Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients.
Soluble CD30 (sCD30) is a suggested marker for kidney transplantation outcomes. We investigated whether sCD30 serum levels are ... membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN ... Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. ... Antigens, Cd30. A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B ...https://www.bioportfolio.com/resources/pmarticle/2020345/Influence-of-immunosuppressive-drugs-on-the-CD30-molecule-in-kidney-transplanted-patients.html
... binding affinity to soluble recombinant antigen as well as cell surface CD30 was measured. Binding affinity to recombinant CD30 ... Results: The binding of MDX-1401 to CD30 antigen was identical to fucose-containing parental anti-CD30 antibody (MDX-060). In ... Although the anti-CD30 antibody with an N297Q mutation bound well to CD30+ cells, this antibody failed to bind to FcγRIIIa- ... Identical antigen-binding properties of fucosylated and nonfucosylated anti-CD30 antibodies. To determine whether ...http://clincancerres.aacrjournals.org/content/15/10/3376
Applications filed at May 24 2018 | INITIATOR COMPOSITION FOR FLUORINATED POLYMER AND METHOD FOR PRODUCING FLUORINATED...
Provided herein are chimeric antigen receptors (CARs) comprising an antigen binding domain (e.g., CD19, CD30, GD2, etc.), ... Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding ... The invention provides an antibody or antigen binding fragments thereof that binds to 3pE A.beta. and methods of making and ... Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies ...http://patents.com/ap-20180524-p91.html
WikiGenes - TNFRSF8 - tumor necrosis factor receptor superfamily...
Bispecific monoclonal antibodies (Bi-mAbs) were designed that bound to a Hodgkin's tumor-associated antigen (CD30) on the tumor ... Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. Hargreaves, P.G., Al-Shamkhani, A. ... Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30 . ... The TRAF-binding domain of CD30 was mapped to the COOH-terminal 36 amino acid residues, which contained two independent binding ...https://www.wikigenes.org/e/gene/e/943.html
CD30-positive malignant lymphomas: time for a change of management? | Haematologica
Upon binding to the target antigen, brentuximab vedotin is internalized and subsequently degraded within the lysosomal ... 4 the CD30 antigen has attracted substantial scientific interest. Initially termed Ki-1, this antigen was clustered as CD30 ... The CD30 antigen was subsequently also detected in mediastinal B-cell lymphoma, immunoblastic lymphoma, adult T-cell lymphoma ... The diagnostic significance of the CD30 (Ki-1) antigen. Histopathology. 1990;16(4):409-13. ...http://www.haematologica.org/content/98/8/1165
Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1 | PNAS
Both 211At-HeFi-1 and 111In-HeFi-1 bound to the CD30-positive cells specifically with the maximum bindings of ,90% of added ... The development of the hybridoma technique rekindled interest in the use of antibodies targeted to cell surface antigens to ... HeFi-1, which is a mouse IgG1 directed toward the ligand-binding site on CD30, was provided by the Biological Response ... Anti-CD30 monoclonal antibodies have been investigated for the treatment of CD30-expressing malignancies in vitro and in vivo ( ...http://www.pnas.org/content/104/20/8444.long
Chemically linked Fab - Wikipedia
Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell ... Two chemically linked fragments antigen-binding form an artificial antibody that binds to two different antigens, making it a ... They are fragments antigen-binding (Fab or Fab') of two different monoclonal antibodies and are linked by chemical means like a ... antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen-dependent and antigen- ...https://en.wikipedia.org/wiki/Chemically_linked_Fab
Frontiers | Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies | Immunology
Additionally, we discuss the use of chimeric-antigen-receptor (CARs) engineered NK cells in cancer immunotherapy. ... Additionally, we discuss the use of chimeric-antigen-receptor (CARs) engineered NK cells in cancer immunotherapy. ... They usually bind both the tumor antigen and the FcγRIIIA/CD16 (68). Recently, a bispecific tetravalent antibody was introduced ... A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00492/full
Engineering AAV-2 Targeting Vectors: A New Insertion Site and scFv Driven Vectors - Kölner UniversitätsPublikationsServer
... were able to effectively transduce HeLa cells and to bind an anti-idiotypic antibody homologue to the recognized antigen ... dass die mit anti-CD30 scFV erhaltenen Ergebnisse nicht spezifisch für den anti-CD30 scFv sind. Vergleicht man Studien, die ... These observations led to generation of an anti-CD30 scFv fused to the N-terminus of a GFP molecule that was fused to the N- ... Substitution of the anti-CD30 scFv by an anti-CEA scFv or an anti-CA19 scFv revealed that the results observed with the anti- ...http://kups.ub.uni-koeln.de/2690/
US Patent # 9,102,736. Multispecific deimmunized CD3-binders - Patents.com
The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically ... binding to human CD3 and an Ig-derived second binding domain. Furthermore, ... CD30, CD44v6, Wue-1, Plasma Cell Antigen (see WO 01/47953), (membrane-bound) IgE, Melanoma Chondroitin Sulfate Proteoglycan ( ... Also particularly comprised by said definition is the binding of an antigen-interaction-site to antigens such as antigens of ...http://patents.com/us-9102736.html
Frontiers | The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future...
These bispecifics (TandAbs) are tetravalent in nature, thus offering four binding sites, two aimed at tumor antigens and two ... Currently, Affimed's AFM13 that targets CD30 on cancer cells and CD16a on NK cells is in clinical Phase II testing in patients ... Further, this MicAbody was engineered with an additional binding site to target tumor antigens of interest, thus enabling ... SOCS1 and SOCS3 bind to JAK1, JAK2, and TYK2 molecules and inhibit JAK activity. Similarly, CIS protein binds to JAK1 and ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00631/full
CD Antigens (Clusters of Differentiation Antigens) < Differentiation Antigens << Surface Antigens <<< Antigens (Antibody...
Cluster of Differentiation Antigens) are a group of monoclonal antibodies, that show similar reactivity with certain ... subpopulations of antigens of a particular lineage or differentiation stage ... CD30 Ligand (CD153 Antigen). In our body, CD30 Ligand (CD153 Antigen) is a glycoprotein membrane-bound tumor necrosis family ... CD30 antigens encoded by the TNFRSF8 gene *CD36 antigens encoded by the CD36 gene *CD38 antigens *CD79 antigens *CD79A antigen ...http://wellnessadvocate.com/?dgl=66700
CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Mouse Monoclonal Antibody [Clone SPM121 ] IHC, IF, FC - Buy...
CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody, Mouse Monoclonal Antibody [Clone SPM121 ] validated in IHC, IF ... Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, ... CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature ... In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also ...http://www.abgent.com/products/AH12690-CD30--TNFRSF8-Hodgkin-Reed-Sternberg-Cell-Marker-Antibody
Competitive binding assay. Clone R24.1 and clone R23.1 | Open-i
Clone R24.1 and clone R23.1 mabs did not block the binding of anti-CD30 (BerH2 antibody) to KMH2 cells. ... The antigen recognized by the clone R23.1 mab and clone R24.1 mab does not share epitopes with CD30 cluster regions A, B, or C ... or C of the CD30 molecule, to bind to KMH2 cells (Figure 5). Similarly, none of the anti-CD30 antibodies blocked the binding of ... or C of the CD30 molecule, to bind to KMH2 cells (Figure 5). Similarly, none of the anti-CD30 antibodies blocked the binding of ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2267462_1476-4598-7-12-5&req=4
CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide
... , Mouse Monoclonal Antibody [Clone Ki-1/ ... Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, ... CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature ... CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology ...http://www.abgent.com/products/AH12693-CD30--TNFRSF8-Hodgkin-Reed-Sternberg-Cell-Marker-Antibody-Without-BSA-and-Azide
Application # 2018/0142210. MODIFIED STEM CELLS AND USES THEREOF - Patents.com
2), OX40, CD30, CD40, lymphocyte function-associated antigen-1 (LFA-1), CD2, CD7, LIGHT, NKG2C, B7-H3, and a ligand that ... The tag cassette can bind an exogenous cognate binding molecule (ExoCBM) or an endogenous cognate binding molecule (EndoCBM). ... or other binding partner) is capable of specifically binding where the binding property can be used to detect, enrich for, ... or eliminated by binding to cognate binding molecule antibodies that specifically bind a tag cassette (e.g., anti-tag ...http://patents.com/us-20180142210.html
Frontiers | Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds | Immunology
Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit effector ... Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit effector ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00038/full
HABP4 - Wikipedia
1992). "Cellular localizations and processing of the two molecular forms of the Hodgkin-associated Ki-1 (CD30) antigen. The ... Intracellular hyaluronan-binding protein 4 is a protein that in humans is encoded by the HABP4 gene. GRCh38: Ensembl release 89 ... 2005). "MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57". FEBS Lett. 579 ( ... "Entrez Gene: HABP4 hyaluronan binding protein 4". Rohde D, Hansen H, Hafner M, et al. ( ...https://en.wikipedia.org/wiki/HABP4
EXBIO Antibodies Product Data Sheet
Franke AC, Jung D, Ellis TM: Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies ... CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. ... The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, ... The mouse monoclonal antibody Ber-H8 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein ...http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000641/7/6/datasheet-1P-153-T100.html?format=html
Patent US20070042017 - Medical device with coating that promotes endothelial cell adherence and ... - Google Patents
... growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to ... bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The ... CD30, stem cell antigen-1 (Sca-1), stem cell factor (SCF or c-Kit ligand), CD133 antigen, VE-cadherin, P1H12, TEK, CD31, Ang-1 ... The endothelial cell, 2.01, is bound via a cell surface antigen, 2.02, to an antibody, 2.03, which in turn is bound, covalently ...http://www.google.ca/patents/US20070042017
Construction and application of bispecific antibody HER2xCD3 - Patent application
... binding capability against surface antigens of tumor cells, comprising HER2, CD20, CD30 or CD133; and (b) a single-chain unit ... 0015] The bispecific antibody is an antibody in which two antigen binding sites in one antibody molecule can bind to two ... the tumor antigen epitope HER2; the light chain binds to the heavy chain through a disulfide bond; and the heavy chain binds to ... binding capability against a surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability ...http://www.patentsencyclopedia.com/app/20160145339
Lymphocyte activation antigen CD30 Immunogen: Human CD30.. Specificity: The antibody binds to CD30.. Application Notes: The ... CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with ... Anti-CD30 [Ki-3]. Clone Number: Ki-3. Description: Recombinant monoclonal antibody to CD30. Manufactured using AbAb's ... Incubation of CD30 positive L540 cells with Ki-3 antibody weakly enhances release of soluble CD30 (in contrast to Ki-4, Ab00475 ...http://absoluteantibody.com/ab/Anti-CD30-Ki-3/
Staining of CD30, IL-6, and IL-2R was observed in the diagnostic lymph node biopsy specimens (Fig. 3A-C) and was mainly ... Nonspecific binding sites were blocked by incubation with 10% nonimmune goat serum. Primary antibodies were added to tissue ... After rinsing with water, the tissue was subjected to antigen retrieval with heated 1 mmol/L EDTA, pH 8.0, and rinsed well with ... Costaining staining of cHL tumor sections with IL-2R and IL-6 followed by CD30 revealed staining of IL-6 in sCD30+ HRS cells. ...http://clincancerres.aacrjournals.org/content/19/24/6812
US Patent # 9,901,647. Conjugates comprising cell-binding agents and cytotoxic agents - Patents.com
... the cell-binding agent is an antigen-binding portion of a monoclonal antibody, sharing sequences critical for antigen-binding ... CD30, CD33, CD36, CD37, CD38, CD40, CD44, CD52, CD55, CD56, CD59, CD70, CD79, CD80. CD81, CD103, CD105, CD134, CD137, CD138, ... The term "cell binding agent" as used herein refers to a compound that can bind a cell (e.g., on a cell-surface ligand) or bind ... includes a family of proteins as cell binding agents that specifically bind desired targets. As is well known, antibodies bind ...http://patents.com/us-9901647.html
Mechanisms of Resistance to Antibody-Drug Conjugates | Molecular Cancer Therapeutics
Decreased cell-surface antigen reduces antibody binding, whereas elevated drug transporters such as MDR1 and MRP1 reduce ... three of these Karpas-299-35R clones also showed significant down-regulation of CD30 antigen (25). In this case, no full length ... First, target antigen downregulation can prevent proper binding and/or internalization into cells. Following internalization, ... ADCs are modular biotherapeutics composed of antibody, linker, and payload (3). The antibody is designed to bind antigens that ...http://mct.aacrjournals.org/content/15/12/2825?utm_source=jan4spot&utm_medium=carousel&utm_campaign=0408