Loading...
*  Mannose Binding Lectins
The collectins are a family of proteins whose individual chains consist of a C-type lectin domain, attached to a collagen ... Mannose-binding Lectin Deficiency. Serum mannose-binding protein (MBP) or mannose-binding lectin initiates the lectin branch of ... 12: Eur J Immunol 2000 Jun; 3 0(6); 1706-13 Mannan-binding lectin and Clq bind to distinct structures and exert differential ... The lectin route of mannose-binding lectin (MBL) activates complements and [from the phylogenetic and functional points of view ...
  https://www.4rhealthproducts.com/Mannose-Binding-Lectins-s/1872.htm
*  Mannan-binding lectin - Wikipedia
One way that the most-recently discovered lectin pathway is activated is through mannose-binding lectin protein. MBL binds to ... Online Mendelian Inheritance in Man (OMIM) mannose-binding protein deficiency -614372 Colley KJ, Baenziger JU (1987). " ... MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in ... It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. ...
  https://en.wikipedia.org/wiki/Mannan-binding_lectin
*  Untitled Document
Five collectins are known in mammals: Mannose binding lectins (MBL), lung surfactant proteins sp-A and sp-D, conglutinins, and ... LECTINS. Lectins are a diverse group of proteins which bind carbohydrates and other ligands such as proteins, lipid, and ... Deficiency of MBL in humans lessens complement binding to microbes (Lu, 2002; Gadieva, 2001). Children without MBL suffer ... The complement pathway can also be activated by the serum mannose binding lectin (MBL, a C-type lectin) to the carbohydrates of ...
  http://bio.sunyorange.edu/updated2/GENETICS/4%20LECTINS.htm
*  Innate immune mechanisms in the resolution of inflammation | Springer for Research & Development
Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM (2001) C1q and mannose binding lectin ... Sano H, Chiba H, Iwaki D, Sohma H, Voelker DR, Kuroki Y (2000) Surfactant proteins A and D bind CD14 by different mechanisms. J ... van de Wetering JK, van Golde LM, Batenburg JJ (2004) Collectins: Players of the innate immune system. Eur J Biochem 271: 1229- ... Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 19: 56-59PubMed ...
  https://rd.springer.com/chapter/10.1007/978-3-7643-7506-5_3
*  SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance |...
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J Biol Chem. 2004, 279: 32728- ... Since GM-CSF [2, 3, 22, 23, 57-62] and SP-D deficiency [24-26, 42] cause a PAP-like phenotype, we examined their potential ... Although Western blot analyses showed that SP-D was present in the BALF, some SP-D was modified or tightly bound to other ... SP-D deficiency results in the accumulation of apoptotic cells, in vivo [30], and PAP airways contain increased number of dead ...
  https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-4-29
*  David A. Stevens | Stanford Medicine Profiles
Collectins and fungal pathogens: roles of surfactant proteins and mannose binding lectin in host resistance MEDICAL MYCOLOGY ... Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida ... By the sandwich immunofluorescent antibody (IFA) method with anti-mouse MBL (MBL-A or -C), we showed that serum MBL bound to B ... and the serum collectins, mannose binding lectins; the binding of these collectins to pathogen associated molecular patterns or ...
  https://med.stanford.edu/profiles/david-stevens
*  ASMscience | Interactions of Capsule
Binding of antibody to the capsule edge to produce the annular rim could be due to localization of epitopes only at the capsule ... Activation of the alternative pathway leads to conversion of C3 to C3b, which in turn, binds to the cryptococcal cell. ... Incubation of acapsular cryptococci in adsorbed serum leads to deposition of C3 onto the cell wall, but C3 binding occurs via ... the consequences of antibody and complement binding for modification of the capsular matrix. Differential interference contrast ...
  http://www.asmscience.org/content/book/10.1128/9781555816858.ch29
*  NAVER Academic | Role of ficolin in innate immunity and its molecular basis
They are similar but with some differences in the expression site, location site, ligand-binding specificity and ability to ... form complexes with MBL-associated serine proteases (MASPs). Like MBL, some ficolins are serum lectins and can form a complex ... The structure is similar to mannose-binding lectin (MBL) and complement C1q owing to the collagen-like stalk. Accumulating data ... Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study (2001) Neth Olaf ...
  https://academic.naver.com/article.naver?doc_id=65285902
*  Frontiers | NET balancing: a problem in inflammatory lung diseases | Immunology
In many inflammatory lung diseases, bronchoalveolar SP-D levels are altered and its deficiency results in the accumulation of ... binds NETs, and enhances the clearance of dying cells and DNA by alveolar macrophages. In many inflammatory lung diseases, ... bronchoalveolar SP-D levels are altered and its deficiency results in the accumulation of DNA in the lungs. Some of the other ... binds NETs, and enhances the clearance of dying cells and DNA by alveolar macrophages. ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00001/full
*  MBL2 gene - Genetics Home Reference
Mannose-binding lectin recognizes and attaches (binds) to sugars, such as mannose, fucose, and glucose, that are found on the ... Several common mutations of the MBL2 gene can lead to a condition called mannose-binding lectin deficiency. People with this ... This binding turns on (activates) the complement system, which is a group of immune system proteins that work together to ... amino acid in the mannose-binding lectin subunit eliminates its ability to assemble into the functional mannose-binding lectin ...
  https://ghr.nlm.nih.gov/gene/MBL2
*  ASMscience | Interplay between Myeloid Cells and Humoral Innate Immunity
Fluid-phase pattern recognition molecules (PRMs), which include collectins, ficolins, and pentraxins, are key components of the ... Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway ... Human pentraxin 3 binds to the complement regulator c4b-binding protein. PLoS One 6:e23991. doi:10.1371/journal.pone.0023991. [ ... Role of collectins in innate immunity against aspergillosis. Med Mycol 43(Suppl 1):S155-S163. [PubMed]. ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0051-2016
*  Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement...
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 279: 32728-32736. ... and PTX3 also bind to dying cells and help their clearance, deficiency of these opsonins does not lead to the development of ... and lectin pathway (via mannose-binding lectin (MBL) and ficolin) (10, 11, 12, 13, 14). It has been suggested that the main ... and lectin pathway (via mannose-binding lectin and ficolin). Herein we report that the only known naturally occurring positive ...
  http://www.jimmunol.org/content/180/11/7613?ijkey=4c7ecf4340af5dabcca70ddb98a75f3703f2602d&keytype2=tf_ipsecsha
*  THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME RELATED TO THE RELEASE OF CYTOKINES FOLLOWING SEVERE ENVENOMATION
MBP is a calcium-dependent sugar binding protein or lectin, a member of collectins family (139). MBP binds to mannose residues ... IL-1 consists of a family of two proteins, namely IL-1a and IL-1b, which overlap in their biological activities and bind to the ... Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase. J. Clin. Invest., 1996, 97, 2680-4. [ ... Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature, 1992, 360, 127-34. [ Links ]. 166 ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000100002
*  NE1334: Genetic Bases for Resistance and Immunity to Avian Diseases - NIMSS
Further, part of the mannose-binding-lectin (MBL) promoter was cloned and sequenced to identify polymorphism in two inbred and ... Structure of a classical MHC class I molecule that binds "non-classical" ligands. PLoS Bio. 8:e1000557. Hee, C. S., S. Gao, M. ... This research also led to the discovery that only few of the MHC-YF class I proteins are expressed in chickens and that at ... Vitamin A deficiency during development diminished B lymphocyte maturation and the breadth of the antibody repertoire. The ...
  https://www.nimss.org/projects/view/mrp/outline/15096
*  Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response
PTX3 interacts also with components of the lectin pathway. The mannose binding lectin (MBL) binds PTX3 via its collagen-like ... The classical short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are acute-phase proteins in humans ... G. D. Norata, P. Marchesi, V. K. Pulakazhi Venu et al., "Deficiency of the long pentraxin ptx3 promotes vascular inflammation ... This heterogeneous group of molecules consists of three clearly defined subgroups, that is, the collectins, the ficolins, and ...
  https://www.hindawi.com/journals/mi/2012/920517/
*  Frontiers | Comparative Evaluation of Heterologous Production Systems for Recombinant Pulmonary Surfactant Protein D |...
... are less effective when pulmonary diseases involve inflammatory complications because two hydrophilic surfactant proteins (A ... These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in the ... These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in the ... are less effective when pulmonary diseases involve inflammatory complications because two hydrophilic surfactant proteins (A ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00623/full
*  Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke | Journal of Neuroinflammation |...
Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins ... Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and ... mannose-binding lectin (MBL) and the recently identified collectins: collectin-10 (CL-L1 or CL-10) and collectin-11 (CL-K1 or ... it binds back to the membrane of the granulocytes and monocytes in a calcium-dependent manner [5, 6]. As a consequence, the ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0481-2
*  ASMscience | Recognition and Removal
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 279:32728-32736.. ... Bijl, M.,, G. Horst,, J. Bijzet,, H. Bootsma,, P. C. Limburg, and, C. G. Kallenberg. 2003. Serum amyloid P component binds to ... Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 19:56-59.. ... Stuart, L. M.,, K. Takahashi,, L. Shi,, J. Savill, and, R. A. Ezekowitz. 2005. Mannose-binding lectin-deficient mice display ...
  http://www.asmscience.org/content/book/10.1128/9781555816650.ch21
*  US5854214A - Therapeutic uses of bactericidal/permeability increasing protein products - Google Patents
Heparin Binding by BPI Protein Products. Heparin binding assays were conducted using membrane bound natural and recombinant BPI ... Collectins: collagenous C-type lectins of the innate immune defense system. Marra et al. 1992. The role of bactericidal/ ... As a result, other proteins which bind to LPS avidly, may also bind tightly to heparin. ... Human mannose-binding protein US5447913A (en) 1995-09-05. Therapeutic uses of bactericidal/permeability-increasing protein ...
  https://patents.google.com/patent/US5854214A/en