Human Metabolome Database: Showing metabocard for Linoleic acid (HMDB0000673)
Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). ... Linoleic acid, ammonium salt, (Z,Z)-isomer. MeSH. Linoleic acid, potassium salt, (Z,Z)-isomer. MeSH. ... The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl ... Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids ( ...http://www.hmdb.ca/metabolites/HMDB00673
Molecules | Free Full-Text | Exploitation of Bile Acid Transport Systems in Prodrug Design
... and reviews the use of bile acids and their derivatives in designing prodrugs capable of exploiting the bile acid transport ... It is a complex process involving numerous transport proteins, which serve to transport bile acids from the small intestine ... This article briefly describes bile acid transport proteins involved in enterohepatic circulation, summarizes the key factors ... and low cost have made bile acids attractive tools in designing pharmacological hybrid molecules and prodrugs with the view of ...http://www.mdpi.com/1420-3049/12/8/1859
Genetic Defects in Synthesis and Transport of Bile Acids | Pediatric Endocrinology and Inborn Errors of Metabolism, 2e |...
Bile salts represent approximately 50% of the organic constituents of the bile dry weight, while 25% is made up by ... This loss of bile acids is compensated for by de novo synthesis of bile acids in the liver. Bile acids synthesized in the liver ... Deficient bile acid synthesis results in reduced production of the primary bile acids, with consequences for the bile flow and ... Synthesis of Bile Acids. ++. Conversion of cholesterol into bile acids illustrates the high capacity of the liver to convert ...http://accesspediatrics.mhmedical.com/content.aspx?bookid=2042§ionid=154112839
SLC27A5 - Bile acyl-CoA synthetase - Homo sapiens (Human) - SLC27A5 gene & protein
Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion ... Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha, ... 7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis ... into bile canaliculi by activating them to their CoA thioesters. ... Acyl-CoA synthetase involved in bile acid metabolism. ...http://www.uniprot.org/uniprot/Q9Y2P5
A enzymatic and fluorimetric determination of total bile acid sulfates in human urine. - Semantic Scholar
In this method, no influence of existing salts in the reaction mixture on fluorescence intensity was observed and solvolysis ... Overall recoveries of glycine- and taurine-conjugated bile acid 3-sulfates from normal urine ranged from 90.5 to 93.7% and ... The level of total urinary bile acid sulfates was estimated on some patients with hepatobiliary diseases and healthy subjects. ... The sulfate fraction of urinary bile acids was separated with lipophilic anion exchange gel, piperidinohydroxypropyl Sephadex ...https://www.semanticscholar.org/paper/A-enzymatic-and-fluorimetric-determination-of-tota-Amakasu-Suzuki/7848ef20e1c0b61eaf5b4d8775278e5d3247dee7
Human Metabolome Database: Showing metabocard for Stearic acid (HMDB0000827)
Bile salt-activated lipase. General function:. Lipid transport and metabolism. Specific function:. Catalyzes fat and vitamin ... Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). ... The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl ... Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids ( ...http://www.hmdb.ca/metabolites/HMDB00827
Phospholipids and bile acids as diffusional carriers of Na+ across nonpolar media - Accatino - 1988 - Hepatology - Wiley Online...
Qiwei Xu, Eldon A. Shaffer, The influence of bile salts on small intestinal motility in the guinea pig in vitro, ... Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid ... Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid ... In contrast, cholic acid as well as other bile acids demonstrated only marginal or no Na+ ionophoretic capability. However, ...http://onlinelibrary.wiley.com/doi/10.1002/hep.1840080432/abstract
Valtsu's: Health Benefits of Glycine
"Bile acids (BAs)3 are synthesized in the liver from cholesterol. After their synthesis, they are conjugated to the amino acids ... It's also interesting to note that bile salts require phosphatidylcholine to prevent mucosal injury. PC is upstream from both ... Conjugation of bile acids increases their solubility and facilitates their secretion into bile (2). [...] the dietary levels of ... Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. Liaset B, Madsen L, Hao Q ...http://valtsus.blogspot.fi/2013/12/glycine.html
Solubilization of lipids from hamster bile-canalicular and contiguous membranes and from human erythrocyte membranes by...
The non-micelle-forming bile salt dehydrocholate solubilized no lipid at all up to 32 mM. All the dihydroxy bile acids are much ... On the other hand, the dihydroxy bile salt ursodeoxycholate and the trihydroxy bile salt cholate solubilize much less lipid. ... All the dihydroxy bile salts have a threshold concentration above which lipid solubilization increases rapidly; this correlates ... We have demonstrated in vitro the efficacy of the taurine-conjugated dihydroxy bile salts deoxycholate and chenodeoxycholate in ...http://www.biochemj.org/content/242/3/825
Human Metabolome Database: Showing metabocard for Chenodeoxycholoyl-CoA (HMDB0006292)
Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts. J ... and an amide bond is formed between the bile acid and the amino acids glycine or taurine. The bile acid-CoA:amino acid N- ... In humans, bile acids conjugated with glycine and taurine are the major solutes in bile, and unconjugated bile acids are almost ... Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). ...http://www.hmdb.ca/metabolites/HMDB0006292
Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile...
Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. Exp Toxicol Pathol. 2001; 53: 227-33.. * ... Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile ... Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile ... Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry. 2005; 44: 12598-605.. *CrossRef, ...http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01586.x/references?globalMessage=0
A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts*† | Annals of Internal Medicine |...
A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts(A Comparative Study of the Choleretic ... Effect of Bile Salts and Oleic Acid and Bile Salts*†)(A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid ... A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts(A Comparative Study of the Choleretic ... Effect of Bile Salts and Oleic Acid and Bile Salts*†)(A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid ...http://annals.org/aim/article-abstract/670366/comparative-study-choleretic-effect-bile-salts-oleic-acid-bile-salts
bile facts, information, pictures | Encyclopedia.com articles about bile
Make research projects and school reports about bile easy with credible articles from our FREE, online encyclopedia and ... Bile, or gall, is composed of water, bile acids and their salts, bile pigments, cholesterol, fatty acids, and inorganic salts. ... bile pigments, and electrolytes (minerals).. Bile acids and bile salts. The function of these remarkable molecules is ... by increasing the bile acid/cholesterol ratio of bile. This is achieved simply by taking synthetic bile acids by mouth. ...https://www.encyclopedia.com/science-and-technology/biochemistry/biochemistry/bile
The Effect of VSL#3 Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease - Full Text...
The Effect of VSL#3 Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease. This study ... Change of the spectrum of bile acids in stools and plasma [ Time Frame: Baseline and 6 weeks (plus or minus 5 days). ]. *Change ... Bile acids (BA) play an important role in the gastrointestinal tract - besides facilitating fat (and protein) digestion and ... Alteration in the rate of bile acid synthesis [ Time Frame: Baseline and 6 weeks (plus or minus 5 days) ]. Will be assessed as ...https://clinicaltrials.gov/ct2/show/NCT01765439
Obeticholic Acid in Bile Acid Diarrhoea - Full Text View - ClinicalTrials.gov
Primary Bile Acid Malabsorption Secondary Bile Acid Malabsorption Chronic Diarrhoea Drug: Obeticholic acid Phase 2 ... Primary bile acid malabsorption. Secondary bile acid malabsorption. Chronic diarrhoea. Obeticholic acid. SeHCAT. FXR. FGF19. ... in patients with bile acid diarrhoea. OCA is a semisynthetic bile acid, also known as 6αethylchenodeoxycholic acid or INT747, ... Serum total bile acids. [ Time Frame: 15 days. ]. Dynamic changes of total bile acids over 6 hour period following OCA ...https://clinicaltrials.gov/ct2/show/NCT01585025?recr=Open&cond=%22Malabsorption+Syndromes%22&rank=1
Age and diet effects on fecal bile acids in infants.
Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 ... Bile Acids and Salts / analysis*. Breast Feeding. Feces / analysis*. Female. Humans. Infant. Infant Food. Infant Nutritional ... At the end of the study, breast-fed infants were excreting 17% of their total bile acids in the form of secondary acids, ... Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 ...http://www.biomedsearch.com/nih/Age-diet-effects-fecal-bile/3335983.html
Mixed oxo-hydroxy bile acids as actual or potential impurities in ursodeoxycholic acid preparation: a 1H and 13C NMR study.
... unprecedented 1H NMR signals and the complete 13C NMR resonances are assigned for the entire set of mixed oxo-hydroxy bile acid ... 0/Bile Acids and Salts; 0/Carbon Isotopes; 0/Protons; 128-13-2/Ursodeoxycholic Acid ... Bile Acids and Salts / isolation & purification*. Carbon Isotopes. Magnetic Resonance Spectroscopy. Protons. Ursodeoxycholic ... of chenodesoxycholic acid, desoxycholic acid and cholic acid, respectively. Partially or totally oxidized products are the ...http://www.biomedsearch.com/nih/Mixed-oxo-hydroxy-bile-acids/10755232.html
Serum, cerebrospinal fluid, and brain levels of bile acids in patients with fulminant hepatic failure.
Serum bile acids in FHF were predominantly conjugated, and total bile acid levels were higher ... Bile acid levels were measured in the sera, cerebrospinal fluid (CSF), and brain tissue of 10 patients immediately after death ... Bile Acids and Salts / analysis*, blood, cerebrospinal fluid. Brain Chemistry*. Female. Hepatic Encephalopathy / metabolism. ... Serum bile acids in FHF were predominantly conjugated, and total bile acid levels were higher in all 10 patients than in normal ...http://www.biomedsearch.com/nih/Serum-cerebrospinal-fluid-brain-levels/604189.html
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR...
Bile acid synthesis is under negative feedback control through activation of the nuclear receptor farnesoid X receptor ( ... acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. ... Bile Acids and Salts / metabolism*. Cholesterol 7-alpha-Hydroxylase / genetics, metabolism. Feedback, Physiological / drug ... These studies suggest that the gut microbiota not only regulates secondary bile acid metabolism but also inhibits bile acid ...http://www.biomedsearch.com/nih/Gut-Microbiota-Regulates-Bile-Acid/23395169.html
Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or...
... thymidine uptake after exposure to either conjugated bile acids or an cocktail of conjugated bile salts (see Methods) for 1 hr ... 0.15 mM sodium glycodeoxycholic acid, and 0.05 mM sodium taurodeoxycholic acid. After exposure to bile salts for 1 hour, the ... Acid and bile salt exposure. Cell lines were first cultured in serum-free media for 48 hours before exposure for various times ... Thus other model systems are needed that may reflect the impact of acid and bile salt exposure on the esophagus in vivo. ...https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-7-24
Intralumenal Effects on Cholesterol Absorption/Synthesis - Full Text View - ClinicalTrials.gov
Experimental: Bile Acid To assess the role of bile acid pool size changes on cholesterol absorption, synthesis and intralumenal ... The effect that these bile acids have on how fast the gall bladder empties and the release of a hormone in the blood after a ... Dietary Supplement: Bile Acids (Cholic, Ursodeoxycholic, Chenodeoxycholic) Dietary Supplement: Sphingomyelin Drug: Pluronic F- ... Dietary Supplement: Bile Acids (Cholic, Ursodeoxycholic, Chenodeoxycholic) 15 mg/kg/day for 18 days ...https://clinicaltrials.gov/ct2/show/NCT00328211?term=cholesterol&rank=15
ABCB14 - ABC transporter B family member 14 - Arabidopsis thaliana (Mouse-ear cress) - ABCB14 gene & protein
R-ATH-159418. Recycling of bile acids and salts. R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha- ... R-ATH-159418. Recycling of bile acids and salts. R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha- ... It always involves more than one amino acid and includes all residues involved in nucleotide-binding.,p>,a href='/help/np_bind ... It always involves more than one amino acid and includes all residues involved in nucleotide-binding.,p>,a href='/help/np_bind ...http://www.uniprot.org/uniprot/Q9C7F2
Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.
Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a ... Bile Acids and Salts / adverse effects. Blotting, Western. Cell Line. DNA Damage / physiology*. Disease Progression. Epithelial ... 0/Bile Acids and Salts; 0/Reactive Oxygen Species; BBX060AN9V/Hydrogen Peroxide; EC 220.127.116.11/Glutathione Peroxidase ... OBJECTIVE: Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen ...http://www.biomedsearch.com/nih/Glutathione-peroxidase-7-protects-against/22157330.html
A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase.
... crystallographically defined bile acid binding site was originally identified in the membrane domain of mammalian and bacterial ... cytochrome c oxidase (CcO). Current studies show other amphipathic molecules including detergents, fatty acid ... Bile Acids and Salts / metabolism. Bilirubin / metabolism. Binding Sites. Deoxycholic Acid / metabolism. Detergents / ... 0/Bile Acids and Salts; 0/Detergents; 0/Protein Subunits; 0/Protoporphyrins; 0/dodecyl maltopyranoside; 005990WHZZ/Deoxycholic ...http://www.biomedsearch.com/nih/Conserved-Amphipathic-Ligand-Binding-Region/23351100.html
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