*  Cyproterone acetate - Wikipedia
CPA is a potent androgen receptor (AR) competitive antagonist. It directly blocks endogenous androgens such as testosterone and ... Other important antiandrogens besides CPA include spironolactone and bicalutamide. The drug is available widely throughout the ... CPA is known to possess the following pharmacological activity: Androgen receptor (AR) antagonist/very weak partial agonist ( ... ISBN 978-1-84076-013-2. Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists ( ...
  https://en.wikipedia.org/wiki/Cyproterone_acetate
*  A Study of Enzalutamide Versus Bicalutamide in Castrate Men With Metastatic Prostate Cancer - Full Text View - ClinicalTrials...
Bicalutamide. Androgen Antagonists. Hormone Antagonists. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... Ongoing androgen deprivation therapy with a Luteinizing Hormone Receptor Hormone (LHRH) agonist or antagonist at a stable dose ... Active Comparator: Bicalutamide Participants received bicalutamide 50 mg orally once daily until confirmed radiographic disease ... A Study of Enzalutamide Versus Bicalutamide in Castrate Men With Metastatic Prostate Cancer. The safety and scientific validity ...
  https://clinicaltrials.gov/ct2/show/NCT01288911
*  Bioequivalence of Bicalutamide New Formulation in Japan - Full Text View - ClinicalTrials.gov
Bicalutamide. Androgen Antagonists. Hormone Antagonists. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... Bioequivalence of Bicalutamide New Formulation in Japan. The safety and scientific validity of this study is the responsibility ... To investigate the bioequivalence of ICI176,334-1 by assessment of t1/2 (half time) of bicalutamide [ Time Frame: Blood samples ... The purpose of this study is to investigate the bioequivalence of Bicalutamide new formation with Casodex commercial tablet ( ...
  https://clinicaltrials.gov/ct2/show/NCT01416870
*  Bicalutamide With or Without Enzastaurin in Treating Patients With Prostate Cancer - Full Text View - ClinicalTrials.gov
Bicalutamide. Androgen Antagonists. Hormone Antagonists. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... RATIONALE: Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as bicalutamide, may lessen the ... PURPOSE: This randomized phase II trial is studying bicalutamide to see how well it works compared with giving bicalutamide ... It is not yet known whether giving bicalutamide together with enzastaurin is more effective than bicalutamide alone in treating ...
  https://clinicaltrials.gov/ct2/show/NCT00685633
*  Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer - Full Text View - ClinicalTrials.gov
Bicalutamide. Androgen Antagonists. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological Effects of Drugs. ... Phase II Study of Antineoplastons A10 and AS2-1 Capsules With Total Androgen Blockade in Patients With Stage III or IV ... Drug: antineoplaston A10 Drug: antineoplaston AS2-1 Drug: bicalutamide Drug: flutamide Drug: leuprolide acetate Procedure: ... Determine the antitumor activity of antineoplastons A10 and AS2-1 capsules in combination with total androgen blockade in ...
  https://clinicaltrials.gov/ct2/show/NCT00003517
*  Safety and Efficacy Study of Enzalutamide Versus Bicalutamide in Men With Prostate Cancer - Full Text View - ClinicalTrials.gov
Bicalutamide. Androgen Antagonists. Hormone Antagonists. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... Willing to maintain androgen deprivation therapy with a gonadotropin releasing hormone (GnRH) agonist/antagonist or has had a ... Bicalutamide In Men With Prostate Cancer Who Have Failed Primary Androgen Deprivation Therapy. ... Randomized to bicalutamide and receiving bicalutamide at the time of study unblinding; ...
  https://clinicaltrials.gov/ct2/show/NCT01664923?term=Medivation&rank=6
*  SECRETED PROTEIN ACIDIC AND RICH IN CYSTEINE (SPARC) AS CHEMOTHERAPEUTIC SENSITIZERS - Patent application
... androgen antagonists such as flutamide and bicalutamide; and gonadotropin-releasing hormone analogs such as leuprolide. ... estrogen antagonists, tamoxifen, anastrozole; androgens, testosterone propionate, fluoxymesterone, androgen antagonists, ... estrogen antagonists such as tamoxifen and anastrozole; androgens such as testosterone propionate and fluoxymesterone and ... Examples of chemotherapeutic agents include alkylating agents, antimetabolites, natural products, hormones and antagonists, and ...
  http://www.patentsencyclopedia.com/app/20130196929
*  Bicalutamide) Casodex vs Placebo in Non-metastatic Early Prostate Cancer
androgen antagonists. *prostate neoplasms. *Prostatic Neoplasms. .map{width:100%;height:300px;margin-bottom:15px}. Name. ... A Randomized, Double-Blind, Parallel-Group Trial Comparing Bicalutamide (Casodex) 150mg Once Daily With Placebo in Patients ... A Randomized, Double-Blind, Parallel-Group Trial Comparing Bicalutamide (Casodex) 150mg Once Daily With Placebo in Patients ...
  http://www.knowcancer.com/cancer-trials/NCT00673205/
*  S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer - Full Text View - ClinicalTrials.gov
Androgens. Bicalutamide. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological Effects of Drugs. ... A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide ... Active Comparator: ADT + Bicalutamide LHRH agonist - given as approved for androgen deprivation at a dose necessary to maintain ... ADT+Bicalutamide for Metastatic Prostate Cancer (S1216). This study is ongoing, but not recruiting participants. ...
  https://clinicaltrials.gov/show/NCT01809691
*  China Factory Supply Best Raw Powder Oral Sarms Andarine / S4 / Gtx-007 401900-40-1 - China Andarine, S4
... using the non-steroidal androgen antagonist bicalutamide as a lead compound.. Andarine is an orally active partial ... As an orally active partial agonist for androgen receptors, S-4 is effective in not only maintaining lean body mass but ... Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed ... agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs.. ...
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*  Bicalutamide and Goserelin or Leuprolide Acetate With or Without Cixutumumab in Treating Patients With Newly Diagnosed...
Androgens. Leuprolide. Goserelin. Bicalutamide. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... Active Comparator: Arm II (androgen deprivation therapy) Patients receive androgen deprivation therapy comprising bicalutamide ... Patients receive androgen deprivation therapy comprising bicalutamide PO QD on days 1-28 and either goserelin acetate SC or ... Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as bicalutamide, goserelin, or leuprolide ...
  https://clinicaltrials.gov/ct2/show/NCT01120236?term=SWOG+0925&rank=1
*  Ligand-Specific Dynamics of the Androgen Receptor at Its Response Element in Living Cells
Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J. Biol. Chem. ... 4A to D) or AR bound to partial antagonist RU486 (Fig. 4M to O) or pure antagonists OHF (Fig.4Q to S) and bicalutamide (data ... In addition, the partial antagonists CPA and RU486 and the pure antagonists bicalutamide and OHF were used. To ensure that the ... Fig.1C).1C). The pure antagonists bicalutamide and OHF had marginal effects on transcriptional activation. Thus, the GFP-AR in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC1820481/?lang=en-ca
*  Bicalutamide Supplier | CAS 90357-06-5 | ICI 176,334 | Casodex | Tocris Bioscience
View and buy high purity Bicalutamide from Tocris Bioscience, the leading worldwide supplier of high performance life science ... Keywords: Bicalutamide, supplier, Non-steroidal, Androgen, receptor, antagonists, Dihydrotestosterone, Receptors, AstraZeneca, ... Selected citations for Bicalutamide include: Gambara et al (2015) TLR3 engagement induces IRF-3-dependent apoptosis in androgen ... Reviews for Bicalutamide. There are currently no reviews for this product. Be the first to review Bicalutamide and earn rewards ...
  https://www.tocris.com/products/bicalutamide_3389
*  Abstract 2460: Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer. | Cancer Research
Androgen Receptor (AR) antagonists have been used in clinic to treat prostate cancer. One example is bicalutamide (Casodex®), ... Abstract 2460: Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer.. Youzhi Tong, Chunyun ... Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer. [abstract]. In: Proceedings of the ... MDV3100, a more potent AR antagonist (∼5x vs bicalutamide) without residual agonism, has demonstrated excellent efficacy in ...
  http://cancerres.aacrjournals.org/content/73/8_Supplement/2460
*  MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and...
... often in combination with competitive androgen receptor antagonists, such as bicalutamide or Casodex (CDX). The initial ... observed a considerable downregulation of 6 miRs after irradiation of androgen-dependent LnCaP and androgen-independent LnCaP ... The concept of androgen deprivation for the treatment of advanced prostate cancer was developed by Huggins and Hodges in 1941 [ ... T. Sun, Q. Wang, S. Balk, M. Brown, G.-S. M. Lee, and P. Kantoff, "The role of microrna-221 and microrna-222 in Androgen- ...
  https://www.hindawi.com/journals/bmri/2014/146170/
*  Comparison of bicalutamide with other antiandrogens - Wikipedia
Rathkopf D, Scher HI (2013). "Androgen receptor antagonists in castration-resistant prostate cancer". Cancer Journal. 19 (1): ... As such, although bicalutamide has not been compared head-to-head to CPA or spironolactone in the treatment of androgen- ... ISBN 978-1-60327-829-4. Singh SM, Gauthier S, Labrie F (February 2000). "Androgen receptor antagonists (antiandrogens): ... This article is a comparison of bicalutamide, a nonsteroidal antiandrogen (NSAA), with other antiandrogens. Bicalutamide and ...
  https://en.wikipedia.org/wiki/Comparison_of_bicalutamide_with_other_antiandrogens
*  Fluorination Ready Pharma-Developed Compounds - Bioactive Small Molecules | Sigma-Aldrich
Bicalutamide (CDX) ≥98% (HPLC), powder Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure ... Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF ( ... ASTAR (Antagonist of Serotonin 5HT2A Receptors). SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release ... SR 142948A is a non-peptide Neurotensin receptor antagonist. SR 142948A is a potent neurotensin receptor antagonist that ...
  https://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=119065071
*  EPI-001 - Wikipedia
Masiello D, Cheng S, Bubley GJ, Lu ML, Balk SP (Jul 2002). "Bicalutamide functions as an androgen receptor antagonist by ... EPI-001 is an antagonist of the androgen receptor (AR) that acts by binding covalently to the N-terminal domain (NTD) of the AR ... Unlike antiandrogens such as bicalutamide, EPI-001 does not cause the AR to bind to androgen response elements on the DNA of ... 2009). "A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen ...
  https://en.wikipedia.org/wiki/EPI-001
*  Flutamide - Wikipedia
"Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor". Journal of ... Flutamide acts as a selective antagonist of the androgen receptor (AR), competing with androgens like testosterone and ... Helsen C, Van den Broeck T, Voet A, Prekovic S, Van Poppel H, Joniau S, Claessens F (Aug 2014). "Androgen receptor antagonists ... Sundblad C, Landén M, Eriksson T, Bergman L, Eriksson E (2005). "Effects of the androgen antagonist flutamide and the serotonin ...
  https://en.wikipedia.org/wiki/Flutamide
*  Side effects of bicalutamide - Wikipedia
Apoptosis induced by the androgen antagonist bicalutamide is receptor mediated (Lin et al., 2006), and hence a dominant effect ... If bicalutamide is combined with a GnRH analogue or surgical castration, the elevation of androgen and estrogen levels in men ... 6.4%, respectively). In phase III studies of bicalutamide monotherapy for LAPC, the rates of diarrhea for bicalutamide and ... Surgical breast reduction may also be employed to correct bicalutamide-induced gynecomastia. Bicalutamide may cause sexual ...
  https://en.wikipedia.org/wiki/Side_effects_of_bicalutamide
*  Familial male-limited precocious puberty - Wikipedia
Alternatively, the combination of the androgen receptor antagonist bicalutamide and the aromatase inhibitor anastrozole may be ... "Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole". The Journal of Pediatrics. 149 (3): ...
  https://en.wikipedia.org/wiki/Familial_male-limited_precocious_puberty
*  SWOG-9346, Hormone Therapy in Treating Men With Stage IV Prostate Cancer - Full Text View - ClinicalTrials.gov
Bicalutamide. Antineoplastic Agents, Hormonal. Antineoplastic Agents. Androgen Antagonists. Hormone Antagonists. Hormones, ... Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med. 2013 Apr 4;368(14):1314-25. doi: 10.1056/ ... Moinpour C, Berry DL, Ely B, et al.: Preliminary quality-of-life outcomes for SWOG-9346: Intermittent androgen deprivation in ... The effectiveness of the current depot LHRH agonist would not extend beyond 8 months after initiation of combined androgen ...
  https://clinicaltrials.gov/ct2/show/NCT00002651
*  Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy
... is currently ongoing evaluating bicalutamide, a commonly used androgen receptor antagonist, in patients with ER/PR-negative ... Androgen Receptor Inhibition. An interesting target that is currently under investigation is the androgen receptor (AR). As ... Androgen receptor mRNA was expressed at an average of 9-fold higher level in this subtype than all the other subtypes [31]. ... The sixth subtype, luminal androgen receptor (LAR), was found to be enriched in genes involved in steroid synthesis and ...
  https://www.hindawi.com/journals/ijbc/2012/217185/
*  Plus it
Bicalutamide is a competitive antagonist of androgen receptor widely used for growth inhibition of androgen-responsive prostate ... The androgen receptor and mechanisms for androgen independence in prostate cancer. Cancer Invest 2005;23:520-8. ... Finally, we used increasing concentrations of the potent nonsteroidal antiandrogen (bicalutamide) to define the androgen ... Androgen receptor immunohistochemistry and mutation analysis. The androgen receptor-signaling pathway mediates the actions of ...
  http://clincancerres.aacrjournals.org/content/14/2/607
*  Synthesis and pharmacological evaluation of novel arylpiperazine derivatives as nonsteroidal androgen receptor antagonists. |...
... which is more potent than bicalutamide (4) which has an IC(50) value of 0.89 microM. ... Synthesis and pharmacological evaluation of novel arylpiperazine derivatives as nonsteroidal androgen receptor antagonists.. [ ...
  https://www.sigmaaldrich.com/catalog/papers/15516756