*  publish.UP Molecular cloning and expression of a prostaglandin E₂ receptor of the EP₃ϐ subtype from rat hepatocytes
PGE₂ binding sites as did the EP₃ receptor agonists M&B 28767 = sulprostone , misoprostol but not the EP₁ receptor antagonist ... Thus, the characteristics of the EP₃ϐ receptor of rat hepatocytes closely resemble those of the EP₃ϐ receptor of mouse ... Here, the isolation of a functional EP₃ϐ receptor cDNA clone from a rat hepatocyte cDNA library is reported. This clone can be ... Transiently transfected HEK 293 cells expressed a single binding site for PGE₂ with an apparent Kd of 15 nM. PGE₂ , PGF₂α , ...
  https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/4393
*  PTGS2 prostaglandin-endoperoxide synthase 2 [Homo sapiens (human)] - Gene - NCBI
... organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an ... prostaglandin H2 synthase 2. prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase). NP_000954.1 ... EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins ... Nuclear Receptor Signaling Atlas (NURSA). * Transcriptomine: regulation of the PTGS2 gene by nuclear receptor signaling ...
  https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=17214885
*  Prostaglandin E Receptors - Prostaglandin E Receptor Summary Report | CureHunter
Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular changes which influence the ... Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and ... Prostaglandin E Receptor; Receptors, Prostaglandin E; PGE Receptor; E Receptor, Prostaglandin; E Receptors, Prostaglandin; ... Eicosanoid Receptors: 9*Prostaglandin Receptors: 102*Prostaglandin E Receptors: 136*EP4 Subtype Prostaglandin E Receptors: 16 ...
  http://www.curehunter.com/public/keywordSummaryD018078-Prostaglandin-E-Receptors-Prostaglandin-E-Receptor.do
*  DailyMed - INDOMETHACIN- indomethacin capsule
Since indomethacin is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in ... When Indomethacin is administered with aspirin, its protein binding is reduced, although the clearance of free indomethacin is ... or angiotensin receptor blockers (ARBs)] (see Drug Interactions). ... Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Moreover, ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6422d983-a063-41ae-aa96-7ae2284cb123
*  AID 1146121 - Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP...
Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8 ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/1146121
*  Synthetic Modification of Prostaglandin F2αIndicates Different Structural Determinants for Binding to the Prostaglandin F...
Prostaglandins and thromboxanes bind to a number of structurally diverse molecules, such as their cell-surface receptors (EP, ... Binding analyses using primarily recombinant prostaglandin (PG) E (EP) receptors and various ligands have revealed the ... Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 ... 1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte ...
  http://molpharm.aspetjournals.org/content/58/6/1511
*  Free Medical Flashcards about biochem test 2 2011
Prostaglandins function as mediators of inflammation and pain.. What type of receptors to prostaglandins bind to?. G protein ... block ACh receptors so Ach cant bind and AP can't propogate. What are the 2 motor proteins involved in axonal transport, which ... Leukotrienes are important regulators in the inflmmatory response and bind to G protein coupled receptors. Leukotrienes are ... 1. Acetaldehyde binds AA's so reduces protein synthesis (ie lipoproteins) 2. it also binds glutathione decreasing it reducing ...
  https://www.studystack.com/flashcard-674385
*  FEM1A - Protein fem-1 homolog A - Homo sapiens (Human) - FEM1A gene & protein
EP4 subtype prostaglandin E2 receptor binding Source: UniProtKB ,p>Inferred from Physical Interaction,/p> ,p>Covers physical ... EP4 subtype prostaglandin E2 receptor binding Source: UniProtKB ,p>Inferred from Physical Interaction,/p> ,p>Covers physical ... "A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling.". Takayama K., Sukhova G.K., ... "A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling.". Takayama K., Sukhova G.K., ...
  http://www.uniprot.org/uniprot/Q9BSK4
*  Recombinant Human FEM1A cell lysate FEM1A-616HCL - Creative BioMart
EP4 subtype prostaglandin E2 receptor binding; binding; ubiquitin-protein ligase activity;. Products Types ◆ Recombinant ... FEM1A; fem-1 homolog a (C. elegans); protein fem-1 homolog A; FEM1-alpha; prostaglandin E receptor 4-associated protein; EPRAP ...
  https://www.creativebiomart.net/description_411458_318.htm
*  Efficacy and Safety Assessment of T2345 in Ocular Hypertensive or Glaucomatous Patients
Receptors, Prostaglandin E. Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular ... Receptors, Prostaglandin. Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes ... They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin ... Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and ...
  https://www.bioportfolio.com/resources/trial/63209/Efficacy-and-Safety-Assessment-of-T2345-in-Ocular-Hypertensive-or-Glaucomatous-Patients.html
*  Effects of PGI2 Analogue Use on the Development of Chronic Allograft Nephropathy
... clinicaltrials.gov The purpose of this study is to evaluate the effect of Prostaglandin I2 analogue use on the development of ... Receptors, Prostaglandin E. Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular ... Receptors, Prostaglandin. Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes ... They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin ...
  https://www.bioportfolio.com/resources/trial/68544/Effects-of-PGI2-Analogue-Use-on-the-Development-of-Chronic-Allograft-Nephropathy.html
*  Median preoptic nucleus - Wikipedia
Prostaglandin E2 binds to E3 receptors in the median preoptic nucleus to inhibit their activity and cause fever. This means ... Thus, glutamate bound to receptors is necessary for the activation of these neurons in the median preoptic nucleus and the ... Activation of these receptors in rats causes decrease in core temperature. These receptors are highly expressed in the median ... Other receptors, neurokinin 3 receptors, which are expressed in the median preoptic nucleus, are also involved in ...
  https://en.wikipedia.org/wiki/Median_preoptic_nucleus
*  Check with your ophthalmologist before undergoing popular eyelid enhancements | Baylor College of Medicine | Houston, Texas
It binds to the prostaglandin receptors in the hair root and stimulates the development and re-growth of the hair follicle. ... Drugs in the prostaglandin class may be used to control blood pressure, contraction of smooth muscle and modulation of ... This drug falls into the prostaglandin class. The active ingredient is called bimatoprost. ...
  https://www.bcm.edu/news/eye/consult-ophthalmologist-before-eye-surgery
*  Meclofenamate - FDA prescribing information, side effects and uses
Meclofenamate sodium was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site ... Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal ... In rat studies with NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, an increased incidence of dystocia, ... When Meclofenamate sodium in administered with aspirin, its protein binding is reduced, although the clearance of free ...
  https://www.drugs.com/pro/meclofenamate.html
*  Abortion Pill
Misoprostol works by binding to prostaglandin receptors on the uterus which causes the uterus to contract and expel the fetus ... It is an anti-progesterone medication and works by binding to the progesterone receptors on the uterus that promote loss of the ... Cytotec (Misoprostol) is a prostaglandin that is FDA approved to prevent gastric ulcers in patients who take chronic anti- ... Progesterone is necessary to maintain uterine quiescence (prevents uterine contractions). Once progesterone is unable to bind ...
  http://www.womenscenter.com/abortion_pill.html
*  PTGER2 Overexpression in Colorectal Cancer Is Associated with Microsatellite Instability, Independent of CpG Island Methylator...
PGE2 produces cellular signaling through binding to prostaglandin E receptors (PTGER), designated as PTGER1 (EP1), PTGER2 (EP2 ... Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer? Mol Cancer Ther 2004;3:1031-9. ... Prostaglandin E2-4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. Oncogene 2007;26: ... Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Δ 716) knockout mice. Nat Med 2001;7:1048-51. ...
  http://cebp.aacrjournals.org/content/19/3/822.long
*  Increased Expression of Peroxisome Proliferator-Activated Receptor-α and -γ in Blood Vessels of Spontaneously Hypertensive Rats...
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell. ... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors1 that heterodimerize with retinoic acid-like ... Lemberger T, Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid ... In vivo study of AT1 and AT2 angiotensin receptors in apoptosis in rat blood vessels. Hypertension. 1999; 34(pt 1): 617-624. ...
  http://hyper.ahajournals.org/content/38/2/249
*  Plus it
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor and promotes adipocyte differentiation. Cell ... ATRA binds to all the three retinoic acid receptors and directly activates them (69); ATRA does not bind to RXRs but shows RXR- ... Discrete roles for peroxisome proliferator-activated receptor γ and retinoid X receptor in recruiting nuclear receptor ... is a member of the nuclear receptor family that forms heterodimers with retinoid X receptor. These heterodimers bind to DNA and ...
  http://mct.aacrjournals.org/content/3/10/1249
*  KAKEN - Research Projects | A study for role of PGE2 on adhesion of mast cells to fibronectin (KAKENHI-PROJECT-15390024)
Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor ... Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor ... Identification and characterization of a novel progesterone receptor-binding element in the mouse prostagiandin E receptor ... Journal Article] Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptors.2004. *. Author(s). ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390024/
*  Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and Heart Rate in Humans | Hypertension
... phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits thromboxane A2/prostaglandin H2 receptor binding and ... It has not yet been established whether DHA inhibits thromboxane synthetase or thromboxane A2/prostaglandin H2 receptor ... For example, EPA and DHA differ in their effects on membrane fluidity and the activities of membrane-bound enzymes5 and on ... Differential effects of dietary fish oil on myocardial prostaglandin I2 and thromboxane A2 production. Am J Physiol. 1991;260( ...
  http://hyper.ahajournals.org/content/34/2/253
*  Prostaglandin analogue - Wikipedia
Prostaglandin analogues are a class of drugs that bind to a prostaglandin receptor. Wider use of prostaglandin analogues is ... Up until the late 1970s prostaglandins were thought to raise IOP, but a paper published in 1977 showed that prostaglandin F2α ... Prostaglandin analogues such as misoprostol are used in treatment of duodenal and gastric ulcers. Misoprostol and other ... CS1 maint: Multiple names: authors list (link) Prostaglandin Analogues at the US National Library of Medicine Medical Subject ...
  https://en.wikipedia.org/wiki/Prostaglandin_analogue
*  Prostaglandinski D2 receptor - Википедија, слободна енциклопедија
Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by ... Eikozanoidni receptor. Spoljašnje veze[уреди]. *. „Prostanoid Receptors: DP1". IUPHAR Database of Receptors and Ion Channels. ... Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A ... 2003). „Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle". Int. J. Impot. Res. ...
  https://sr.wikipedia.org/wiki/Prostaglandinski_D2_receptor
*  Inhibition of MMP-9 expression by PPARγ activators in human bronchial epithelial cells | Thorax
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. ... In addition, PPARγ seems to limit binding of the NF-κB proteins to the respective DNA binding site. Previous work has shown ... 10 PPARγ belongs to the group of nuclear hormone receptors consisting of a ligand and DNA binding domain which, upon activation ... peroxisome proliferator activated receptor (PPAR)γ. Chronic inflammatory processes in the respiratory system such as bronchial ...
  http://thorax.bmj.com/content/58/9/778
*  M.D. | Einstein/Montefiore Department of Medicine
Structural requirements for binding of prostaglandins to the prostaglandin FP receptor versus the prostaglandin transporter PGT ... Mapping the substrate binding site of the prostaglandin transporter PGT by cysteine scanning mutagenesis. J Biol Chem 274: ... Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. Pharmacology Research & ... The two-step model of prostaglandin signal termination: in vitro reconstitution with the transporter PGT and prostaglandin 15 ...
  http://www.einstein.yu.edu/departments/medicine/faculty/profile.asp?id=7819
*  COMPOSITIONS AND METHODS FOR MODULATING C-REL-DEPENDENT CYTOKINE PRODUCTION - Patent application
These compounds bind to the prostaglandins receptors. Such binding is readily determined by those skilled in the art of ... The term prostaglandin agonist/antagonist refers to compounds which bind to prostaglandin receptors (e.g., An S. et al., ... anti-IL-3 receptor antibodies, anti-IL-4 receptor antibodies, anti-IL-6 receptor antibodies, anti-IL-10 receptor antibodies, ... anti-IL-12 receptor antibodies, anti-IL-13 receptor antibodies, anti-IL-15 receptor antibodies, and anti-IL-23 receptor ...
  http://www.patentsencyclopedia.com/app/20120208203