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*  Antibodies with altered effector functions - Scotgen Biopharmaceuticals Incorporated
... altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the C1 component of complement is produced by ... But other reports have shown that this fragment was capable of inhibiting Fc gamma R1 binding (Barnett-Foster et al 1980) ... of 125 I-labelled pooled human IgG binding to high affinity receptors on U937 cells by mouse gamma 2b immunoglobulins; ... In man, and in mouse, three Fc gamma receptors have been partially characterised: Fc gamma R1, Fc gamma RII, and FC gamma Rlo, ...
  http://www.freepatentsonline.com/5624821.html
*  Frontiers | Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds | Immunology
Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... and multispecific antibodies have evolved successfully into a range of formats from full bispecific immunoglobulin gammas [IgGs ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... focuses on the progress of Fc engineering in generating bispecific molecules and on the use of small antibody fragment as ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00038/full
*  FCGRT elisa kit | Human Fc fragment of IgG, receptor, transporter, alpha ELISA Kit-NP 001129491.1
Human Fc fragment of IgG, receptor, transporter, alpha ELISA Kit-NP_001129491.1 (MBS937383) product datasheet at MyBioSource, ... FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in ... IgG receptor FcRn large subunit p51; FcRn alpha chain; neonatal Fc receptor; neonatal Fc-receptor for Ig; IgG Fc fragment ... major histocompatibility complex class I-like Fc receptor; neonatal Fc-recepto; Fc fragment of IgG; receptor; transporter; ...
  https://www.mybiosource.com/prods/ELISA-Kit/Human/Fc-fragment-of-IgG-receptor-transporter-alpha/FCGRT/datasheet.php?products_id=937383
*  PPT - Immunoglobulins: Structure and Function PowerPoint presentation | free to download - id: 3b45a9-MTZmY
Structure and Function Immunoglobulins:Structure and Function Definition: Glycoprotein molecules that are produced by plasma ... Ag binding *Fc *Effector functions *F(ab)2. 13. Human Immunoglobulin Classes*IgG - Gamma (?) heavy chains ... Immunoglobulin Fragments Structure/Function Relationships 12. Immunoglobulin Fragments Structure/Function Relationships*Fab ... Immunoglobulins as Binding Proteins - Immunoglobulins as Binding Proteins Lecture 10, Medical Biochemistry Lecture 10, Outline ...
  http://www.powershow.com/view/3b45a9-MTZmY/Immunoglobulins_Structure_and_Function_powerpoint_ppt_presentation
*  PPT - Immunoglobulins: Structure and Function PowerPoint presentation | free to download - id: 228514-ZDc1Z
Ag binding *Fc *Effector functions *F(ab)2. 13. Human Immunoglobulin Classes*IgG - Gamma (?) heavy chains ... Immunoglobulin Fragments Structure/Function Relationships 12. Immunoglobulin Fragments Structure/Function Relationships*Fab ... Immunoglobulins: Structure and Function - Immunoglobulins: Structure and Function Immunoglobulins:Structure and Function ... Immunoglobulins: Structure and Function - Immunoglobulins: Structure and Function Immunoglobulins:Structure and Function ...
  http://www.powershow.com/view1/228514-ZDc1Z/Immunoglobulins_Structure_and_Function_powerpoint_ppt_presentation
*  SpAB protein domain - Wikipedia
... each domain can bind Fc-gamma (the constant region of IgG involved in effector functions) and Fab (the Ig fragment responsible ... Protein A contains five highly homologous immunoglobulin (Ig)-binding domains in tandem (designated domains E, D, A, B and C), ... It does this though SpAB binding to the Fc fragment of IgG. The B domain of SpA (SpAB) consists of three a-helices which are ... In molecular biology, the domain B, refers to the immunoglobulin-binding domain found in the Staphylococcus aureus virulence ...
  https://en.wikipedia.org/wiki/SpAB_protein_domain
*  Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate...
... upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, ... Immunoglobulin Fc Fragments. Immunotherapy. Interleukin-2 Receptor alpha Subunit. K562 Cells. Kaplan-Meier Estimate ... Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg ... Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate ...
  https://repository.icr.ac.uk/handle/internal/635
*  FCGR1A - Wikipedia
High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene. FCGR1A has been ... The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. GRCh38: Ensembl ... "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)". Morton HC, van den Herik-Oudijk IE, Vossebeld P, ... the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599-606. PMID ...
  https://en.wikipedia.org/wiki/FCGR1A
*  Humanized anti-CCR2 antibodies and methods of use therefor - Patent # 8227211 - PatentGenius
... or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of ... inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments ... fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) ... said immunoglobulin or fragment comprising a humanized immunoglobulin light chain or antigen-binding fragment thereof ...
  http://www.patentgenius.com/patent/8227211.html
*  Recombinant Human FCGR2B, His-tagged, Biotinylated FCGR2B-258H - Creative BioMart
Fc fragment of IgG, low affinity IIb, receptor for (CD32) , FCG2, FCGR2; low affinity immunoglobulin gamma Fc region receptor ... Fc gamma R-mediated phagocytosis, conserved biosystem;. Function:. IgG binding; protein binding; receptor activity;. ... Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); ... The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded ...
  https://www.creativebiomart.net/description_391716_12.htm
*  Recombinant Human FCGR2B cell lysate FCGR2B-1988HCL - Creative BioMart
Fc fragment of IgG, low affinity IIb, receptor for (CD32) , FCG2, FCGR2; low affinity immunoglobulin gamma Fc region receptor ... Fc gamma R-mediated phagocytosis, conserved biosystem;. Function:. IgG binding; protein binding; receptor activity;. ... Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); ... FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) [ Homo sapiens ]. ...
  https://www.creativebiomart.net/description_399759_318.htm
*  IGHG1 - Wikipedia
2002). "Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding". J. Biol. Chem. 276 (49): 45539-47. doi:10.1074/ ... "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1 ... Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII ... Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of ...
  https://en.wikipedia.org/wiki/IGHG1
*  Frontiers | FCγ Chimeric Receptor-Engineered T Cells: Methodology, Advantages, Limitations, and Clinical Relevance | Immunology
Thus, we and others have developed the Fc gamma chimeric receptors (FcCRs)-based strategy. Like CARs, FcCRs are composed of ... In contrast, the extracellular CAR single chain variable fragment (scFv), which recognizes the targeted TAA, has been replaced ... FcCRs)-based strategy. Like CARs, FcCRs are composed of an intracellular tail resulting from the fusion of a co-stimulatory ... FcCR T cells have a few intriguing features. First, given in combination with mAbs, FcCR T cells mediate anti-cancer ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00457/full
*  Patent US8088908 - Humanized anti-prostate stem cell antigen monoclonal antibody - Google Patents
These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take ... Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the ... The term "antibody" as used herein refers to any immunoglobulin, including antibodies and fragments thereof, that binds to a ... Fc specific) to capture hu1G8 constructs and alkaline-phosphatase-conjugated goat anti-human IgG (Fc specific) antibodies (both ...
  http://www.google.co.uk/patents/US8088908
*  Frontiers | Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for...
... the Fc receptor expressed by NK cells (FcγRIII or CD16) binds to the Fc portion of the therapeutic antibody, which in turn is ... Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/ ... Fc gamma receptor polymorphisms as predictive markers of cetuximab efficacy in epidermal growth factor receptor downstream- ... Patients with a FcγRIIIa polymorphism, resulting in high-affinity binding of FcγRIII to IgG1, demonstrate enhanced clinical ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00601/full
*  SCOPe 2.06: Domain d3sgjb1: 3sgj B:227-341
d3sgjb1 b.1.1.2 (B:227-341) Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma {Human (Homo sapiens) [TaxId: 9606]} ... PDB Compounds: (B:) human Fc fragment. SCOPe Domain Sequences for d3sgjb1:. Sequence; same for both SEQRES and ATOM records: ( ... PDB Description: Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgIII and ... Protein Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species). ...
  http://scop.berkeley.edu/sunid=216397
*  US Patent # 9,393,268. Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same ...
... or a GCC-binding membrane-bound fusion protein that comprises at least a functional fragment of an antibody that binds to at ... domain linked to a T-cell chain such as CD3zeta chain or the gamma-signal-transducing subunit of the Ig Fc receptor complex. ... Essentially, most CARs are an immunoglobulin-derived antigen binding domain fused to a T cell signaling domain such as the ... As used herein the terms "a CNS antigen-binding membrane bound fusion protein" and "a membrane bound fusion protein that binds ...
  http://patents.com/us-9393268.html
*  Emerging patterns of genetic overlap across autoimmune disorders | Genome Medicine | Full Text
FCGR2A (Fc fragment of IgG). Binds to the Fc region of immunoglobulins gamma ... Inhibits the synthesis of a number of cytokines, including interferon-gamma, IL-2, IL-3, TNF and GM-CSF; produced by activated ... For example, variants in NOD2 (nucleotide-binding oligomerization domain containing 2) and ATG16L1 (ATG16 autophagy-related-16- ... Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 ... a member of the immunoglobulin superfamily that is expressed on ...
  https://0-genomemedicine-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/gm305
*  FCGR2A - Low affinity immunoglobulin gamma Fc region receptor II-a precursor - Homo sapiens (Human) - FCGR2A gene & protein
By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized ... Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. ... Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses ... Fc fragment of IgG receptor IIa. GORGO. 317. Uncharacterized protein. RHIBE. 316. ...
  https://www.uniprot.org/uniprot/P12318
*  List of MeSH codes (D12.776.124) - Wikipedia
... immunoglobulin fab fragments MeSH D12.776.124.486.485.538.500 -- immunoglobulin fc fragments MeSH D12.776.124.486.485.538. ... immunoglobulin g MeSH D12.776.124.486.485.114.619.393.522 -- immunoglobulin gamma-chains MeSH D12.776.124.486.485.114.619.393. ... progesterone-binding globulin MeSH D12.776.124.790.106.750 -- retinol-binding proteins MeSH D12.776.124.790.106.901 -- ... immunoglobulin fab fragments MeSH D12.776.124.790.651.538.500 -- immunoglobulin fc fragments MeSH D12.776.124.790.651.538. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
*  Antibody - Wikipedia
Fc) that may be attached to the antigen-binding fragments. The five different types of Fc regions allow antibodies to be ... Antibodies are glycoproteins belonging to the immunoglobulin superfamily. They constitute most of the gamma globulin fraction ... IgE's Fab paratope binds to allergic antigen, for example house dust mite particles, while its Fc region binds to Fc receptor ε ... binding to FcγR), lysis of cells (binding to complement), and degranulation of mast cells, basophils, and eosinophils (binding ...
  https://en.wikipedia.org/wiki/Antibody
*  US Patent # 9,750,803. Lipid vesicle compositions and methods of use - Patents.com
... bispecific antibody that binds simultaneously to HER-2/neu oncogene protein product and type I Fc receptors for immunoglobulin ... B) Anti-VMP IgG antibodies elicited with VMP-ICMVs+MPLA (blue) or VMP+MPLA (red) were further analyzed for binding to fragments ... 10). These OVA-loaded particles also elicited the highest frequency of functionally-competent interferon-gamma (IFN-gamma)- ... Such Ab bound to VMP-ICMVs, but not to OVA-ICMVs or VMP-ICMVs treated with trypsin to digest surface-bound protein. Blockade of ...
  http://patents.com/us-9750803.html
*  The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer | Journal for ImmunoTherapy of Cancer ...
Most of these immunomodulatory antibodies are of IgG isotypes that have low, or no, binding to the Fc gamma receptors (FcγRs) ... Here we review the biology of the FcγRs and IgG isotypes in both humans and mice, detail the potential roles that FcγR ... However, recent preclinical data highlight a potential role for FcγR engagement in the activity of such antibodies. ... Weng WK, Levy R: Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients ...
  https://jitc.biomedcentral.com/articles/10.1186/s40425-014-0029-x
*  Fc gamma RII/CD32 Research Products: Novus Biologicals
Browse our Fc gamma RII/CD32 product catalog backed by our Guarantee+. ... Fc gamma RII/CD32 products available through Novus Biologicals. ... fc-gamma-RIIb. *Fc fragment of IgG, low affinity IIb, receptor ... CD32 is a receptor for the Fc region of complexed or aggregated immunoglobulins gamma. This is a low affinity receptor. It is ... Binding to this receptor results in downmodulation of previous state of cell activation triggered via antigen receptors on B ...
  https://www.novusbio.com/common-name/fc-gamma-rii-cd32
*  bonvictor.blogspot.com: December 2009
Fc region) includes part of the constant domain that occupies the stem. There are 2 antigen-binding fragments (Fab region), ... They bind antigens with high specificity and affinity.. Structure of Immunoglobulins. This glycoprotein is Y-shaped molecules ... IFN-gamma is produced by the Th1 subpopulation of helper T cells (CD4+), cytotoxic T cells (CD8+), and NK cells. IFN-gamma ... Fc and Fab regions. The proteolytic enzyme papain breaks each Ig molecule into 3 fragments at the hinge region. The single ...
  http://bonvictor.blogspot.com/2009/12/