*  Global and Chinese Histamine Dihydrochloride Industry, 2017 Market Research Report
... The ' Global and Chinese Histamine Dihydrochloride Industry, 2012-2022 Market Research Report ' is a professional and - Market research report and industry analysis - 10790459
  https://www.marketresearch.com/Prof-Research-v4036/Global-Chinese-Histamine-Dihydrochloride-Research-10790459/
*  Maintenance Therapy With Histamine Dihydrochloride and Interleukin-2 in Adult Acute Myeloid Leukemia (AML) Patients With...
This is a non-interventional multi-center study (NIS) in adult patients with AML in first complete remission with measurable minimal residual disease (MRD). Patients are eligible when gene status was already determined for previous induction and consolidation therapy of AML and showed carrier of NPM1, CBFβ-MYH11, or MLL-AF9 mutation. The study objective is to observe the impact of pre-emptive therapy with histamine dihydrochloride (HDC) and interleukin-2 (IL-2) with regard to assess leukemia-free survival/time to relapse and to monitor MRD level trend over time. HDC and IL-2 are approved drugs for AML patients in first complete remission. Therapy is administered for 10 treatment cycles as outlined in the Summary of Product Characteristics ...
  https://clinicaltrials.gov/show/NCT01770158
*  Effect of caffeine on histamine bronchoprovocation in asthma. | Thorax
It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechallenge FEV1 84% of predicted value). The PC20 for histamine bronchoprovocation after caffeine ingestion was 2.65 (95% confidence limits 0.99, 7.10) mg/ml. After placebo the PC20 was 1.89 (0.96, 3.71) mg/ml. It is concluded that caffeine in a dose equivalent to about three cups of coffee has a very small effect, if any, on histamine bronchoprovocation in those with mild asthma. Specific instructions about not having drinks containing caffeine before histamine challenge are therefore not necessary.. ...
  http://thorax.bmj.com/content/45/8/630
*  Aortic endothelial and smooth muscle histamine metabolism in experimental diabetes. | Arteriosclerosis, Thrombosis, and...
We studied histamine metabolism, i.e., histidine decarboxylase (HD)-mediated synthesis and histaminase-mediated catabolism, in relation to intracellular histamine content in both aortic endothelial and subjacent smooth muscle cells of control and diabetic rats. Diabetes was induced by a single jugular vein injection of streptozotocin (55 mg/kg in acidified saline, pH 4.5), and animals were held for either 2 or 4 weeks following overt manifestation of diabetes. An additional 4-week diabetic group received insulin (Iletin NPH, 10 U per 24 hour) during the last week. With respect to control values, the histamine content of aortic endothelial cells increased 138%, HD activity increased 250%, and histaminase activity decreased 50% over the 4-week period. In subjacent smooth muscle cells, the histamine content increased in excess of 150%, HD activity increased more than 300%, and histaminase activity decreased in excess of 30%. Insulin treatment ...
  http://atvb.ahajournals.org/content/2/2/142
*  Histamine is an intracellular messenger mediating platelet aggregation | Science
Inhibition of human platelet aggregation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl (DPPE), a novel antagonist of histamine binding, suggested that histamine might serve a critical role in cell function. Phorbol-12-myristate-13-acetate (PMA) or collagen was found to increase platelet histamine content in parallel with promotion of aggregation. Inhibitors of histidine decarboxylase (HDC) suppressed both aggregation and the elevation of histamine content, whereas DPPE inhibited aggregation only. In saponin-permeabilized platelets, added histamine reversed the inhibition by DPPE or HDC inhibitors on aggregation induced by PMA or collagen. The results indicate a role for histamine as an intracellular messenger, which in platelets promotes aggregation. ...
  http://science.sciencemag.org/content/243/4898/1596
*  Histamine H2 receptor - Wikipedia
H2 receptors are positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H2 receptor agonist. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The histamine receptor H2 belongs to the rhodopsin-like family of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Histamine H2 receptors are expressed in the following tissues: Peripheral tissues Gastric parietal cells (oxyntic cells) Vascular ...
  https://en.wikipedia.org/wiki/Histamine_H2_receptor
*  Frontiers | Identification of amino acids involved in histamine potentiation of GABAA receptors | Pharmacology
Histamine is a neurotransmitter involved in a number of physiological and neuronal functions. In mammals, such as humans and rodents, the histaminergic neurons found in the tuberomamillary nucleus (TMN) project widely throughout the central nervous system (CNS). Histamine acts as positive modulator of GABA(A) receptors (GABA(A)Rs) and, in high concentrations (10 mM), as negative modulator of the strychnine-sensitive glycine receptor. However, the exact molecular mechanisms by which histamine acts on GABA(A)Rs are unknown. In our study, we aimed to identify amino acids potentially involved in the modulatory effect of histamine on GABA(A)Rs. We expressed GABA(A)Rs with 12 different point mutations in Xenopus laevis oocytes and characterized the effect of histamine on GABA-induced currents using the two-electrode voltage clamp technique. Our data demonstrate that the amino acid residues ß2(N265) and ß2(M286), ...
  https://www.frontiersin.org/articles/10.3389/fphar.2015.00106/full
*  More Than Allergies: Histamine May Be A Possible Drug Target For Multiple Sclerosis - Redorbit
New research published in the Journal of Leukocyte Biology suggests that histamine plays an important role as an immune modulator, which could be a significant finding for multiple sclerosis research. If you think histamines are your nemesis during allergy season, here's something that might change your perspective. New research published in the Journal of Leukocyte Biology (http://www.jleukbio.org) shows that histamine could be an important molecule to developing new treatments for multiple sclerosis (MS). In the study, the scientists analyzed the role of histamine in an animal model of multiple sclerosis and found that histamine plays a critical role in preventing MS or lessening its effects.. "We hope that our study will help design new therapies for autoimmune diseases and in particular MS, for which there is still not a definitive cure," said Rosetta Pedotti, MD, Ph.D., a researcher involved in the work from the ...
  http://www.redorbit.com/news/health/1987892/more_than_allergies_histamine_may_be_a_possible_drug_target/
*  Multiple EU countries report outbreaks caused by histamine
Levels of histamine didn't meet microbiological criteria laid down in regulation (EC) no. 2073/2005. However these levels are not very high, please pay attention that for fish in brine the levels are 200 and 400 mg/kg.​. "In [the] case of histamine in fish, each batch may be different. Finding histamine in one batch doesn't mean that in the next batch [the] level of histamine will be above [the] criteria."​. Hrvatska Agencija Za Hranu (HAH/Croatian Food Agency) told us positive histamine findings were in a sample of refined yellow-tuna filet from Spain.. Additional sampling by veterinary inspectors on two more lots from the same distributor or supplier from Spain were negative. Inspections on the market did not find other positive samples.. HAH said less than five histamine poisoning cases are reported annually.. Agencies from other countries mentioned above did not respond to our request for information.. ...
  https://www.foodqualitynews.com/Article/2017/08/08/Multiple-EU-countries-report-outbreaks-caused-by-histamine?nocount
*  Histamine dihydrochloride | Phion
Product Number , 45055253. CAS Number , 56-92-8. EC , 200-298-4. Molecular Formula , C5H9N32HCl. Molecular Weight , 184.07. Storage Temp , +4°C. Harmonized Tariff code , 29332990. Signal Word , ...
  http://phionchemicals.com/product/histamine-dihydrochloride
*  "Histamine H3 receptor enhanced negative feedback control in rat brain " by James Brandon Shaw
Histamine receptors provide feedback inhibition for the synthesis and release of histamine from the hypothalamus, as well as inhibition of other neurotransmitters, such as acetylcholine from intestinal cholinergic nerves, and norepinephrines from the retina and cerebral cortex. Our previous results suggest that the regulation of histamine release by histamine H3 receptors changes with the progression of hypertension in Spontaneously Hypertensive Rats (SHR). Therefore, we believe that the histamine H3 receptor plays a role in the promotion and sustained development of hypertension. Analysis of saturation binding data from Spontaneously Hypertensive Rat cerebral cortex indicate that as animals aged from six to sixteen weeks the maximal number of receptor sites (Bmax) increased whereas the affinity of [3H]-N-a-methylhistamine for these sites decreased. B max was 38 + 1.58, 59.63 + 2.48, 79.17 + ...
  https://digitalscholarship.tnstate.edu/dissertations/AAI3107464/
*  German guideline for the management of adverse reactions to ingested histamine | SpringerLink
Adverse reactions are more often subjectively perceived than objectively verifiable. There are large deficits particularly in our scientific knowledge on non-allergic adverse reactions. Histamine intolerance is an example in point: due to the fact that it is increasingly discussed in the media and Internet, subjectively affected individuals often suspect it to be the trigger of their symptoms. The scientific evidence to support this postulated link is limited, and a reliable laboratory test for the purpose of conclusive diagnosis is lacking. Although scientific studies on adverse reactions to ingested histamine have been carried out predominantly in adults to date, the diagnosis is also made in children and adolescents, often with significant consequences to the diets of affected individuals. Two reports on digestive disorders in children caused by histamine are now available [1, 2]. A retrospective observational study conducted in Spain [1] discusses ...
  https://link.springer.com/article/10.1007/s40629-017-0011-5
*  Allergy Notes: Histamine H3 receptor in the nasal mucosa
The seminal work on histamine was published in 1910, but histamine was not identified as a mediator of anaphylactic reactions until 1932. Histamine is a major mediator responsible for the symptoms of allergic rhinitis, with its activities mediated through 4 G protein-coupled receptors. Most of histamine's effects are exerted through the H₁ receptor, but some effects are through the H₂ and H₃ receptors, and possibly also through the H₄ receptor ...
  http://allergynotes.blogspot.com/2008/10/histamine-h3-receptor-in-nasal-mucosa.html
*  AID 221484 - In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea...
BioAssay record AID 221484 submitted by ChEMBL: In vitro for histamine H1 receptor antagonist activity against histamine-induced contractions on isolated guinea pig ileum.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/221484
*  10 High & Low Histamine Foods - Nature's Sunshine
If you've ever dealt with seasonal allergies, or you happen to have a serious food allergy, then you've likely heard the term "histamine" in one context or another. While histamine is directly related to allergic reactions, it's technically a chemical in your immune system which cause an immediate inflammatory response after coming in contact with any food or drink item that your body deems a potential health threat.. It works a bit like this: imagine a peanut allergy. When you eat a peanut, histamine automatically inflames your blood vessels. This lets your body know it needs to send as many white blood cells - the kinds that attack infection - to the affected areas as possible. However, too much histamine sent at once can obviously cause a severe allergic reaction that, if not treated quickly, can cause anaphylaxis.. However, it's also possible to have too much histamine present in your immune system - even if you're not ...
  http://blog.naturessunshine.com/en/10-high-histamine-foods/
*  Histamine r legal definition of histamine r
Definition of histamine r in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is histamine r? Meaning of histamine r as a legal term. What does histamine r mean in law?
  https://legal-dictionary.thefreedictionary.com/histamine+r
*  Vitamin C antagonists can raise histamine levels
Vitamin C can lower high histamine levels. Conversely, high doses of vitamin C's cofactors, taken without C, might raise histamine.
  http://www.adnuther.com/2012/07/vitamin-c-antagonists-can-raise-histamine-levels/
*  JCI - Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial...
Using a sensitive single isotope enzymatic assay we measured bronchoalveolar lavage (BAL) fluid histamine in asymptomatic normal (nonallergic), allergic rhinitic, and allergic asthmatic subjects. Normal subjects were found to have little or no detectable amounts of histamine in BAL fluid (11 +/- 11 pg/ml), and few BAL fluid mast cells. In comparison, the allergic rhinitics and allergic asthmatics had much higher amounts of BAL fluid histamine (113 +/- 53 and 188 +/- 42 pg/ml, respectively), and a significantly greater number of BAL fluid mast cells. Furthermore, despite having equivalent baseline pulmonary function values, allergic asthmatics with BAL fluid histamine levels greater than 100 pg/ml required only 7 +/- 2 breath units of methacholine to induce a 20% drop in forced expiratory volume in 1 s (FEV1) (PD20FEV1) while asthmatics with BAL fluid histamine levels less than 100 pg/ml required 49 +/- 19 breath units (P ...
  https://www.jci.org/articles/view/112937
*  Short Communication: Endogenous Histamine Liberation in Man - Ciba Foundation Symposium - Histamine - Lecomte - Wiley Online...
Lecomte, J. (1956) Short Communication: Endogenous Histamine Liberation in Man, in Ciba Foundation Symposium - Histamine (eds G. E. W. Wolstenholme and C. M. O'Connor), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470718957.ch21 ...
  http://onlinelibrary.wiley.com/doi/10.1002/9780470718957.ch21/summary?globalMessage=0
*  MIB - Histamine
Histamine, b-imidazolethylamine is an intercellular mediator exerting potent effects on various target tissues. Histamine is stored in large amounts in metachromatic granules of mast cells and basophils, and it is one of the major mediators of immediate hypersensitivity. It is released actively from mast cells and basophils when challenged with allergens to which the allergic patient is sensitized or with non-specific histamine releasers such as IgE or pharmacological agents. Histamine is also an important mediator in the central nervous system and the gastric mucosa.. ...
  http://www.immunotech.cz/histamine-2
*  Plus it
The effects of blockade of the autonomic ganglia by administration of hexamethonium on blood pressure responses to histamine were studied in the dog anesthetized with sodium pentobarbital. A series of graded doses of histamine acid phosphate were administered before and after the blockade of the ganglia, and blood pressure responses elicited by these doses of histamine were analyzed for minimum attained blood pressure and actual fall and duration of fall in blood pressure. In all cases the minimum attained blood pressure was lower after administration of the ganglionic blocking agent than before. The amount of lowering of the minimum attainable blood pressure was about the same as that of lowering of the control blood pressure produced by the ganglionic blocking agent. Actual fall in blood pressure was unaffected by administration of the ganglionic blocking agent but duration of the fall following all the larger doses of histamine was ...
  http://ajplegacy.physiology.org/content/199/5/745
*  Low Histamine Food List | Mast Cells & Collagen Behaving Badly
This blog covers my personal journey with mast cell disease and histamine intolerance. I'm not advocating that you should follow the diet I follow, or that my diet is perfectly low histamine. I tried a basic low histamine diet, based on information from the International Chronic Urticaria Society and written by histamine researcher Dr Janice Joneja because I…
  https://mastcellblog.wordpress.com/food/list/
*  SYNTHESIZING IDEAS: The Histamine H4 Receptor : Drug Discovery in the Post-genomic Era.
The high expression of the histamine H4 receptor in cells of hemopoietic lineage and immune cells suggests that this new histamine receptor plays a role in inflammatory and immune responses. Activation of the Histamine receptor can mediate calcium mobilisation and chemotaxis in mast cells ...
  http://syntheticorganic.blogspot.com/2008/03/histamine-h4-receptor-drug-discovery-in.html
*  Histamine H1 receptor - Wikipedia
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the phosphatidylinositol (PIP2) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs. The crystal structure of the receptor has been determined (shown on the right) and used to discover new histamine H1 receptor ligands in structure-based virtual screening studies. The expression of NF-κB, the transcription factor that regulates inflammatory processes, is promoted by the constitutive activity of the H1 receptor as well as by agonists that bind at the receptor. H1-antihistamines have been ...
  https://en.wikipedia.org/wiki/Histamine_H1_receptor