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*  Adenovirus-Mediated Overexpression of c-Jun and c-Fos Induces Intercellular Adhesion Molecule-1 and Monocyte Chemoattractant...
Using an adenovirus-mediated gene transfer protocol, we found that the AP-1 proteins c-Fos and c-Jun directly cause phenotypic ... These trans-acting elements interact with AP-1 binding sites in target genes to mediate cellular responses to environmental ... Fos-associated protein p39 is the product of the jun proto-oncogene. Science. 1988;240:1010-1016. ... Stein B, Baldwin ASJ, Ballard DW, Greene WC, Angel P, Herrlich P. Cross-coupling of the NF-κB p65 and Fos/Jun transcription ...
  http://atvb.ahajournals.org/content/19/9/2078
*  Protocols and Video Articles Authored by Gaoqing Yang
While the sequence of the decorin core protein is determined by the gene encoding its structure, the structure of its GAG chain ... The sequence length and the binding site of the probe with a target sequence have obvious effects on the detection. The optimal ... We found also that the ORF3 proteins of genotype 4 and rabbit HEV interacted with all of the human proteins identified by the ... Jun, 2013 , Pubmed ID: 23423786 GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in ...
  https://www.jove.com/author/Gaoqing_Yang
*  Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 | Cancer Research
NF-κB proteins play an important role through sites in HS1,2 and HS4. In vivo binding of NF-κB to these sites was demonstrated ... In addition, two Sp1 binding sites in HS4 were also found to positively influence bcl-2 activity, and Sp1 was observed to ... CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA, 94: 2927-2932, 1997. ... GGCCTATGCTGGGAGTCGAGCATCCCCAAGGCTGG. Although neither HS4 region contained an exact Sp1 binding site, both contained a GGA ...
  http://cancerres.aacrjournals.org/content/63/20/6666.long
*  Plus it
The siRNAs targeting the human GSK-3β gene (5′-AAG AAT CGA GAG CTC CAG ATC-3′, designated as #4 and 5′-AAG TAA TCC ACC TCT GGC ... Protein concentration in the cell lysates was measured by a Protein Assay Kit (Bio-Rad). An equal amount of protein from each ... The quality of the synthesized siRNA was estimated by agarose gel analysis and found to be very clean. RNAs were quantified by ... Briefly, after treatment, cells were collected and washed with ice-cold PBS and then suspended in Annexin V binding buffer. ...
  http://mct.aacrjournals.org/content/2/11/1215
*  Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis | Retrovirology | Full Text
The HTLV-1 bZIP factor (HBZ) gene was discovered in 2002 and has been found to promote T-cell proliferation and cause lymphoma ... Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax ... HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene. ... miR17 and miR21 target and suppress the expression of OBFC2A, the gene that encodes hSSB2, a single-stranded DNA-binding ...
  https://retrovirology.biomedcentral.com/articles/10.1186/s12977-016-0249-x
*  Plus it
... p300 and CBP can bind not only to target proteins and regulate DNA binding affinity, transcriptional activation, protein- ... we found that p300 depletion leads to a decreased p65 level, apparently through increased turnover of the protein. This is in ... p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ... Acetylation and deacetylation of non-histone proteins. Gene 2005;363:15-23. ...
  http://mct.aacrjournals.org/content/10/9/1644
*  US5962415A - Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods...
Novel compositions of immunosuppressants, such as cyclosporin, and polypeptide inhibitors of cytoplasmic protein nuclear ... The gene can be placed under the control of a promoter, ribosome binding site (for bacterial expression) and, optionally, an ... A discussion of NLSs and a list of NLSs can be found in Boulikas (1993) Crit. Rev. Eukaryotic Gene Expression 3:193-227, and ... In unstimulated cells, a major form of NF-κB is a heterodimer of p50 and p65 (RelA) subunits. Nonactive NF-κB is retained in ...
  https://patents.google.com/patent/US5962415?oq=ascentive
*  Patente US6025194 - Nucleic acid sequence of senescence asssociated gene - Google Patentes
Isolated, purified, and recombinant nucleic acids and proteins corresponding to the human GC6 gene and its mRNA and protein ... such agents as well as GC6 gene and gene products and products corresponding thereto can be used to prevent and treat diseases ... identify agents that alter senescent gene expression generally and GC6 expression specifically; ... products, as well as peptides and antibodies corresponding to the GC6 protein can be used to identify senescent cells, ...
  http://www.google.es/patents/US6025194
*  AKT3 AKT serine/threonine kinase 3 [Homo sapiens (human)] - Gene - NCBI
BioAssay by Target (List) BioAssays related to the gene by protein target or RNAi target ... gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires ... RAC-gamma serine/threonine protein kinase. v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma). NP_ ... organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream ...
  https://www.ncbi.nlm.nih.gov/gene/10000
*  Other | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors
... terminal hydrophilic and an extended extracellular C-terminal hydrophilic site separated with a hydrophobic site of 26 proteins ... GAGs) such as for example hyaluronic acidity (HA) heparan sulfate (HS) and chondroitin sulfate can be found in the vitreous gel ... The CD16 blocks the binding of soluble immune complexes to granulocytes. Avasimibe BX-795 Cabozantinib Calcitetrol CCT128930 ... LOX-1 represents a novel target for the modulation of Rabbit polyclonal to ALDH1A2. the inflammatory response within the ...
  http://researchreport-digital.com/category/other/
*  Protocols and Video Articles Authored by Jing Huang (Translated to Portuguese)
... a domain found in mammalian RIPK proteins forming functional amyloids during necroptosis. Here we found that despite sequence ... Further, oncogene HOXB5 was evidenced to be a potential target of miR-1275, and its expression was conversely correlated with ... gene single nucleotide polymorphisms (SNPs), additional gene-gene, and gene-smoking interaction with ischemic stroke (IS) risk. ... PbWoxT1 is rich in CUCU polypyrimidine domains and its mRNAs interact with a polypyrimidine tract binding protein, PbPTB3. ...
  https://www.jove.com/author/Jing_Huang?language=Portuguese
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... were found to bind fibrils of certain other amyloidogenic proteins besides β2m fibrils19. Ylera et al. described RNA aptamers ... nuclear translocation of the p65 subunit of NF-κB (p65), and secretion of the hallmark proinflammatory cytokine, tumor necrosis ... Gene-environment interaction models have utility in unmasking the impact of specific cellular pathways in toxicity that may not ... While on-site training of the LE pipeline is preferable, readily available visual teaching tools with interactive training ...
  https://www.jove.com/visualize/abstract/25062013/granulocyte-colony-stimulating-factor-attenuates-oligomeric-amyloid
*  Brain Infection by Neuroinvasive but Avirulent Murine Oncornaviruses - PDF
The DNA -, RNA -, Protein Pathway The DNA -, RNA -, Protein Pathway RNA Polymerase = enzyme that makes mrna from the DNA gene ... Rabbit Polyclonal antibody to NFkB p65 (v-rel reticuloendotheliosis viral oncogene homolog A (avian)) Datasheet GeneTex, Inc : ... and membrane proteins are sorted to these sites based on the recognition of sequence motifs (sorting signals) by the protein- ... Previous studies found that the envelope protein of FrCas E accumulates in the cell bodies of granule cells (Fig. 7, left) as ...
  http://healthdocbox.com/Aids_and_Hiv/65517162-Brain-infection-by-neuroinvasive-but-avirulent-murine-oncornaviruses.html
*  Inhibition of Elastase-Pulmonary Emphysema in Dominant-Negative MafB Transgenic Mice
Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human ... Elastin, the major target protein of MMP-12, is downregulated in the lung parenchyma of emphysema patients [43]. It has been ... and 10 ng of nuclear protein was used to assess the activity of NF-kB p65 and AP-1, c-fos, using TransAM® NFκB Family ... also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, is a member of the Maf protein family and possesses a ...
  http://www.ijbs.com/v10p0882.htm