*  The Chediak-Higashi Syndrome: Studies of Host Defenses | Annals of Internal Medicine | American College of Physicians
A striking clinical feature of the Chediak-Higashi syndrome (CHS) is a markedly increased susceptibility to pyogenic infections. Recent investigations have documented multiple defects in host defenses in patients with the syndrome. Neutropenia, a characteristic finding, is most likely related to intramedullary destruction of granulocytes. Defective leukocyte migration has been found in vivo by the skin window technique, and a cellular defect in Chemotaxis has been documented in vitro. Although phagocytosis is quantitatively normal, there is a failure in postphagocytic degranulation, as well as diminished intracellular bactericidal capacity, findings that may be related to ineffective delivery of lysosomal contents to the phagocytic vacuole. An abnormal distribution and reduced quantities of lysosomal enzymes have been shown. Some or all of these deficiencies in leukocyte regulation, structure, and function may contribute to the increased susceptibility to ...
*  A skin chamber to investigate wound infection and healing in the mouse - Murdoch Research Repository
The development of a simple, convenient, and reliable polypropylene screw-capped skin chamber, which can be inserted into mice, is described. All implanted chambers of normal immuno-competent mice (n ≤ 10), or immuno-suppressed mice (n ≤ 10) remained in-situ for 15 days. Wound infection was established by a clinical isolate of Pseudomonas aeruginosa in immuno-competent mice (n ≤ 10) 1 day after chamber implantation and chambers remained in-situ for 10 days. Similar infections of wounds among mice immuno-suppressed with cyclophosphamide resulted in the mouse becoming moribund due to systemic invasion by the bacterium. The authors conclude that this mouse skin chamber will be of potential value for studying wound healing during the inflammatory and early proliferative phases, and the influence of infection and treatments on these processes in immuno-suppressed and immuno-competent mice.. ...
*  Plus it
Vascular hyperpermeability and excessive neovascularization are hallmarks of early and late vascular endothelial cell dysfunction induced by diabetes. Vascular endothelial growth factor (VEGF) appears to be an important mediator for these early and late vascular changes. We reported previously, using skin chambers mounted on backs of SD rats, that neutralizing antibodies directed against VEGF blocked vascular permeability and blood flow changes induced by elevated tissue glucose and sorbitol levels in a dosage-dependent manner. We report in this study, using the same skin chamber model and neutralizing antibodies directed against basic fibroblast growth factor (FGF-2), that another member of the heparin-binding growth factor family also mediates glucose- and sorbitol-induced vascular permeability and blood flow increases. In addition, we show that 1) TBC1635, a novel heparin-binding growth factor antagonist, blocks the vascular hyperpermeability and blood flow increases ...
*  LOX-DB - LipOXygenases DataBase - Literature
Although cigarette smoke (CS) has been identified as an independent risk factor for atherogenesis and sudden cardiac death, the underlying pathomechanism has not been clarified. A common factor of both atherogenesis and ischemia/reperfusion damage associated with myocardial infarction is the adhesion of circulating leukocytes to the vascular endothelium. Searching for the mechanism by which CS exerts its deleterious effects on the cardiovascular system, we used a dorsal skinfold chamber model in hamsters for intravital microscopy to examine the effect of CS on the interaction of fluorescently stained leukocytes with the microvascular endothelium in striated muscle. Exposure of awake animals (n = 7) for 5 minutes to the mainstream smoke of one cigarette (2R1 research cigarette) elicited rolling and subsequent adhesion of circulating leukocytes to the endothelium of both arterioles and postcapillary venules with a maximum 30 minutes after CS-exposure. In order to test a putative mediator role ...
*  In vivo characterization of the integration and vascularization of a silk-derived surgical scaffold | The Interface Group
SERI® Surgical Scaffold was implanted into a full-thickness skin defect in male C57BL/6J mice (n=45) via the dorsal skinfold chamber (DSC). Skin tissue samples were collected for histology on days 2, 5, 7, 10, 14, and 21 (n=5 per time point) post implantation. Immunohistochemistry was performed for various angiogenic and inflammatory markers, as well as collagen deposition (CD31, VEGF, CD3, CD45, Desmin, and Sirius red). Vascular corrosion casting was used to assess the neovasculature within the silk and was visualized with scanning electron microscopy.. Results ...
*  Patrón estacional de crecimiento radical en relación a la fenología aérea y temperatura de suelo en árboles de cerezo dulce ...
Introduction. The root system serves diverse functions, including anchorage and water and nutrient uptake. The absorptive portion of the root system is associated with the fine lateral roots, which may be replaced several times per year and represent the most dynamic portion of the root system (Comas et al., 2002). There is no information about root growth patterns for many woody plants, including cherry trees (Prunus avium L.). This information is important for the optimization of soil and nutrient management. However, studies on root systems are scarce because most of the methods used are extremely time-consuming, tedious, and destructive, particularly in large perennial plants such as fruit trees. In general terms, there are five approaches for root growth studies, including whole tree excavation, root sampling methods, observation windows (rhizotrons), root activity measurements, and indirect methods (Black et al., 2010). The observation window technique ...
*  December 2013 | Free Utilities Evaluation and Reviews
While most of the 2013 holidays freebies are for Windows users, Mac fans may also benefit from the promotional giveaways. I would like to present a Christmas giveaway with BlazeVideo Video Converter Pro for Mac. As a leading video converter for Mac, it is capable of converting most videos to popular formats like MKV, MPEG, ASF, AVI, Divx, MOV, FLV, MP4, WMV, WebM, Xvid and more. This Christmas gift is good at converting and enhancing nearly all HD/SD videos on Mac screen to make them playable on iPhone 5S/5C, iPad Air, iPad Mini, Samsung Galaxy S4, Galaxy Note 10.1, HTC One, Google new Nexus 7, etc. for playback on iPhone, iPad, iPod, PSP, Android/Windows cell phone, etc ...
*  The degradation of KCa3.1 in FRT polarised epithelium
The intermediate conductance calcium activated potassium channel (KCa3.1) has a prominent role in numerous physiological functions, and has recently emerged as the main therapeutic target for many disorders and diseases ranging from lymphoma to Alzheimer's disease. Much is known about the physiology and pharmacology of this channel, but how the numbers of the channel are regulated at the cell surface remains elusive today. Previous studies aimed to unravel the degradation pathway of KCa3.1 are predominantly based on non-polarised models, as KCa3.1 is widely expressed in polarised epithelial tissues, it is likely that the degradation pathway can present different patterns. In this study, I investigated the key molecular components that regulate the degradation of KCa3.1 using polarised epithelium generated by Fisher rat thyroid (FRT) cells stably expressing KCa3.1. Using immunoblot and Ussing chamber techniques, I demonstrated that KCa3.1 is degraded via an ubiquitin ...
*  Tux Paint - Pobieranie - Windows
which you can double-click to begin the installation process.. Compatibility note: This version of Tux Paint is for modern Windows systems, including: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 8, and Windows 10. If you're using an older version of Windows (Windows95, Windows98 and WindowsME), you can download this version of Tux Paint for older Windows.. Tux Paint for Windows comes as two parts, the main program and the optional add-on 'stamps' collection.. (If you would prefer not to install Tux Paint onto your Windows system, you can instead use the Tux Paint ZIP-file, which runs from within its own folder. This is also known as a "Portable" version.). ...
*  Windows 10 and Outlook - HowTo-Outlook
If you are running Windows 8 but haven't upgraded to Windows 8.1 yet, then you won't be offered to upgrade to Windows 10 in Windows Update. However, when you have the Windows 10 installation media, you can still start that within Windows 8 and upgrade to Windows 10 without losing any of your Windows settings, personal files or apps.. When doing an in-place upgrade, it will automatically run the Windows 10 Upgrade Assistant (which is not yet available as a standalone tool for Windows 10). This tool will indicate which drivers and applications you need to uninstall or update before or after the installation process. This will increase the speed of the upgrade, its chance of success and decrease the chance of ending up with broken applications or other troubleshooting requirements.. A common application that you'll need to uninstall on ...
*  Polygon Class (System.Windows.Shapes)
Add the Polygon Element myPolygon = new Polygon(); myPolygon.Stroke = System.Windows.Media.Brushes.Black; myPolygon.Fill = System.Windows.Media.Brushes.LightSeaGreen; myPolygon.StrokeThickness = 2; myPolygon.HorizontalAlignment = HorizontalAlignment.Left; myPolygon.VerticalAlignment = VerticalAlignment.Center; System.Windows.Point Point1 = new System.Windows.Point(1, 50); System.Windows.Point Point2 = new System.Windows.Point(10,80); System.Windows.Point Point3 = new System.Windows.Point(50,50); PointCollection myPointCollection = new PointCollection(); myPointCollection.Add(Point1); myPointCollection.Add(Point2); myPointCollection.Add(Point3); myPolygon.Points = myPointCollection; myGrid.Children.Add(myPolygon ...
*  Windows 8.1 Update important refinements to the Windows
As Joe mentioned here, today we re announcing two important updates to the Windows platform: Windows Phone 8.1 and Windows 8.1 Update. With these upda
*  13.9. Emulating Windows: Wine
drive at where the Windows partition is mounted in Debian, as Wine is likely to overwrite some of the data on that partition, making Windows unusable. Other settings can be kept to their default values. To run Windows programs, you will first need to install them by running their (Windows) installer under Wine, with a command such as ...
*  An Open and Honest Review of the HTC Arrive & Windows Phone 7 - PPCGeeks
--> To begin, I am/was a 'fanboy' of Windows and Windows Mobile. My first 'smartphone' was the Toshiba 2032 running Windows Mobile
*  Which windows updates do I avoid on win 7 to avoid windows 10 adware? - Windows 7 Help Forums
Which of these updates do I need to avoid in order to not get the 'upgrade to windows 10!!!!' adware installed again? I currently don't have it installed (I had to go through a lot to get it
*  3 Ways to Make Window Clings - wikiHow
How to Make Window Clings. Window clings are a fun way to decorate your windows for the holidays and other occasions. They are easy to peel off, rearrange, and replace. Unfortunately, store-bought ones don't come in a lot of designs, and...
*  Windows 8 Pro フリーセルやっとできたが?!: デジログ
windows 8 Pro デスクトップ タッチパネル無しで、ようやくフリーセルができるようになったが、動作が遅い!!. windows 7 Ultimate に搭載されている、フリーセルとはスピードが全く違うのだ。こちらは32bitで、windows 8 Proは64bitでデュアルブートのマシンなので、ハードの面では問題ないと思うのだが、どうも腑に落ちない気持ちちである。. そして、すぐにプレミアムアップグレードをと要求される。その中身は広告が表示されなくなるだけで、お金 ...
*  Windows Help Information | Pearltrees
800-760-5113-Windows 10 Update Technical Support Phone Number. 800-760-5113-Windows 10 Upgrade Technical Support Phone Number. Windows 8.1 Support. Web Notes
*  0x80070570 Error Code on install - One Easy Solution - Windows 7 Help Forums
If you just want the solution page down .. it's in this blue New shiny windows 7 disk arrives. ...... doesn't want to install ... keep getting error message 0x80070570 when Windows 7 is expanding file
*  Black Screen of Death - Windows 7 Help Forums
Hello, here is my first post for ask for help here: I have a problem with my Windows 7 Professional X64. I went back from my vacactions and now, when i tried to initialize windows 7, it only shows the
*  Lenovo Y410 not booting with Bootable USB - Install Windows from USB - MSFN
Hi All,I have window vista and I am trying to replace it with Window7. I have a bootable USB and used the tool poweriso to create bootable usb drive(from wi...
*  Dell 5510/5520 and 1709 BSOD - Windows 10 - Spiceworks
It's noticed more on the Dell 5510 laptopsWe are having an issue with BSOD's in the office. Don't know where to s... | 11 replies | Windows 10 and Dell Hardware
*  DataGridView.GetCellCount Method (DataGridViewElementStates) (System.Windows.Forms)
The following code example illustrates how to use this method to determine whether there are any cells selected in a DataGridView control. In this example, if any cells are selected, their values are retrieved through the GetClipboardContent method and displayed in a TextBox control.. This code is part of a larger example illustrating the use of the Clipboard features of the DataGridView control. This example is part of a larger example available in How to: Enable Users to Copy Multiple Cells to the Clipboard from the Windows Forms DataGridView Control.. ...
*  RoseWill BlackHawk Window mod | TechPowerUp Forums
Cut out stock side panel and make a window with 3 fans in it. 3D this is not my case. my first paid job :D stock...