payloads are a very ideal delivery system for ... Unlike the BiTEs, TandAb has two binding sites for one antigen and another two binding sites for the second antigen. TandAb ... CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. mAbs 2014, 6, 727-738. [Google Scholar] [CrossRef ... based molecules usually target tumor-associated antigens with one antigen binding site and target leukocyte antigens with ...
  http://www.mdpi.com/1422-0067/18/1/48/htm
*  TRANSIENT IMMORTALIZATION - Patent application
... binds to the natural killer cell CD16 antigen and, at the other end, recognizes the human Hodgkin tumor CD30 antigen. Using the ... This virus expresses what is termed the large tumor antigen, TAg, which binds to the tumor suppressor proteins p53 and pRB, ... 0095] Expression constructs which enable both VP22-T-antigen and T-antigen-VP22, i.e. both N-terminal and C-terminal fusion ... SV40 small T antigen and SV40 large T antigen (and subfragments and truncated versions thereof), including the small and large ...
  http://www.patentsencyclopedia.com/app/20140186311
*  TARGETING CD138 IN CANCER - Patent application
In certain embodiments, the antigen recognition domain binds to CD138, although it may bind to Melanoma-associated antigen ( ... antigen (MAGE), Preferentially expressed antigen of melanoma (PRAME), survivin, CD19, CD20, CD22, k light chain, CD30, CD33, ... and an antigen recognition domain that binds to a target cell antigen, e.g., an antigen expressed on the surface of a tumor ... antigen, urinary tumor associated antigen, fetal antigen, tyrosinase (p97), gp68, TAG-72, HMFG, Sialyl Lewis Antigen, MucA, ...
  http://www.patentsencyclopedia.com/app/20160017048
*  Pathobiology of Anaplastic Large Cell Lymphoma
O. Josimovic-Alasevic, H. Durkop, R. Schwarting, E. Backe, H. Stein, and T. Diamantstein, "Ki-1 (CD30) antigen is released by ... the antibodies against CD30 produce different types of positivity: membrane-bound, dot-like in the Golgi area (corresponding to ... I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... CD30 overexpression has been reported to induce constitutive NF-κB activation [27, 28]. As expected, the CD30 ligand (CD30L) ...
  https://www.hindawi.com/journals/ah/2010/345053/
*  Plus it
... have potent and target-specific cytotoxicity against tumors expressing the CD30 ( 37), extended Lewis Y ( 38), or CD20 antigens ... B, binding of the anti-CD70 mAb 2F2 and a control IgG to fresh frozen tumor sections derived from two RCC donors was determined ... high percentage of patients with tumor displaying antigen, and minimal antigen shedding are much favored features ( 39). ... 2A and B ). Binding of these ADCs to CD70-expressing cells was similar to unconjugated 1F6 ( Fig. 2A and B, right). These ...
  http://cancerres.aacrjournals.org/content/66/4/2328