*  Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier | PNAS
Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. T Saga, R D Neumann, T Heya, J Sato, S ... Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. T Saga, R D Neumann, T Heya, J Sato, S ... Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. T Saga, R D Neumann, T Heya, J Sato, S ... Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier Message Subject (Your Name) has sent you a ...
  http://www.pnas.org/content/92/19/8999
*  An antibody binding site on cytochrome c defined by hydrogen exchange and two-dimensional NMR | Science
An antibody binding site on cytochrome c defined by hydrogen exchange and two-dimensional NMR ... The hydrogen exchange labeling approach can be used to map binding sites on small proteins in antibody-antigen complexes and ... An antibody binding site on cytochrome c defined by hydrogen exchange and two-dimensional NMR ... An antibody binding site on cytochrome c defined by hydrogen exchange and two-dimensional NMR ...
  http://science.sciencemag.org/content/249/4970/755
*  The N276 Glycosylation Site Is Required for HIV-1 Neutralization by the CD4 Binding Site Specific HJ16 Monoclonal Antibody
A tier 2 neutralizing monoclonal antibody (mAb), HJ16 recognizes a new epitope in the CD4 binding site (CD4bs) region that only ... We aimed to identify the critical binding site by resistance induction in a sensitive primary CRF02_AG strain. In four ... This mutation removes an N-linked glycosylation site. The effect of N276D was very selective, as it failed to confer resistance ... These data indicate that binding of the CD4bs specific HJ16 mAb critically depends on the interaction with the N276-glycan, ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068863
*  Targeting Ligand-Induced Binding Sites on GPIIb/IIIa via Single-Chain Antibody Allows Effective Anticoagulation Without...
Targeting Ligand-Induced Binding Sites on GPIIb/IIIa via Single-Chain Antibody Allows Effective Anticoagulation Without ... Targeting Ligand-Induced Binding Sites on GPIIb/IIIa via Single-Chain Antibody Allows Effective Anticoagulation Without ... Targeting Ligand-Induced Binding Sites on GPIIb/IIIa via Single-Chain Antibody Allows Effective Anticoagulation Without ... Targeting Ligand-Induced Binding Sites on GPIIb/IIIa via Single-Chain Antibody Allows Effective Anticoagulation Without ...
  http://atvb.ahajournals.org/content/early/2007/02/22/ATVBAHA.106.138875
*  JCI Insight - Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site
Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. ... Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. ... we studied the fine epitope specificity of a panel of CD4-binding site (CD4bs) antibodies to define the molecular recognition ... Heatmap of the relative binding of sera before (. A. ) and after (. B. ) STG-based enrichment for a set of 10 samples from a ...
  https://insight.jci.org/articles/view/97018/figure/5
*  JCI Insight - Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site
Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. ... Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. ... we studied the fine epitope specificity of a panel of CD4-binding site (CD4bs) antibodies to define the molecular recognition ... The residues most important to the classifier were mutated to generate a triple mutant probe (STG). The binding of each CD4bs ...
  https://insight.jci.org/articles/view/97018/figure/2
*  JCI Insight - Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site
Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. Hao D. Cheng,1,2 Sebastian K ... The development of CD4 binding site antibodies during HIV-1 infection. J Virol. 2012;86(14):7588-7595.. View this article via: ... A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site. Mol ... Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nat Med. 2007;13(9):1032-1034.. View this article via: ...
  https://insight.jci.org/articles/view/97018
*  Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited...
N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody ... We focused on the conserved CD4 binding site (CD4bs) since this is a known neutralizing determinant that is devoid of ... Use of this site constitutes acceptance of the PhysiciansWeekly.com Terms of Use and Privacy Policy. The material on this site ... The first was to delete 4 PNGS sites and then boost with fully glycosylated Env; the second was to delete 4 sites and gradually ...
  https://www.physiciansweekly.com/targeted-n-glycan-deletion-at-the-receptor-binding-site-retains-hiv-env-nfl-trimer-integrity-and-accelerates-the-elicited-antibody-response-2/
*  Antigen-binding sites dominate the surface properties of antibodies - Lund University
Antigen-binding sites dominate the surface properties of antibodies. Research output: Contribution to journal › Article ... Hence, the surface properties of the antigen binding sites dominate over all other surfaces of the free antibody molecule.. ... HomeResearch Outputs Antigen-binding sites dominate the surface properties of ant... ... LLPC may also be used to detect conformational changes occuring upon binding of antigen by antibody. Antigen-antibody complexes ...
  http://portal.research.lu.se/portal/en/publications/antigenbinding-sites-dominate-the-surface-properties-of-antibodies
*  "Boosting of HIV Envelope Cd4 Binding Site Antibodies with Long Variabl" by David Easterhoff, M. Anthony Moody et al.
Although the vaccine Env AE.A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broadly neutralizing antibody ( ... Boosting of HIV Envelope Cd4 Binding Site Antibodies with Long Variable Heavy Third Complementarity Determining Region in the ... "Boosting of HIV Envelope Cd4 Binding Site Antibodies with Long Variable Heavy Third Complementarity Determining Region in the ... Home , About , FAQ , My Account , Accessibility Statement , Terms and Conditions of Use ...
  https://digitalcommons.dartmouth.edu/facoa/2568/
*  IDEALS @ Illinois: Antibody active site contributions to fluorescein ligand binding
Antibody active site contributions to fluorescein ligand binding. Welcome to the IDEALS Repository. ... responsible for the observed Fl binding characteristics. To begin active site structure-function assessments, V$\sb{\rm H}$ and ... To verify this, Fl binding assays, following in vitro H and L chain reassociations, were performed. Results indicated: (1) L34 ... A panel of idiotypically cross-reactive murine monoclonal antibodies (Mabs) isolated in response to fluorescein (Fl) was ...
  https://www.ideals.illinois.edu/handle/2142/23366
*  Monoclonal antibodies against human erythrocyte band 3 protein. Localization of proteolytic cleavage sites and...
One of the antibodies binds to a site near the N terminus of the membrane domain; another binds to a site near the C terminus. ... The antibody that binds to the N-terminal portion of the membrane domain has been used to identify a new S-cyanylation cleavage ... The cleavage site, in human band 3, corresponds to Lys-761 in mouse band 3; the site is 168 residues from the C terminus of the ... This is the first intracellular site in the membrane domain (other than the N terminus) that has been localized in the primary ...
  https://www.semanticscholar.org/paper/Monoclonal-antibodies-against-human-erythrocyte-3-Jennings-Anderson/8b9011fed97254e5d1dcaa6531e8c03d14e0c7e9
*  Patent US6242570 - Production and use of recombinant protein multimers with increased ... - Google Patents
Biosynthetic antibody binding sites. US5114711. Jul 13, 1989. May 19, 1992. G. D. Searle & Co.. Covalently linked polypeptide ... such as necessary ribosome binding sites, a poly-adenylation site, splice donor and acceptor sites, and transcriptional ... Feldman, L., et al., "Four Unique Monoclonal Antibodies to the Putative Receptor Binding Domain of Erythropoietin Inhibit the ... Half a NaeI restriction site was designed into the 3′ end of EPO A DNA and half a ScaI restriction site into the 5′ end of EPO ...
  http://www.google.com/patents/US6242570
*  Patente US8093043 - β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing ... - Google Patentes
Biosynthetic antibody binding sites. US5168062. 10 Sep 1990. 1 Dic 1992. University Of Iowa Research Foundation. Transfer ... antibody binding is detected by detecting a label on the primary antibody. In another embodiment, the primary antibody is ... Also, the primary antibody was added. The dilution of antibody used was antibody-dependent. The range of dilution was from 1:5 ... assays that measure selective binding of test compounds to BimEL, to the BimEL binding site on β-TrCP1/2, or RSK1/2 or another ...
  http://www.google.es/patents/US8093043?hl=es&dq=flatulence
*  Final Flashcards by Tabatha O'Keefe | Brainscape
is an antibody that competes for binding sites: Heterophile antibody 65 You can only report and exact value when it is within ... Brainscape is a web and mobile study platform that helps you learn things faster. Our mission is to create a smarter world by ...
  https://www.brainscape.com/flashcards/final-6006073/packs/8763088
*  Patent US5395754 - Membrane-based immunoassay method - Google Patents
... first binding pair being covalently cross-linked such that any remaining binding sites on said first immobilized antibody are ... labelled second antibody specifically bound in the test zone versus the amount of labelled second antibody specifically bound ... analyte in the test and calibrator zones with a labelled second antibody capable of binding to a second antigen site on the ... but at least some of said analyte is capable of specifically binding to a preselected amount of a labelled second antibody. The ...
  http://www.google.com.au/patents/US5395754
*  In Vivo Imaging Using Quantum Dot-Conjugated Probes - Current Protocols
... analysis of ligand binding constants and receptor density ... Cytometric Quantitation of the Number of Antibody Binding Sites ... Basic Protocol 3: Flow Cytometric Quantitation of the Number of Antibody Binding Sites. ... Basic Protocol 2: Flow Cytometric Determination of the Binding Constants of Ligands or Antibodies. ... Basic Protocol 2: Flow Cytometric Determination of the Binding Constants of Ligands or Antibodies ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cb2501.html
*  Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin 1, in patients with localized scleroderma.
Binding Sites, Antibody / immunology. Humans. Immunoglobulin G / metabolism. Immunoglobulin M / metabolism. Microfilament ... 0/Autoantibodies; 0/Binding Sites, Antibody; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Microfilament Proteins; 0/fibrillin ... No correlations between antifibrillin 1 antibodies and active skin disease or antinuclear antibody positivity were found. ... This study was undertaken to determine whether antifibrillin 1 antibodies could be detected in patients with localized forms of ...
  http://www.biomedsearch.com/nih/Autoantibodies-to-extracellular-matrix-microfibrillar/10616014.html
*  Patent US7078492 - Human antipneumococcal antibodies from non-human animals - Google Patents
The invention further provides methods for making the antibodies in a non-human animal and for expressing the antibodies in ... Kits and pharmaceutical compositions comprising the antibodies are also provided in addition to methods of treating, inhibitng ... The invention described herein provides human antibodies produced in non-human animals that specifically bind to Streptococcus ... Thus, an intact IgG antibody has two binding sites. Except in bifunctional or bispecific antibodies, the two binding sites are ...
  http://www.google.com/patents/US7078492?dq=5910382
*  Navigating the Cancer Immunotherapy Maze - Revisiting Trifunctional Antibodies with Dr Horst Lindhofer PhD Friday, June 27, 2014
Revisiting Trifunctional Antibodies with Dr Horst Lindhofer PhD Friday, June 27, 2014 on Navigating the Cancer Maze , ... family of antibodies which are able to treat a wide range of cancers. Trifunctional antibodies have three binding sites; they ... Since this interview was first broadcast, there have been some company changes for production of these antibodies & new web ... Navigating the Cancer Immunotherapy Maze - Revisiting Trifunctional Antibodies with Dr Horst Lindhofer PhD June 27, 2014. ...
  https://www.voiceamerica.com/episode/78809/navigating-the-cancer-immunotherapy-maze-revisiting-trifunctional-antibodies-with-dr-horst-lindhofer
*  Anti-PBR antibody [EPR5384] KO Tested Recombinant (ab109497) | Abcam
Rabbit recombinant monoclonal PBR antibody [EPR5384] validated for WB, IP, IHC, Flow Cyt, ICC/IF and tested in Human and Mouse ... Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding ... Primary antibodies. Secondary antibodies. ELISA, Matched Antibody Pairs and Multiplex Immunoassays. Cell and tissue imaging ... Control 1: primary antibody (1/100) and secondary antibody, ab150120, an Alexa Fluor® 594-conjugated goat anti-mouse IgG (1/500 ...
  http://www.abcam.com/pbr-antibody-epr5384-ab109497.html?productwalltab=abreviews
*  Paper Chase | HMS
Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat. Struct. Mol. ... N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat. Struct. Mol. Biol. ... p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics. Nat. Struct. Mol. Biol. ...
  https://hms.harvard.edu/research/paper-chase?pcs=3&pcq=Nature%20Structural%20and%20Molecular%20Biology
*  Previous Exam 4
An epitope is the specific binding site on an antibody.. Monoclonal antibodies will bind to only one epitope. ... or analysis of this antibody and the design of the assay for kangaroo meat in hamburger..(15 pts.) ...
  http://www.uky.edu/Ag/FoodScience/test4-535.html
*  Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes |...
This website is best viewed using the latest versions of all modern web browsers. Older browsers may not display correctly. ... The next day, the beads were washed three times with 300 mM calmodulin‐binding buffer, then 2 × SDS sample was added and the ... we immunoprecipitated yeast containing a TAP tag on Ahc2 or Sgf29 and probed with an antibody to Ada3, a known component of the ... If SAGA is present, Gal4‐VP16 bound to the GAL1 promoter drives LacZ expression. ...
  http://msb.embopress.org/content/7/1/503