... is known to cause apoptosis in several types of malignant tumor cells through its interaction with the death domain-containing ... Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) ... Apoptosis Regulatory Proteins / pharmacology * Binding Sites * ... TGZ elevated DR5 expression at the promoter level through the CCAAT/enhancer-binding protein homologous protein (CHOP) binding ... Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to cause apoptosis in several types of malignant tumor ...
Here we demonstrate that the C-terminal half of EGL-1 is necessary and sufficient for binding to CED-9 an … ... Programmed cell death in Caenorhabditis elegans is initiated by the binding of EGL-1 to CED-9, which disrupts the CED-4/CED-9 ... Apoptosis Regulatory Proteins * Apoptosis* * Caenorhabditis elegans Proteins / chemistry* * Caenorhabditis elegans Proteins / ... A surface patch on CED-9, different from that required for binding to EGL-1, was identified to be responsible for binding to ...
"Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis". The EMBO Journal. 15 (5): 1012-20. ... Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ( ... SREBF2 has been shown to interact with INSIG1 and CREB-binding protein. Sterol regulatory element-binding protein GRCh38: ... Nagoshi E, Imamoto N, Sato R, Yoneda Y (Jul 1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic ...
A fusion protein containing C-terminal amino acids 833-1141 of human SREBP-2, was used as immunogen. The antibody recognizes ... A fusion protein containing C-terminal amino acids 833-1141 of human SREBP-2, was used as immunogen. The antibody recognizes ... Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 1996; 15(5):1012-1020. ( ... SREBP-1 and -2 (sterol-regulatory element binding proteins-1 and -2) are transcription factors which participate in the control ...
... and IL-17 protein and IL-1,i,β,/i, protein and mRNA were better than those of mesalazine (,span class=inline_break,,svg xmlns ... Western blot was used to detect the expression of autophagic and immune-related proteins in the colon, such as LC3II, SQSTM1/ ... i,Results,/i,. Herb-partitioned moxibustion reduced the protein levels of ATG16L1, NOD2, IRGM, LC3II, and Beclin1 (,span class ... and both the protein and mRNA levels of IL-1,i,β,/i,, IL-17, and TNF-,i,β,/i, in CD rats (,span class=inline_break,,svg xmlns ...
Apoptosis Regulatory Proteins. *Chromosome 1. *Virus Integration. *Leukemic Gene Expression Regulation. *Translocation ... CTCF-binding sites, and regulatory regions. STV analysis found a significant association with replication timing and identified ... What pathways are this gene/protein implicaed in?. Show (1). ASH1L is involved in:. - Tight junction KEGG. Data from KEGG and ... The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles ...
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15, 1012-1020.. Waris, G., ... Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway. J ... Hepatitis C virus genotype-3a core protein enhances sterol regulatory element- binding protein-1 activity through the ... Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor ...
PP1-binding protein of 114 kDa. phosphatase 1 nuclear targeting subunit. protein phosphatase 1, regulatory (inhibitor) subunit ... The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by ... Protein interactions. Protein. Gene. Interaction. Pubs. Tat tat Depletion of protein phosphatase 1, regulatory subunit 10 ( ... PPP1R10 protein phosphatase 1 regulatory subunit 10 [Homo sapiens] PPP1R10 protein phosphatase 1 regulatory subunit 10 [Homo ...
Nelson N, Marks MS, Driggers PH, Ozato K. Interferon consensus sequence-binding protein, a member of the interferon regulatory ... The ISG-encoded proteins include TFs, immune modulators, apoptosis mediators, and anti-viral factors [30]. Previously, the ... Thus, the alteration of the profile of the GGAA-motif-binding proteins or their associated protein factors may allow for the ... A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017;. 355. (6331):1312-1317 ...
Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the ... cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner. Depletion of OTUD3 results in a ... Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis. Although two ubiquitin ligases that ... Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Struct, Funct, post- ...
AhR regulates the transcription of diverse genes through binding to the xenobiotic-responsive element (XRE). Since the AhR has ... CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells. J Biol ... Total protein concentrations were determined by Bio-Rad Protein Assay (Bio Rad Laboratories Inc., USA). Proteins (30 μg/lane) ... The AhR is activated by binding to ligands, including dioxins, translocates from the cytoplasm to the nucleus and then binds to ...
Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell ... Monomeric GTP-Binding Proteins; Mouth Neoplasms; RNA, Messenger Ras association domain family member 5 (RASSF5), a member of ... Adult; Alleles; Brazil; Carrier Proteins; Case-control studies; Cation Transport Proteins; Diabetes, Gestational; Female; Gene ... Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 ...
... induces apoptosis by binding to and inhibiting the antiapoptotic proteins Bcl-2 and Bcl-xL.57 Hypoxia induced apoptosis ... Apoptosis regulatory proteins are delicately balanced. In solid tumours, hypoxia is a common phenomenon. Cells adapt to this ... 35 Apoptosis is regulated by a cascade of proteins called caspases. Caspases are the apoptosis executor proteins and are ... "Apoptosis is regulated by a cascade of proteins called caspases". An important regulator of apoptosis after DNA damage is the ...
... a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling ... pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to ...
Autophagy has also been shown to enhance the major histocompatibility complex presentation of at least two viral proteins, the ... and the accumulation of misfolded proteins. It also acts as a cellular defense mechanism against microorganisms by contributing ... The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles and proteins, but it ... also suggests that HCMV targets several regulatory pathways [71]. In view of the interplay known to exist between apoptosis and ...
Adenine, Age Factors, Alcohol Drinking, Apoptosis Regulatory Proteins, Ataxia Telangiectasia Mutated Proteins, Body Height, ... DNA-Binding Proteins, Environment, Female, Genotype, High Mobility Group Proteins, Hormone Replacement Therapy, Humans, Leucine ... Protein Serine-Threonine Kinases, Receptor, Fibroblast Growth Factor, Type 2, Receptors, Progesterone, Risk Factors, Trans- ... Body Mass Index, Breast Feeding, Breast Neoplasms, Caspase 8, Cell Cycle Proteins, Cytosine, ...
Mechanistically, ASPP2 induces MET through its PAR3-binding amino-terminus, independently of p53 binding. ASPP2 prevents β- ... Here we identify ASPP2, a haploinsufficient tumour suppressor, p53 activator and PAR3 binding partner, as a molecular switch of ... Apoptosis Regulatory Proteins, beta Catenin, Kruppel-Like Transcription Factors, Epithelial-Mesenchymal Transition, Wnt ... Mechanistically, ASPP2 induces MET through its PAR3-binding amino-terminus, independently of p53 binding. ASPP2 prevents β- ...
By binding to p63 and p73 in vitro and in vivo, ASPP1 and ASPP2 stimulate the transactivation function of p63 and p73 on the ... We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. ... Amino Acid Sequence, Apoptosis, Apoptosis Regulatory Proteins, Carrier Proteins, DNA-Binding Proteins, Genes, Tumor Suppressor ... We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. By binding to p63 and p73 in vitro and in vivo, ...
... on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with ... Alleles, Alzheimer Disease, Apoptosis Regulatory Proteins, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinases, Case- ... on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with ... Control Studies, Chromosomes, Human, Pair 9, Databases, Nucleic Acid, Death-Associated Protein Kinases, Female, Gene Frequency ...
... human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein ... human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein ... human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein ... human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein ...
IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral ... These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental ... interferon receptor 1-bound protein 4; IR1B4; Mrmt1; PRMT1; protein arginine methyltransferase 1; protein arginine N- ... Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen ...
Our recent research showed the crucial role of Z-DNA binding protein 1 (ZBP1)-mediated necroptosis and apoptosis in the ... It was found that metformin has a regulatory role in cell necroptosis and apoptosis. But whether and how metformin regulates ... Based on molecular docking, PPH could bind to kelch-like ECH-associated protein 1 (KEAP1) protein. PPH and RPE treatments could ... MiR-26a-3p was directly bound to PTEN. MiR-26a-3p overexpression reduced cell apoptosis, and inflammation and promoted ...
... including recently identified regulatory roles in microRNA processing. Advances in research into many of these diseases may ... The increased apoptosis was correlated with increased activation of PKR and interferon regulatory transcription factor-3, ... of ADAR2-editing of GluA2 in mouse motor neurons results in the mislocation of transaction response DNA-binding protein 43, an ... A recent study investigated the role of ADAR1 in RNAi pathways [82]. ADAR1 was found to have direct protein-protein ...
... such as those that promote apoptosis via the Bcl-2 family of regulatory proteins and those that act by binding to death ... which predominantly binds to Bcl-2 and Bcl-xL to induce or sensitize cells to apoptosis through the intrinsic pathway. As a ... proteins [23, 32]. Small molecules that antagonize pro-survival Bcl-2 proteins, namely BH3 mimetics, are currently under pre- ... of anti-apoptotic and down-regulation of pro-apoptotic Bcl-2 proteins and an over-expression of inhibitor of apoptosis AZD 7545 ...
... for 48 h to measure apoptosis and cell cycle arrest as well as apoptosis and cell cycle regulatory gene and protein expression ... C/EBPhomologous protein expression (CHOP), immunoglobulin-heavy-chain-binding protein (BiP), sliced X-box-binding protein 1 ( ... which activates IRE1α and its downstream transcription factor X-box binding protein 1 (XBP1). X-box binding protein 1 directly ... activation of signaling protein activity involved in unfolded protein response - DNA binding - endoplasmic reticulum unfolded ...
Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial ... Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins. Biochem. ... The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins Salah Abu-Hamad, ... apoptosis and the regulation of apoptosis by anti-apoptotic proteins such as hexokinase and Bcl2. Cells expressing N-terminal ...
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper ... should we have a new protein binding term to describe binding of anti-/pro-apoptotic Bcl-2 proteins? The binding between Bcl-2 ... on prosurvival proteins (Bcl-2 related), i.e. the BH3-only proteins bind to and neutralize the pro-survival proteins. Maybe ... Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis ...
The CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor, which was first identified as a regulator of ... CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells. J Biol ... The CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor, which was first identified as a regulator of ... CCAAT/enhancer-binding protein β (C/EBPβ), is a member of a family of transcription factors consisting of six structurally ...
Signal-regulatory protein (SIRP). CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane ... Rebres RA, Vaz LE, Green JM, Brown EJ (2001). "Normal ligand binding and signaling by CD47 (integrin-associated protein) ... However, apoptosis was not observed following culture with other anti-CD47 antibodies. The apoptosis inducing function of CD47 ... CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans ...
TP53, which is located on band 17p13.1, codes for a 53-kd nuclear protein transcription factor that has important regulatory ... a portion of the gene that codes for the core DNA-binding domain of the protein. Missense mutations lead to a stable but ... control over cell proliferation and homeostasis, specifically the cell cycle, DNA repair processes, and apoptosis. Somatic ( ... Alterations of p53 function are the result of either loss of function of wild type p53, increased or aberrant protein function ...