eIF4E (phospho S209)抗体[EP2151Y]|Abcam中国|Anti-eIF4E (phospho S209)抗体[EP2151Y]
Messanger RNA Cap Binding Protein eIF 4E antibody. *MGC111573 antibody. *mRNA cap binding protein antibody ... Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex. ... Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and ... Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1- ...http://www.abcam.cn/eif4e-phospho-s209-antibody-ep2151y-ab76256.html
Anti-eIF4E 抗体 (ab1126) | アブカム
Messanger RNA Cap Binding Protein eIF 4E antibody. *MGC111573 antibody. *mRNA cap binding protein antibody ... Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex. ... Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and ... Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1- ...http://www.abcam.co.jp/eif4e-antibody-ab1126.html
GEMIN5 Gene - GeneCards | GEMI5 Protein | GEMI5 Antibody
Protein Coding), Gem Nuclear Organelle Associated Protein 5, including: function, proteins, disorders, pathways, orthologs, and ... The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. (PMID: 27507887) Francisco- ... Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.25 ... Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. (PMID: 11714716) Gubitz AK … Dreyfuss G ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=GEMIN5
Post-translational regulation of rotavirus protein NSP1 expression in mammalian cells, Archives of Virology | 10.1007/s00705...
"Post-translational regulation of rotavirus protein NSP1 expression in mammalian cells, Archives of Virology" on DeepDyve, the ... RNA-binding and capping activities of proteins in rotavirus open cores. Patton, JT; Chen, D ... Rotavirus protein NSP3 (NS34) is bound to the 3′ end consensus sequence of viral mRNAs in infected cells ... Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F ...https://www.deepdyve.com/lp/springer_journal/post-translational-regulation-of-rotavirus-protein-nsp1-expression-in-ynxz1I2cNz
Thomas C Vanaman | Molecular & Cellular Biochemistry
"Structural analysis of the messenger RNA cap-binding protein. Presence of phosphate, sulfhydryl, and disulfide groups." The ... a peripheral membrane protein with covalently bound palmitic acid." The Journal of biological chemistry 262, 3 (1987): 1300-4. ... Specific probes for protein-binding domains." The Journal of biological chemistry 259, 24 (1984): 15414-24. [PubMed Link] , [ ... the vitamin D-dependent 28 kDa calcium binding protein." FEBS letters 297, 1-2 (1992): 127-31. [PubMed Link] , [ Full text ] ...https://biochemistry.med.uky.edu/users/vanaman
Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels
Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell. 2009;138:328-339. [PMC free ... is required for the nuclear export of CBC bound to capped RNAs and the subsequent re-import of CBC along with importin-β (44,45 ... A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell. 1994;78:657-668. [PubMed] ... A cap-binding protein complex mediating U snRNA export. Nature. 1995;376:709-712. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3605737/?lang=en-ca
Five-prime cap - Wikipedia
"Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP". Cell. 89 (6): 951-961. doi: ... Nuclear export of RNA is regulated by the cap binding complex (CBC), which binds exclusively to 7-methylguanylate-capped RNA. ... "ab initio capping mechanism." For capping with 7-methylguanylate, the capping enzyme complex (CEC) binds to RNA polymerase II ... this kind of mechanism ensures capping, as with polyadenylation). The enzymes for capping can only bind to RNA polymerase II, ...https://en.wikipedia.org/wiki/Five-prime_cap
RNA cap binding. RNA 7-methylguanosine cap binding. RNA binding. mRNA binding. protein binding. snRNA binding. poly(A) RNA ... The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' ... nuclear cap binding protein subunit 2, 20kD; nuclear cap binding protein subunit 2, 20kDa; Nuclear cap-binding protein subunit ... The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC ...https://www.thermofisher.com/antibody/product/NCBP2-Antibody-Polyclonal/PA5-38625
PBAD promoter - Wikipedia
The two bound AraC proteins dimerize and cause looping of the DNA. The looping prevents binding of CAP and RNA Polymerase, ... Additionally, CAP binds to two CAP binding sites upstream of the I1 and I2 operators and helps activate the PBAD promoter. In ... The cyclic AMP receptor protein CAP binds between the PBAD and PC promoters, stimulating transcription of both when bound by ... The N-terminal arm of AraC interacts with its DNA binding domain, allowing two AraC proteins to bind to the O2 and I1 operator ...https://en.wikipedia.org/wiki/PBAD_promoter
DEAD box - Wikipedia
Sonenberg N (1988). "Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation". ... which makes the branch point recognition sequence of U2 available to bind the branch point sequence. Prp28 may have a role in ... Tanaka N, Schwer B (July 2005). "Characterization of the NTPase, RNA-binding, and RNA helicase activities of the DEAH-box ... but DEAD box proteins use ATP and DEAH does not. DEAD box proteins are considered to be RNA helicases and many have been found ...https://en.wikipedia.org/wiki/DEAD_box
OriGene - NCBP2 (NM 007362) cDNA Clone
Human nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 1 available for purchase from OriGene - Your ... The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC ... Gene Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the ... Mouse nuclear cap binding protein subunit 2 (Ncbp2). $390. Next day. MG219175. Ncbp2 (GFP-tagged) - Mouse nuclear cap binding ...http://www.origene.com/human_cdna/NM_007362/SC115562.aspx
Capping enzyme - Wikipedia
Wen, Y; Yue, Z; Shatkin, AJ (Oct 13, 1998). "Mammalian capping enzyme binds RNA and uses protein tyrosine phosphatase mechanism ... domain and a C-terminal oligonucleotide binding (OB) domain. The NTase domain, conserved in capping enzymes, DNA and RNA ... When this complex of RNA polymerase II and the capping enzymes is achieved, the capping enzymes are able to add the cap to the ... cap is therefore specific to RNAs synthesized by this polymerase rather than those synthesized by RNA polymerase I or RNA ...https://en.wikipedia.org/wiki/Capping_enzyme
Bacteria: Third RNA binding protein identified
This protein and the RNA molecules that bind to it represent a largely unresearched class of gene activity regulators in the ... Baffin Island - Disappearing ice caps. Giff Miller, geologist and paleoclima-tologist, is walking the margins of melting ... Bacteria: Third RNA binding protein identified. 18.10.2016. Small regulatory RNA molecules are vital for salmonella and other ... The structures of the different regulatory RNA molecules are shown left, their preferred protein binding partners on the right ...http://www.innovations-report.com/html/reports/life-sciences/bacteria-third-rna-binding-protein-identified.html
Nuclear cap-binding protein complex - Wikipedia
Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap- ... When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. ... Human nuclear cap-binding protein complex plays important role in the maturation of pre-mRNA and uracil-rich small nuclear RNA ... Human nuclear cap-binding protein complex shows the large subunit, CBC80 consists of 757 amino acid residues. Its secondary ...https://en.wikipedia.org/wiki/Nuclear_cap-binding_protein_complex
Eukaryotic initiation factor 4F - Wikipedia
The eIF4F complex is composed of three non-identical subunits: the DEAD-box RNA helicase eIF4A, the cap-binding protein eIF4E, ... Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the 5' cap of messenger RNAs (mRNAs) to ... via eIF4A's RNA helicase activity. The eIF4F proteins interact with a number of different binding partners, and there are ... eIF4E binds the m7G 5' cap and the eIF4G scaffold, connecting the mRNA 5' terminus to a hub of other initiation factors and ...https://en.wikipedia.org/wiki/Eukaryotic_initiation_factor_4F
After fertilization of sea urchin eggs, eIF4G is post-translationally modified and associated with the cap-binding protein...
... eIF4G binds independently of eIF4E to a large secondary structure element within the RNA called the internal ribosome entry ... Protein A Sepharose beads with anti-SgIF4G but without proteins and protein A Sepharose beads with proteins but without anti- ... Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. ... Repression of cap-dependent translation by 4E-binding protein 1, competition with p220 for binding to eukaryotic initiation ...http://jcs.biologists.org/content/120/3/425
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.
The eIF4F complex is composed of the 5′ cap binding protein eIF4E, a scaffolding protein eIF4G, and the RNA helicase eIF4A 23. ... Alternatively, H1a bound, and constitutively active mGluR5 which drives total protein synthesis rates (Fig. 3) 20 could elevate ... 0/Carrier Proteins; 0/Fmr1 protein, mouse; 0/Grm5 protein, mouse; 0/Grm5 protein, rat; 0/Homer protein; 0/Peptides; 0/Protein ... which in turn phosphorylates the cap-binding protein eIF4E (S209) 23. ERK also phosphorylates eIF4E binding protein (4EBP) at ...http://www.biomedsearch.com/nih/Disrupted-Homer-scaffolds-mediate-abnormal/22267161.html
PRPF8 - Wikipedia
Hinz M, Moore MJ, Bindereif A (Aug 1996). "Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and ... "A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein". ... which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a ... Grainger RJ, Beggs JD (May 2005). "Prp8 protein: at the heart of the spliceosome". RNA. 11 (5): 533-57. doi:10.1261/rna.2220705 ...https://en.wikipedia.org/wiki/PRPF8
Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects | Journal...
We also examined levels of the RNA binding protein FMRP and a number of cap-dependent translation regulators as these proteins ... 2008) Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds ... PRMT8 can physically interact with a number of RNA binding proteins, and numerous RNA binding proteins, such as FMRP, are ... Despite the requirement of this protein complex for global cellular protein synthesis, alterations in cap binding complex ...http://www.jneurosci.org/content/37/36/8655?rss=1
Karla M Neugebauer, PhD > Biological & Biomedical Sciences | Yale...
Specialized Terms: pre-mRNA splicing, transcription, gene architecture, SR proteins, cap-binding complex, RNA-protein ... Illustration of the nucleus and cytoplasm of a eukaryotic cell containing nonmembrane-bound cellular bodies, such as nucleoli, ... The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Änkö, M-L., M. Müller ... The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Genome Biology 13: ...http://medicine.yale.edu/bbs/people/karla_neugebauer-2.profile
Frontiers | Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs | Frontiers in Molecular...
... and cytoplasmic polyadenylation-element-binding proteins (CPEBs), selectively bind to numerous hypoxia-regulated transcripts ... iron-response element binding proteins (IRPs), and cytoplasmic polyadenylation-element-binding proteins (CPEBs), selectively ... RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we review the RBPs and miRNAs that modulate mRNA turnover and ... RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we review the RBPs and miRNAs that modulate mRNA turnover and ...https://www.frontiersin.org/articles/10.3389/fnmol.2011.00007/full
PB2 - Polymerase basic protein 2 - Influenza A virus (strain A/USA:Memphis/10/1996 H1N1) - PB2 gene & protein
Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 ... in which cellular capped pre-mRNAs are used to generate primers for viral transcription. ... nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity ... of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein ...http://www.uniprot.org/uniprot/A3DRQ0
ncbp2 - Nuclear cap-binding protein subunit 2 - Danio rerio (Zebrafish) - ncbp2 gene & protein
In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the ... The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in ... before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of ... movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. ...http://www.uniprot.org/uniprot/Q8JGR6
The Human Glucocorticoid Receptor as an RNA-Binding Protein: Global Analysis of Glucocorticoid Receptor-Associated Transcripts...
In addition to potential RNA-binding through the GR RNA-binding domain, GR could associate to other RBP components that bind ... The cap-to-tail guide to mRNA turnover. Nat. Rev. Mol. Cell Biol. 2: 237-246. ... Identification of a target RNA motif for RNA-binding protein HuR. Proc. Natl. Acad. Sci. U S A 101: 2987-2992. ... complexes in dynamic association with a host of RNA-binding proteins (RBP). These regulatory factors bind to conserved ...http://www.jimmunol.org/content/186/2/1189.long
EIF3D Gene - GeneCards | EIF3D Protein | EIF3D Antibody
Protein Coding), Eukaryotic Translation Initiation Factor 3 Subunit D, including: function, proteins, disorders, pathways, ... The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of EIF3D into the full ... EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). *EIF3D_HUMAN,O15371 ... and subsequent binding to 43S. Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=EIF3D
Download our free solidary book to support research on VHL disease