*  Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP)
Sialic Acid Binding Ig-like Lectin 3. A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE- ... The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl ... Calcium-binding Protein, Vitamin D-dependent. A protein that plays a fundamental role in the Vitamin D mediated transport of ... Vitamin D Binding Protein (DBP) Deficiency in Mice Decreases Systemic and Select Tissue Levels of Inflammatory Cytokines in a ...
  https://www.bioportfolio.com/resources/trial/163215/Safety-Study-of-EF-022-in-Adults-With-Recurrent-Respiratory-Papillomatosis-RRP.html
*  CD83 - Wikipedia
"CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T ... de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (1997). "CD84 leukocyte antigen is a new member of the Ig superfamily". ... Kozlow EJ, Wilson GL, Fox CH, Kehrl JH (1993). "Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed ... Cao W, Lee SH, Lu J (2005). "CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably ...
  https://en.wikipedia.org/wiki/CD83
*  Anti-Siglec 7 antibody (ab38574) | Abcam
SIGLEC (sialic acid binding Ig-like lectin) family.. Contains 2 Ig-like C2-type (immunoglobulin-like) domains.. Contains 1 Ig- ... Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2 ... Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High ... Sialic acid binding Ig like lectin 7 antibody. *Sialic acid binding immunoglobulin like lectin 7 antibody ...
  https://www.abcam.com/siglec-7-antibody-ab38574.html
*  The Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1 Is an Intrinsic Central Regulator of Dendritic Cell...
... and sialic acid-binding Ig-like lectins) recruit SHP-1 to their cytoplasmic domains (7, 12). Despite the implications of such ... SHP-1 can bind and dephosphorylate VAV1 (35), a key signaling molecule that functions as a cytoplasmic guanine nucleotide ... RIP2 mediates LPS-induced p38 and IκBα signaling including IL-12 p40 expression in human monocyte-derived dendritic cells. Eur ... paired Ig-like receptor-B. RNAi. RNA interference. SFM. serum-free RPMI 1640 medium. SHP-1. Src homology region 2 domain- ...
  http://www.jimmunol.org/content/186/7/3934.full
*  CD83 Antibody (HB15e) [Unconjugated] (MAB1774): Novus Biologicals
Human CD83 is a 40‑50 kDa member of the Siglec (or sialic-acid-binding immunoglobulin-like lectin) family of transmembrane ... monocytes and macrophages (11). Except for dendritic cells, CD83 expression is often transient. CD83 binds to sialic acids on ... It contains one V type Ig-like domain in the extracellular region with no inhibitory cytoplasmic motif(s). Although in vitro ... On monocytes, CD83 is suggested to drive monocytes into a fibrocyte phenotype (13). A lack of membrane-expressed CD83 leads to ...
  https://www.novusbio.com/products/cd83-antibody-hb15e_mab1774
*  PLA | Inhibition of DNA Glycosylases via Small Molecules
... sialic acid-binding Ig superfamily lectin) category of sialic acid-recognizing cell-surface lectins. bloodstream is expressed ... Also unlike hCD33 mCD33 didn't bind to α2-3- or α2-6-connected sialic acids on lactosamine systems. Instead it demonstrated ... For instance hSiglec-7/AIRM-1 is portrayed on normal killer cells and monocytes (14 26 hSiglec-8 is normally portrayed on ... sialic acid-binding Ig superfamily lectin) family of molecules defined by their mutual sequence similarity in the 1st two Ig- ...
  http://cancer-colorectal.com/category/pla/
*  Sialoadhesin - Wikipedia
... but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid ... It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant ... Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed ... and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also ...
  https://en.wikipedia.org/wiki/Sialoadhesin
*  An Essential Role of Sialylated O-Linked Sugar Chains in the Recognition of Mouse CD99 by Paired Ig-Like Type 2 Receptor (PILR)...
... of amino acids of PILR are identical with the sialic acid-binding Ig-like lectin (Siglec) family of proteins, which recognizes ... neither PILRα-Ig nor PILRβ-Ig bound to Ba/F3 cells cotransfected with C2GnT and CD99, whereas PILRα-Ig and PILRβ-Ig bound well ... The inhibitory PILRα is highly expressed on most CD14+ monocytes in humans and CD11b+ granulocytes and dendritic cells in mice ... sialic acid-binding Ig-like lectin; ST3GalI, β-galactoside α-2,3-sialyltransferase 1. ...
  http://www.jimmunol.org/content/180/3/1686
*  Siglec-3/CD33 Antibody (C33/69) [PE] (NBP2-34580PE): Novus Biologicals
Mouse Monoclonal Anti-Siglec-3/CD33 Antibody (C33/69) [PE]. Validated: Flow. Tested Reactivity: Human. 100% Guaranteed. ... sialic acid binding Ig-like lectin 3. *Sialic acid-binding Ig-like lectin 3 ... CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a ... CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, ...
  https://www.novusbio.com/products/siglec-3-cd33-antibody-c33-69_nbp2-34580pe
*  Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines
sialic acid-binding Ig-type lectin. DISCLOSURES. The authors declare no conflicts of interest. ... It binds to galactose and N-acetylgalactosamine and has 2 homologs in mice, MGL1 and MGL2, and mouse MGL2 has a similar binding ... macrophage galactose-type lectin. moDC. monocyte-derived dendritic cell. MR. mannose receptor. pDC. plasmacytoid dendritic cell ... a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains. EMBO J. 13, 4490-4503. [ ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5597514/
*  Gene expression profile of AIDS-related Kaposi's sarcoma | BMC Cancer | Full Text
... a prototypical member of the Siglec family of sialic acid binding immunoglobulin (Ig)-like lectins, which are involved in ... HHV8 is known to replicate in monocytes/macrophages found in KS lesions [5, 49], so these types of cells may contribute ... and the 3'restriction fragments were bound to streptavidin-coated magnetic beads (Dynabeads M280 from Dynal, Oslo, Norway). ... Sialoadhesin, a lectin-like sialic acid-binding receptor, is expressed on macrophages in a regulated fashion, with high levels ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-3-7
*  SIGLEC8 - Wikipedia
Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene. This gene is located on ... no other siglecs bind effectively to these Siglec-8 ligands, as demonstrated by selective binding to eosinophils in human blood ... In addition, baboon eosinophils as well as monocytes, a subset of lymphocytes, and neutrophils express on their cell surface a ... "Entrez Gene: SIGLEC8 sialic acid binding Ig-like lectin 8". Foussias G, Yousef GM, Diamandis EP (November 2000). "Molecular ...
  https://en.wikipedia.org/wiki/SIGLEC8
*  SIGLEC - Wikipedia
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found ... Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid ... This occurs in a sialic acid-dependent manner and brings NK cells and monocytes, on which Siglec-7 is expressed, into contact ... Each lectin domain is specific for the linkage that connects sialic acid to the glycan. Sialic acid contains numerous hydroxyl ...
  https://en.wikipedia.org/wiki/SIGLEC
*  Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells - Dana-Farber Cancer Institute, Inc.
... a B lineage-restricted member of the Ig-superfamily which serves as an adhesion receptor expresse ... Sgroi et al., "CD22, a B Cell-specific Immunoglobulin Superfamily Member, Is a Sialic Acid-binding Lectin," J. Biol. Chem. 268( ... monocyte and erythrocyte binding to COS-CD22 cells. These results suggest that each of these cell types binds through the ... From these studies, it appears that all CD22 mAb which block ligand binding bind to the first Ig-like domain or to epitopes ...
  http://www.freepatentsonline.com/5484892.html
*  Most recent papers with the keyword Siglec | Read by QxMD
CD22 and sialic acid-binding Ig-like lectin (Siglec)-G are members of the Siglec family of inhibitory coreceptors expressed on ... PILRα belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA. PILRα ... We show that monocyte-derived macrophages (MDMs) could be divided into two distinct subsets: CD14(+)Siglec-1(hi)CD4(+) (non- ... Amino acid residues 283-297 from sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) form a cyclic peptide ligand ...
  https://www.readbyqxmd.com/keyword/75205
*  Patent US20020031508 - Methods for diagnosing and treating hemostatic disorders by modulating P ... - Google Patents
... a lectin domain, an EGF-like repeat, a complement binding domain, and a cytoplasmic domain. Furthermore, amino acid or ... wherein said first binding region comprises an antibody, or an antigen binding fragment thereof, that binds to VCAM-1, ... In one embodiment, the P-selectin fusion protein is a P-selectin-Ig fusion protein comprising a signal sequence, a lectin ... The P-selectin ligand includes the Lex carbohydrate structure, sialic acid, and the PSGL-1 protein (U.S. Pat. No. 5,843,707). ...
  http://www.google.com/patents/US20020031508?dq=6,460,050
*  Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic and Asymptomatic Influenza A Infection
... the sialic acid binding Ig-like lectin 1 (SIGLEC1 or Sialoadhesin) was strongly activated in Sx hosts at mid-to-late stage of ... Rempel2004Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load.J Neuroimmunol1579398 * View ... 2004) The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta ... A set of four peptide nucleic acid (PNA) oligomers whose sequences are complementary to the 3′ portions of the alpha and beta ...
  http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002234
*  Outline of immunology - Wikipedia
Sialic acid binding lectins SIGLEC1 (Sialoadhesin) SIGLEC2 (CD22) SIGLEC3 (CD33) SIGLEC4 (MAG) SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC8 ... Ig-α (CD79A) Ig-β (CD79B) T cells Antigen receptor - T cell receptor (TCR) Subunits - TRA@ / TRB@ / TRD@ / TRG@ Co-receptors ... Membrane-bound PRRs Toll-like receptors (TLRs) TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TLR10 TLR11 TLR12 TLR13 C-type ... Granulocytes Neutrophils Eosinophils Basophils Mast cells Monocytes Macrophages Histiocytes (Tissue resident macrophages) ...
  https://en.wikipedia.org/wiki/Outline_of_immunology
*  Anti-CD33 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: WM53] | VWR
Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, CD33, SIGLEC-3, SIGLEC3, p67. ... By accessing or using the Web Site, you agree that you have read, understand and agree to be bound by these Terms of Use, as ... CD33 is expressed on monocytes, granulocytes, dendritic cells, mast cells, and myeloid progenitors to the exclusion of ... It functions to assist sialic acid-dependent cell adhesion.. Type: Primary. Antigen: CD33. Clonality: Monoclonal. Clone: WM53. ...
  https://us.vwr.com/store/product/16757097/anti-cd33-mouse-monoclonal-antibody-fitc-fluorescein-isothiocyanate-clone-wm53
*  Selectin - Wikipedia
Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers ... "Differences between human eosinophils and neutrophils in the function and expression of sialic acid-containing counterligands ... At high stresses, the binding affinities are still reduced because the selectin-ligand bond is still a normal slip bond. It is ... This triggers the activation of integrins from the cancer cells allowing their firmer adhesion to members of the Ig-CAM family ...
  https://en.wikipedia.org/wiki/Selectin
*  Cellular Mechanisms of Leukocyte Adhesion | Springer for Research & Development
Carlos T, Kovach N, Schwartz B, Rosa M, Newman B, Wayner E, Benjamin C, Osborn L, Lobb R, Harlan J (1991) Human monocytes bind ... Corral L, Singer MS, Macher BA, Rosen SD (1990) Requirement for sialic acid on neutrophils in a GMP-140 (PADGEM) mediated ... Moore KL, Varki A, McEver RP (1991) GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like ... Lobb RR, Chi-Rosso G, Leone DR, Rosa MD, Bixler S, Newman BM, Luhowskyj S, Benjamin CD, Douglas IG, Goelz SE et al. (1991) ...
  https://rd.springer.com/chapter/10.1007/978-3-642-76736-4_6
*  Frontiers | Molecular Recognition of Paired Receptors in the Immune System | Microbiology
... the immunoglobulin-like and the C-type lectin-like receptors, and explain how these receptors distinguish self and non-self ... the immunoglobulin-like and the C-type lectin-like receptors, and explain how these receptors distinguish self and non-self ... evidence clearly reveals that the members of cell surface receptor families have very similar extracellular ligand-binding ... evidence clearly reveals that the members of cell surface receptor families have very similar extracellular ligand-binding ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full
*  MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN - Patent application
0145] 5. Uses of DVD-Ig Binding Proteins [0146] Given their ability to bind to two or more antigen binding sites, including two ... n-acetylglucosamine and sialic acid. Preferably the glycosylated binding protein comprises glycosyl residues such that the ... other specific binding pairs can include biotin and avidin (or streptavidin), carbohydrates and lectins, complementary ... monocytes, other cells, organs, tissues, bone marrow, lymph nodes and spleen. [0084] "Component," "components," and "at least ...
  http://www.patentsencyclopedia.com/app/20120009196