*  Biomedicines | Free Full-Text | Decoding the Pluripotency Network: The Emergence of New Transcription Factors | HTML
... transcriptional regulation is situated in the central position and appears to be dominant over other regulatory controls. In ... The binding of GCNF and Nr5a2 to the same site suggests a reciprocal regulatory model for Oct4 expression by these two proteins ... Cavalli, L.R.; Liang, B.C. Mutagenesis, tumorigenicity, and apoptosis: Are the mitochondria involved? Mutat. Res. 1998, 398, 19 ... Other Zinc Finger Proteins. Besides the above zinc finger proteins, several other identified zinc finger proteins, including ...
  http://www.mdpi.com/2227-9059/1/1/49/htm
*  Therapeutic Targeting of the Survivin Pathway in Cancer | Clinical Cancer Research
Salvesen G. S., Duckett C. S. Apoptosis: IAP proteins: blocking the road to death's door. Nat. Rev. Mol. Cell. Biol., 3: 401- ... In this study, we have positioned the survivin pathway as a novel regulatory mechanism of mitochondrial-dependent apoptosis. ... Naïve normal rabbit antiserum was used at an equivalent dilution and produced no staining (data not shown). Binding of the ... Silke J., Vaux D. L. Two kinds of BIR-containing protein: inhibitors of apoptosis, or required for mitosis. J. Cell Sci., 114: ...
  http://clincancerres.aacrjournals.org/content/9/7/2683.long
*  The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty...
0/Apoptosis Regulatory Proteins; 0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/PUMA protein, mouse; 0/Reactive Oxygen ... Apoptosis Regulatory Proteins / metabolism. Cell Cycle Proteins / deficiency, genetics, metabolism*. DNA Damage. DNA-Binding ... The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty ... EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/ataxia telangiectasia mutated protein ...
  http://www.biomedsearch.com/nih/DNA-damage-checkpoint-protein-ATM/22544329.html
*  PDCD2 | Cancer Genetics Web
Protein Binding. *Apoptosis Regulatory Proteins. *Western Blotting. *Protein Kinases. *Vincristine. *K562 Cells ... increases PDCD2 protein expression and apoptosis, and knockdown of the PDCD2 protein in this cell line by PDCD2-specific small ... What does this gene/protein do?. Show (6). PDCD2 is implicated in:. - apoptotic process - cytoplasm - DNA binding - nucleus - ... PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade. ...
  http://www.cancerindex.org/geneweb/PDCD2.htm
*  Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells | Breast Cancer Research | Full Text
The same regulatory proteins are activated in MCF-7 cells resistant or not resistant to adriamycin, leading to their apoptosis ... T-oligo and telomeric repeat binding factor dominant negative construct (TRF2DN) activate cell cycle- and apoptosis-regulatory ... T-oligo and TRF2DNactivate cell cycle and apoptosis regulatory proteins. MCF-7 and NME cells were treated as above and total ... a telomere-specific single-stranded DNA binding protein [69], also elicits apoptosis (in MCF-7 cells) and senescence (in ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1646
*  Plus it
1996) Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J 15:1012-1020. ... 1997) Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction ... PC12 cells were treated with or without Aβ1-42 (10 μm) for 6 hr (n = 3). Cells were extracted with 0.5% NP-40, and protein was ... We found little evidence in our studies that free radicals play a key role in Aβ1-42-induced apoptosis in culture. The lack of ...
  http://www.jneurosci.org/content/20/4/1386
*  Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin | Cancer Research
... we found that the actin-binding protein cofilin is a key target of oxidation that mediates induction of apoptosis by taurine ... Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Stephanie Zdanov, Fabio Klamt, ... Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin ... Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/3405
*  Structural overview of the p73-ASPP2 complex. Stereo | Open-i
Apoptosis Regulatory Proteins/chemistry*/metabolism*. *DNA-Binding Proteins/chemistry*/metabolism*. *Nuclear Proteins/chemistry ... S4a), as well as other protein-protein interactions (Supplementary Fig. S4b). Superposition of the free p73 structure with the ... S4a), as well as other protein-protein interactions (Supplementary Fig. S4b). Superposition of the free p73 structure with the ... S4b). Binding of ASPP2 to p53 and p73 DBD was confirmed in the low micromolar range by native-gel mobility shift assay (Fig. 5 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3472557_gr6&req=4
*  ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. - Nuffield Department of Orthopaedics,...
... is transactivated by ATF4 in severe hypoxia through direct binding of ATF4 to the promoter region. Furthermore, we demonstrate ... Here we demonstrate that ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. We find that the BH3- ... In particular, we show that the BH3-only protein harakiri (HRK) ... only proteins HRK, PUMA, and NOXA are transcriptionally induced ... Protein Binding, Autophagy, Female, Apoptosis Regulatory Proteins, Activating Transcription Factor 4, Genes, Neoplasm, Promoter ...
  https://www.ndorms.ox.ac.uk/publications/356171
*  Apitherapy News: 2015
... and Western blotting assay for detection of apoptosis regulatory proteins.. We found that BV inhibited growth of colon cancer ... Besides, we found that BV blocked NF-κB activation by directly binding to NF-κB p50 subunit. Moreover, combination treatment ... Lipid and protein content from Rio Grande do Sul presented higher mean values (pb0.05) compared with the other two states. Some ... Moisture, pH, total protein, 10-hydroxy-2-decenoic acid (10-HDA) and sugars were analyzed from 18 samples. Total phenolic ...
  http://apitherapy.blogspot.com/2015/
*  Sterol regulatory element-binding protein 2 - Wikipedia
"Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis". The EMBO Journal. 15 (5): 1012-20. ... Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ( ... SREBF2 has been shown to interact with INSIG1 and CREB-binding protein. Sterol regulatory element-binding protein GRCh38: ... Nagoshi E, Imamoto N, Sato R, Yoneda Y (Jul 1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic ...
  https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_2
*  Recombinant Human Caspase-1 protein (ab158029) | Abcam
Ab158029 is a full length protein produced in Wheat germ and has been validated in WB, ELISA. Abcam provides free… ... Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. ... Recombinant Human Caspase-1 protein. See all Caspase-1 proteins and peptides. ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ...
  https://www.abcam.com/recombinant-human-caspase-1-protein-ab158029.html
*  SIVA1 - Wikipedia
Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes a protein with an ... induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A. 94 (12): 6346-51. doi:10.1073/pnas. ... 2000). "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein ... is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis". Apoptosis. 9 (1): 83-95. doi:10.1023/B: ...
  https://en.wikipedia.org/wiki/SIVA1
*  Emricasan - DrugBank
It is developed by Pfizer and made in such a way that it protects liver cells from excessive apoptosis. ... Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribos.... Gene Name ... Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it ... Protein binding. Not Available. Metabolism. Not Available. Route of elimination. Not Available. Half life. Not Available. ...
  https://www.drugbank.ca/drugs/DB05408
*  Sandra Quackenbush - Wikipedia
Her lab is trying to determine the mode by which transcription, apoptosis, and transduction are controlled by viral regulatory ... It was determined that he RV-cyclin bound to cyclin-dependent kinase 8 (CDK8) and increased its activity. The genes IEGs are ... Retroviruses within these genera cause disease by containing RNA sequences that code for proteins that promote oncogenesis ... The retroviral cyclin of walleye dermal sarcoma virus binds cylin-dependent kinases 3 and 8. Transgenic expression of walleye ...
  https://en.wikipedia.org/wiki/Sandra_Quackenbush
*  Apoptosis regulatory proteins | definition of Apoptosis regulatory proteins by Medical dictionary
Apoptosis regulatory proteins explanation free. What is Apoptosis regulatory proteins? Meaning of Apoptosis regulatory proteins ... Looking for online definition of Apoptosis regulatory proteins in the Medical Dictionary? ... apoptosis (ap´ətō´sis),. n cell reduction by fragmentation into membrane-bound particles that are phagocytosed by other cells. ... Apoptosis regulatory proteins , definition of Apoptosis regulatory proteins by Medical dictionary https://medical-dictionary. ...
  https://medical-dictionary.thefreedictionary.com/Apoptosis+regulatory+proteins
*  Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Pipeline Review, H1...
It cleaves and activates sterol regulatory element binding proteins. The report 'Caspase 7 - Pipeline Review, H1 2018' outlays ... is a human protein encoded by the CASP7 gene. It is involved in the activation cascade of caspases responsible for apoptosis ... Fusion Protein to Activate Caspases for Age Related Macular Degeneration, Diabetic Retinopathy and Solid Tumors - Drug Profile ...
  https://www.researchandmarkets.com/reports/4576099/caspase-7-apoptotic-protease-mch-3-or-ice-like
*  APAF1 - Wikipedia
This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein ... Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves Procaspase 9 ... Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (Aug 1997). "Apaf-1, a human protein homologous to C. elegans CED-4, participates in ... APAF1 contains a CARD domain with a Greek key motif composed of six helices, a Rossman fold nucleotide binding domains, a short ...
  https://en.wikipedia.org/wiki/APAF1
*  Protein phosphatase 1 regulatory subunits (PPP1R) Gene Family | HUGO Gene Nomenclature Committee
FK506 binding protein 15. KIAA0674. FKBP133, WAFL, PPP1R76. 9q32. AATK apoptosis associated tyrosine kinase. AATYK1, PPP1R77, ... tumor protein p53 binding protein 2. ASPP2, 53BP2, PPP1R13A. 1q41. PPP1R13B protein phosphatase 1 regulatory subunit 13B. ... protein phosphatase 1 regulatory subunit 3D. PPP1R6. 20q13.33. PPP1R3E protein phosphatase 1 regulatory subunit 3E. FLJ00089. ... protein phosphatase 1 regulatory subunit 7. sds22. 2q37.3. PPP1R8 protein phosphatase 1 regulatory subunit 8. ard-1, NIPP-1, ...
  https://www.genenames.org/cgi-bin/genefamilies/set/694
*  APB592Ra01 | Active Caspase 1 (CASP1) | Rattus norvegicus (Rat) USCN(Wuhan USCN Business Co., Ltd. )
Apoptosis-Related Cysteine Peptidase; Interleukin-1 beta convertase , Products for research use only! ... cleaves and activates sterol regulatory element binding proteins (SREBPs), promotes apoptosis. Besides, Interleukin 1 Alpha ( ... BCA Protein Quantification Kit. Monoclonal Antibody Customized Service. Polyclonal Antibody Customized Service. Protein ... The binding activity of of CASP1 and IL1a was shown in Figure 1, and this effect was in a dose dependent manner. ...
  http://uscnk.com/uscn/Active-Caspase-1-
*  FLIP Antibody
Caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory protein ... protease binding. death receptor binding. protein binding. enzyme activator activity. protein complex binding. cysteine-type ... Protein Aliases: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8 and FADD-like apoptosis regulator; CASP8AP1; Caspase homolog; ... testis secretory sperm-binding protein Li 233m; Usurpin; usurpin beta Gene Aliases: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; ...
  https://www.thermofisher.com/antibody/product/CFLAR-Antibody-Polyclonal/PA1-30106
*  Plus it
... binding site CCAAT/enhancer binding protein-β has been shown to have a regulatory function in differentiation and apoptosis of ... CCAAT/enhancer-binding protein β plays a regulatory role in differentiation and apoptosis of neuroblastoma cells. J Biol Chem ... predicted proteins do not show significant homology to known proteins or conserved domains as determined by a protein-protein- ... The highest homology was found for transcription factor binding sites of Nkx-2.5, Pbx-1, GATA-1, and CCAAT/enhancer binding ...
  http://mcr.aacrjournals.org/content/5/12/1276
*  Activating protein 2 - Wikipedia
"Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science. 251 (4997): ... Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate ... development, apoptosis and cell-cycle control". Gene. 260 (1-2): 1-12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286. ... Activating Protein 2 (AP-2) is a family of closely related transcription factors which plays a critical role in regulating gene ...
  https://en.wikipedia.org/wiki/Activating_protein_2
*  Human Metabolome Database: Showing metabocard for 25-Hydroxycholesterol (HMDB0006247)
25-Hydroxycholesterol is steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs ... It also induces apoptosis through down-regulation of Bcl-2 expression and activation of caspases. 25-Hydroxycholesterol also ... 2. Oxysterol-binding protein 1. General function:. Involved in steroid metabolic process. Specific function:. Binds cholesterol ... role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP ...
  http://www.hmdb.ca/metabolites/HMDB0006247
*  Nae1 - NEDD8-activating enzyme E1 regulatory subunit - Mus musculus (Mouse) - Nae1 gene & protein
Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). ... Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue ... NEDD8-activating enzyme E1 regulatory subunit. Alternative name(s):. Amyloid beta precursor protein-binding protein 1, 59 kDa. ... This protein is involved in the pathway protein neddylation, which is part of Protein modification.. View all proteins of this ...
  http://www.uniprot.org/uniprot/Q8VBW6