*  Antibodies with altered effector functions - Scotgen Biopharmaceuticals Incorporated
... altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the C1 component of complement is produced by ... But other reports have shown that this fragment was capable of inhibiting Fc gamma R1 binding (Barnett-Foster et al 1980) ... of 125 I-labelled pooled human IgG binding to high affinity receptors on U937 cells by mouse gamma 2b immunoglobulins; ... In man, and in mouse, three Fc gamma receptors have been partially characterised: Fc gamma R1, Fc gamma RII, and FC gamma Rlo, ...
  http://www.freepatentsonline.com/5624821.html
*  Frontiers | Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds | Immunology
Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... and multispecific antibodies have evolved successfully into a range of formats from full bispecific immunoglobulin gammas [IgGs ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... focuses on the progress of Fc engineering in generating bispecific molecules and on the use of small antibody fragment as ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00038/full
*  PPT - Immunoglobulins: Structure and Function PowerPoint presentation | free to download - id: 3b45a9-MTZmY
Structure and Function Immunoglobulins:Structure and Function Definition: Glycoprotein molecules that are produced by plasma ... Ag binding *Fc *Effector functions *F(ab)2. 13. Human Immunoglobulin Classes*IgG - Gamma (?) heavy chains ... Immunoglobulin Fragments Structure/Function Relationships 12. Immunoglobulin Fragments Structure/Function Relationships*Fab ... Immunoglobulins as Binding Proteins - Immunoglobulins as Binding Proteins Lecture 10, Medical Biochemistry Lecture 10, Outline ...
  http://www.powershow.com/view/3b45a9-MTZmY/Immunoglobulins_Structure_and_Function_powerpoint_ppt_presentation
*  PPT - Immunoglobulins: Structure and Function PowerPoint presentation | free to download - id: 228514-ZDc1Z
Ag binding *Fc *Effector functions *F(ab)2. 13. Human Immunoglobulin Classes*IgG - Gamma (?) heavy chains ... Immunoglobulin Fragments Structure/Function Relationships 12. Immunoglobulin Fragments Structure/Function Relationships*Fab ... Immunoglobulins: Structure and Function - Immunoglobulins: Structure and Function Immunoglobulins:Structure and Function ... Immunoglobulins: Structure and Function - Immunoglobulins: Structure and Function Immunoglobulins:Structure and Function ...
  http://www.powershow.com/view1/228514-ZDc1Z/Immunoglobulins_Structure_and_Function_powerpoint_ppt_presentation
*  SpAB protein domain - Wikipedia
... each domain can bind Fc-gamma (the constant region of IgG involved in effector functions) and Fab (the Ig fragment responsible ... Protein A contains five highly homologous immunoglobulin (Ig)-binding domains in tandem (designated domains E, D, A, B and C), ... It does this though SpAB binding to the Fc fragment of IgG. The B domain of SpA (SpAB) consists of three a-helices which are ... In molecular biology, the domain B, refers to the immunoglobulin-binding domain found in the Staphylococcus aureus virulence ...
  https://en.wikipedia.org/wiki/SpAB_protein_domain
*  FCGR1A - Wikipedia
High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene. FCGR1A has been ... The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. GRCh38: Ensembl ... "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)". Morton HC, van den Herik-Oudijk IE, Vossebeld P, ... the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599-606. PMID ...
  https://en.wikipedia.org/wiki/FCGR1A
*  Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate...
... upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, ... Immunoglobulin Fc Fragments. Immunotherapy. Interleukin-2 Receptor alpha Subunit. K562 Cells. Kaplan-Meier Estimate ... Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg ... Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate ...
  https://repository.icr.ac.uk/handle/internal/635
*  Humanized anti-CCR2 antibodies and methods of use therefor - Patent # 8227211 - PatentGenius
... or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of ... inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments ... fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) ... said immunoglobulin or fragment comprising a humanized immunoglobulin light chain or antigen-binding fragment thereof ...
  http://www.patentgenius.com/patent/8227211.html
*  Frontiers | FCγ Chimeric Receptor-Engineered T Cells: Methodology, Advantages, Limitations, and Clinical Relevance | Immunology
Thus, we and others have developed the Fc gamma chimeric receptors (FcCRs)-based strategy. Like CARs, FcCRs are composed of ... In contrast, the extracellular CAR single chain variable fragment (scFv), which recognizes the targeted TAA, has been replaced ... FcCRs)-based strategy. Like CARs, FcCRs are composed of an intracellular tail resulting from the fusion of a co-stimulatory ... FcCR T cells have a few intriguing features. First, given in combination with mAbs, FcCR T cells mediate anti-cancer ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00457/full
*  Patent US8088908 - Humanized anti-prostate stem cell antigen monoclonal antibody - Google Patents
These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take ... Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the ... The term "antibody" as used herein refers to any immunoglobulin, including antibodies and fragments thereof, that binds to a ... Fc specific) to capture hu1G8 constructs and alkaline-phosphatase-conjugated goat anti-human IgG (Fc specific) antibodies (both ...
  http://www.google.co.uk/patents/US8088908
*  Frontiers | Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for...
... the Fc receptor expressed by NK cells (FcγRIII or CD16) binds to the Fc portion of the therapeutic antibody, which in turn is ... Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/ ... Fc gamma receptor polymorphisms as predictive markers of cetuximab efficacy in epidermal growth factor receptor downstream- ... Patients with a FcγRIIIa polymorphism, resulting in high-affinity binding of FcγRIII to IgG1, demonstrate enhanced clinical ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00601/full
*  SCOPe 2.06: Domain d3sgjb1: 3sgj B:227-341
d3sgjb1 b.1.1.2 (B:227-341) Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma {Human (Homo sapiens) [TaxId: 9606]} ... PDB Compounds: (B:) human Fc fragment. SCOPe Domain Sequences for d3sgjb1:. Sequence; same for both SEQRES and ATOM records: ( ... PDB Description: Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgIII and ... Protein Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species). ...
  http://scop.berkeley.edu/sunid=216397
*  Antibody - Wikipedia
Fc) that may be attached to the antigen-binding fragments. The five different types of Fc regions allow antibodies to be ... Antibodies are glycoproteins belonging to the immunoglobulin superfamily. They constitute most of the gamma globulin fraction ... IgE's Fab paratope binds to allergic antigen, for example house dust mite particles, while its Fc region binds to Fc receptor ε ... binding to FcγR), lysis of cells (binding to complement), and degranulation of mast cells, basophils, and eosinophils (binding ...
  https://en.wikipedia.org/wiki/Antibody
*  US Patent # 9,393,268. Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same ...
... or a GCC-binding membrane-bound fusion protein that comprises at least a functional fragment of an antibody that binds to at ... domain linked to a T-cell chain such as CD3zeta chain or the gamma-signal-transducing subunit of the Ig Fc receptor complex. ... Essentially, most CARs are an immunoglobulin-derived antigen binding domain fused to a T cell signaling domain such as the ... As used herein the terms "a CNS antigen-binding membrane bound fusion protein" and "a membrane bound fusion protein that binds ...
  http://patents.com/us-9393268.html
*  IGHG1 - Wikipedia
2002). "Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding". J. Biol. Chem. 276 (49): 45539-47. doi:10.1074/ ... "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1 ... Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII ... Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of ...
  https://en.wikipedia.org/wiki/IGHG1
*  List of MeSH codes (D12.776.124) - Wikipedia
... immunoglobulin fab fragments MeSH D12.776.124.486.485.538.500 -- immunoglobulin fc fragments MeSH D12.776.124.486.485.538. ... immunoglobulin g MeSH D12.776.124.486.485.114.619.393.522 -- immunoglobulin gamma-chains MeSH D12.776.124.486.485.114.619.393. ... progesterone-binding globulin MeSH D12.776.124.790.106.750 -- retinol-binding proteins MeSH D12.776.124.790.106.901 -- ... immunoglobulin fab fragments MeSH D12.776.124.790.651.538.500 -- immunoglobulin fc fragments MeSH D12.776.124.790.651.538. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
*  Fc gamma RII/CD32 Research Products: Novus Biologicals
Browse our Fc gamma RII/CD32 product catalog backed by our Guarantee+. ... Fc gamma RII/CD32 products available through Novus Biologicals. ... fc-gamma-RIIb. *Fc fragment of IgG, low affinity IIb, receptor ... CD32 is a receptor for the Fc region of complexed or aggregated immunoglobulins gamma. This is a low affinity receptor. It is ... Binding to this receptor results in downmodulation of previous state of cell activation triggered via antigen receptors on B ...
  https://www.novusbio.com/common-name/fc-gamma-rii-cd32
*  US Patent # 9,750,803. Lipid vesicle compositions and methods of use - Patents.com
... bispecific antibody that binds simultaneously to HER-2/neu oncogene protein product and type I Fc receptors for immunoglobulin ... B) Anti-VMP IgG antibodies elicited with VMP-ICMVs+MPLA (blue) or VMP+MPLA (red) were further analyzed for binding to fragments ... 10). These OVA-loaded particles also elicited the highest frequency of functionally-competent interferon-gamma (IFN-gamma)- ... Such Ab bound to VMP-ICMVs, but not to OVA-ICMVs or VMP-ICMVs treated with trypsin to digest surface-bound protein. Blockade of ...
  http://patents.com/us-9750803.html
*  bonvictor.blogspot.com: December 2009
Fc region) includes part of the constant domain that occupies the stem. There are 2 antigen-binding fragments (Fab region), ... They bind antigens with high specificity and affinity.. Structure of Immunoglobulins. This glycoprotein is Y-shaped molecules ... IFN-gamma is produced by the Th1 subpopulation of helper T cells (CD4+), cytotoxic T cells (CD8+), and NK cells. IFN-gamma ... Fc and Fab regions. The proteolytic enzyme papain breaks each Ig molecule into 3 fragments at the hinge region. The single ...
  http://bonvictor.blogspot.com/2009/12/
*  Monkey IgG (gamma chain) Antibody Fluorescein Conjugated 617-102-012
Each IgG has two antigen binding sites. Representing approximately 75% of serum immunoglobulins, IgG is the most abundant ... and host-species source and fragment composition. This Anti-Monkey IgG gamma is conjugated to fluorescein. ... generated in goat detects monkey Immunoglobulin G (gamma chain). It is a protein complex composed of four peptide chains - two ... When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate ...
  https://rockland-inc.com/Product.aspx?id=37743
*  Preparation of Purified Covalently Cross-linked Abeta Oligomers and Uses Thereof - Patent application
Use of immunoglobulin heavy and light chains or fragments thereof to bind to aggregated amyloidogenic proteins. ... but are not limited to Fc, Fab, Fab', F(ab')2 and single chain immunoglobulins. [0059]As used herein, "gamma globulin", is the ... 25B shows competition binding studies involving Aβ40 monomer purified antibody F(ab') fragment binding with Aβ40 monomer in the ... fragments thereof to modulate formation of amyloid deposits, and allowing the antibodies or fragments thereof to bind the ...
  http://www.patentsencyclopedia.com/app/20090246191
*  Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function -...
... antibody fragment containing the Fc region, or fusion polypeptide containing the Fc region of an immunoglobulin of the ... is quantified using a gamma counter; ... Binding of the Fc region, of the target-cell bound antibodies, ... Preferably, the increased Fc receptor binding affinity is increased binding to a Fcγ activating receptor, such as the FcγRIIIa ... The increased Fc receptor binding affinity is preferably increased binding to Fc activating receptors such as FcγRIIIa. ...
  http://www.freepatentsonline.com/8859234.html
*  Expression of FCGR2B in cancer - Summary - The Human Protein Atlas
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded ... Fc fragment of IgG receptor IIb. Protein classi. Protein class the gene product belongs to according to selected gene lists. ... GO:0005515 [protein binding]. GO:0005886 [plasma membrane]. GO:0006955 [immune response]. GO:0007165 [signal transduction]. GO: ... Fc fragment of IgG receptor IIb (HGNC Symbol). Entrez gene summary. ...
  http://www.proteinatlas.org/ENSG00000072694-FCGR2B/pathology
*  Immunology and Pregnancy Losses: HLA, Autoantibodies and Cellular Immunity - Madame Curie Bioscience Database - NCBI Bookshelf
Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid ... Membrane-bound HLA-G activates proliferation and interferon-{gamma} production by uterine natural killer cells. Mol Hum Reprod ... The fact that F(ab)'2 fragments of aPL antibodies do not mediate fetal injury and that C4-deficient mice are protected from ... aPL binds specifically to apoptotic, but not viable, thymocytes, and that binding is dependent upon the presence of beta 2GPI. ...
  https://www.ncbi.nlm.nih.gov/books/NBK6615/
*  FCER1A - Wikipedia
2000). "Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha". Nature. 406 (6793): ... "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome ... "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma- ... Fc epsilon RI) alpha-chain". J. Immunol. 151 (11): 6166-74. PMID 8245459. "Entrez Gene: FCER1A Fc fragment of IgE, high ...
  https://en.wikipedia.org/wiki/FCER1A