*  The Human Glucocorticoid Receptor as an RNA-Binding Protein: Global Analysis of Glucocorticoid Receptor-Associated Transcripts...
Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N. Engl. J. Med. 353: 1711-1723. ... The Human Glucocorticoid Receptor as an RNA-Binding Protein: Global Analysis of Glucocorticoid Receptor-Associated Transcripts ... The Human Glucocorticoid Receptor as an RNA-Binding Protein: Global Analysis of Glucocorticoid Receptor-Associated Transcripts ... The Human Glucocorticoid Receptor as an RNA-Binding Protein: Global Analysis of Glucocorticoid Receptor-Associated Transcripts ...
  http://www.jimmunol.org/content/186/2/1189.long
*  Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis.
... and mineralocorticoid receptors. The data have been a ... have been measured for the cytosol glucocorticoid receptor (GR ... 0/Glucocorticoids; 0/Receptors, Androgen; 0/Receptors, Glucocorticoid; 0/Receptors, Mineralocorticoid; 0/Receptors, ... Receptors, Glucocorticoid / metabolism*. Receptors, Mineralocorticoid. Receptors, Progesterone / metabolism*. Receptors, ... The relative binding affinities of over 30 steroids have been measured for the cytosol glucocorticoid receptor (GR) of thymus, ...
  http://www.biomedsearch.com/nih/Binding-steroids-to-progestin-glucocorticoid/2897467.html
*  A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells | BMC Neuroscience | Full Text
In the brain there are two receptors for glucocorticoids, the mineralocorticoid receptor (MR) and the glucocorticoid receptor ( ... Yu CY, Mayba O, Lee JV, Tran J, Harris C, Speed TP, Wang JC: Genome-wide analysis of glucocorticoid receptor binding regions in ... Genomic distribution of Glucocorticoid Receptor binding sites (GBS) upstream of the Tyrosine Hydroxylase gene (TH). Two ... Glucocorticoid receptorNeuronal contextGlucocorticoid response elementPC12 cellsChIP-Seq. Background. The brain is a major ...
  https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-13-118
*  Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the...
Footprinting experiments showed that the GRU binds not only the glucocorticoid receptor (GR), but also ubiquitous [nuclear ... We found that both glucocorticoids and insulin act via the glucocorticoid response unit (GRU) located in the first intron. ... involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase ... involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase ...
  https://dial.uclouvain.be/pr/boreal/object/boreal:21596
*  System among the corticosteroids | Journal of The Royal Society Interface
Glucocorticoid activity assays. 2.3.1. Relative binding affinity for glucocorticoid receptor. L929 fibroblasts grown in DMEM/10 ... the role of C ring flexibility in glucocorticoids and A ring flexibility in glucocorticoids is ambiguous. Thus, C ring ... 2002 Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and ... Molecular shape is surely important in binding to a receptor, but the distinct glucocorticoid and mineralocorticoid activities ...
  http://rsif.royalsocietypublishing.org/content/early/2011/05/20/rsif.2011.0183
*  Active Motif » TransAM GR (glucocorticoid or NR3C1 DNA binding ELISA)
TransAM GR is a DNA-binding ELISA that quantifies the activated transcription factor using a method that is faster and more ... Glucocorticoids play an essential role in maintaining basal and stress-related homeostasis. Glucocorticoid Receptor (GR), also ... dna-binding ELISA for activated glucocorticoid receptor. TransAM® Kits are DNA-binding ELISAs that facilitate the study of ... TransAM GR Kits provide everything needed to study activated Glucocorticoid Receptor (GR), including a positive control extract ...
  https://www.activemotif.com/catalog/202/transam-gr
*  JCI - Glucocorticoid receptors: finding the middle ground
Nuclear integration of glucocorticoid receptor and nuclear factor-κB signaling by CREB-binding protein and steroid receptor ... Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor- ... PPARα blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor α ... DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 1998;93(4):531-541.. View this article via: ...
  https://www.jci.org/articles/view/88886
*  Mycosis Fungoides (MF) - DrugBank
... whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor. ... Glucocorticoid receptor. target. DB00860. Prednisolone. Solute carrier organic anion transporter family member 1A2. transporter ... Isotretinoin binds to and activates nuclear retinoic acid receptors (RAR), thereby regulating cell proliferation and ... ATP-binding cassette sub-family G member 2. transporter. DB00741. Hydrocortisone. Solute carrier family 22 member 8. ...
  https://www.drugbank.ca/indications/DBCOND0057197
*  Acquired immune hemolytic anemia - DrugBank
... whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor. ... Glucocorticoid receptor. target. DB00860. Prednisolone. Solute carrier organic anion transporter family member 1A2. transporter ... An anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]. DB00741. Hydrocortisone. The main glucocorticoid secreted by the ... A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which ...
  https://www.drugbank.ca/indications/DBCOND0022249
*  Acne Rosacea - DrugBank
... whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor. ... Glucocorticoid receptor. target. DB00860. Prednisolone. Solute carrier organic anion transporter family member 1A2. transporter ... A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which ... Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, ...
  https://www.drugbank.ca/indications/DBCOND0029985
*  Glucocorticoids Enhance the Excitability of Principal Basolateral Amygdala Neurons | Journal of Neuroscience
2000) Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers. Nat Neurosci 3:977-978. ... 2001) Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc Natl Acad Sci USA ... glucocorticoids readily pass the blood-brain barrier and bind to two types of intracellular steroid receptors: high-affinity ... 2001) Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J Psychiatr Res 34:383-392. ...
  http://www.jneurosci.org/content/27/16/4482
*  Glucocorticoid receptor - Wikipedia
... nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is ... The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor- ... Membrane glucocorticoid receptor Familial/sporadic glucocorticoid resistance (Chrousos Syndrome) Selective glucocorticoid ... "RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding". J. Biol. ...
  https://en.wikipedia.org/wiki/Glucocorticoid_receptor
*  11β-Hydroxysteroid dehydrogenase - Wikipedia
Cortisol, a glucocorticoid, binds the glucocorticoid receptor. However, because of its molecular similarity to aldosterone it ... thus regulating the access of glucocorticoids to the steroid receptors: 11β-hydroxysteroid + NADP+ ⇌ an 11-oxosteroid + NADPH ... which can no longer bind to the mineralocorticoid receptor. 11β-HSD co-localizes with intracellular adrenal steroid receptors. ... is also capable of binding the mineralcorticoid receptor. Both aldosterone and cortisol have a similar affinity for the ...
  https://en.wikipedia.org/wiki/11%CE%B2-Hydroxysteroid_dehydrogenase
*  GRLF1 - Wikipedia
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor ... The level of expression is regulated by glucocorticoids. GRCh38: Ensembl release 89: ENSG00000160007 - Ensembl, May 2017 GRCm38 ... "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1". Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase ... Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene. ...
  https://en.wikipedia.org/wiki/GRLF1
*  Selective glucocorticoid receptor modulator - Wikipedia
... glucocorticoids and selective glucocorticoid receptor agonists work by binding to and activating the glucocorticoid receptor ( ... Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as ... Binding of glucocorticoids to the GR activates the receptor by causing a conformational change in the GR and thus a ... In in vitro studies in cellular models these SEGRAM molecules bind to the glucocorticoid receptor with an affinity similar to ...
  https://en.wikipedia.org/wiki/Selective_glucocorticoid_receptor_modulator
*  Neurobiological effects of physical exercise - Wikipedia
The "stress hormone", cortisol, is a glucocorticoid that binds to glucocorticoid receptors. Psychological stress induces the ... Stress and glucocorticoids inhibit, and a wide variety of antidepressant drugs, exercise, and enriched environments activate ... IGF-1 elicits its physiological effects by binding to a specific receptor tyrosine kinase, the IGF-1 receptor, to control ... VEGF is a neurotrophic and angiogenic (i.e., blood vessel growth-promoting) signaling protein that binds to two receptor ...
  https://en.wikipedia.org/wiki/Neurobiological_effects_of_physical_exercise
*  Stress (biology) - Wikipedia
Steroid hormones bind to glucocorticoid receptors in the brain, providing negative feedback by reducing ACTH release. Some ... There is also some activation of the HPA axis, producing glucocorticoids (cortisol, aka the S-hormone or stress-hormone). ... The secretion of ACTH into systemic circulation allows it to bind to and activate Melanocortin receptor, where it stimulates ... travel through the hypophysial portal vessel where they travel to and bind to the corticotropin-releasing hormone receptor on ...
  https://en.wikipedia.org/wiki/Stress_(biology)
*  Glucocorticoid - Wikipedia
Glucocorticoids bind to the cytosolic glucocorticoid receptor (GR), a type of nuclear receptor that is activated by ligand ... glucocorticoid-induced TNF receptor) Glucocorticoid receptor Immunosuppressive drug Membrane glucocorticoid receptor Metyrapone ... Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor (GR), that is present in almost every vertebrate ... GCs affect cells by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression ...
  https://en.wikipedia.org/wiki/Glucocorticoid
*  Roxibolone - Wikipedia
It does not bind to the glucocorticoid receptor however, and its antiglucocorticoid activity may instead be mediated by enzyme ... which is responsible for the biosynthesis of the potent endogenous glucocorticoids cortisol and corticosterone (from the ... Dahlberg E, Snochowski M, Gustafsson JA (1981). "Regulation of the androgen and glucocorticoid receptors in rat and mouse ... roxibolone is devoid of affinity for the androgen receptor and possesses no androgenic or myotrophic activity in animal assays ...
  https://en.wikipedia.org/wiki/Roxibolone
*  Progestogen - Wikipedia
"Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha ... glucocorticoids, and mineralocorticoids, as well as the neurosteroids. All endogenous progestogens are characterized by their ... are a class of steroid hormones that bind to and activate the progesterone receptor (PR). Progesterone is the major and most ... biosynthesis and receptor interaction". Mol. Cell. Endocrinol. 336 (1-2): 92-101. doi:10.1016/j.mce.2010.11.016. PMID 21095220 ...
  https://en.wikipedia.org/wiki/Progestogen
*  Progesterone - Wikipedia
In addition, progesterone binds to and behaves as a partial agonist of the glucocorticoid receptor (GR), albeit with very low ... prevents MR activation by binding to this receptor with an affinity exceeding even those of aldosterone and glucocorticoids ... "Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha ... The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including in keratinocytes and ...
  https://en.wikipedia.org/wiki/Progesterone
*  17α-Hydroxyprogesterone - Wikipedia
"Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha ... glucocorticoids, and mineralocorticoids, as well as neurosteroids. 17α-OHP is an agonist of the progesterone receptor (PR) ... In addition, it is an antagonist of the mineralocorticoid receptor (MR) as well as a partial agonist of the glucocorticoid ... "Progesterone Acts via the Nuclear Glucocorticoid Receptor to Suppress IL-1β-Induced COX-2 Expression in Human Term Myometrial ...
  https://en.wikipedia.org/wiki/17%CE%B1-Hydroxyprogesterone
*  E)-N--METHANESULFONAMIDE AS GLUCOCORTICOID RECEPTOR MODULATOR FOR THE TREATMENT OF RHEUMATOID ARTHRITIS - Patent application
... glucocorticoids is that it binds to GR with greater affinity relative to the other steroid hormone receptors. [0005]Recent ... complex with the glucocorticoid receptor (GR). Following glucocorticoid binding, the GR-glucocorticoid complex translocates to ... glucocorticoid receptor), AR (androgen receptor), MR (mineralocorticoid receptor), or PR (progesterone receptor) are used for ... receptor-ligand competition binding assays to determine Ki values. [0022]Briefly, steroid receptor competition binding assays ...
  http://www.patentsencyclopedia.com/app/20100280062
*  Learn: FA PHARM (by laracrystalo) - Memorize.com - Remember and Understand
binds mTOR to decrease IL2 and decrease T cell activation. monoclonal antibody against IL2 receptor?. Daclizumab. ... Fibrates, Niacin, colchicine, hodroxychloroquine, IFNalpha, penicillamine, statins, glucocorticoids. Osteoporosis. ... HPA suppression secondary to glucocorticoid withdrawal. hot flashes. Tamoxifen, clomiphene. hyperglycemia. Tacrolimus, Protease ...
  http://memorize.com/fa-pharm/laracrystalo
*  Systemic Inflammatory Response Syndrome
These antagonists either bind the cytokine, and thereby inactivate it, or block the receptors. Comorbidities and other factors ... It has glucocorticoid and mineralocorticoid properties. The biologic half-life is 8-12 hours. The easiest way to set up an ... In vitro research suggests that glucocorticoids may function by inhibiting NF-kB. TNF-α and IL-1 have been shown to be released ... The inflammatory mediators and receptors associated with infectious insults (ie, septic shock) are the same as those linked to ...
  http://misc.medscape.com/pi/android/medscapeapp/html/A168943-business.html