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*  E2F4 Modulates Differentiation and Gene Expression in Hematopoietic Progenitor Cells during Commitment to the Lymphoid Lineage ...
This leads to the binding of E2F factors, including E2F4. The active E2F transcription factors E2F1, E2F2, and E2F3a are ... E2F4 and E2F5, have the ability to bind similar promoter regions to those bound by the activating E2Fs (11), but are ... Thus, we crossed E2F4 heterozygous mice to generate fetuses of all three genotypes: e2f4+/+, e2f4+/− and e2f4−/−. Fetuses were ... e2f4+/− (CD45.2+) cells mixed with e2f4+/+ (CD45.1+) cells, or e2f4−/− (CD45.2+) cells mixed with e2f4+/+ (CD45.1+) cells. ...
  http://www.jimmunol.org/content/180/6/3699.long
*  E2F - Wikipedia
... analysis has shown that the E2F family of transcription factors has a fold similar to the winged-helix DNA-binding motif. E2F ... to the promoter. E2F3b, E2F4, E2F5 are expressed in quiescent cells and can be found associated with E2F-binding elements on ... Binding with DP1,2 provides a second DNA binding site, increasing E2F binding stability. Most E2F have a pocket protein binding ... binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription machinery. In the absence ...
  https://en.wikipedia.org/wiki/E2F
*  Transcriptional Regulation of Cyclin A2 by RASSF1A through the Enhanced Binding of p120E4F to the Cyclin A2 Promoter | Cancer...
pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc Natl Acad Sci U ... Interestingly, repression of the cyclin A2 promoter in quiescent cells was found to be associated with recruitment of the E2F-4 ... which did not compete with p120E4F binding. A similar EMSA profile is also seen in HeLa cells (lanes 8-11). EMSA results ( Fig ... DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation. Genes Dev 1989; 3: 620 ...
  http://cancerres.aacrjournals.org/content/65/7/2690
*  Similar articles for PubMed (Select 8446173) - PubMed - NCBI
E2F site activates transcription in fission yeast Schizosaccharomyces pombe and binds to a 30-kDa transcription factor. ... E2F-4, a new member of the E2F transcription factor family, interacts with p107. ... Regulation of adenovirus 12 E1A transcription: E2F and ATF motifs in the E1A promoter bind nuclear protein complexes including ... Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=8446173
*  Plus it
However, we previously provided the first in vivo evidence that a specific fragment of ER-α promoter is bound by pRb2/p130-E2F4 ... E2F4 and E2F5 transcription factors, and chromatin-modifying enzymes DNMT1, HDAC1, histone methyltransferase (SUV39H1), and ... which we found to be differentially associated with pRb2/p130 on the ER-α promoter, is similar in MDA-MB-231 and MCF-7 cells. ... In vivo binding of pRb1/p105, p107, and pRb2/p130 to ER-α promoter. We studied whether pRb1/p105 and p107 bind in vivo to ER-α ...
  http://cancerres.aacrjournals.org/content/67/16/7731
*  E2F8 is a nonreceptor activator of heterotrimeric G proteins | Journal of Molecular Signaling | Full Text
In yeast, E2F8 is a guanine nucleotide exchange factor (GEF) for the α subunit of heterotrimeric G proteins. The molecular ... The human transcription factor E2F8 was found to activate heterotrimeric G proteins, suggesting a specific biological role for ... consists of proteins that are bound by pRb; the E2F moiety is released to serve as a transcription factor when pRb is ... E2F4 and 5 also bind to pocket proteins (pRb, p107, and p130) but act primarily to repress E2F target genes by occupying ...
  https://jmolecularsignaling.biomedcentral.com/articles/10.1186/1750-2187-2-3
*  SMAD (protein) - Wikipedia
When there is no TGF-B present, a repressor complex composed of Smad3, and the transcription factors E2F4 and p107 exist in the ... where they can bind to DNA and regulate transcription. However, I-Smads are predominantly found in the nucleus, where they can ... of the Myc promoter to repress its transcription. In addition to Myc, Smads are also involved in the downregulation of ... A similar screen done in the Caenorhabditis elegans protein SMA (from gene sma for small body size) revealed three genes, Sma-2 ...
  https://en.wikipedia.org/wiki/SMAD_(protein)
*  Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation | BMC Genomics | Full Text
We found a highly significant enrichment for several transcription factor binding sites (TFBS) leading to the prediction that ... expressed genes between TPA-treated wt and Rage-deficient skin and performed computational analysis of their proximal promoter ... corresponding transcription factors, such as Sp1, Tcfap2, E2f, Myc and Egr, are regulated by Rage signaling. Accordingly, we ... and Rage-deficient mice revealed that Rage signaling is not essential for initial changes in TPA-induced transcription, but ...
  https://0-bmcgenomics-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2164-11-537
*  Frontiers | Skin Tumors Rb(eing) Uncovered | Oncology
... unique and overlapping functions as master regulators of cell cycle progression and transcriptional modulation by similar ... unique and overlapping functions as master regulators of cell cycle progression and transcriptional modulation by similar ... p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes. Oncogene (2012) 31(38): ... E2F1-E2F6 factors have a domain to bind DP and DNA, E2F1-5 have a pocket protein binding domain, and E2F7 and 8 can bind DNA ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00307/full
*  Recombinant human SIRT1 protein (ab54334) | Abcam
Represses HNF1A-mediated transcription. Required for the repression of ESRRG by CREBZF. Modulates AP-1 transcription factor ... a promoter clearing mechanism after reach round of transcription is proposed. Involved in lipid metabolism. Implicated in ... Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation. Proposed to play role ... Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis. Deacetylates DNMT1; ...
  https://www.abcam.com/recombinant-human-sirt1-protein-ab54334.html
*  Plus it
1 Promoter. To identify the FLP/MYB88 binding sites in CDKB1;1, we cloned the 5′ region of CDKB1;1 from the transcription start ... and potentially other similar E2F factors, can recognize this element in vivo (Figures 7A and 7B). ... the human equivalent of the dREAM complex associates with the E2F4 repressor so that the complex represses cell cycle genes, ... FLP/MYB88 Binding Sites in the CDKB1;1 Promoter.. (A) Structure of the CDKB1;1 promoter showing the position of two putative ...
  http://www.plantcell.org/content/22/7/2306
*  QSER1 - Wikipedia
Predicted transcription factors with conservation include (but are not limited to) EGR1, p53, E2F3, E2F4, PLAG1, NeuroD2, Myf5 ... The structurally similar region is on the exterior of the protein molecule and forms part of the DNA binding cleft. Further ... The promoter region for QSER1 is 683 bp in length and is found on chromosome 11 between 32,914,224 bp and 32,914,906. There is ... An image of the structurally similar region and sequence alignment is shown on the right. Regions before the identified ...
  https://en.wikipedia.org/wiki/QSER1
*  Oncogene - Biological reprogramming in acquired resistance to endocrine therapy of breast cancer
... the representation of predicted transcription factor binding sites (TFBSs) at promoters was evaluated using predictions from ... Balciunaite et al., 2005) showed similar results for E2F4 response elements (underexpressed set, infra-representation P=0.072; ... 2008). JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. ... Figure 4a, bottom panels), a transcription factor involved in stem cell self-renewal (. Galan-Caridad et al., 2007). The ...
  http://www.nature.com/onc/journal/v29/n45/full/onc2010333a.html?foxtrotcallback=true&error=cookies_not_supported&code=4e4de2b9-362c-43f6-b1eb-2244ff9569fc
*  WikiGenes - HCFC1 - host cell factor C1
The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the ... Luman and VP16 appear to have similar mechanisms for binding HCF, as in vitro each competitively inhibited the binding of the ... Host Cell Factor-1 and E2F4 Interact Via Multiple Determinants in Each Protein. Knez, J., Piluso, D., Bilan, P., Capone, J.P. ... Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. Misra, V., Rapin, N., ...
  http://www.wikigenes.org/e/gene/e/3054.html
*  Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
Through its ability to bind the E2F transcription factors, the RB family of proteins (RB, p107, and p130) plays a major role in ... as well as a switch between the E2F3 activator and the E2F4 repressor at the Foxn1 promoter (Fig. 4 I). Collectively, these ... However, we found that the expression of Eya1, Pax1, Pax9, Six1, Hoxa3, and Tbx1 was similar in control and mutant TECs at 3 mo ... We found that E2F3 and E2F4, a repressor E2F, can bind to both site 1 and site 2-3 but do not bind significantly to regions of ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3674705/?lang=en-ca
*  Protocols and Video Articles Authored by Patrick Collins
Transcription Factor Binding and Modified Histones in Human Bidirectional Promoters Genome Research. Jun, 2007 , Pubmed ID: ... We found that a small set of motifs, including GABPA, MYC, E2F1, E2F4, NRF-1, CCAAT, YY1, and ACTACAnnTCC are overrepresented ... Five samples showed levels of resistance similar to the reference strong-resistance strain. A representative highly resistant ... including the ubiquitous ets-family transcription factor GA-binding protein (GABP). Here we show that GABP binds to more than ...
  https://www.jove.com/author/Patrick_Collins
*  EEF1A1 | Cancer Genetics Web
Mechanistically, E2F-4 binds constitutively to the TP53 gene and induces transcription. TGF-β1-activated Smads are recruited to ... regulation of transcription, DNA-dependent - transcription, DNA-dependent - translation - translation elongation factor ... Similar results were obtained with mHLA-G(EF1α)-hESC-derived epidermal progenitors (hEEP). One way mixed T lymphocyte reactions ... The XPG-TFIIH complex was recruited to promoter and coding regions of both EGF-induced (FOS) and housekeeping (EEF1A1) genes. ...
  http://www.cancerindex.org/geneweb/EEF1A1.htm
*  Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line ...
... integration and provirus transcription and other cellular responses such as apoptosis and proliferation were modulated. For ... Most prominently, factors reported to be engaged in early stages of acute viral infection were affected, e.g. entry, ... two RNA export factors (SAM68, XPO1), and the HIV Rev-binding protein HRB. Moreover, PLAU (plasminogen activator, urokinase ... Obviously, similar mechanisms seem to accompany the chronic infection with HIV-1 and SIV of human T cell lines. The affected ...
  https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-11-152
*  Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line | BMC...
... the elongation factor 1-alpha promoter (EF1α) or the phosphoglycerate kinase-1 promoter (PGK), and compared the resulting cell ... In contrast to cells produced using the CMV and PGK promoters, those produced using the EF1α and TRE promoters expressed high ... We generated retroviruses in which tTA expression was controlled by one of three promoters: a synthetic tetracycline responsive ... lines to one generated using a cytomegalovirus immediate early gene promoter (CMV). ...
  https://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-2199-3-13
*  Regulation of the cyclin D3 promoter by E2F1. - Semantic Scholar
E2F4, -5, and -6) have little effect. Third, recombinant E2F1 binds with high affinity to the cyclin D3 promoter in vitro. ... Second, all of the growth-stimulatory members of the E2F family (E2F1, -2, and -3A) potently activate a cyclin D3 promoter ... Finally, mapping experiments localize the essential E2F regulatory element of the cyclin D3 promoter to a noncanonical E2F site ... Fourth, chromatin immunoprecipitation assays demonstrate that endogenous E2F1 is associated with the cyclin D3 promoter in vivo ...
  https://www.semanticscholar.org/paper/Regulation-of-the-cyclin-D3-promoter-by-E2F1.-Ma-Yuan/14b5e3bd9b99d1b87b642b1781407849855fcf26
*  Frontiers | "Till Death Do Us Part": A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in...
SVZ and OE neurogenesis is associated with compensatory pro-survival mechanisms in the aging OB which are interestingly similar ... In the SVZ, such regulatory factors include mitogens, growth factors, transcription factors, chromatin modifiers and non-coding ... Similar Pro-Survival Mechanisms Are Detected During Aberrant OB Neurogenesis and Neurodegenerative Diseases. The OB has been ... One way to resolve this issue is to generate inducible conditional KO-reporter mice under the control of specific promoters and ...
  https://www.frontiersin.org/articles/10.3389/fnins.2018.00144/full
*  Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
In detail, we searched for the transcription factor binding sites (TFBSs) in the promoter regions and microRNA binding motifs ... the most significant transcription factors potentially dysregulated in MS are YY1 (yin and yang 1), E2F-1/DP-1 and E2F-4/DP-2 ... MS and normal networks were characterized by similar topological behaviors (Figure 2): both of them were composed of nodes with ... Overrepresented Transcription Factors Binding Sites. Many of the transcription factor binding sites (TFBSs) enriched in both ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4926469/
*  Gavin Sherlock | Stanford Medicine Profiles
Analysis of ChIP-seq data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) from the Encyclopedia ... We identify genomic loci bound by the G2/M transcription factor FOXM1 by chromatin immunoprecipitation followed by high- ... Resultant tumors had a phenotypic diversity similar to that of the original tumor and behaved in a similar manner when passaged ... Furthermore, we analyzed our set of cell cycle-regulated genes for known and new promoter elements and show that several known ...
  https://med.stanford.edu/profiles/gavin-sherlock
*  INSIG2 Gene - GeneCards | INSI2 Protein | INSI2 Antibody
Transcription Factor. Binding Sites. Gene Targets. GH02J118084. Promoter/Enhancer. 2.5. EPDnew FANTOM5 Ensembl ENCODE dbSUPER ... The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this ... Top Transcription factor binding sites by QIAGEN in the INSIG2 gene promoter:. *E2F-5 ... Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=INSIG2
*  E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells
E2Fs function as transcription factors, with E2F1-3 as activators and E2F4-8 as repressors3-8. Although it is a maxim of ... The binding of E2F4 (b) and p130 (c) to E2F target promoters in control (−) or cre-treated (+) E2f1−/−;E2f2−/−;E2f3LoxP/LoxP ... We utilized an unbiased method similar to Gene Set Enrichment Analysis to identify genes that were differentially expressed16. ... A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 1992;70:337-350. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2806193/