*  beta.3 adrenergic receptor agonists and uses thereof - Patent # 6706743 - PatentGenius
... adrenergic receptor-mediated diseases, conditions, or disorders in a mammal which methods comprise administering to the mammal ... R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, X, and Y, are as defined herein.The invention further provides ... beta..sub.3 adrenergic receptor agonists of structural Formula (I), ##STR1##the stereoisomers and prodrugs thereof, and the ... beta..sub.1 and .beta..sub.2 Receptor Selectivity. In vivo selectivity for .beta..sub.1 and .beta..sub.2 receptors may be ...
  http://www.patentgenius.com/patent/6706743.html
*  Frontiers | TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue | Endocrinology
We recently described an important role played by the TGF-beta/Smad3 signaling pathway in modulating the appearance of brown ... We recently described an important role played by the TGF-beta/Smad3 signaling pathway in modulating the appearance of brown ... Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure ... Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity. Mol. Endocrinol. 11, ...
  https://www.frontiersin.org/articles/10.3389/fendo.2012.00035/full
*  Urinary Incontinence Treatment & Management: Approach Considerations, Absorbent Products, Urethral Occlusion
Beta-adrenergic agonists. These agents relax beta-adrenergic receptors that are contained in smooth muscle, such as the bladder ... Steers W, Corcos J, Foote J. An investigation of dose titration with darifenacin, an M3-selective receptor antagonist. BJU Int ... Alpha-adrenergic agonists. Alpha agonists, such as midodrine (Pro-Amatine) or pseudoephedrine (Sudafed), may improve symptoms ... They possess both a central and peripheral anticholinergic effect, as well as being alpha-adrenergic agonists and central ...
  https://emedicine.medscape.com/article/452289-treatment
*  Antaeus Labs Introduces: Lipomorph - AnabolicMinds.com
... beta-adrenergic hormones, retinoids, PPARγ and PPARα agonists, and the liver X receptor.. Exercise and peroxisome proliferator- ... Unlike other beta adrenergic receptors, which are widely distributed about the body, being found in cardiac tissue, skeletal ... 14] Carp n , C., Galitzky, J., Fontana, E., Atgi , C., Lafontan, M., and Berlan, M. (1999). Selective activation of beta3- ... Liver X Receptor Beta (LXRβ). The Kuding in LipoMorph suppresses lipogenesis through antagonism of LXRβ.. * Beta- ...
  http://anabolicminds.com/forum/antaeus-labs/251859-antaeus-labs-introduces.html
*  Arotinolol - Wikipedia
It also acts as a β3 receptor agonist. A 1979 publication suggests arotinolol as having first been described in the scientific ... Zhao, Jin; Golozoubova, Valeria; Cannon, Barbara; Nedergaard, Jan (July 2001). "Arotinolol is a weak partial agonist on beta 3- ... adrenergic receptors in brown adipocytes". Can J Physiol Pharmacol. 79 (7): 585-593. doi:10.1139/cjpp-79-7-585. PMID 11478592. ... Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. ...
  https://en.wikipedia.org/wiki/Arotinolol
*  Beta-adrenergic agonist - Wikipedia
"The beta-adrenergic receptors". Yoo, B.; et al. "Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII ... adrenergic receptor function, response, and regulation". Lowell, B.B.; Flier, J.S. (1997). "Brown adipose tissue, beta 3- ... In general, pure beta-adrenergic agonists have the opposite function of beta blockers. Beta adrenoreceptor agonist ligands ... Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, which widen the airways and result ...
  https://en.wikipedia.org/wiki/Beta-adrenergic_agonist
*  The Pharmacist Activist
Has a unique mechanism of action (a beta-3 adrenergic receptor agonist); * Does not cause anticholinergic adverse events (e.g ... Anticholinergic agents acting as muscarinic receptor antagonists have been the primary treatment and include tolterodine, ... Mirabegron is a beta-3 adrenergic receptor agonist and its activation of these receptors relaxes the detrusor muscle during the ... 3). Many Prescription Medications Should be Available Without a Prescription from a Pharmacist. New Drug Review: Fidaxomicin ( ...
  http://www.pharmacistactivist.com/2012/December_2012.shtml
*  Developing Functional Monoclonal Antibodies for Beta-3 Adrenergic Receptor
... showed that several mAb clones speci cally bound to the receptor while increasing the receptor function by acting as agonists. ... G protein-coupled receptors (GPCRs), one of the most commonly used and successful targets for drugs, are a large family of ... Developing Functional Monoclonal Antibodies for Beta-3 Adrenergic Receptor Poster Sep 10, 2014 ... These cell surface receptors are acted on by a wide variety of ligands, including small molecules and soluble proteins. ...
  https://www.technologynetworks.com/tn/posters/developing-functional-monoclonal-antibodies-for-beta3-adrenergic-receptor-229675
*  Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1...
Liver X receptors (LXRs) are nuclear receptors that heterodimerize with retinoid X receptors (RXRs) and bind to LXR-responsive ... Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with ... We already know that thyroid hormone receptor (TR) and β3-AR agonists can increase thermogenesis (42;43). However, rhein did ... or β3-adrenergic receptor (β3-AR) (Figure 3A). In skeletal muscle, rhein significantly decreased the expression of ACC1, and ...
  http://www.ijbs.com/v08p1375.htm
*  APS is looking for tester for Phenadrine 'Superior Lipolytic Stimulant' - AnabolicMinds.com - Page 2
... unlike beta-2 receptor agonists such as ephedrine that trigger anxiety and irregular heartbeat. As a beta-3-receptor agonist, ... adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr. 2002 Oct;76(4):780-8.. ... Carp n C, Galitzky J, Fontana E, Atgi C, Lafontan M, Berlan M. Selective activation of beta3-adrenoceptors by octopamine: ... It does this by inhibiting the so-called adenosine receptors, leading to higher levels of free adenosine. Now, adenosine, ...
  http://anabolicminds.com/forum/company-promotions/102173-aps-looking-tester-2.html
*  Beta adrenergic receptor kinase-2 - Wikipedia
... kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. ... Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the ... Beta-adrenergic receptor kinase 2 (beta-ARK-2) also known as G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in ... 1991). "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor ...
  https://en.wikipedia.org/wiki/Beta_adrenergic_receptor_kinase-2
*  Adrenergic Receptors
... surface receptors for two major catecholamine hormones and neurotransmitters that regulate key physiological responses, ... Hadcock JR and Malbon CC (1988) Down‐regulation of betaadrenergic receptors: agonist‐induced reduction in receptor mRNA levels ... Shumay E, Gavi S, Wang HY and Malbon CC (2004) Trafficking of beta2‐adrenergic receptors: insulin and betaagonists regulate ... 1996) The betaadrenergic receptor is a substrate for the insulin receptor tyrosine kinase. Journal of Biological Chemistry 271 ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0000005.html
*  Frontiers | The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series | Medicine
Propranolol, a non-selective beta-adrenergic antagonist with good penetration of the blood brain barrier, has not been ... Propranolol, a non-selective beta-adrenergic antagonist with good penetration of the blood brain barrier, has not been ... Introduction Recent studies have examined the effectiveness of alpha-2-adrenergic agonists for controlling delirium and ... IntroductionRecent studies have examined the effectiveness of alpha-2-adrenergic agonists for controlling delirium and ...
  https://www.frontiersin.org/articles/10.3389/fmed.2017.00044/full
*  41st week of 2009 patent applcation highlights part 42
... are antagonists/inverse agonists of the human ghrelin receptor. They are therefore useful for the treatment, control, or ... and their exogenous agonists, of neuronal cholinergic receptors and/or acting as cholinesterase inhibitors and/or ... HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), ... There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium ...
  http://www.patentsencyclopedia.com/hgl/10-08-09/10-08-09_42
*  Lecture 26: CV effects of Autonomic ANTAGONIST drugs Flashcards - Cardio Week 3 | Brainscape
B-blockers with ISA are partial agonists that may produce blocked by shielding receptors from more potent agonists. 3. lipid ... What are the classification schemes for beta adrenergic antagonists? 1. Beta1 selectivity. -B2 blockers can cause ... Alpha 1 receptor antagonist >> alpha 2 antagonist. Results in decreased SVR and decreased blood pressure. Inhibition of ... 4. Raynaud phenomenon (beta-blockers would reduce blood flow to already blue tissue lol). 5. Symptomatic peripheral vascular ...
  https://www.brainscape.com/flashcards/lecture-26-cv-effects-of-autonomic-antago-1247680/packs/2392386
*  Norepinephrine Directly Activates Adult Hippocampal Precursors via β3-Adrenergic Receptors | Journal of Neuroscience
1998) Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci ... 5.) beta3-AR selectivity of BRL37,344. Finally Jhaveri et al. used BRL37,344 (1 and 10 µM) as a selective beta3-AR agonist, but ... To study the influence of β-adrenergic receptor stimulation on adult hippocampal progenitors, the β-adrenergic receptor agonist ... A, Neither the α1-adrenergic receptor antagonist prazosin nor the α2-adrenergic receptor blocker yohimbine had any effect on ...
  http://www.jneurosci.org/content/30/7/2795
*  Receptors/Ligands/CNS Flashcards by I M | Brainscape
Study Receptors/Ligands/CNS flashcards from I M ... which receptor does not react to neorepinephrine?. Beta 2 ... adrenergic and cholinergic nerve terminals → inhibits NE release → inhibits sympathetic outflow → decerased BP and HR ... 5-hydroxytryptamine receptors or 5-HT receptors. there are at least 14 subtypes - different kinds of receptors, different ...
  https://www.brainscape.com/flashcards/receptors-ligands-cns-4846616/packs/7055189
*  Quiz 1 Flashcards by Clare Burchenal | Brainscape
Direct adrenergic stimulation of JG cells via beta adrenergic receptors 37 ... 2. sympathetic stimulation - beta receptors 3. decreased Na load as sensed by the macula densa ... 2. Urea --> interstitium of inner medulla (UTA1, UTA3) 3. H2O: thin descending limb --> interstitium (AQP1) 4. NaCl thin ... angiotensin receptor antagonists/ACE inhibitors - •mineralocorticoid receptor blockers 21 summary of diuretics ...
  https://www.brainscape.com/flashcards/quiz-1-6710904/packs/10667550
*  Beta-3 adrenergic receptor - Wikipedia
"Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic ... selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog". ... is a beta-adrenergic receptor, and also denotes the human gene encoding it. Actions of the β3 receptor include Enhancement of ...
  https://en.wikipedia.org/wiki/Beta-3_adrenergic_receptor
*  Beta-2 adrenergic receptor - Wikipedia
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... ISBN 0-443-07145-4. Philipson, L. H. (December 2002). "beta-Agonists and metabolism". The Journal of Allergy and Clinical ... The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor ... "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ...
  https://en.wikipedia.org/wiki/Beta-2_adrenergic_receptor
*  Adrenergic receptor - Wikipedia
... a Gq coupled receptor) and α2 (a Gi coupled receptor). Phenylephrine is a selective agonist of the α receptor. β receptors have ... Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 Cannon WB, Rosenbluth A (31 May 1933). "Studies On Conditions ... Basic Neurochemistry: α- and β-Adrenergic Receptors Brief overview of functions of the β3 receptor Theory of receptor ... ISBN 0-443-06911-5. Alpha receptors illustrated The Adrenergic Receptors "Adrenoceptors". IUPHAR Database of Receptors and Ion ...
  https://en.wikipedia.org/wiki/Adrenergic_receptor
*  G protein-coupled receptor - Wikipedia
"The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into ... Rubenstein LA, Lanzara RG (1998). "Activation of G protein-coupled receptors entails cysteine modulation of agonist binding". ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors ( ... "The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor". Nature. 469 (7329): 241-4. doi: ...
  https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor
*  ICI-118,551 - Wikipedia
"Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic ... Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed ... ICI-118,551 is a selective β2 adrenergic receptor (adrenoreceptor) antagonist. ICI binds to the β2 subtype with at least 100 ... "A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors". Journal ...
  https://en.wikipedia.org/wiki/ICI-118,551
*  Discovery and development of beta-blockers - Wikipedia
β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the ... β1-receptors are located in the heart and consist of about 75% of all β-receptors. β2-receptors can be found in the smooth ... partial adrenergic agonist activity (pindolol), concomitant α-adrenergic blocking activity (for example labetalol and ... β-blockers can be selective for either β1, β2 adrenergic receptor, or to be non-selective. By blocking β1 receptor it is ...
  https://en.wikipedia.org/wiki/Discovery_and_development_of_beta-blockers
*  GPCR oligomer - Wikipedia
Limbird LE, Meyts PD, Lefkowitz RJ (June 1975). "Beta-adrenergic receptors: evidence for negative cooperativity". Biochem. ... "A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers". Proc. Natl. Acad. Sci. U.S.A. ... and hetero-oligomerization of β2-adrenergic receptor in receptor trafficking, signaling pathways and receptor pharmacology". ... "The size of the mammalian lung beta 2-adrenergic receptor as determined by target size analysis and immunoaffinity ...
  https://en.wikipedia.org/wiki/GPCR_oligomer