*  A short note on adhesion molecules
e.g. alpha1-beta1 integrin binds type IV collagen e.g. cadherin-E acts as a universal intercellular epithelial 'glue'. e.g. ... beta-5: bind vitronectin * beta-6: bind fibronectin * beta-7: bind fibronectin, VCAM-1 * beta 8: ?. Integrins on cell surfaces ... Binds to... alpha4beta1 integrin = VLA-4 = CD49d/CD29 VCAM, FN=CS-1, PP-HEV alpha5beta1 integrin = VLA-5 = CD49e/CD29 FN(RGD). ... Integrin binding probably alters the mechanical structure of the cytoskeleton. Cross-linking and/or clustering of integrins on ...
  http://anaesthetist.com/icu/organs/immune/adhere.htm
*  ITGA7 - Wikipedia
The primary binding partners of alpha-7 integrin are laminin-1 (alpha1-beta1-gamma1), laminin-2 (alpha2-beta1-gamma1) and ... alpha-7 integrin (complexed to beta-1 integrin) is localized to Z-discs and costamere structures, bound to the four and one ... and functions as the major laminin-binding integrin. It was later shown that alpha-7 integrin is also highly expressed in ... Kramer RH, Vu MP, Cheng YF, Ramos DM, Timpl R, Waleh N (1992). "Laminin-binding integrin alpha 7 beta 1: functional ...
  https://en.wikipedia.org/wiki/ITGA7
*  Laminin, alpha 1 - Wikipedia
1998). "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the ... Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin, alpha 1 has been shown to interact ... 1990). "Sulfatide-binding domain of the laminin A chain". J. Biol. Chem. 265 (21): 12253-8. PMID 2373692. Olsen D, Nagayoshi T ... Utani A, Nomizu M, Yamada Y (1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid ...
  https://en.wikipedia.org/wiki/Laminin,_alpha_1
*  Non-structural glycoprotein 4 - Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A)
Possible receptors for NSP4 are alpha-1/beta-1 and alpha-2/beta-1 integrin heterodimers (By similarity).By similarity ... Binds 1 calcium ion per tetramer. The calcium ion is bound by a glutamine from each tetrameric partner and by a glutamic acid ... Interacts with host integrin ITGA1/ITGB1 heterodimer. Interacts with host integrin ITGA2/ITGB1 heterodimer. Interaction with ... ICP binding domainBy similarityAdd BLAST. 17. Coiled coil. Feature key. Position(s). DescriptionActions. Graphical view. Length ...
  http://www.uniprot.org/uniprot/Q9PYD2
*  KAKEN - Research Projects | Molecular and cell biolobical analysis of the smooth muscle cell differentiation (KAKENHI-PROJECT...
We also characterized transcriptional regulation of the CaD and the alpha1 integrin promoters in SMCs. These analyzes revealed ... Publications] Ozawa K.: 'Phase specific association of heterotrimeric GTP binding proteins with the actin-based cytoskeleton ... Publications] Obata H.: 'Smooth muscle cell phenotype-dependent transcriptional regulation of the alpha1 integrin gene' J.Biol. ... smooth muscle cell / phenotypic modulation / laminin / IGFI / caldesmon / alpha-tropomyosin / alpha1 integrin / alpha-smooth ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457029/
*  Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective...
EMS16 inhibits binding of isolated, recombinant I domain of alpha2 integrin to collagen in an ELISA assay, but not the ... interaction of isolated I domain of alpha1 integrin with collagen IV. Studies with monoclonal antibodies suggested that EMS16 ... binds to the alpha2 subunit of the integrin. EMS16 inhibits collagen-induced platelet aggregation, but has no effect on ... In conclusion, we report a new, potent viper venom-derived inhibitor of alpha2beta1 integrin, which does not belong to the ...
  https://www.semanticscholar.org/paper/Isolation-and-characterization-of-EMS16-a-C-lectin-Marcinkiewicz-Lobb/bf7f6fcb378ec94a55b9ae1ecfad39fdf76c4a7b
*  US7767219B2 - Localized drug delivery using drug-loaded nanocapsules - Google Patents
Preferred integrins are those which specifically bind to laminin and/or collagen, and can rapidly stabilize contact between the ... Examples include several members of the integrin very late antigen (VLA) superfamily: (A) Alpha1/beta1 is a receptor for ... Integrins are one preferred group of ligands for functionalizing the surface of the nanocapsules, particularly those integrins ... Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the ...
  https://patents.google.com/patent/US7767219
*  Integrins as receptors give insight into rotavirus and diarrhea
The two, integrin alpha1 beta1 and integrin alpha2 beta1, are members of a class of molecules that are involved in attaching ... "It's a new ligand for binding to integrins," she said. "It begins to give us an understanding of how the enterotoxin works in ... One domain is for binding and the other domain is for signaling through the receptor." ... cells to other cells and to the extracellular matrix (a part of tissue that is not part of any cell). Integrins also are ...
  http://www.biologynews.net/archives/2008/06/30/integrins_as_receptors_give_insight_into_rotavirus_and_diarrhea.html
*  NCAM1 Gene - GeneCards | NCAM1 Protein | NCAM1 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... Binding Sites for Transcription Factors within promoters. ENSR00000045075. 453. 1000. PKNOX1 SIN3A FEZF1 GLI4 ZNF2 GLIS2 KLF7 ... Integrin α4β1 inhibitor, Highly potent and selective inhibitor of integrin alpha4beta1. 0. ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH11G112960. 1.6. FANTOM5 ENCODE dbSUPER 17.2. + ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=NCAM1
*  SELE Gene - GeneCards | LYAM2 Protein | LYAM2 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH01G169571. 1.1. FANTOM5 ENCODE 9.7. +192.4. ... Transcription factor binding sites by QIAGEN in the SELE gene promoter:. *CREB ... Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SELE
*  SELP Gene - GeneCards | LYAM3 Protein | LYAM3 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... GO annotations related to this gene include carbohydrate binding and calcium-dependent protein binding. An important paralog of ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH01H169667. 1.1. Ensembl ENCODE dbSUPER 25.3. - ... Transcription factor binding sites by QIAGEN in the SELP gene promoter:. *c-Jun ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SELP
*  ANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ... GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is ... The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change ... The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=ANXA1&rf=/home/genecards/current/website/carddisp.pl&bioalma_dis_art=all
*  Collagen-IV and laminin-1 regulate estrogen receptor α expression and function in mouse mammary epithelial cells | Journal of...
Lochter, A., Navre, M., Werb, Z. and Bissell, M. J. (1999). alpha1 and alpha2 integrins mediate invasive activity of mouse ... Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells. Clin. Exp. Metastasis 13,223 -235. ... The regulation of ERα by BM is mediated by integrins: relevance to tumorigenesis. We have found that integrin-activated signal ... These changes in integrin expression may result in altered cell surface ratios of individual integrins, which could, in turn, ...
  http://jcs.biologists.org/content/116/14/2975
*  US8414611B2 - Main vessel constraining side-branch access balloon - Google Patents
... integrin-binding cyclic Arg-Gly-Asp peptide, cytochalasin D, mitoxantrone, carvedilol, alpha-1-antitrypsin (AAT), methotrexate ...
  https://patents.google.com/patent/US8414611
*  Recombinant Human CCN1 protein (Fc Chimera) (ab191971)
PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the ... expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin ... cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. ...
  http://www.abcam.com/recombinant-human-ccn1-protein-fc-chimera-ab191971.html
*  ORBi: Browsing ORBi
GFOGER, the classical collagen binding peptide of alpha1- alpha2- and alpha11-beta1 integrins, in triple helical or denatured ... The [Ca2+]i signalling induced by RGDS and DGEA is inhibited by antibodies against beta1 integrin subunit while that mediated ... Our results suggest that free integrins and associated focal complexes generate a Ca2+ signal upon recognition of DGEA and RGDS ... during cell adhesion and spreading on a coat of fibronectin for RGDS or collagen for DGEA or on a coat of the specific integrin ...
  https://orbi.uliege.be/browse?type=author&value=Amblard%2C+M
*  Collagen, type XVII, alpha 1 - Wikipedia
... is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration into ... Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a- ... The C-terminus of collagen XVII binds to laminin 5, and correct integration of laminin 5 into the matrix requires collagen XVII ... Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of ...
  https://en.wikipedia.org/wiki/Collagen,_type_XVII,_alpha_1
*  Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase elisa and antibody
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A. Alpha-1,6-mannosylglycoprotein 6-beta-N- ... Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in ... Molecular Function: protein binding. MGAT5B ELISA Kit. MGAT5B Recombinant. MGAT5B Antibody. KIAA2008 ELISA Kit. KIAA2008 ... Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B. Alpha-1,6-mannosylglycoprotein 6-beta-N- ...
  https://www.mybiosource.com/protein_family.php?root=alpha-1-6-mannosylglycoprotein-6-beta-n-acetylglucosaminyltransferase
*  Collagen, type IV, alpha 1 - Wikipedia
NC1 binds to the α1β1 integrin and inhibits specific integrin signaling pathways in vascular epithelial cells. It also ... "Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin". The ... Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ... "COL4A1 - Collagen alpha-1(IV) chain precursor - Homo sapiens (Human) - COL4A1 gene & protein". www.uniprot.org. Retrieved 2016- ...
  https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_1
*  Anti-Human ITGA1 scFv Stable Cell Line-CHO CSC-P1204 - Creative BioMart
ITGA1; integrin, alpha 1; integrin alpha-1; CD49a; VLA1; VLA-1; laminin and collagen receptor; very late activation protein 1; ... collagen binding; integrin binding; protein binding; protein heterodimerization activity; receptor activity. Products Types ◆ ... Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in ...
  https://www.creativebiomart.net/description_174561_309.htm
*  Reactome | 5Hyl-COL4A1(173-1669) [extracellular region]
Integrin cell surface interactions (Homo sapiens) * Collagen type IV binds integrin alpha10beta1 (Homo sapiens) * Collagen type ... Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens) * Tropocollagen alpha-1(IV).alpha-1(IV). ... Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens) * Tropocollagen alpha-1(IV).alpha-1(IV). ... Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens) * Tropocollagen alpha-1(IV).alpha-1(IV). ...
  https://reactome.org/content/detail/R-HSA-2127356
*  Cyr61/CCN1 Antibody (NB100-356): Novus Biologicals
... integrins alpha-3 and alpha-5. CYR61 down-regulates the expression of alpha-1/alpha-2 subunits of collagen type-1 and promotes ... Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma. J Biol Chem. ... cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. CYR61 has been reported ... CYR61 (cysteine-rich angiogenic inducer 61), a heparin-binding growth factor, belongs to CCN family whose members are: cysteine ...
  https://www.novusbio.com/products/cyr61-ccn1-antibody_nb100-356
*  ITGB1 / Integrin Beta 1 / CD29 Antibody (aa34-141, clone K2D5) - Mouse Monoclonal Antibody WB, IHC-P, E - Buy Now! |Abgent
Integrin Beta 1 / CD29 Antibody (aa34-141, clone K2D5), Mouse Monoclonal Antibody validated in WB, IHC-P, E (ALS12568), Abgent ... Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/ ... and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ... Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/ ...
  http://www.abgent.com/products/ALS12568-Anti-ITGB1--Integrin-Beta-1--CD29-Antibody-aa34-141-clone-K2D5-ALS12568
*  KEGG SSDB Paralog Search Result: ame:411466
ame:411238 LIM domain-binding protein 2 K15617 684 212 ( -) 54 0.206 669 -, ame:550645 max-binding protein MNT K00871 827 212 ... ame:406097 integrin beta-PS K05719 813 156 ( -) 41 0.281 192 -, ame:408280 cell surface glycoprotein 1-like 573 156 ( -) 41 ... ame:552446 collagen alpha-1(I) chain-like 1073 202 ( -) 52 0.216 668 -, ame:726219 lebercilin 836 202 ( -) 52 0.203 710 -, ame: ... ame:411218 WW domain-binding protein 11 K12866 564 213 ( -) 54 0.199 554 -, ame:552718 protein son of sevenless K03099 1324 213 ...
  http://www.kegg.jp/ssdb-bin/ssdb_paralog?org_gene=ame:411466
*  Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2 - Roy Zent
The beta-1 subunit binds 12 alpha subunits, suggesting that specif... ... Integrins are transmembrane receptors formed by non-covalently bound alpha and beta subunits. ... This is seen in the two major collagen binding receptors, integrins alpha-1-beta-1 and alpha-2-beta-1, which not only have ... Integrins are transmembrane receptors formed by non-covalently bound alpha and beta subunits. The beta-1 subunit binds 12 alpha ...
  http://grantome.com/grant/NIH/R01-DK083187-04