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*  Weekly Paclitaxel Plus Carboplatin in Preoperative Treatment of Breast Cancer - Full Text View - ClinicalTrials.gov
Albumin-Bound Paclitaxel. Carboplatin. Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. ...
  https://clinicaltrials.gov/ct2/show/NCT01203267
*  Tubulin binding cofactor C-like domain (IPR012945) | InterPro | EMBL-EBI
Tubulin binding cofactor C-like domain (IPR012945). Short name: Tubulin-bd_cofactor_C_dom ... This domain is found in tubulin-binding cofactor C (or tubulin-specific chaperone C) (TBCC) and in protein XRP2. TBCC is a ... Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.. Exp. Cell Res. 313 425-36 2007 ... Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana.. Curr. Biol. 12 1519-23 2002 ...
  http://www.ebi.ac.uk/interpro/entry/IPR012945
*  Update on tubulin-binding agents. - Semantic Scholar
... response rates have been seen but randomised trials need to be completed before the role of specific novel tubulin-binding ... Update on tubulin-binding agents.. @article{Attard2006UpdateOT, title={Update on tubulin-binding agents.}, author={Gerhardt ...
  https://www.semanticscholar.org/paper/Update-on-tubulin-binding-agents.-Attard-Greystoke/fa923182199aa2fd5045692fe21221bd7bbc8e9a
*  Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity | Cancer Research
Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity. A.L. Risinger, J. Li, M.J. Bennett ... Mass spectrometry confirmed a covalent interaction of AJ with a peptide of β-tubulin containing the cyclostreptin-binding sites ... Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity ... Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity ...
  http://cancerres.aacrjournals.org/content/early/2013/11/07/0008-5472.CAN-13-1346
*  The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes...
The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes ... The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes ... The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes ... The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes ...
  http://mct.aacrjournals.org/content/early/2016/10/14/1535-7163.MCT-16-0252
*  Download Tubulin Binding Agents Synthetic Structural And Mechanistic Insights
co-organised PurchaseI Moreover are selecting a download tubulin binding agents synthetic of this other spin around for those ... I down was the download tubulin binding agents and found a change from it. 3 pleas fused this essential. ... download tubulin binding agents synthetic structural disc LinkedIn? 9) is not use on a download tubulin binding agents ... exudes an download tubulin binding to Start agency under execution practice. May install been without download tubulin binding ...
  http://procurio-me.com/scripts/ebook/download-tubulin-binding-agents%3A-synthetic%2C-structural-and-mechanistic-insights
*  Lirias: Evidence for an alternative pathway for colchicine binding to tubulin, based on the binding-kinetics of the constituent...
Evidence for an alternative pathway for colchicine binding to tubulin, based on the binding-kinetics of the constituent rings. ... The kinetics of tropolone methyl ether binding to tubulin were measured by following the loss of colchicine binding capacity ... upon preincubation of tubulin with tropolone methyl ether. At 25-degrees-C a bimolecular association rate constant of 2.7 (+/- ...
  https://lirias.kuleuven.be/handle/123456789/31922
*  AID 756583 - Competitive binding affinity to pig brain tubulin colchicine binding site after 1 hr by mass spectrophotometric...
Competitive binding affinity to pig brain tubulin colchicine binding site after 1 hr by mass spectrophotometric analysis in ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/756583
*  The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of...
There is little information on how TBCA might interact with β-tubulin en route to microtubule biogenesis. To address this, the ... Tubulin-binding cofactor A (TBCA) participates in microtubule formation, a key process in eukaryotic biology to create the ... of conserved features infers that electrostatic interactions that are likely to involve the C-terminal tail of β-tubulin are ... Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major. *Keri L. Barrack, Paul K. Fyfe ...
  https://www.semanticscholar.org/paper/The-structure-of-tubulin-binding-cofactor-A-from-a-Barrack-Fyfe/2643ea7b26a95354f011d33c21081cb778838d26
*  Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1
Along with the known interaction of the Cx43-CT with ZO-1 and tubulin, the data presented here for drebrin indicate non- ... overlapping and separated binding sites for all three proteins for which simultaneous binding could be important in regulating ... Three Cx43-CT areas were found to be involved in drebrin binding, with residues 264-275 being critical for the interaction. ... Several studies described the interaction between Cx43 and the cytoskeleton involving the actin binding proteins Zonula ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157073
*  The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density | PNAS
Understanding tubulin-Taxol interactions: Mutations that impart Taxol binding to yeast tubulin ... The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density. James P. Snyder, James H. ... The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density ... Binding-Site Interactions.. In our model, the binding pocket for PTX resides in a deep hydrophobic cleft near the surface of β- ...
  http://www.pnas.org/content/98/9/5312.long
*  CiNii 論文 - Transferrin Synthesized in Cultured Human Fibroblasts is Associated with Tubulins...
Transferrin Synthesized in Cultured Human Fibroblasts is Associated with Tubulins and has Iron Binding Capacity * * Sakaguchi ... its posttranscriptional regulation and association with tubulin. KONDO T. ...
  https://ci.nii.ac.jp/naid/10002420502
*  Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA :: MPG.PuRe
Atomic resolution structure of human alpha-tubulin acetyltransferase,br/, bound to acetyl-CoA ... Taschner, M., Vetter, M., & Lorentzen, E. (2012). Atomic resolution structure of human alpha-tubulin acetyltransferase bound to ... Here, we present the structure of the human alpha-tubulin acetyltransferase catalytic domain bound to its cosubstrate acetyl- ... Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA ...
  http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1609330
*  Abstract 3223: Novel tubulin inhibitor DJ101 targets the colchicine binding site and suppresses melanoma growth and metastasis ...
... that specifically targets the colchicine binding site on the beta tubulin subunit, disrupts tubulin polymerization and ... Abstract 3223: Novel tubulin inhibitor DJ101 targets the colchicine binding site and suppresses melanoma growth and metastasis ... Novel tubulin inhibitor DJ101 targets the colchicine binding site and suppresses melanoma growth and metastasis [abstract]. In ... Abstract 3223: Novel tubulin inhibitor DJ101 targets the colchicine binding site and suppresses melanoma growth and metastasis ...
  http://cancerres.aacrjournals.org/content/77/13_Supplement/3223
*  Bioinformatics Based Understanding of Effect of Mutations in the Human β Tubulin Outside Drug Binding Sites and its...
Bioinformatics Based Understanding of Effect of Mutations in the Human β Tubulin Outside Drug Binding Sites and its ... Bioinformatics Based Understanding of Effect of Mutations in the Human β Tubulin Outside Drug Binding Sites and its ... Human β tubulin displays resistance to drugs like Taxol and Vinblastine due to amino acids substitutions within and outside the ... This study throws light on the mechanism of drug resistance due to amino acid substitutions outside the drug binding site. It ...
  https://benthamopen.com/ABSTRACT/TOBIOIJ-11-29
*  Bioinformatics Based Understanding of Effect of Mutations in the Human β Tubulin Outside Drug Binding Sites and its...
Bioinformatics Based Understanding of Effect of Mutations in the Human β Tubulin Outside Drug Binding Sites and its ... Chang P, Stearns T. δ-tubulin and ϵ-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and ... δ-tubulin and ϵ-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. Nat Cell ... Human beta tubulin with mutations outside the drug binding sites (R306C, D197N, K350N are highlighted in wireframe format. ...
  https://benthamopen.com/FULLTEXT/TOBIOIJ-11-29
*  Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport | JCB
Labeled tubulin was mixed with unlabeled tubulin so that ∼10% of the tubulin was labeled with Alexa Fluor dye, and was diluted ... C and D) Motor domain binding sites in axons. KIF5 binding sites (C) and KIF1A binding sites (D). Dronpa-fused motors (green) ... Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. Takao Nakata ... MT-binding assay. Tubulin was purified from porcine brains by six cycles of polymerization and depolymerization. A high- ...
  http://jcb.rupress.org/content/194/2/245
*  Free Pharmacology Flashcards about USU Pharm lec 70-72
binds B-tubulin and promotes polymerization and stabilizes microtubules. Arrests cell in G2/M. Use for taxane/anthracycline res ... binds tubulin. inhibits polymerization. spindle fiber formation and mitosis inhibited. cytoskeletal movement disrupted. ... binds tubulin. inhibits polymerization. spindle fiber formation and mitosis inhibited. cytoskeletal movement disrupted. ... Binds plasma proteins. if other drugs that bind plasma proteins are present, they knock off MTX and inc. concentration of free ...
  https://www.studystack.com/flashcard-924562
*  Lymphoproliferative Disorders Medication: Antineoplastic agents, Antiemetic agents, Uroprotective antidote
Inhibits mitosis by binding tubulin. Inhibits microtubule formation in mitotic spindle, arresting metaphase. ... With release of 5-HT and its subsequent binding to 5-HT3-receptors, vagal neurons are stimulated and transmit signals to the ... Combines ubiquitous uses and likely to downregulate inflammatory proteins by directly signaling with intrachromosomal binding ...
  https://emedicine.medscape.com/article/987765-medication
*  Mebendazole - Wikipedia
"The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer ... Protein binding. 95%. Metabolism. Extensive liver. Elimination half-life. 3-6 hours. ...
  https://en.wikipedia.org/wiki/Vermox
*  Pyrantel - Wikipedia
Binds tubulin. *benzimidazole *Albendazole#. Other/unknown. *quinoline *Praziquantel#. *salicylanilide *Niclosamide#. * ...
  https://en.wikipedia.org/wiki/Pyrantel
*  IFT81 Gene - GeneCards | IFT81 Protein | IFT81 Antibody
... forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH ( ... forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH ( ... forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within ... Interacts with tubulin; the interaction is direct. Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFT81