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*  A short note on adhesion molecules
e.g. alpha1-beta1 integrin binds type IV collagen e.g. cadherin-E acts as a universal intercellular epithelial 'glue'. e.g. ... beta-5: bind vitronectin * beta-6: bind fibronectin * beta-7: bind fibronectin, VCAM-1 * beta 8: ?. Integrins on cell surfaces ... Binds to... alpha4beta1 integrin = VLA-4 = CD49d/CD29 VCAM, FN=CS-1, PP-HEV alpha5beta1 integrin = VLA-5 = CD49e/CD29 FN(RGD). ... Integrin binding probably alters the mechanical structure of the cytoskeleton. Cross-linking and/or clustering of integrins on ...
  http://anaesthetist.com/icu/organs/immune/adhere.htm
*  Non-structural glycoprotein 4 - Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A)
Possible receptors for NSP4 are alpha-1/beta-1 and alpha-2/beta-1 integrin heterodimers (By similarity).By similarity ... Binds 1 calcium ion per tetramer. The calcium ion is bound by a glutamine from each tetrameric partner and by a glutamic acid ... Interacts with host integrin ITGA1/ITGB1 heterodimer. Interacts with host integrin ITGA2/ITGB1 heterodimer. Interaction with ... ICP binding domainBy similarityAdd BLAST. 17. Coiled coil. Feature key. Position(s). DescriptionActions. Graphical view. Length ...
  http://www.uniprot.org/uniprot/Q9PYD2
*  KAKEN - Research Projects | Molecular and cell biolobical analysis of the smooth muscle cell differentiation (KAKENHI-PROJECT...
We also characterized transcriptional regulation of the CaD and the alpha1 integrin promoters in SMCs. These analyzes revealed ... Publications] Ozawa K.: 'Phase specific association of heterotrimeric GTP binding proteins with the actin-based cytoskeleton ... Publications] Obata H.: 'Smooth muscle cell phenotype-dependent transcriptional regulation of the alpha1 integrin gene' J.Biol. ... smooth muscle cell / phenotypic modulation / laminin / IGFI / caldesmon / alpha-tropomyosin / alpha1 integrin / alpha-smooth ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457029/
*  ITGA7 - Wikipedia
The primary binding partners of alpha-7 integrin are laminin-1 (alpha1-beta1-gamma1), laminin-2 (alpha2-beta1-gamma1) and ... alpha-7 integrin (complexed to beta-1 integrin) is localized to Z-discs and costamere structures, bound to the four and one ... and functions as the major laminin-binding integrin. It was later shown that alpha-7 integrin is also highly expressed in ... Kramer RH, Vu MP, Cheng YF, Ramos DM, Timpl R, Waleh N (1992). "Laminin-binding integrin alpha 7 beta 1: functional ...
  https://en.wikipedia.org/wiki/ITGA7
*  Reactome | Collagen alpha-1(II) chains [extracellular region]
Integrin cell surface interactions (Xenopus tropicalis) * Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis) * ... Collagen alpha-1(II) chains [extracellular region] (Xenopus tropicalis) * Tropocollagen type XI [extracellular region] (Xenopus ... Non-integrin membrane-ECM interactions (Xenopus tropicalis) * DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus ... PTK2 binds activated MET (Xenopus tropicalis) * Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma ...
  http://www.reactome.org/content/detail/R-XTR-2127295
*  ITGA1 Gene - GeneCards | ITA1 Protein | ITA1 Antibody
Integrin Subunit Alpha 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer ... Gene Ontology (GO) annotations related to this gene include signaling receptor binding and collagen binding. An important ... Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in ...
  https://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=3672
*  US7767219B2 - Localized drug delivery using drug-loaded nanocapsules - Google Patents
Preferred integrins are those which specifically bind to laminin and/or collagen, and can rapidly stabilize contact between the ... Examples include several members of the integrin very late antigen (VLA) superfamily: (A) Alpha1/beta1 is a receptor for ... Integrins are one preferred group of ligands for functionalizing the surface of the nanocapsules, particularly those integrins ... Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the ...
  https://patents.google.com/patent/US7767219
*  CDH5 cadherin 5 [Homo sapiens (human)] - Gene - NCBI
It was found that the levels of integrin alpha1 and VE-cadherin mRNA increased during co-culturing of activated endothelium ... calcium ion binding IBA Inferred from Biological aspect of Ancestor. more info ... cytoskeletal protein binding IBA Inferred from Biological aspect of Ancestor. more info ... Title: HIF-2α promotes the formation of vasculogenic mimicry in pancreatic cancer by regulating the binding of Twist1 to the VE ...
  https://www.ncbi.nlm.nih.gov/gene/1003
*  Integrins as receptors give insight into rotavirus and diarrhea
The two, integrin alpha1 beta1 and integrin alpha2 beta1, are members of a class of molecules that are involved in attaching ... "It's a new ligand for binding to integrins," she said. "It begins to give us an understanding of how the enterotoxin works in ... One domain is for binding and the other domain is for signaling through the receptor." ... cells to other cells and to the extracellular matrix (a part of tissue that is not part of any cell). Integrins also are ...
  http://www.biologynews.net/archives/2008/06/30/integrins_as_receptors_give_insight_into_rotavirus_and_diarrhea.html
*  NCAM1 Gene - GeneCards | NCAM1 Protein | NCAM1 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... Binding Sites for Transcription Factors within promoters. ENSR00000045075. 453. 1000. PKNOX1 SIN3A FEZF1 GLI4 ZNF2 GLIS2 KLF7 ... Integrin α4β1 inhibitor, Highly potent and selective inhibitor of integrin alpha4beta1. 0. ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH11G112960. 1.6. FANTOM5 ENCODE dbSUPER 17.2. + ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=NCAM1
*  SELE Gene - GeneCards | LYAM2 Protein | LYAM2 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH01G169571. 1.1. FANTOM5 ENCODE 9.7. +192.4. ... Transcription factor binding sites by QIAGEN in the SELE gene promoter:. *CREB ... Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SELE
*  SELP Gene - GeneCards | LYAM3 Protein | LYAM3 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... GO annotations related to this gene include carbohydrate binding and calcium-dependent protein binding. An important paralog of ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH01H169667. 1.1. Ensembl ENCODE dbSUPER 25.3. - ... Transcription factor binding sites by QIAGEN in the SELP gene promoter:. *c-Jun ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SELP
*  ANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is ... The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change ... The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=ANXA1&rf=/home/genecards/current/website/carddisp.pl&bioalma_dis_art=all
*  CACNA2D1 - Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor - Homo sapiens (Human) - CACNA2D1 gene & protein
The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 ( ... CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity ... metal ion binding Source: UniProtKB-KW. *voltage-gated calcium channel activity Source: BHF-UCL ,p>Inferred from Direct Assay,/ ... p>This subsection of the 'Function' section indicates at which position the protein binds a given metal ion. The nature of the ...
  https://www.uniprot.org/uniprot/P54289
*  Laminin, alpha 1 - Wikipedia
1998). "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the ... Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin, alpha 1 has been shown to interact ... 1990). "Sulfatide-binding domain of the laminin A chain". J. Biol. Chem. 265 (21): 12253-8. PMID 2373692. Olsen D, Nagayoshi T ... Utani A, Nomizu M, Yamada Y (1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid ...
  https://en.wikipedia.org/wiki/Laminin,_alpha_1
*  RCSB PDB - 1TYE: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet...
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen ... Allostery in the beta3 I domain alters three metal binding sites, associated loops and alpha1- and alpha7-helices. Piston-like ... Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Xiao, T., Takagi, J., Coller, B.S. ... Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen ...
  https://www.rcsb.org/structure/1tye
*  Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective...
EMS16 inhibits binding of isolated, recombinant I domain of alpha2 integrin to collagen in an ELISA assay, but not the ... interaction of isolated I domain of alpha1 integrin with collagen IV. Studies with monoclonal antibodies suggested that EMS16 ... binds to the alpha2 subunit of the integrin. EMS16 inhibits collagen-induced platelet aggregation, but has no effect on ... In conclusion, we report a new, potent viper venom-derived inhibitor of alpha2beta1 integrin, which does not belong to the ...
  https://www.semanticscholar.org/paper/Isolation-and-characterization-of-EMS16-a-C-lectin-Marcinkiewicz-Lobb/bf7f6fcb378ec94a55b9ae1ecfad39fdf76c4a7b
*  Collagen-IV and laminin-1 regulate estrogen receptor α expression and function in mouse mammary epithelial cells | Journal of...
Lochter, A., Navre, M., Werb, Z. and Bissell, M. J. (1999). alpha1 and alpha2 integrins mediate invasive activity of mouse ... Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells. Clin. Exp. Metastasis 13,223 -235. ... The regulation of ERα by BM is mediated by integrins: relevance to tumorigenesis. We have found that integrin-activated signal ... These changes in integrin expression may result in altered cell surface ratios of individual integrins, which could, in turn, ...
  http://jcs.biologists.org/content/116/14/2975
*  Vanderbilt Center for Kidney Disease
Selective binding of integrins from different renal cell types to the NC1 domain of alpha3 and alpha1 chains of type IV ... Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.. Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, ... Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain ... Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice ...
  http://www.vckd.org/vckd-members/billy-hudson
*  US8414611B2 - Main vessel constraining side-branch access balloon - Google Patents
... integrin-binding cyclic Arg-Gly-Asp peptide, cytochalasin D, mitoxantrone, carvedilol, alpha-1-antitrypsin (AAT), methotrexate ...
  https://patents.google.com/patent/US8414611
*  Recombinant Human CCN1 protein (Fc Chimera) (ab191971)
PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the ... expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin ... cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. ...
  http://www.abcam.com/recombinant-human-ccn1-protein-fc-chimera-ab191971.html
*  ORBi: Browsing ORBi
GFOGER, the classical collagen binding peptide of alpha1- alpha2- and alpha11-beta1 integrins, in triple helical or denatured ... The [Ca2+]i signalling induced by RGDS and DGEA is inhibited by antibodies against beta1 integrin subunit while that mediated ... Our results suggest that free integrins and associated focal complexes generate a Ca2+ signal upon recognition of DGEA and RGDS ... during cell adhesion and spreading on a coat of fibronectin for RGDS or collagen for DGEA or on a coat of the specific integrin ...
  https://orbi.uliege.be/browse?type=author&value=Amblard%2C+M
*  Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase elisa and antibody
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A. Alpha-1,6-mannosylglycoprotein 6-beta-N- ... Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in ... Molecular Function: protein binding. MGAT5B ELISA Kit. MGAT5B Recombinant. MGAT5B Antibody. KIAA2008 ELISA Kit. KIAA2008 ... Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B. Alpha-1,6-mannosylglycoprotein 6-beta-N- ...
  https://www.mybiosource.com/protein_family.php?root=alpha-1-6-mannosylglycoprotein-6-beta-n-acetylglucosaminyltransferase
*  Reactome | 3x4Hyp-3Hyp-5Hyl-COL9A1 [extracellular region]
Integrin cell surface interactions (Homo sapiens) * Collagen type IX binds integrin alpha11beta1 (Homo sapiens) * Collagen type ... 3,4-Hyp 5-Hyl-collagen alpha-1(IX) chain, 3,4-hydroxyprolyl-collagen alpha-1(IX) chain, CO9A1_HUMAN, COL9A1 ... Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens) * Collagen tupe VI network, Collagen type IX:Integrin ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) * Collagen types III, IV ...
  https://reactome.org/content/detail/R-HSA-2193028
*  Reactome | GalHyl-COL4A1(173-1669) [extracellular region]
Integrin cell surface interactions (Homo sapiens) * Collagen type IV binds integrin alpha10beta1 (Homo sapiens) * Collagen type ... Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens) * Tropocollagen alpha-1(IV).alpha-1(IV). ... Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens) * Tropocollagen alpha-1(IV).alpha-1(IV). ... Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens) * Tropocollagen alpha-1(IV).alpha-1(IV). ...
  https://reactome.org/content/detail/R-HSA-2127432